choline has been researched along with Cardiac Failure in 32 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)." | 8.02 | Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021) |
| "We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using 16S rRNA gene amplicon analysis." | 8.02 | Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. ( Emoto, T; Gotoh, Y; Hayashi, T; Hirata, KI; Kami, K; Matsumoto, K; Saito, Y; Tabata, T; Takahashi, T; Tanaka, H; Watanabe, H; Yamada, T; Yamashita, T; Yoshida, N, 2021) |
| "A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling." | 7.96 | High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. ( Li, X; Li, Y; Shuai, W; Wang, D; Wen, J; Xiang, J, 2020) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 7.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "A panel of gut-related biomarkers including metabolites of the choline/carnitine- pathway (acetyl-L-carnitine, betaine, choline, γ-butyrobetaine, L-carnitine and trimethylamine-N-oxide [TMAO]) and the gut peptide, Trefoil factor-3 (TFF-3), were investigated in 1,783 patients with worsening HF enrolled in the systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) cohort and associations with HF severity and outcomes, and use in risk stratification were assessed." | 4.12 | Surrogate markers of gut dysfunction are related to heart failure severity and outcome-from the BIOSTAT-CHF consortium. ( Anker, SD; Cleland, JG; Israr, MZ; Lang, CC; Metra, M; Ng, LL; Salzano, A; Samani, NJ; Suzuki, T; van Veldhuisen, DJ; Voors, AA; Zannad, F; Zhan, H, 2022) |
| "Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)." | 4.02 | Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021) |
| "Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes." | 4.02 | Association of gut-related metabolites with outcome in acute heart failure. ( Bernieh, D; Cassambai, S; Heaney, LM; Israr, MZ; Jones, DJL; Ng, LL; Salzano, A; Suzuki, T; Yazaki, Y, 2021) |
| "We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using 16S rRNA gene amplicon analysis." | 4.02 | Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. ( Emoto, T; Gotoh, Y; Hayashi, T; Hirata, KI; Kami, K; Matsumoto, K; Saito, Y; Tabata, T; Takahashi, T; Tanaka, H; Watanabe, H; Yamada, T; Yamashita, T; Yoshida, N, 2021) |
| "Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine." | 3.96 | Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure. ( Goodchild, TT; Gupta, N; Hazen, SL; Lefer, DJ; Li, Z; Organ, CL; Polhemus, DJ; Sharp, TE; Tang, WHW, 2020) |
| "A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling." | 3.96 | High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. ( Li, X; Li, Y; Shuai, W; Wang, D; Wen, J; Xiang, J, 2020) |
| "To determine if differences exist in plasma concentrations of TMAO, choline, or l-carnitine among dogs with DMVD and congestive heart failure (CHF), dogs with asymptomatic DMVD, and healthy control dogs." | 3.91 | A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure. ( Freeman, LM; Karlin, ET; Rush, JE, 2019) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 3.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| " Thirty-nine dogs were divided into five groups: rapid atrial pacing (RAP), chronic mitral regurgitation (MR), congestive heart failure (CHF), methylcholine (Meth), and control." | 3.73 | Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling. ( Everett, TH; Foreman, S; Guerra, JM; Olgin, JE; Verheule, S; Wilson, EE, 2006) |
