Page last updated: 2024-10-16

choline and Canavan Disease

choline has been researched along with Canavan Disease in 4 studies

Canavan Disease: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)

Research Excerpts

ExcerptRelevanceReference
"MR studies of these infants showed obstructive hydrocephalus caused by mass effect produced by an enlarged cerebellum."1.30Imaging studies in a unique familial dysmyelinating disorder. ( Duhaime, AC; Gripp, KW; Molloy, PT; Muenke, M; Rorke, LB; Schut, L; Tucker, SH; Wang, ZJ; Zackai, EH; Zimmerman, RA, 1998)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Assadi, M1
Janson, C1
Wang, DJ1
Goldfarb, O1
Suri, N1
Bilaniuk, L1
Leone, P1
Engelbrecht, V1
Rassek, M1
Gärtner, J1
Kahn, T1
Mödder, U1
Toft, PB1
Geiss-Holtorff, R1
Rolland, MO1
Pryds, O1
Müller-Forell, W1
Christensen, E1
Lehnert, W1
Lou, HC1
Ott, D1
Hennig, J1
Gripp, KW1
Zimmerman, RA1
Wang, ZJ1
Rorke, LB1
Duhaime, AC1
Schut, L1
Molloy, PT1
Tucker, SH1
Zackai, EH1
Muenke, M1

Other Studies

4 other studies available for choline and Canavan Disease

ArticleYear
Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2010, Volume: 14, Issue:4

    Topics: Aspartic Acid; Basal Ganglia; Canavan Disease; Cerebral Cortex; Choline; Citrates; Creatine; Diffusi

2010
[Magnetic resonance tomography and localized proton spectroscopy in 2 siblings with Canavan's disease].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1995, Volume: 163, Issue:3

    Topics: Aspartic Acid; Brain; Canavan Disease; Child, Preschool; Choline; Chromatography, Gas; Creatine; Hum

1995
Magnetic resonance imaging in juvenile Canavan disease.
    European journal of pediatrics, 1993, Volume: 152, Issue:9

    Topics: Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Child; Child, Preschool; Choline; Corpus Str

1993
Imaging studies in a unique familial dysmyelinating disorder.
    AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:7

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Canavan Disease; Cerebellar Diseases; Cerebral Cortex; Chol

1998