choline has been researched along with Carcinoma, Ehrlich Tumor in 34 studies
Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-N,N-Dimethylamiloride protects Ehrlich ascites tumor cells against the antiproliferative effect of nitrogen mustard." | 1.27 | Protection of Ehrlich ascites tumor cells against the antiproliferative effect of mechlorethamine (nitrogen mustard) by 5-N,N-dimethylamiloride. ( Doppler, W; Grunicke, HH; Hofmann, J; Maly, K, 1988) |
| "2." | 1.25 | Phosphorylation of choline and ethanolamine in Ehrlich ascites-carcinoma cells. ( Johnstone, RM; Sung, CP, 1967) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (97.06) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SZENDE, B | 1 |
| ANGELES, LT | 1 |
| SCHUELER, FW | 1 |
| LIM, PR | 1 |
| SOTTO, A | 1 |
| MARUYAMA, M | 1 |
| UCHIDA, M | 1 |
| Bowen, JW | 1 |
| Levinson, C | 1 |
| Smith, TC | 1 |
| Robinson, SC | 1 |
| Hara, T | 1 |
| Kosaka, N | 1 |
| Kishi, H | 1 |
| Johnstone, RM | 8 |
| Kilberg, MS | 1 |
| Christensen, HN | 2 |
| Handlogten, ME | 2 |
| Khmelevskiĭ, OV | 1 |
| Khmelevskiĭ, VI | 1 |
| Haeffner, EW | 4 |
| Ritter, C | 1 |
| Rutman, RJ | 1 |
| Lambert, IH | 1 |
| Hoffmann, EK | 1 |
| Christensen, P | 1 |
| Doppler, W | 2 |
| Hofmann, J | 2 |
| Maly, K | 2 |
| Grunicke, HH | 1 |
| Grunicke, H | 1 |
| McCormick, JI | 1 |
| Silvius, JR | 1 |
| De Cespedes, C | 1 |
| Ronquist, G | 1 |
| Mayer, D | 1 |
| Werner, D | 1 |
| Sung, CP | 2 |
| Rutz, K | 1 |
| Rosenberg, HM | 1 |
| Shank, BB | 1 |
| Gregg, EC | 1 |
| McClellan, WM | 1 |
| Schafer, JA | 1 |
| Colombini, M | 1 |
| Fishman, PH | 1 |
| Bailey, JM | 1 |
| Rytter, DJ | 1 |
| Cornatzer, WE | 1 |
| Reid, WD | 1 |
| Haubrich, DR | 1 |
| Krishna, G | 1 |
| Jacquez, JA | 1 |
| Sherman, JH | 1 |
| Terris, J | 1 |
| Sinclair, AJ | 1 |
| Donisch, V | 1 |
| Rossiter, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Value of [18]Fluoroethylcholine Positron-Emission-Tomography Combined With Endorectal Magnetic Resonance Imaging by Software Fusion for Pre-therapeutic Staging of Prostate Cancer[NCT00520546] | Phase 3 | 44 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
PET positive lesions (n=128) were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative and positive predictive values were determined. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI
| Intervention | lesions (Number) | |||||
|---|---|---|---|---|---|---|
| True positive | False positive | True negative | False negative | Total true | Total false | |
| FEC-PET | 59 | 26 | 19 | 24 | 78 | 50 |
| Magnetic Resonance Imaging (MRI) | 40 | 27 | 18 | 43 | 58 | 70 |
| PET/MRI | 55 | 8 | 37 | 28 | 92 | 36 |
PET positive lesions in patients with Gleason >6(3+3),n=43 were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative & positive predictive values were determined. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI
| Intervention | lesions (Number) | |||||
|---|---|---|---|---|---|---|
| True positive | False positive | True negative | False negative | Total true | Total false | |
| FEC-PET | 27 | 5 | 8 | 3 | 35 | 8 |
| Magnetic Resonance Imaging (MRI) | 22 | 9 | 4 | 8 | 26 | 17 |
| PET/MRI | 27 | 1 | 11 | 4 | 38 | 5 |
PET positive lesions were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative and positive predictive values were determined without malign lesions <=5mm. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI
| Intervention | lesions (Number) | |||||
|---|---|---|---|---|---|---|
| True positive | False positive | True negative | False negative | Total true | Total false | |