| "Choline was not a marker for myocardial necrosis but indicated high-risk unstable angina in patients without acute myocardial infarction (sensitivity 86." | 1.32 | Prognostic implications of elevated whole blood choline levels in acute coronary syndromes. ( Danne, O; Frei, U; Lueders, C; Lufft, H; Möckel, M; Mügge, C; Müller, C; Zschunke, GA, 2003) |
| "The creatine level was independently correlated with half-recovery time and duration of heart failure symptoms in PWM (r = -0." | 1.30 | Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy. ( Hong, MK; Kim, JJ; Kim, ST; Lee, CW; Lee, JH; Lim, TH; Park, SJ; Park, SW, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (28.13) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 13 (40.63) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, S | 1 |
| Wang, Y | 1 |
| Zhang, W | 1 |
| Shang, H | 1 |
| Bin-Jumah, MN | 1 |
| Gilani, SJ | 1 |
| Hosawi, S | 1 |
| Al-Abbasi, FA | 1 |
| Zeyadi, M | 1 |
| Imam, SS | 1 |
| Alshehri, S | 1 |
| Ghoneim, MM | 1 |
| Nadeem, MS | 1 |
| Kazmi, I | 1 |
| Israr, MZ | 3 |
| Zhan, H | 1 |
| Salzano, A | 3 |
| Voors, AA | 1 |
| Cleland, JG | 1 |
| Anker, SD | 1 |
| Metra, M | 1 |
| van Veldhuisen, DJ | 1 |
| Lang, CC | 1 |
| Zannad, F | 1 |
| Samani, NJ | 1 |
| Ng, LL | 2 |
| Suzuki, T | 3 |
| Cassambai, S | 2 |
| Yazaki, Y | 2 |
| Bernieh, D | 2 |
| Wong, M | 1 |
| Wargny, M | 1 |
| Croyal, M | 1 |
| Ragot, S | 1 |
| Gand, E | 1 |
| Jacobi, D | 1 |
| Trochu, JN | 1 |
| Prieur, X | 1 |
| Le May, C | 1 |
| Goronflot, T | 1 |
| Cariou, B | 1 |
| Saulnier, PJ | 1 |
| Hadjadj, S | 1 |
| Yoshida, Y | 2 |
| Shimizu, I | 1 |
| Shimada, A | 1 |
| Nakahara, K | 1 |
| Yanagisawa, S | 1 |
| Kubo, M | 1 |
| Fukuda, S | 1 |
| Ishii, C | 1 |
| Yamamoto, H | 1 |
| Ishikawa, T | 1 |
| Kano, K | 1 |
| Aoki, J | 1 |
| Katsuumi, G | 1 |
| Suda, M | 1 |
| Ozaki, K | 1 |
| Okuda, S | 1 |
| Ohta, S | 1 |
| Okamoto, S | 1 |
| Minokoshi, Y | 1 |
| Oda, K | 1 |
| Sasaoka, T | 1 |
| Abe, M | 1 |
| Sakimura, K | 1 |
| Kubota, Y | 1 |
| Yoshimura, N | 1 |
| Kajimura, S | 1 |
| Zuriaga, M | 1 |
| Walsh, K | 1 |
| Soga, T | 1 |
| Minamino, T | 1 |
| Organ, CL | 2 |
| Li, Z | 1 |
| Sharp, TE | 1 |
| Polhemus, DJ | 2 |
| Gupta, N | 1 |
| Goodchild, TT | 1 |
| Tang, WHW | 1 |
| Hazen, SL | 2 |
| Lefer, DJ | 2 |
| Shuai, W | 1 |
| Wen, J | 1 |
| Li, X | 1 |
| Wang, D | 1 |
| Li, Y | 1 |
| Xiang, J | 1 |
| Esposito, G | 1 |
| Schiattarella, GG | 1 |
| Papandreou, C | 1 |
| Bulló, M | 1 |
| Hernández-Alonso, P | 1 |
| Ruiz-Canela, M | 1 |
| Li, J | 1 |
| Guasch-Ferré, M | 1 |
| Toledo, E | 1 |
| Clish, C | 1 |
| Corella, D | 1 |
| Estruch, R | 1 |
| Ros, E | 1 |
| Fitó, M | 1 |
| Alonso-Gómez, A | 1 |
| Fiol, M | 1 |
| Santos-Lozano, JM | 1 |
| Serra-Majem, L | 1 |
| Liang, L | 1 |
| Martínez-González, MA | 1 |
| Hu, FB | 1 |
| Salas-Salvadó, J | 1 |
| Heaney, LM | 1 |
| Jones, DJL | 1 |
| Emoto, T | 1 |
| Hayashi, T | 2 |
| Tabata, T | 1 |
| Yamashita, T | 1 |
| Watanabe, H | 1 |
| Takahashi, T | 1 |
| Gotoh, Y | 1 |
| Kami, K | 1 |
| Yoshida, N | 1 |
| Saito, Y | 1 |
| Tanaka, H | 1 |
| Matsumoto, K | 1 |
| Yamada, T | 1 |
| Hirata, KI | 1 |
| Wei, H | 1 |
| Zhao, M | 1 |
