choline has been researched along with Breast Neoplasms in 159 studies
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluates the associations between dietary intakes and circulating blood levels of methionine, choline or betaine and breast cancer risk, which remains currently unclear." | 9.41 | The association between dietary intakes of methionine, choline and betaine and breast cancer risk: A systematic review and meta-analysis. ( De Bacquer, D; Dimou, N; Godderis, L; Huybrechts, I; Indave Ruiz, BI; Katsikari, A; Van Puyvelde, H, 2023) |
| "We present a case report of incidental detection of breast cancer in a female patient referred for 18F-fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) due to primary hyperparathyroidism." | 8.12 | Incidental detection of breast cancer by 18F-fluorocholine PET/CT performed for primary hyperparathyroidism. ( Huic, D; Jozanovic, V, 2022) |
| "Our study confirms that 3 T breast H-MRS can be a valid additional tool to obtain further information about breast cancer biology and to predict tumor aggressiveness, because the detection of elevated levels of total choline in the spectrum is associated with a biologically aggressive breast cancer phenotype (large dimensions, grade 3, high values of Ki-67)." | 7.91 | Breast Magnetic Resonance Spectroscopy at 3 T in Biopsy-Proven Breast Cancers: Does Choline Peak Correlate With Prognostic Factors? ( Caramanico, C; Catalano, C; Galati, F; Luciani, ML; Moffa, G; Pediconi, F, 2019) |
| "To determine whether measurements of total choline (tCho) by 1H spectroscopy could predict morphological or pathological complete response (pCR) of neoadjuvant treatment and whether breast cancer subgroups are related to prediction accuracy." | 7.88 | Total choline quantification measured by 1H MR spectroscopy as early predictor of response after neoadjuvant treatment for locally advanced breast cancer: The impact of immunohistochemical status. ( Chao, SL; Chintinne, M; Drisis, S; Flamen, P; Ignatiadis, M; Lemort, M; Metens, T, 2018) |
| "Total choline (tCho) was documented as a biomarker for breast cancer diagnosis by in vivo MRS." | 7.85 | Is there an association between enhanced choline and β-catenin pathway in breast cancer? A pilot study by MR Spectroscopy and ELISA. ( Agarwal, K; Hariprasad, G; Jagannathan, NR; Mathur, SR; Parshad, R; Rani, K; Seenu, V; Sharma, U, 2017) |
| "An inverse association with breast cancer risk was observed for serum betaine (fourth vs first quartile adjusted OR 0." | 7.85 | Serum betaine but not choline is inversely associated with breast cancer risk: a case-control study in China. ( Du, YF; Lin, FY; Long, WQ; Luo, WP; Mo, XF; Xu, M; Yan, B; Zhang, CX, 2017) |
| "MDA-MB-468, BT474 and SKBr3 breast cancer cell lines were treated with metformin and [3H-methyl]choline and [14C(U)]glucose incorporation and lipid accumulation determined in the presence and absence of lipase inhibitors." | 7.83 | Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells. ( Phyu, SM; Smith, TA, 2016) |
| "Choline and betaine are essential nutrients involved in one-carbon metabolism and have been hypothesised to affect breast cancer risk." | 7.83 | Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China. ( Du, YF; Huang, J; Huang, WQ; Lian, ZQ; Lin, FY; Luo, WP; Mo, XF; Xu, M; Yan, B; Zhang, CX, 2016) |
| "Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood." | 7.80 | Interplay of choline metabolites and genes in patient-derived breast cancer xenografts. ( Bathen, TF; Borgan, E; Børresen-Dale, AL; Engebraaten, O; Gribbestad, IS; Grinde, MT; Kristian, A; Marangoni, E; Moestue, SA; Mælandsmo, GM; Rødland, EA; Sitter, B; Skrbo, N; Sørlie, T, 2014) |
| "The relative amounts of choline (Cho), phosphocholine (PC), and glycerophosphocholine (GPC) may be sensitive indicators of breast cancer and the degree of malignancy." | 7.79 | 1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer. ( Cecil, KM; Chu, WJ; Komoroski, RA; Lee, JH; Mahoney, MC; Pearce, JM; Strakowski, SM, 2013) |
| "Few epidemiological studies have evaluated the association of choline and betaine intake with breast cancer risk and the results remain inconsistent." | 7.79 | Choline and betaine intake is inversely associated with breast cancer risk: a two-stage case-control study in China. ( Chen, YM; Ho, SC; Li, B; Lin, FY; Mo, XF; Pan, MX; Wang, L; Zhang, CX, 2013) |
| "The association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) status of breast cancer patients with total choline (tCho) concentration and tumor volume was investigated using in vivo proton magnetic resonance spectroscopy and MRI at 1." | 7.78 | Association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status with total choline concentration and tumor volume in breast cancer patients: an MRI and in vivo proton MRS study. ( Jagannathan, NR; Mathur, SR; Parshad, R; Sah, RG; Seenu, V; Sharma, U, 2012) |
| "Altered choline phospholipid metabolism is a hallmark of cancer, leading to malignant choline metabolite profiles consisting of low glycerophosphocholine (GPC) and high phosphocholine (PC) in human breast cancers." | 7.78 | Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. ( Bhujwalla, ZM; Cao, MD; Döpkens, M; Gadiya, MM; Glunde, K; Gribbestad, IS; Krishnamachary, B; Lønning, PE; Vesuna, F, 2012) |
| "The purpose of this article is to determine whether the peak integral and signal-to-noise ratio (SNR) of total choline-containing compounds obtained by MR spectroscopy (MRS) correlate with histologic biomarkers currently used for predicting prognosis in patients with breast cancer." | 7.78 | Evaluation of breast cancer using proton MR spectroscopy: total choline peak integral and signal-to-noise ratio as prognostic indicators. ( Baek, HM; Cha, JH; Kim, HH; Shin, HJ, 2012) |
| "This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer." | 7.77 | Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS. ( Baek, HM; Chen, JH; Lin, MQ; Liu, H; Mehta, RS; Nalcioglu, O; Nie, K; Su, MY; Yu, HJ, 2011) |
| "Choline metabolism and proliferation as assessed by PET were correlated in ER-positive breast cancer, indicating that high CHO uptake is a measure of cellular proliferation in this setting." | 7.77 | Biological basis of [¹¹C]choline-positron emission tomography in patients with breast cancer: comparison with [¹⁸F]fluorothymidine positron emission tomography. ( Aboagye, EO; Al-Nahhas, A; Challapalli, A; Contractor, KB; Coombes, RC; De Nguyen, Q; Hogben, K; Kenny, LM; Lewis, JS; Palmieri, C; Shousha, S; Stebbing, J, 2011) |
| "To explore factors determining the detection of total choline (tCho) by in vivo MR spectroscopy (MRS) in locally advanced breast cancer and to evaluate the ability of in vivo tCho to predict treatment response after one cycle of neoadjuvant chemotherapy (NAC)." | 7.77 | In vivo MRS of locally advanced breast cancer: characteristics related to negative or positive choline detection and early monitoring of treatment response. ( Bathen, TF; Bofin, A; Gribbestad, IS; Heldahl, MG; Lundgren, S; Sitter, B; Vettukattil, R, 2011) |
| "Choline and betaine, similar to folate, are nutrients involved in one-carbon metabolism and hypothesised to reduce breast cancer risk." | 7.76 | Choline and betaine intake and risk of breast cancer among post-menopausal women. ( Cho, E; Hankinson, SE; Holmes, MD; Willett, WC, 2010) |