| FEC-PET | 48 | 24 | 18 | 8 | 66 | 32 |
| Magnetic Resonance Imaging (MRI) | 37 | 26 | 16 | 19 | 53 | 45 |
| PET/MRI | 48 | 8 | 32 | 10 | 80 | 18 |
PET positive lesions were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. At least 1 histological confirmed cancer lesion has to be detected by each of the 3 methods to be patient based true positive. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI
| Intervention | participants (Number) | |||||
|---|---|---|---|---|---|---|
| True Positive | False Positive | True Negative | False Negative | Total True | Total False | |
| [18F]Fluoroethylcholine Positron-Emission-Tomography (FEC-PET) | 36 | 1 | 0 | 1 | 36 | 2 |
| Magnetic Resonance Imaging (MRI) | 26 | 1 | 0 | 11 | 27 | 11 |
| PositronEmissionTomography/MagneticResonanceImaging (PET/MRI) | 35 | 0 | 1 | 2 | 36 | 2 |
34 other studies available for choline and Carcinoma, Ehrlich Tumor
| Article | Year |
|---|---|
[The effect of choline chloride treatment on the growth of transplanted neoplasms].
Topics: Animals; Carcinoma; Carcinoma, Ehrlich Tumor; Choline; Humans; Neoplasm Transplantation; Physiologic | 1962 |
EFFECT OF CHOLINE-DEFICIENCY ON HC-3 ACTION.
Topics: Animals; Biphenyl Compounds; Carcinoma; Carcinoma, Ehrlich Tumor; Choline; Choline Deficiency; Defic | 1964 |
Studies on the mode of action of RC4, a new anti-cancer agent containing ethyleneimino ring. I. Effects of RC4 and allied agents on glycolysis, respiration, hexokinase and phosphatase of Ehrlich ascites tumor cells and on choline-esterase of human blood.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Choline; Cholinesterases; Esterases; Glyco | 1960 |
Phosphate concentration and transport in Ehrlich ascites tumor cells: effect of sodium.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cells, Cultured; Choline; Phosphates; Potas | 1982 |
Variable coupling of active Na+ + K+ transport in Ehrlich ascites tumor cells: regulation by external Na+ and K+.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; Cells, | 1981 |
Development of (18)F-fluoroethylcholine for cancer imaging with PET: synthesis, biochemistry, and prostate cancer imaging.
Topics: Adenosine Triphosphate; Alcohol Oxidoreductases; Animals; Carbon Radioisotopes; Carcinoma, Ehrlich T | 2002 |
Is Na+-dependent exchange diffusion a true exchange?
Topics: Amino Acids; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Choline; Diffusion; Glycine; G | 1979 |
Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; C | 1979 |
The basic asymmetry of Na+-dependent glycine transport in Ehrlich cells.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Choline; Glycine; Kinetics; Lithium | 1978 |
[Effect of choline on division of Ehrlich ascitic carcinoma cells].
Topics: Animals; Carcinoma, Ehrlich Tumor; Choline; Mice; Mitosis | 1976 |
Studies on choline permeation through the plasma membrane and its incorporation into phosphatidyl choline of Ehrlich-Lettré-ascites tumor cells in vitro.
Topics: Animals; Benzoates; Carcinoma, Ehrlich Tumor; Cell Fractionation; Cell Membrane; Chlorine; Chloromer | 1975 |
Choline uptake is increased by Ca++ and liposomes+ Ca++ in ascites tumor cells.
Topics: Animals; Biological Transport; Calcium; Carcinoma, Ehrlich Tumor; Carrier Proteins; Choline; Liposom | 1989 |
Role of prostaglandins and leukotrienes in volume regulation by Ehrlich ascites tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; Choline; Dinoprostone; Intracellular | 1987 |
Protection of Ehrlich ascites tumor cells against the antiproliferative effect of mechlorethamine (nitrogen mustard) by 5-N,N-dimethylamiloride.