| Huang, M | 1 |
| Li, C | 1 |
| Gao, J | 1 |
| Yu, T | 1 |
| Zhang, Q | 1 |
| Shen, X | 1 |
| Ji, L | 1 |
| Ni, L | 1 |
| Zhao, C | 1 |
| Wang, Z | 2 |
| Dong, E | 1 |
| Zheng, L | 1 |
| Wang, DW | 1 |
| Karlin, ET | 1 |
| Rush, JE | 1 |
| Freeman, LM | 1 |
| SANDRI, A | 1 |
| Woo, MA | 1 |
| Yadav, SK | 1 |
| Macey, PM | 1 |
| Fonarow, GC | 1 |
| Harper, RM | 1 |
| Kumar, R | 1 |
| Trøseid, M | 1 |
| Ueland, T | 1 |
| Hov, JR | 1 |
| Svardal, A | 1 |
| Gregersen, I | 1 |
| Dahl, CP | 1 |
| Aakhus, S | 1 |
| Gude, E | 1 |
| Bjørndal, B | 1 |
| Halvorsen, B | 1 |
| Karlsen, TH | 1 |
| Aukrust, P | 1 |
| Gullestad, L | 1 |
| Berge, RK | 1 |
| Yndestad, A | 1 |
| Otsuka, H | 1 |
| Bhushan, S | 1 |
| Bradley, J | 1 |
| Trivedi, R | 1 |
| Tang, WH | 1 |
| Wu, Y | 1 |
| Danne, O | 1 |
| Möckel, M | 1 |
| Lueders, C | 1 |
| Mügge, C | 1 |
| Zschunke, GA | 1 |
| Lufft, H | 1 |
| Müller, C | 1 |
| Frei, U | 1 |
| GOVIER, WM | 1 |
| FREYBURGER, WA | 1 |
| GIBBONS, AJ | 1 |
| HOWES, BG | 1 |
| SMITS, E | 1 |
| PEARSON, S | 1 |
| HAAR, H | 1 |
| BROH-KAHN, RH | 1 |
| McGAVACK, TH | 1 |
| BATTERMAN, RC | 2 |
| GROSSMAN, AJ | 1 |
| BLACKMAN, AL | 2 |
| BROOKS, AM | 1 |
| SCHWIMMER, J | 2 |
| CROSSMAN, AJ | 1 |
| PELECH, JT | 1 |
| VALERIO, VM | 1 |
| FROLLO, A | 1 |
| Lee, CW | 3 |
| Lee, JH | 3 |
| Yang, HS | 2 |
| Lim, KH | 1 |
| Ahn, JM | 1 |
| Hong, MK | 3 |
| Park, SW | 3 |
| Park, SJ | 3 |
| Song, MG | 1 |
| Kim, JJ | 3 |
| Everett, TH | 1 |
| Wilson, EE | 1 |
| Verheule, S | 1 |
| Guerra, JM | 1 |
| Foreman, S | 1 |
| Olgin, JE | 1 |
| SPADOLINI, I | 1 |
| Al-Damluji, S | 1 |
| Nathan, AW | 1 |
| Johnston, A | 1 |
| Banim, SO | 1 |
| Spurrell, RA | 1 |
| Camm, AJ | 1 |
| Kim, ST | 1 |
| Lim, TH | 2 |
| Malloy, CR | 1 |
| Song, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| GutHeart: Targeting Gut Microbiota to Treat Heart Failure[NCT02637167] | Phase 2 | 150 participants (Anticipated) | Interventional | 2016-03-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for choline and Cardiac Failure
| Article | Year |
|---|---|
Trimethylamine oxide: a potential target for heart failure therapy.
Topics: Cardiotonic Agents; Carnitine; Choline; Diuretics; Gastrointestinal Microbiome; Heart Failure; Human | 2022 |
Pathobiological Relationship of Excessive Dietary Intake of Choline/L-Carnitine: A TMAO Precursor-Associated Aggravation in Heart Failure in Sarcopenic Patients.
Topics: Biodiversity; Biomarkers; Carnitine; Choline; Dietary Supplements; Disease Susceptibility; Dysbiosis | 2021 |
The Gut Axis Involvement in Heart Failure: Focus on Trimethylamine N-oxide.
Topics: Choline; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines | 2022 |
1 trial available for choline and Cardiac Failure
| Article | Year |
|---|---|
Prognostic significance of cerebral metabolic abnormalities in patients with congestive heart failure.
Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Female; Follow-Up Studies | 2001 |
28 other studies available for choline and Cardiac Failure
| Article | Year |
|---|---|
Surrogate markers of gut dysfunction are related to heart failure severity and outcome-from the BIOSTAT-CHF consortium.
Topics: Acetylcarnitine; Biomarkers; Carnitine; Choline; Chronic Disease; Heart Failure; Humans | 2022 |
Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort.