| "High levels of choline kinase (ChoK) expression and choline phospholipid metabolites are often associated with malignant transformation, invasion, and metastasis, particularly in breast cancer." | 7.75 | Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Nimmagadda, S; Pomper, MG, 2009) |
| " As choline metabolism increases during malignant transformation and progression of human mammary epithelial cells, we examined the ability of [(11)C]choline (CHO) positron emission tomography imaging to detect clinically aggressive phenotype in patients with estrogen receptor (ER)-positive breast cancer in vivo." | 7.75 | [11C]choline positron emission tomography in estrogen receptor-positive breast cancer. ( Aboagye, EO; Al-Nahhas, A; Contractor, KB; Coombes, RC; Hogben, K; Kenny, LM; Lewis, JS; Lowdell, C; Osman, S; Palmieri, C; Shousha, S; Sinnett, D; Stebbing, J, 2009) |
| " By utilizing a population-based study of 1508 cases and 1556 controls, we investigated the associations of dietary intake of choline and two related micronutrients, methionine and betaine, and risk of breast cancer." | 7.74 | Choline metabolism and risk of breast cancer in a population-based study. ( Bradshaw, PT; Chen, J; Gammon, MD; Lee, YL; Neugut, AI; Santella, RM; Teitelbaum, SL; Wetmur, JG; Xu, X; Zeisel, SH, 2008) |
| "2 ppm, which includes contributions from choline, phosphocholine (PC), glycerophosphocholine (GPC), myo-inositol and taurine, was found not to be a unique marker for malignancy providing a diagnostic sensitivity and specificity of 80." | 7.73 | Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T. ( Baker, L; Clark, D; Giuffrè, B; Gluch, L; Lean, C; Malycha, P; Mountford, C; Stanwell, P; Tomanek, B, 2005) |
| "We sought to evaluate spectroscopic measurements in breast cancer and compare variability in choline peak parameters related to contrast administration versus that inherent to repeated measurements." | 7.73 | Evaluation of 1H-magnetic resonance spectroscopy of breast cancer pre- and postgadolinium administration. ( Bae, KT; Chen, VY; Fuangtharntip, P; Hildebolt, CF; Joe, BN; Salibi, N, 2005) |
| "Choline kinase is overexpressed in breast cancer cells and activated by oncogenes and mitogenic signals, making it a potential target for cancer therapy." | 7.73 | RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. ( Bhujwalla, ZM; Glunde, K; Mori, N; Raman, V, 2005) |
| " The treatment of human breast cancer cells with a nonsteroidal anti-inflammatory agent, indomethacin, reverted the high PC/low GPC pattern to a low PC/high GPC pattern indicative of a less malignant phenotype, supported by decreased invasion." | 7.73 | Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Jie, C, 2006) |
| "[11C]Choline has been evaluated as a potential positron emission tomography (PET) marker for imaging of breast cancer." | 7.71 | [11C]Choline as a potential PET marker for imaging of breast cancer athymic mice. ( Fei, X; Glick-Wilson, BE; Hutchins, GD; Liu, X; Miller, KD; Mock, BH; Sledge, GW; Stone, KL; Wang, JQ; Zheng, QH, 2002) |
| "Choline metabolism in breast cancer cells and tumors has been investigated by multinuclear NMR in order to provide the biochemical basis for the presence of high phosphocholine in breast carcinoma relative to benign breast tumors and normal breast tissue." | 7.70 | Choline metabolism in breast cancer; 2H-, 13C- and 31P-NMR studies of cells and tumors. ( Bendel, P; Degani, H; Katz-Brull, R; Margalit, R, 1998) |
| "31P- and 13C-NMR were used to determine the kinetics of choline and ethanolamine incorporation in T47D clone 11 human breast cancer cells grown as large (300 microns) spheroids." | 7.68 | Lipid metabolism in large T47D human breast cancer spheroids: 31P- and 13C-NMR studies of choline and ethanolamine uptake. ( Degani, H; Ronen, SM; Rushkin, E, 1992) |
| "31P and 13C-NMR were used to determine the kinetics of choline and ethanolamine incorporation in T47D clone 11 human breast cancer cells grown as small (150 microns) spheroids." | 7.68 | Lipid metabolism in T47D human breast cancer cells: 31P and 13C-NMR studies of choline and ethanolamine uptake. ( Degani, H; Ronen, SM; Rushkin, E, 1991) |
| "Women with breast cancer were all treated with chemotherapy." | 6.78 | Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy. ( Kesler, SR; Koovakkattu, D; Lee, C; Mahaffey, ML; O'Hara, R; Watson, C; Wefel, JS, 2013) |
| "Twenty of the 23 breast cancer lesions (87%) with a consistent Cho peak expressed a CaSR score of 3-5, and ten of the 11 breast lesions negative for Cho (91%) had a CaSR score of 1-2." | 5.42 | Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study. ( Baio, G; Basso, L; Boccardo, S; Calabrese, M; Neumaier, CE; Pace, D; Rescinito, G; Rosa, F; Salvi, S; Truini, M, 2015) |
| "This study evaluates the associations between dietary intakes and circulating blood levels of methionine, choline or betaine and breast cancer risk, which remains currently unclear." | 5.41 | The association between dietary intakes of methionine, choline and betaine and breast cancer risk: A systematic review and meta-analysis. ( De Bacquer, D; Dimou, N; Godderis, L; Huybrechts, I; Indave Ruiz, BI; Katsikari, A; Van Puyvelde, H, 2023) |
| "Perifosine is an anticancer alkylphospholipid used in clinical trials." | 5.38 | Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells. ( Ronen, SM; Su, JS; Woods, SM, 2012) |
| "A choline peak was present in 34 of 57 lesions (including all cancers) and in three of 26 benign lesions, giving MR spectroscopy a sensitivity of 100% and a specificity of 88%." | 5.33 | Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study. ( Bartella, L; Dershaw, DD; Guido, J; Huang, W; Liberman, L; Morris, EA; Moskowitz, C; Thakur, SB, 2006) |
| " Corresponding DCE kinetics was measured from each voxel, and analyzed with a 2-compartmental model to obtain pharmacokinetic parameters Ktrans and k(ep)." | 5.33 | Comparison of choline and pharmacokinetic parameters in breast cancer measured by MR spectroscopic imaging and dynamic contrast enhanced MRI. ( Baik, HM; Chen, JH; Mehta, RS; Nalcioglu, O; Su, MY; Yu, HJ, 2006) |
| "Choline is an essential nutrient participating as the initial substrate in major metabolic pathways." | 5.31 | Differential routing of choline in implanted breast cancer and normal organs. ( Degani, H; Katz-Brull, R; Margalit, R, 2001) |
| "It was concluded that in brain metastases of mammary carcinoma Lact represents a product of ischemia preceding/during tissue decay resulting in central necrosis, rather than tumor specific metabolism resulting in increased glycolysis." | 5.29 | Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma. ( Oudkerk, M; Sijens, PE; van Dijk, P, 1994) |
| "Choline (Cho) signal identification and quantification in (1)H MRS are used in breast cancer diagnosis." | 5.16 | Effect of contrast agent on the results of in vivo ¹H MRS of breast tumors - is it clinically significant? ( Baltzer, PA; Camara, O; Dietzel, M; Gajda, M; Gussew, A; Kaiser, WA; Reichenbach, JR; Rzanny, R, 2012) |
