choline has been researched along with Canavan Disease in 4 studies
Canavan Disease: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)
| Excerpt | Relevance | Reference |
|---|---|---|
| "MR studies of these infants showed obstructive hydrocephalus caused by mass effect produced by an enlarged cerebellum." | 1.30 | Imaging studies in a unique familial dysmyelinating disorder. ( Duhaime, AC; Gripp, KW; Molloy, PT; Muenke, M; Rorke, LB; Schut, L; Tucker, SH; Wang, ZJ; Zackai, EH; Zimmerman, RA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Assadi, M | 1 |
| Janson, C | 1 |
| Wang, DJ | 1 |
| Goldfarb, O | 1 |
| Suri, N | 1 |
| Bilaniuk, L | 1 |
| Leone, P | 1 |
| Engelbrecht, V | 1 |
| Rassek, M | 1 |
| Gärtner, J | 1 |
| Kahn, T | 1 |
| Mödder, U | 1 |
| Toft, PB | 1 |
| Geiss-Holtorff, R | 1 |
| Rolland, MO | 1 |
| Pryds, O | 1 |
| Müller-Forell, W | 1 |
| Christensen, E | 1 |
| Lehnert, W | 1 |
| Lou, HC | 1 |
| Ott, D | 1 |
| Hennig, J | 1 |
| Gripp, KW | 1 |
| Zimmerman, RA | 1 |
| Wang, ZJ | 1 |
| Rorke, LB | 1 |
| Duhaime, AC | 1 |
| Schut, L | 1 |
| Molloy, PT | 1 |
| Tucker, SH | 1 |
| Zackai, EH | 1 |
| Muenke, M | 1 |
4 other studies available for choline and Canavan Disease
| Article | Year |
|---|---|
Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease.
Topics: Aspartic Acid; Basal Ganglia; Canavan Disease; Cerebral Cortex; Choline; Citrates; Creatine; Diffusi | 2010 |
[Magnetic resonance tomography and localized proton spectroscopy in 2 siblings with Canavan's disease].
Topics: Aspartic Acid; Brain; Canavan Disease; Child, Preschool; Choline; Chromatography, Gas; Creatine; Hum | 1995 |
Magnetic resonance imaging in juvenile Canavan disease.
Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Child; Child, Preschool; Choline; Corpus Str | 1993 |
Imaging studies in a unique familial dysmyelinating disorder.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Canavan Disease; Cerebellar Diseases; Cerebral Cortex; Chol | 1998 |