Topics: Aged; Betaine; Biomarkers; Carnitine; Choline; Cohort Studies; Cysteine; Diabetes Mellitus, Type 2; | 2022 |
Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.
Topics: Adipocytes, Brown; Adipose Tissue, Brown; Animals; Choline; Heart Failure; Methylamines; Mice; Myoca | 2022 |
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Down-Regulation; Enzyme Inhi | 2020 |
High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction.
Topics: Animals; Choline; Diet; Fibrosis; Heart Failure; Humans; Inflammation; Mice; Mice, Inbred C57BL; Str | 2020 |
Feeding Diastolic Dysfunction: Is It a Bug?
Topics: Animals; Choline; Diet; Fibrosis; Heart Diseases; Heart Failure; Inflammation; Mice; Stroke Volume | 2020 |
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.
Topics: Aged; Atrial Fibrillation; Betaine; Carnitine; Case-Control Studies; Choline; Female; Heart Failure; | 2021 |
Association of gut-related metabolites with outcome in acute heart failure.
Topics: Acetylcarnitine; Acute Disease; Aged; Aged, 80 and over; Betaine; Carnitine; Choline; Female; Gastro | 2021 |
Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure.
Topics: Choline; Gastrointestinal Microbiome; Heart Failure; Humans; Metagenome; Methylamines; RNA, Ribosoma | 2021 |
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population.
Topics: Carnitine; Choline; Chronic Disease; Heart Failure; Humans; Methylamines; Oxygenases; Prospective St | 2022 |
A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure.
Topics: Animals; Carnitine; Case-Control Studies; Choline; Cross-Sectional Studies; Dog Diseases; Dogs; Echo | 2019 |
[Use of lipotropic factors in the therapy of chronic cardiac insufficiency].
Topics: Choline; Heart Failure; Humans; Lipotropic Agents | 1950 |
Brain metabolites in autonomic regulatory insular sites in heart failure.
Topics: Adult; Autonomic Nervous System; Cerebral Cortex; Choline; Creatine; Female; Heart Failure; Humans; | 2014 |
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.
Topics: Aged; Betaine; Biomarkers; Choline; Chronic Disease; Female; Heart Failure; Humans; Intestinal Mucos | 2015 |
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi | 2016 |
Prognostic implications of elevated whole blood choline levels in acute coronary syndromes.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Arrhythmias, Cardiac; Biomarkers; Choline; Female; | 2003 |
The relation of the choline cycle to cardiac decompensation; acetylcholine metabolism in the dog heart-lung preparation.
Topics: Acetylcholine; Animals; Choline; Dogs; Heart; Heart Failure; Humans | 1953 |
The inhibition by choline theophyllinate of water retention induced by pitressin.
Topics: Arginine Vasopressin; Choline; Heart Failure; Theophylline; Vasopressins | 1954 |
Choline theophyllinate, a new xanthine drug for the effective oral treatment of congestive heart failure; a preliminary report.
Topics: Choline; Heart Failure; Humans; Theophylline; Treatment Outcome; Xanthine; Xanthines | 1954 |
Treatment of congestive heart failure and anginal syndrome with choline theophyllinate.
Topics: Angina Pectoris; Choline; Heart Failure; Humans; Theophylline | 1955 |
Management of chronic congestive failure and angina pectoris in geriatric patients with choline theophyllinate.
Topics: Aged; Angina Pectoris; Choline; Disease Management; Heart Failure; Humans; Lung Diseases; Theophylli | 1957 |
[Clinical observations on the therapeutic use of choline theophyllinate].
Topics: Choline; Coronary Disease; Heart Failure; Humans; Hypertension; Theophylline | 1959 |
Effects of heart transplantation on cerebral metabolic abnormalities in patients with congestive heart failure.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Heart Failure; Heart Transplantation; Humans | 2006 |
Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling.
Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Function, Left; Atrial Function, Right; C | 2006 |
Graduated reactions and maximal reactions (T. or N.) in the ventricular myocardium of amphibians in relation to the release of neurohormone factors (acetylcholine)
Topics: Choline; Heart Failure | 1949 |
Oral theophylline in chronic heart failure.
Topics: Choline; Heart Failure; Heart Function Tests; Humans; Male; Theophylline; Time Factors | 1982 |
Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Echocardiography, Doppler; Exercise Test; | 1999 |
Correlation of cerebral metabolites with clinical outcome among patients with severe congestive heart failure.
Topics: Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Heart Failure; Hu | 2001 |