| "This study sought to evaluate the reproducibility of [(11)C]choline-positron emission tomography and the effect of trastuzumab in breast cancer." | 5.14 | Reproducibility of [11C]choline-positron emission tomography and effect of trastuzumab. ( Aboagye, EO; Al-Nahhas, A; Contractor, KB; Coombes, RC; Hinz, R; Jiang, J; Kenny, LM; Palmieri, C; Shousha, S; Stebbing, J, 2010) |
| "Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; 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| "We present a case report of incidental detection of breast cancer in a female patient referred for 18F-fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) due to primary hyperparathyroidism." | 4.12 | Incidental detection of breast cancer by 18F-fluorocholine PET/CT performed for primary hyperparathyroidism. ( Huic, D; Jozanovic, V, 2022) |
| " Therefore, we investigated the proposed cancer inhibitory effects of methyl-donors (in a mixture of L-methionine, choline chloride, folic acid, and vitamin B12) on MCF7 and T47D breast cancer as well as A549 and H1650 lung cancer cell lines." | 4.02 | Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines. ( Dank, M; Forika, G; Kiss, E; Krenacs, T; Mohacsi, R; Nemeth, Z, 2021) |
| "(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015." | 4.02 | Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). ( Agudo, A; Ardanaz, E; Bakker, MF; Biessy, C; Casagrande, C; Chiodini, P; Chirlaque López, MD; Clasen, J; De Bacquer, D; Ericson, U; Ferrari, P; Fortner, RT; Godderis, L; Gunter, MJ; Gylling, B; Halkjær, J; Heath, AK; Huybrechts, I; Karlsson, T; Katzke, V; Manjer, J; Masala, G; Muller, D; Nicolas, G; Overvad, K; Pala, V; Papadimitriou, N; Sacerdote, C; Sánchez, MJ; Schmidt, JA; Schulze, MB; Tjønneland, A; Tumino, R; Van Herck, K; Van Puyvelde, H; Weiderpass, E, 2021) |
| "Our study confirms that 3 T breast H-MRS can be a valid additional tool to obtain further information about breast cancer biology and to predict tumor aggressiveness, because the detection of elevated levels of total choline in the spectrum is associated with a biologically aggressive breast cancer phenotype (large dimensions, grade 3, high values of Ki-67)." | 3.91 | Breast Magnetic Resonance Spectroscopy at 3 T in Biopsy-Proven Breast Cancers: Does Choline Peak Correlate With Prognostic Factors? ( Caramanico, C; Catalano, C; Galati, F; Luciani, ML; Moffa, G; Pediconi, F, 2019) |
| "To determine whether measurements of total choline (tCho) by 1H spectroscopy could predict morphological or pathological complete response (pCR) of neoadjuvant treatment and whether breast cancer subgroups are related to prediction accuracy." | 3.88 | Total choline quantification measured by 1H MR spectroscopy as early predictor of response after neoadjuvant treatment for locally advanced breast cancer: The impact of immunohistochemical status. ( Chao, SL; Chintinne, M; Drisis, S; Flamen, P; Ignatiadis, M; Lemort, M; Metens, T, 2018) |
| "Total choline (tCho) was documented as a biomarker for breast cancer diagnosis by in vivo MRS." | 3.85 | Is there an association between enhanced choline and β-catenin pathway in breast cancer? A pilot study by MR Spectroscopy and ELISA. ( Agarwal, K; Hariprasad, G; Jagannathan, NR; Mathur, SR; Parshad, R; Rani, K; Seenu, V; Sharma, U, 2017) |
| "An inverse association with breast cancer risk was observed for serum betaine (fourth vs first quartile adjusted OR 0." | 3.85 | Serum betaine but not choline is inversely associated with breast cancer risk: a case-control study in China. ( Du, YF; Lin, FY; Long, WQ; Luo, WP; Mo, XF; Xu, M; Yan, B; Zhang, CX, 2017) |
| "MDA-MB-468, BT474 and SKBr3 breast cancer cell lines were treated with metformin and [3H-methyl]choline and [14C(U)]glucose incorporation and lipid accumulation determined in the presence and absence of lipase inhibitors." | 3.83 | Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells. ( Phyu, SM; Smith, TA, 2016) |
| "Choline and betaine are essential nutrients involved in one-carbon metabolism and have been hypothesised to affect breast cancer risk." | 3.83 | Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China. ( Du, YF; Huang, J; Huang, WQ; Lian, ZQ; Lin, FY; Luo, WP; Mo, XF; Xu, M; Yan, B; Zhang, CX, 2016) |
| "Noninvasive metabolic profiling by 3D (31) P MRSI can discriminate between subtypes of breast cancer based on different concentrations of choline- and ethanolamine-containing phospholipids." | 3.81 | In vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts. ( Bathen, TF; Engebråten, O; Esmaeili, M; Gribbestad, IS; Hamans, BC; Heerschap, A; Kristian, A; Maelandsmo, GM; Moestue, SA; Veltien, A, 2015) |
| "Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood." | 3.80 | Interplay of choline metabolites and genes in patient-derived breast cancer xenografts. ( Bathen, TF; Borgan, E; Børresen-Dale, AL; Engebraaten, O; Gribbestad, IS; Grinde, MT; Kristian, A; Marangoni, E; Moestue, SA; Mælandsmo, GM; Rødland, EA; Sitter, B; Skrbo, N; Sørlie, T, 2014) |
| "The relative amounts of choline (Cho), phosphocholine (PC), and glycerophosphocholine (GPC) may be sensitive indicators of breast cancer and the degree of malignancy." | 3.79 | 1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer. ( Cecil, KM; Chu, WJ; Komoroski, RA; Lee, JH; Mahoney, MC; Pearce, JM; Strakowski, SM, 2013) |
| "Few epidemiological studies have evaluated the association of choline and betaine intake with breast cancer risk and the results remain inconsistent." | 3.79 | Choline and betaine intake is inversely associated with breast cancer risk: a two-stage case-control study in China. ( Chen, YM; Ho, SC; Li, B; Lin, FY; Mo, XF; Pan, MX; Wang, L; Zhang, CX, 2013) |
| "Accumulation of GBCA in breast cancer could affect the choline peak on MRS." | 3.78 | ¹H-magnetic resonance spectroscopy of the breast at 3.0-T: comparison of results obtained before and after administration of gadolinium-based contrast agent. ( Ishigaki, S; Kawai, H; Maruyama, K; Mori, M; Naganawa, S; Sakurai, Y; Satake, H, 2012) |
| "The association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) status of breast cancer patients with total choline (tCho) concentration and tumor volume was investigated using in vivo proton magnetic resonance spectroscopy and MRI at 1." | 3.78 | Association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status with total choline concentration and tumor volume in breast cancer patients: an MRI and in vivo proton MRS study. ( Jagannathan, NR; Mathur, SR; Parshad, R; Sah, RG; Seenu, V; Sharma, U, 2012) |
| "Altered choline phospholipid metabolism is a hallmark of cancer, leading to malignant choline metabolite profiles consisting of low glycerophosphocholine (GPC) and high phosphocholine (PC) in human breast cancers." | 3.78 | Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. ( Bhujwalla, ZM; Cao, MD; Döpkens, M; Gadiya, MM; Glunde, K; Gribbestad, IS; Krishnamachary, B; Lønning, PE; Vesuna, F, 2012) |
| "The purpose of this article is to determine whether the peak integral and signal-to-noise ratio (SNR) of total choline-containing compounds obtained by MR spectroscopy (MRS) correlate with histologic biomarkers currently used for predicting prognosis in patients with breast cancer." | 3.78 | Evaluation of breast cancer using proton MR spectroscopy: total choline peak integral and signal-to-noise ratio as prognostic indicators. ( Baek, HM; Cha, JH; Kim, HH; Shin, HJ, 2012) |