Topics: Amiloride; Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cell Division; Choline; DNA, Neo | 1988 |
Amiloride and 5-N,N-dimethylamiloride inhibit the carrier mediated uptake of choline in Ehrlich ascites tumor cells.
Topics: Amiloride; Animals; Binding, Competitive; Carcinoma, Ehrlich Tumor; Carrier Proteins; Choline; Choli | 1987 |
Effect of alkali cations on freeze-thaw-dependent reconstitution of amino acid transport from Ehrlich ascites cell plasma membrane.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; | 1985 |
Modified transport substrates as probes for intramembrane gradients.
Topics: Adenosine Triphosphate; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; C | 1974 |
Factors affecting the incorporation of precursors into the phospholipids of Ehrlich ascites cells.
Topics: Amino Alcohols; Animals; Autoradiography; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Choline; Chroma | 1967 |
Inhibition of choline kinase by selectively cytotoxic purinyl-6-histamine.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Choline; Culture Media; Histamine; Humans; | 1974 |
Evidence for active transport of choline in rat kidney cortex slices.
Topics: Animals; Betaine; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Choline; Chromatography, P | 1965 |
Diurnal rhythm of choline-14C incorporation into lecithin in Ehrlich-Lettré ascites tumour cells.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Choline; Circadian Rhythm; Mice; Mitosis; P | 1974 |
Proceedings: Factors influencing the mode of choline uptake by Ehrlich-Lettré-ascites tumor cells in vitro.
Topics: Animals; Carcinoma, Ehrlich Tumor; Choline; In Vitro Techniques; Kinetics | 1974 |
[Studies on choline incorporation in the lecithin fraction of Ehrlich-Lettré-ascites cells in vitro].
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Choline; Chromatography, Thin Layer; In Vitro Te | 1972 |
Volume changes of mammalian cells subjected to hypotonic solutions in vitro: evidence for the requirement of a sodium pump for the shrinking phase.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cells, Cultured; Cesium; Choline; Cricetinae; Culture | 1972 |
Transport of the amino acid analog, 2-aminobicyclo(2,2,1)-heptane-2-carboxylic acid, by Ehrlich ascites tumor cells.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Antineoplastic Agents; Binding Sites; Biological Transp | 1973 |
Na+-dependent amino acid transport in plasma membrane vesicles from Ehrlich ascites cells.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Antimetabolites; Biological Transport; Carbon Radioisot | 1974 |
Mutarotases X. Anomer specific glucose transport in ascites tumor cells.
Topics: Animals; Biological Transport; Carbohydrate Epimerases; Carcinoma, Ehrlich Tumor; Cells, Cultured; C | 1974 |
Role of ATP on the initial rate of amino acid uptake in Ehrlich ascites cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Carbon Radioisotopes; Carcinoma, Ehrl | 1974 |
Phospholipid metabolism in cells in culture 1,2.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Cell Line; Choline; C | 1972 |
Enzymic radioassay for acetylcholine and choline in brain.
Topics: Acetates; Acetylcholine; Adenosine Triphosphate; Amino Alcohols; Ammonium Sulfate; Animals; Benzoate | 1971 |
Temperature dependence of amino acid transport in Ehrlich ascites cells: with results which bear on the A-L distinction.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Biological Transport, Ac | 1970 |
The incorporation of ethanolamine and methionine into sphingomyelin in Ehrlich ascites tumor cells.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Fractionation; Chlorides; C | 1971 |
Phosphorylation of choline and ethanolamine in Ehrlich ascites-carcinoma cells.
Topics: Adenosine Triphosphate; Amino Alcohols; Animals; Calcium; Carbon Isotopes; Carcinoma, Ehrlich Tumor; | 1967 |
Metabolism of phospholipids in Ehrlich ascites tumor.
Topics: Acetates; Amino Alcohols; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Choline; Female; Forma | 1965 |