| " Test-retest [(11)C]choline scans of nine patients with breast cancer were considered and the percent test-retest variability %VAR(TEST-RETEST) of tumor volume (TV) was employed to assess the results." | 3.78 | Comparative assessment of segmentation algorithms for tumor delineation on a test-retest [(11)C]choline dataset. ( Aboagye, E; Shepherd, T; Tomasi, G; Turkheimer, F; Visvikis, D, 2012) |
| "This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer." | 3.77 | Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS. ( Baek, HM; Chen, JH; Lin, MQ; Liu, H; Mehta, RS; Nalcioglu, O; Nie, K; Su, MY; Yu, HJ, 2011) |
| "To compare total choline concentrations ([Cho]) and water-to-fat (W/F) ratios of subtypes of malignant lesions, benign lesions, and normal breast parenchyma and determine their usefulness in breast cancer diagnosis." | 3.77 | Diagnostic usefulness of water-to-fat ratio and choline concentration in malignant and benign breast lesions and normal breast parenchyma: an in vivo (1) H MRS study. ( Bartella, L; Brennan, SB; Dershaw, DD; Huang, W; Ishill, NM; Koutcher, JA; Liberman, L; Morris, EA; Thakur, SB, 2011) |
| "Choline metabolism and proliferation as assessed by PET were correlated in ER-positive breast cancer, indicating that high CHO uptake is a measure of cellular proliferation in this setting." | 3.77 | Biological basis of [¹¹C]choline-positron emission tomography in patients with breast cancer: comparison with [¹⁸F]fluorothymidine positron emission tomography. ( Aboagye, EO; Al-Nahhas, A; Challapalli, A; Contractor, KB; Coombes, RC; De Nguyen, Q; Hogben, K; Kenny, LM; Lewis, JS; Palmieri, C; Shousha, S; Stebbing, J, 2011) |
| "To explore factors determining the detection of total choline (tCho) by in vivo MR spectroscopy (MRS) in locally advanced breast cancer and to evaluate the ability of in vivo tCho to predict treatment response after one cycle of neoadjuvant chemotherapy (NAC)." | 3.77 | In vivo MRS of locally advanced breast cancer: characteristics related to negative or positive choline detection and early monitoring of treatment response. ( Bathen, TF; Bofin, A; Gribbestad, IS; Heldahl, MG; Lundgren, S; Sitter, B; Vettukattil, R, 2011) |
| "Choline and betaine, similar to folate, are nutrients involved in one-carbon metabolism and hypothesised to reduce breast cancer risk." | 3.76 | Choline and betaine intake and risk of breast cancer among post-menopausal women. ( Cho, E; Hankinson, SE; Holmes, MD; Willett, WC, 2010) |
| "The potential of total choline (tCho) signal-to-noise ratio (SNR) (ChoSNR) and tumor volume in the assessment of tumor response in locally advanced breast cancer (LABC) patients (n = 30) undergoing neoadjuvant chemotherapy (NACT) was investigated using magnetic resonance spectroscopic imaging (MRSI) and conventional MRI at 1." | 3.76 | Assessment of therapeutic response of locally advanced breast cancer (LABC) patients undergoing neoadjuvant chemotherapy (NACT) monitored using sequential magnetic resonance spectroscopic imaging (MRSI). ( Danishad, KK; Jagannathan, NR; Parshad, R; Sah, RG; Seenu, V; Sharma, U, 2010) |
| "This study determined that in the MCF-7 breast cancer model inhibition of Hsp90 by 17-AAG results in a significant MRS-detectable increase in choline, PC and GPC, which is likely due to an increase in choline transport into the cell and phospholipase activation." | 3.76 | 17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2. ( Brandes, AH; Ronen, SM; Ward, CS, 2010) |
| "High levels of choline kinase (ChoK) expression and choline phospholipid metabolites are often associated with malignant transformation, invasion, and metastasis, particularly in breast cancer." | 3.75 | Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Nimmagadda, S; Pomper, MG, 2009) |
| " As choline metabolism increases during malignant transformation and progression of human mammary epithelial cells, we examined the ability of [(11)C]choline (CHO) positron emission tomography imaging to detect clinically aggressive phenotype in patients with estrogen receptor (ER)-positive breast cancer in vivo." | 3.75 | [11C]choline positron emission tomography in estrogen receptor-positive breast cancer. ( Aboagye, EO; Al-Nahhas, A; Contractor, KB; Coombes, RC; Hogben, K; Kenny, LM; Lewis, JS; Lowdell, C; Osman, S; Palmieri, C; Shousha, S; Sinnett, D; Stebbing, J, 2009) |
| "Folate, vitamin B6, vitamin B12, methionine, choline, and betaine are nutrients involved in one-carbon metabolism and have been hypothesized to reduce the risk of breast cancer." | 3.74 | Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women. ( Cho, E; Hankinson, SE; Holmes, M; Willett, WC, 2007) |
| " By utilizing a population-based study of 1508 cases and 1556 controls, we investigated the associations of dietary intake of choline and two related micronutrients, methionine and betaine, and risk of breast cancer." | 3.74 | Choline metabolism and risk of breast cancer in a population-based study. ( Bradshaw, PT; Chen, J; Gammon, MD; Lee, YL; Neugut, AI; Santella, RM; Teitelbaum, SL; Wetmur, JG; Xu, X; Zeisel, SH, 2008) |
| "2 ppm, which includes contributions from choline, phosphocholine (PC), glycerophosphocholine (GPC), myo-inositol and taurine, was found not to be a unique marker for malignancy providing a diagnostic sensitivity and specificity of 80." | 3.73 | Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T. ( Baker, L; Clark, D; Giuffrè, B; Gluch, L; Lean, C; Malycha, P; Mountford, C; Stanwell, P; Tomanek, B, 2005) |
| "We sought to evaluate spectroscopic measurements in breast cancer and compare variability in choline peak parameters related to contrast administration versus that inherent to repeated measurements." | 3.73 | Evaluation of 1H-magnetic resonance spectroscopy of breast cancer pre- and postgadolinium administration. ( Bae, KT; Chen, VY; Fuangtharntip, P; Hildebolt, CF; Joe, BN; Salibi, N, 2005) |
| "Choline kinase is overexpressed in breast cancer cells and activated by oncogenes and mitogenic signals, making it a potential target for cancer therapy." | 3.73 | RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. ( Bhujwalla, ZM; Glunde, K; Mori, N; Raman, V, 2005) |
| " The treatment of human breast cancer cells with a nonsteroidal anti-inflammatory agent, indomethacin, reverted the high PC/low GPC pattern to a low PC/high GPC pattern indicative of a less malignant phenotype, supported by decreased invasion." | 3.73 | Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. ( Bhujwalla, ZM; Glunde, K; Jie, C, 2006) |
| "To assess the relationship between breast cancer subtypes and choline detection by using in vivo proton magnetic resonance (MR) spectroscopy and to assess the feasibility of proton MR spectroscopy in the study of axillary lymph node metastases." | 3.71 | Breast cancer: in vivo proton MR spectroscopy in the characterization of histopathologic subtypes and preliminary observations in axillary node metastases. ( Tse, GM; Yang, WT; Yeung, DK, 2002) |
| "[11C]Choline has been evaluated as a potential positron emission tomography (PET) marker for imaging of breast cancer." | 3.71 | [11C]Choline as a potential PET marker for imaging of breast cancer athymic mice. ( Fei, X; Glick-Wilson, BE; Hutchins, GD; Liu, X; Miller, KD; Mock, BH; Sledge, GW; Stone, KL; Wang, JQ; Zheng, QH, 2002) |
| "Choline metabolism in breast cancer cells and tumors has been investigated by multinuclear NMR in order to provide the biochemical basis for the presence of high phosphocholine in breast carcinoma relative to benign breast tumors and normal breast tissue." | 3.70 | Choline metabolism in breast cancer; 2H-, 13C- and 31P-NMR studies of cells and tumors. ( Bendel, P; Degani, H; Katz-Brull, R; Margalit, R, 1998) |
| "The purpose of this study was to evaluate whether the detection of choline-containing compounds in in vivo (1)H magnetic resonance spectroscopy (MRS) of breast lesions is specific for carcinomas, whether a choline peak in in vivo (1)H MRS can be detected under physiological conditions of increased metabolism in breast parenchyma, and whether analysis of lipid signals can differentiate between various breast lesions and tissues." | 3.70 | Characterization of neoplastic and normal human breast tissues with in vivo (1)H MR spectroscopy. ( Bakken, IJ; Ehrnholm, B; Fjøsne, HE; Gribbestad, IS; Haraldseth, O; Kvistad, KA; Lundgren, S, 1999) |
| "31P- and 13C-NMR were used to determine the kinetics of choline and ethanolamine incorporation in T47D clone 11 human breast cancer cells grown as large (300 microns) spheroids." | 3.68 | Lipid metabolism in large T47D human breast cancer spheroids: 31P- and 13C-NMR studies of choline and ethanolamine uptake. ( Degani, H; Ronen, SM; Rushkin, E, 1992) |
| "31P and 13C-NMR were used to determine the kinetics of choline and ethanolamine incorporation in T47D clone 11 human breast cancer cells grown as small (150 microns) spheroids." | 3.68 | Lipid metabolism in T47D human breast cancer cells: 31P and 13C-NMR studies of choline and ethanolamine uptake. ( Degani, H; Ronen, SM; Rushkin, E, 1991) |
| "Addition of choline, ethanolamine, or hemicholinium-3 (a choline kinase inhibitor) to the perfusate of human breast cancer cells monitored by 31P NMR spectroscopy resulted in significant changes to phosphomonoester (PME) and phosphodiester (PDE) signals." | 3.67 | Phospholipid metabolism in cancer cells monitored by 31P NMR spectroscopy. ( Cohen, JS; Daly, PF; Faustino, PJ; Lyon, RC, 1987) |
| "Women with breast cancer were all treated with chemotherapy." | 2.78 | Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy. ( Kesler, SR; Koovakkattu, D; Lee, C; Mahaffey, ML; O'Hara, R; Watson, C; Wefel, JS, 2013) |
| " However, dose-response relationships between egg intake and such cancers are unclear." | 2.52 | Egg intake and cancers of the breast, ovary and prostate: a dose-response meta-analysis of prospective observational studies. ( Aune, D; Giovannucci, EL; Greenwood, DC; Keum, N; Lee, DH; Liu, H; Marchand, N; Oh, H, 2015) |
| "It is overexpressed in about 25% of breast cancers." | 2.46 | Towards detecting the HER-2 receptor and metabolic changes induced by HER-2-targeted therapies using medical imaging. ( Smith, TA, 2010) |
| "Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998." | 2.45 | Choline: an essential nutrient for public health. ( da Costa, KA; Zeisel, SH, 2009) |
| "A panel of breast cancer cell lines of different molecular subtypes were used to investigate expression and activity of EDI3 in vitro." | 1.91 | Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth. ( AlWahsh, M; Baumann, M; Brenner, W; Cadenas, C; Demirci, Ö; Derksen, K; Edlund, K; Glotzbach, A; Göçener, D; Hellwig, B; Hengstler, JG; Keller, M; Lambert, J; Leonhardt, G; Lindskog, C; Lüke, S; Madjar, K; Marchan, R; Overbeck, N; Rahnenführer, J; Reinders, J; Rohlf, K; Schmidt, M; Zent, E; Zischinsky, ML, 2023) |
| "The histological type of breast cancer was assessed." | 1.48 | Is there a correlation between 3T multiparametric MRI and molecular subtypes of breast cancer? ( Caliò, A; Camera, L; Caumo, F; Cavedon, C; Giri, MG; Meliadò, G; Montemezzi, S; Pozzetto, A, 2018) |
| "Fatty acids composition in breast cancer using in vivo magnetic resonance spectroscopy (MRS) is gaining its importance in clinical settings (Coum et al." | 1.48 | Alteration in lipid composition differentiates breast cancer tissues: a ( Jain, S; Kumar, S; Paul, A; Raj, A; Roy, R; Singhai, A; Sonkar, AA, 2018) |
| "Twenty of the 23 breast cancer lesions (87%) with a consistent Cho peak expressed a CaSR score of 3-5, and ten of the 11 breast lesions negative for Cho (91%) had a CaSR score of 1-2." | 1.42 | Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study. ( Baio, G; Basso, L; Boccardo, S; Calabrese, M; Neumaier, CE; Pace, D; Rescinito, G; Rosa, F; Salvi, S; Truini, M, 2015) |
| "Choline peaks were detected in 18 of 19 malignant lesions and in 3 of 11 benign counterparts." | 1.42 | Comparative Investigation of Single Voxel Magnetic Resonance Spectroscopy and Dynamic Contrast Enhancement MR Imaging in Differentiation of Benign and Malignant Breast Lesions in a Sample of Iranian Women. ( Baniasadipour, B; Faeghi, F; Jalalshokouhi, J, 2015) |
| "We analyzed 328 tissue samples from 228 breast cancer patients using HR MAS MRS." | 1.39 | Feasibility of MR metabolomics for immediate analysis of resection margins during breast cancer surgery. ( Bathen, TF; Buydens, LM; Fjøsne, HE; Geurts, B; Giskeødegård, GF; Gribbestad, IS; Lundgren, S; Postma, G; Sitter, B, 2013) |
| "Perifosine is an anticancer alkylphospholipid used in clinical trials." | 1.38 | Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells. ( Ronen, SM; Su, JS; Woods, SM, 2012) |
| "Seventy-four patients with breast cancer (mean age 54 years) who underwent (11)C-choline and 2-[(18)F]fluoro-2-deoxy-d-glucose ((18)F-FDG) PET/CT prior to surgery on the same day were enrolled in the present study." | 1.38 | Comparative study of the value of dual tracer PET/CT in evaluating breast cancer. ( Akashi-Tanaka, S; Daisaki, H; Kano, D; Kinoshita, T; Macapinlac, HA; Murano, T; Tateishi, U; Terauchi, T; Tsuda, H, 2012) |
| "Human MDA-MB-231 breast cancer cells and tumors, which were genetically engineered to express red fluorescent tdTomato protein under hypoxic conditions, were used to investigate hypoxia." | 1.38 | Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models. ( Artemov, D; Bhujwalla, ZM; Glunde, K; Greenwood, TR; Heeren, RM; Jiang, L; Raman, V; Winnard, PT, 2012) |
| "Sixteen patients with breast cancer were included." | 1.36 | Predicting pathological response to neoadjuvant chemotherapy in breast cancer with quantitative 1H MR spectroscopy using the external standard method. ( Fukuma, E; Maruyama, K; Oyama, Y; Sakamoto, M; Tozaki, M, 2010) |
| "While malignant brain tumors typically show high choline concentrations and neovascularity, we have anecdotally noted that a substantial number of brain metastases from lung cancer demonstrate only mildly elevated choline resonances on proton MR spectroscopy ((1)H-MRS)." | 1.36 | Association of choline levels and tumor perfusion in brain metastases assessed with proton MR spectroscopy and dynamic susceptibility contrast-enhanced perfusion weighted MRI. ( Castillo, M; Huang, BY; Kwock, L; Smith, JK, 2010) |
| "The results suggest improved breast cancer detection through the combination of morphological and enhancement information from DCE-MRI and metabolic information from 2D MRS." | 1.36 | Combined DCE-MRI and single-voxel 2D MRS for differentiation between benign and malignant breast lesions. ( Bassett, LW; Debruhl, N; Lipnick, S; Liu, X; Sayre, J; Thomas, MA, 2010) |
| "Choline (Cho) signals were clearly visible in malignant lesion areas, while there was no detectable Cho in normal appearing breast or in benign lesions." | 1.35 | A high spatial resolution in vivo 1H magnetic resonance spectroscopic imaging technique for the human breast at 3 T. ( Feng, W; Haacke, EM; Hu, J; Hua, J; Jiang, Q; Li, T; Xuan, Y, 2009) |
| "ER negative breast cancer had bigger tumors compared to ER positive cancer (3." | 1.35 | Estrogen receptor and breast MR imaging features: a correlation study. ( Baek, HM; Chen, JH; Nalcioglu, O; Su, MY, 2008) |
| "Choline SNR was significantly different (P < 0." | 1.33 | Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study. ( Argani, P; Barker, PB; Bhujwalla, ZM; Bluemke, DA; Jacobs, MA; Ouwerkerk, R, 2005) |
| "NBD-choline was easily internalised into drug sensitive MCF-7 and in multidrug resistant MCF-7/DX cells." | 1.33 | Choline and phosphatidylcholine fluorescent derivatives localization in carcinoma cells studied by laser scanning confocal fluorescence microscopy. ( Amboldi, N; Caporizzo, E; Del Buttero, P; Doglia, SM; Fazio, F; Giglioni, B; Grilli, MD; Miozzo, L; Papagni, A; Villa, AM, 2005) |
| "A choline peak was present in 34 of 57 lesions (including all cancers) and in three of 26 benign lesions, giving MR spectroscopy a sensitivity of 100% and a specificity of 88%." | 1.33 | Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study. ( Bartella, L; Dershaw, DD; Guido, J; Huang, W; Liberman, L; Morris, EA; Moskowitz, C; Thakur, SB, 2006) |
| " Corresponding DCE kinetics was measured from each voxel, and analyzed with a 2-compartmental model to obtain pharmacokinetic parameters Ktrans and k(ep)." | 1.33 | Comparison of choline and pharmacokinetic parameters in breast cancer measured by MR spectroscopic imaging and dynamic contrast enhanced MRI. ( Baik, HM; Chen, JH; Mehta, RS; Nalcioglu, O; Su, MY; Yu, HJ, 2006) |
| "Choline peak in vivo is a specific but not sensitive marker of malignancy." | 1.33 | Evaluation of spectral selected press sequence in breast lesion characterization. ( Bao, RX; Liu, PF; Lu, H; Sun, F, 2006) |
| "Choline was observed in all 19 cancer patients, while it was not detected in all other benign diseases." | 1.32 | In vivo 1H-MRS evaluation of malignant and benign breast diseases. ( Chung, DS; Kim, JK; Kim, OD; Lee, HM; Lee, YH; Park, SH; Sung, NK, 2003) |
| "PLD expression was elevated in human breast tumors compared with normal breast tissues." | 1.31 | Overexpression of phospholipase D1 in human breast cancer tissues. ( Ahn, SJ; Han, JS; Kim, JH; Lee, KH; Lee, RA; Noh, DY; Park, IA; Ryu, SH; Suh, PG, 2000) |
| "Choline is an essential nutrient participating as the initial substrate in major metabolic pathways." | 1.31 | Differential routing of choline in implanted breast cancer and normal organs. ( Degani, H; Katz-Brull, R; Margalit, R, 2001) |
| "PET revealed FCH uptake in biopsy-proven recurrent brain tumor with little confounding uptake by normal brain tissues." | 1.31 | Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers. ( Baldwin, SW; Coleman, RE; DeGrado, TR; Friedman, HS; Liao, RP; Orr, MD; Price, DT; Reiman, R; Wang, S, 2001) |
| "To determine whether invasive breast cancer can be distinguished from benign lesions with proton magnetic resonance (MR) spectroscopy ex vivo on the basis of altered cellular chemistry." | 1.30 | Fine-needle biopsy specimens of benign breast lesions distinguished from invasive cancer ex vivo with proton MR spectroscopy. ( Barraclough, BH; Barry, PA; Bilous, M; Doran, ST; Gillett, DJ; Lean, CL; Mackinnon, WB; Malycha, PL; Mountford, CE; Russell, P, 1997) |
| "It was concluded that in brain metastases of mammary carcinoma Lact represents a product of ischemia preceding/during tissue decay resulting in central necrosis, rather than tumor specific metabolism resulting in increased glycolysis." | 1.29 | Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma. ( Oudkerk, M; Sijens, PE; van Dijk, P, 1994) |
| " After oral application He-PC was well absorbed from the intestine and metabolized in the liver by phospholipases C and D." | 1.28 | Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo. ( Breiser, A; Damenz, W; Eibl, H; Engel, J; Fleer, EA; Hilgard, P; Kim, DJ; Nagel, G; Unger, C, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.52) | 18.7374 |
| 1990's | 10 (6.29) | 18.2507 |
| 2000's | 47 (29.56) | 29.6817 |
| 2010's | 82 (51.57) | 24.3611 |
| 2020's | 16 (10.06) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, LA | 1 |
| Yen, RF | 1 |
| Shih, TT | 2 |
| Chen, KL | 1 |
| Wang, J | 7 |
| Radzikowski, KC | 1 |
| Rendl, G | 1 |
| Beheshti, M | 1 |
| Pirich, C | 1 |
| Jozanovic, V | 1 |
| Huic, D | 1 |
| Chen, W | 1 |
| Li, Q | 1 |
| Hou, R | 1 |
| Liang, H | 1 |
| Zhang, Y | 5 |
| Yang, Y | 4 |
| Santamaría, G | 1 |
| Naude, N | 1 |
| Watson, J | 1 |
| Irvine, J | 1 |
| Lloyd, T | 1 |
| Bennett, I | 1 |
| Galloway, G | 1 |
| Malycha, P | 3 |
| Mountford, C | 3 |
| Romeo, V | 1 |
| Helbich, TH | 3 |
| Pinker, K | 3 |
| Keller, M | 1 |
| Rohlf, K | 1 |
| Glotzbach, A | 1 |
| Leonhardt, G | 1 |
| Lüke, S | 1 |
| Derksen, K | 1 |
| Demirci, Ö | 1 |
| Göçener, D | 1 |
| AlWahsh, M | 1 |
| Lambert, J | 2 |
| Lindskog, C | 1 |
| Schmidt, M | 1 |
| Brenner, W | 1 |
| Baumann, M | 1 |
| Zent, E | 1 |
| Zischinsky, ML | 1 |
| Hellwig, B | 1 |
| Madjar, K | 1 |
| Rahnenführer, J | 1 |
| Overbeck, N | 1 |
| Reinders, J | 1 |
| Cadenas, C | 1 |
| Hengstler, JG | 2 |
| Edlund, K | 1 |
| Marchan, R | 3 |
| Van Puyvelde, H | 2 |
| Dimou, N | 1 |
| Katsikari, A | 1 |
| Indave Ruiz, BI | 1 |
| Godderis, L | 2 |
| Huybrechts, I | 2 |
| De Bacquer, D | 2 |
| Oz, M | 1 |
| King, JR | 1 |
| Yang, KS | 1 |
| Khushaish, S | 1 |
| Tchugunova, Y | 1 |
| Khajah, MA | 1 |
| Luqmani, YA | 1 |
| Kabbani, N | 1 |
| Liu, F | 1 |
| Zhou, H | 1 |
| Peng, Y | 1 |
| Qiao, Y | 1 |
| Wang, P | 1 |
| Si, C | 1 |
| Wang, X | 4 |
| Gong, J | 1 |
| Chen, K | 3 |
| Song, F | 1 |
| Beyer, J | 1 |
| Couch, R | 1 |
| Ruddy, KJ | 1 |
| Zeydan, B | 1 |
| Tosakulwong, N | 1 |
| Lesnick, TG | 1 |
| Novotny, PJ | 1 |
| Kohli, S | 1 |
| Cerhan, JH | 1 |
| Pruthi, S | 1 |
| Kantarci, K | 1 |
| Kara, F | 1 |
| Sodano, C | 1 |
| Clauser, P | 2 |
| Dietzel, M | 4 |
| Kapetas, P | 1 |
| Gussew, A | 2 |
| Baltzer, PA | 5 |
| Nese, M | 1 |
| Riboli, G | 1 |
| Brighetti, G | 1 |
| Sassi, V | 1 |
| Camela, E | 1 |
| Caselli, G | 1 |
| Sassaroli, S | 1 |
| Borlimi, R | 1 |
| Aucoin, M | 1 |
| Cooley, K | 1 |
| Saunders, PR | 1 |
| Carè, J | 1 |
| Anheyer, D | 1 |
| Medina, DN | 1 |
| Cardozo, V | 1 |
| Remy, D | 1 |
| Hannan, N | 1 |
| Garber, A | 1 |
| Velayos, M | 1 |
| Muñoz-Serrano, AJ | 1 |
| Estefanía-Fernández, K | 1 |
| Sarmiento Caldas, MC | 1 |
| Moratilla Lapeña, L | 1 |
| López-Santamaría, M | 1 |
| López-Gutiérrez, JC | 1 |
| Li, J | 1 |
| Zhang, J | 1 |
| Shen, S | 1 |
| Zhang, B | 2 |
| Yu, WW | 1 |
| Toyoda, H | 1 |
| Huang, DQ | 1 |
| Le, MH | 1 |
| Nguyen, MH | 1 |
| Huang, R | 1 |
| Zhu, L | 1 |
| Xue, L | 1 |
| Liu, L | 2 |
| Yan, X | 2 |
| Huang, S | 1 |
| Li, Y | 6 |
| Xu, T | 1 |
| Li, C | 2 |
| Ji, F | 1 |
| Ming, F | 1 |
| Zhao, Y | 2 |
| Cheng, J | 1 |
| Wang, Y | 3 |
| Zhao, H | 1 |
| Hong, S | 1 |
| Zhao, XA | 1 |
| Zou, L | 1 |
| Sang, D | 1 |
| Shao, H | 1 |
| Guan, X | 1 |
| Chen, X | 2 |
| Chen, Y | 4 |
| Wei, J | 1 |
| Zhu, C | 1 |
| Wu, C | 1 |
| Moore, HB | 1 |
| Barrett, CD | 1 |
| Moore, EE | 1 |
| Jhunjhunwala, R | 1 |
| McIntyre, RC | 1 |
| Moore, PK | 1 |
| Hajizadeh, N | 1 |
| Talmor, DS | 1 |
| Sauaia, A | 1 |
| Yaffe, MB | 1 |
| Liu, C | 3 |
| Lin, Y | 2 |
| Dong, Y | 1 |
| Wu, Y | 1 |
| Bao, Y | 1 |
| Yan, H | 2 |
| Ma, J | 1 |
| Fernández-Cuadros, ME | 1 |
| Albaladejo-Florín, MJ | 1 |
| Álava-Rabasa, S | 1 |
| Usandizaga-Elio, I | 1 |
| Martinez-Quintanilla Jimenez, D | 1 |
| Peña-Lora, D | 1 |
| Neira-Borrajo, I | 1 |
| López-Muñoz, MJ | 1 |
| Rodríguez-de-Cía, J | 1 |
| Pérez-Moro, OS | 1 |
| Abdallah, M | 1 |
| Alsaleh, H | 1 |
| Baradwan, A | 1 |
| Alfawares, R | 1 |
| Alobaid, A | 1 |
| Rasheed, A | 1 |
| Soliman, I | 1 |
| Wendel Garcia, PD | 1 |
| Fumeaux, T | 1 |
| Guerci, P | 1 |
| Heuberger, DM | 1 |
| Montomoli, J | 2 |
| Roche-Campo, F | 1 |
| Schuepbach, RA | 1 |
| Hilty, MP | 1 |
| Poloni, TE | 1 |
| Carlos, AF | 1 |
| Cairati, M | 1 |
| Cutaia, C | 1 |
| Medici, V | 1 |
| Marelli, E | 1 |
| Ferrari, D | 1 |
| Galli, A | 1 |
| Bognetti, P | 1 |
| Davin, A | 1 |
| Cirrincione, A | 1 |
| Ceretti, A | 1 |
| Cereda, C | 1 |
| Ceroni, M | 1 |
| Tronconi, L | 1 |
| Vitali, S | 1 |
| Guaita, A | 1 |
| Leeds, JS | 1 |
| Raviprakash, V | 1 |
| Jacques, T | 1 |
| Scanlon, N | 1 |
| Cundall, J | 1 |
| Leeds, CM | 1 |
| Riva, A | 1 |
| Gray, EH | 1 |
| Azarian, S | 1 |
| Zamalloa, A | 1 |
| McPhail, MJW | 1 |
| Vincent, RP | 1 |
| Williams, R | 1 |
| Chokshi, S | 1 |
| Patel, VC | 1 |
| Edwards, LA | 1 |
| Alqarawi, W | 1 |
| Birnie, DH | 1 |
| Golian, M | 1 |
| Nair, GM | 1 |
| Nery, PB | 1 |
| Klein, A | 1 |
| Davis, DR | 1 |
| Sadek, MM | 1 |
| Neilipovitz, D | 1 |
| Johnson, CB | 1 |
| Green, MS | 1 |
| Redpath, C | 1 |
| Miller, DC | 1 |
| Beamer, P | 1 |
| Billheimer, D | 1 |
| Subbian, V | 1 |
| Sorooshian, A | 1 |
| Campbell, BS | 1 |
| Mosier, JM | 1 |
| Novaretti, JV | 1 |
| Astur, DC | 1 |
| Cavalcante, ELB | 1 |
| Kaleka, CC | 1 |
| Amaro, JT | 1 |
| Cohen, M | 1 |
| Huang, W | 3 |
| Li, T | 2 |
| Ling, Y | 1 |
| Qian, ZP | 1 |
| Zhang, YY | 1 |
| Huang, D | 1 |
| Xu, SB | 1 |
| Liu, XH | 1 |
| Xia, L | 1 |
| Lu, SH | 1 |
| Lu, HZ | 1 |
| Zhang, R | 2 |
| Ma, JX | 1 |
| Tang, S | 1 |
| Li, CM | 1 |
| Wan, J | 1 |
| Wang, JF | 1 |
| Ma, JQ | 1 |
| Luo, JJ | 1 |
| Chen, HY | 2 |
| Mi, SL | 1 |
| Chen, SY | 1 |
| Su, YG | 1 |
| Ge, JB | 1 |
| Milheiro, SA | 1 |
| Gonçalves, J | 1 |
| Lopes, RMRM | 1 |
| Madureira, M | 1 |
| Lobo, L | 1 |
| Lopes, A | 1 |
| Nogueira, F | 1 |
| Fontinha, D | 1 |
| Prudêncio, M | 1 |
| M Piedade, MF | 1 |
| Pinto, SN | 1 |
| Florindo, PR | 1 |
| Moreira, R | 1 |
| Castillo-Lora, J | 1 |
| Delley, MF | 1 |
| Laga, SM | 1 |
| Mayer, JM | 1 |
| Sutjarit, N | 1 |
| Thongon, N | 1 |
| Weerachayaphorn, J | 1 |
| Piyachaturawat, P | 1 |
| Suksamrarn, A | 1 |
| Suksen, K | 1 |
| Papachristou, DJ | 1 |
| Blair, HC | 1 |
| Hu, Y | 1 |
| Shen, P | 1 |
| Zeng, N | 1 |
| Wang, L | 4 |
| Yan, D | 1 |
| Cui, L | 1 |
| Yang, K | 2 |
| Zhai, C | 1 |
| Yang, M | 1 |
| Lao, X | 1 |
| Sun, J | 1 |
| Ma, N | 1 |
| Wang, S | 2 |
| Ye, W | 2 |
| Guo, P | 1 |
| Rahimi, S | 1 |
| Singh, MP | 1 |
| Gupta, J | 1 |
| Nakanishi, I | 1 |
| Ohkubo, K | 1 |
| Shoji, Y | 1 |
| Fujitaka, Y | 1 |
| Shimoda, K | 1 |
| Matsumoto, KI | 1 |
| Fukuhara, K | 1 |
| Hamada, H | 1 |
| van der Boom, T | 1 |
| Gruppen, EG | 1 |
| Lefrandt, JD | 1 |
| Connelly, MA | 1 |
| Links, TP | 1 |
| Dullaart, RPF | 1 |
| Berry, JD | 1 |
| Bedlack, R | 1 |
| Mathews, D | 1 |
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| Meloncelli, S | 1 |
| Divizia, M | 1 |
| Germani, G | 1 |
| Adefegha, SA | 1 |
| Bottari, NB | 1 |
| Leal, DB | 1 |
| de Andrade, CM | 1 |
| Schetinger, MR | 1 |
| Martínez-Velasco, A | 1 |
| Perez-Ortiz, AC | 1 |
| Antonio-Aguirre, B | 1 |
| Martínez-Villaseñor, L | 1 |
| Lira-Romero, E | 1 |
| Palacio-Pastrana, C | 1 |
| Zenteno, JC | 1 |
| Ramirez, I | 1 |
| Zepeda-Palacio, C | 1 |
| Mendoza-Velásquez, C | 1 |
| Camacho-Ordóñez, A | 1 |
| Ortiz Bibriesca, DM | 1 |
| Estrada-Mena, FJ | 1 |
| Martin, BL | 1 |
| Thompson, LC | 1 |
| Kim, YH | 2 |
| Snow, SJ | 1 |
| Schladweiler, MC | 1 |
| Phillips, P | 1 |
| Harmon, M | 1 |
| King, C | 1 |
| Richards, J | 1 |
| George, I | 1 |
| Haykal-Coates, N | 1 |
| Gilmour, MI | 1 |
| Kodavanti, UP | 1 |
| Hazari, MS | 1 |
| Farraj, AK | 1 |
| Shen, Z | 1 |
| Zou, Y | 1 |
| Gao, K | 1 |
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| Goldfinger, LE | 1 |
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| Kyttaris, VC | 1 |
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| Chen, J | 4 |
| Xun, J | 1 |
| Hu, Z | 1 |
| Huang, Q | 2 |
| Steinhart, C | 1 |
| Shen, Y | 1 |
| Lu, H | 2 |
| Mansuri, A | 1 |
| Lokhande, K | 1 |
| Kore, S | 1 |
| Gaikwad, S | 1 |
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| Swamy, KV | 1 |
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| Shaheen, MY | 1 |
| Basudan, AM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Presurgical Treatment With Ribociclib and Letrozole in Patients With Locally Advanced Breast Cancer: the NEOLETRIB Study.[NCT05163106] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-12-01 | Recruiting | ||
| Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| What Are the Factors Affecting Neoadjuvant Chemotherapy Efficacy in Breast Cancer? A Non-invasive in Vivo Study Using Specialist Magnetic Resonance (MR) Methods[NCT03501394] | 25 participants (Anticipated) | Interventional | 2018-05-02 | Recruiting | |||
| [NCT00155090] | 80 participants | Observational | 2005-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for choline and Breast Neoplasms
| Article | Year |
|---|---|
Breast PET/MRI Hybrid Imaging and Targeted Tracers.
Topics: Artificial Intelligence; Breast Neoplasms; Choline; Female; Fluorodeoxyglucose F18; Humans; Magnetic | 2023 |
The association between dietary intakes of methionine, choline and betaine and breast cancer risk: A systematic review and meta-analysis.
Topics: Betaine; Breast Neoplasms; Choline; Eating; Female; Humans; Methionine; Prospective Studies; Racemet | 2023 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Magnetic resonance spectroscopy of the breast: current status.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Magnetic Resona | 2013 |
1H-MRS evaluation of breast lesions by using total choline signal-to-noise ratio as an indicator of malignancy: a meta-analysis.
Topics: Breast; Breast Neoplasms; Choline; Diagnosis, Differential; Female; Humans; Proton Magnetic Resonanc | 2015 |
Egg intake and cancers of the breast, ovary and prostate: a dose-response meta-analysis of prospective observational studies.
Topics: Breast Neoplasms; Cholesterol; Choline; Databases, Factual; Diet; Dose-Response Relationship, Drug; | 2015 |
Choline: an essential nutrient for public health.
Topics: Adolescent; Adult; Aged; Animals; Breast Neoplasms; Child; Child, Preschool; Choline; Choline Defici | 2009 |
Uncovering the metabolomic fingerprint of breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Transformation, Neoplastic; Choline; Female; Glycolysis; H | 2011 |
Towards detecting the HER-2 receptor and metabolic changes induced by HER-2-targeted therapies using medical imaging.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers, Tumor; | 2010 |
In vivo 1H MRS in the assessment of the therapeutic response of breast cancer patients.
Topics: Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Spectroscopy; Protons; Treatment Outco | 2011 |
In vivo proton magnetic resonance spectroscopy of breast cancer: a review of the literature.
Topics: Breast; Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium; Humans; Magnetic Resonance Sp | 2012 |
MR-spectroscopy at 1.5 tesla and 3 tesla. Useful? A systematic review and meta-analysis.
Topics: Biomarkers, Tumor; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted; Female; Humans; Magnetic | 2012 |
The role of fluorodeoxyglucose, 18F-dihydroxyphenylalanine, 18F-choline, and 18F-fluoride in bone imaging with emphasis on prostate and breast.
Topics: Bone Neoplasms; Breast Neoplasms; Choline; Dihydroxyphenylalanine; Fluorine Radioisotopes; Fluorodeo | 2006 |
In vivo proton magnetic resonance spectroscopy of breast lesions: an update.
Topics: Breast; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Choline; Disease Progression; False | 2007 |
MR spectroscopy of the breast.
Topics: Breast; Breast Neoplasms; Choline; Female; Humans; Lymphatic Metastasis; Magnetic Resonance Imaging; | 2008 |
6 trials available for choline and Breast Neoplasms
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Choline; Cognition; Female; Humans; Inositol; | 2013 |
MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial.
Topics: Adult; Aged; Algorithms; Biomarkers, Tumor; Breast Neoplasms; Choline; Early Detection of Cancer; Fe | 2017 |
Reproducibility of [11C]choline-positron emission tomography and effect of trastuzumab.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breas | 2010 |
Effect of contrast agent on the results of in vivo ¹H MRS of breast tumors - is it clinically significant?
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Contrast Media | 2012 |
Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Choline; Combined | 2001 |
139 other studies available for choline and Breast Neoplasms
| Article | Year |
|---|---|
Diagnostic Performance of Proton Magnetic Resonance Spectroscopy and 18F-Fluorocholine PET to Differentiate Benign From Malignant Breast Lesions.
Topics: Breast Neoplasms; Choline; Female; Humans; Positron-Emission Tomography; Proton Magnetic Resonance S | 2021 |
18F Choline PET/CT in a patient with HRPT2 mutation: Detecting parathyroid carcinoma recurrence and concomitant breast carcinoma.
Topics: Breast Neoplasms; Choline; Female; Humans; Mutation; Parathyroid Neoplasms; Positron Emission Tomogr | 2022 |
Incidental detection of breast cancer by 18F-fluorocholine PET/CT performed for primary hyperparathyroidism.
Topics: Breast Neoplasms; Choline; Female; Humans; Hyperparathyroidism, Primary; Parathyroid Glands; Positro | 2022 |
An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer.
Topics: Animals; Arginine; Breast Neoplasms; Choline; Female; Glutamic Acid; Histidine; Humans; Isoleucine; | 2022 |
Breast Tissue Chemistry Measured In Vivo In Healthy Women Correlate with Breast Density and Breast Cancer Risk.
Topics: Breast Density; Breast Neoplasms; Choline; Female; Glucose; Glutamates; Glutamine; Humans; Lipids; M | 2022 |
Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth.
Topics: Breast Neoplasms; Cell Line, Tumor; Choline; Drug Resistance, Neoplasm; Female; Humans; Phosphatidyl | 2023 |
α7 nicotinic acetylcholine receptor interaction with G proteins in breast cancer cell proliferation, motility, and calcium signaling.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Breast Neoplasms; Calcium; Calcium Signaling; Cell Prolifer | 2023 |
Plasma One-Carbon Metabolism-Related Micronutrients and the Risk of Breast Cancer: Involvement of DNA Methylation.
Topics: Breast Neoplasms; Carbon; Case-Control Studies; Choline; Cysteine; DNA Methylation; Female; Folic Ac | 2023 |
Longitudinal cognitive function and brain metabolites in women receiving chemotherapy for stage 1 to 3 breast cancer: Observational study.
Topics: Aspartic Acid; Brain; Breast Neoplasms; Choline; Cognition; Creatine; Female; Gyrus Cinguli; Humans | 2023 |
Clinical relevance of total choline (tCho) quantification in suspicious lesions on multiparametric breast MRI.
Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Diseases; Breast Neoplasms; Carcinoma, Ductal, Breast | 2020 |
Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines.
Topics: Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Choline; F | 2021 |
[Influences of Tumor Volume and FWHM of the Water Peak and T
Topics: Breast Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Prot | 2021 |
Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Topics: Adult; Aged; Betaine; Breast Neoplasms; Choline; Diet; Europe; Female; Folic Acid; Humans; Methionin | 2021 |
[Effect of peripheral bloodgenomic DNA methylation on the relationship between methyl donor status and risk of breast cancer].
Topics: Betaine; Breast Neoplasms; Case-Control Studies; Choline; Colonic Neoplasms; Diet; DNA Methylation; | 2017 |
Is there an association between enhanced choline and β-catenin pathway in breast cancer? A pilot study by MR Spectroscopy and ELISA.
Topics: Adult; Aged; beta Catenin; Breast Neoplasms; Choline; Cyclin D1; Enzyme-Linked Immunosorbent Assay; | 2017 |
A new method to reduce false positive results in breast MRI by evaluation of multiple spectral regions in proton MR-spectroscopy.
Topics: Algorithms; Area Under Curve; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Imaging; | 2017 |
Molecular Effects of Doxorubicin on Choline Metabolism in Breast Cancer.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2017 |
The FAQUIRE Approach: FAst, QUantitative, hIghly Resolved and sEnsitivity Enhanced
Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; Choline; Female; Humans; Hydrogen; | 2018 |
Total choline quantification measured by 1H MR spectroscopy as early predictor of response after neoadjuvant treatment for locally advanced breast cancer: The impact of immunohistochemical status.
Topics: Adult; Analysis of Variance; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Female; Follow-Up | 2018 |
Imaging biomarkers from multiparametric magnetic resonance imaging are associated with survival outcomes in patients with brain metastases from breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Breast Neopla | 2018 |
Diffusion Kurtosis at 3.0T as an in vivo Imaging Marker for Breast Cancer Characterization: Correlation With Prognostic Factors.
Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Diffusion Magnetic Resonance Imaging; Diffusion Tens | 2019 |
Is there a correlation between 3T multiparametric MRI and molecular subtypes of breast cancer?
Topics: Adult; Aged; Area Under Curve; Breast Neoplasms; Choline; Estrogen Receptor alpha; Female; Humans; I | 2018 |
CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Choline; Colorectal Neoplasms; Cytidine Dipho | 2019 |
Application of in vivo MR methods in the study of breast cancer metabolism.
Topics: Breast Neoplasms; Choline; Contrast Media; Female; Humans; Magnetic Resonance Imaging; Models, Biolo | 2019 |
18F-Choline PET/CT in Leptomeningeal Breast Cancer Metastases.
Topics: Breast Neoplasms; Choline; Female; Humans; Meningeal Carcinomatosis; Middle Aged; Positron Emission | 2019 |
Alteration in lipid composition differentiates breast cancer tissues: a
Topics: Breast Neoplasms; Choline; Female; Glutamic Acid; Glycine; Humans; Lipids; Metabolomics; Middle Aged | 2018 |
Role of diffusion weighted imaging and magnetic resonance spectroscopy in breast cancer patients with indeterminate dynamic contrast enhanced magnetic resonance imaging findings.
Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Contrast Media; Diffusion Magnetic Resonance Imaging | 2019 |
Breast Magnetic Resonance Spectroscopy at 3 T in Biopsy-Proven Breast Cancers: Does Choline Peak Correlate With Prognostic Factors?
Topics: Adult; Aged; Biopsy; Breast; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Spectrosc | 2019 |
Application value of 3T ¹H-magnetic resonance spectroscopy in diagnosing breast tumors.
Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Differential; Female; Humans; Ima | 2013 |
Feasibility of MR metabolomics for immediate analysis of resection margins during breast cancer surgery.
Topics: Adult; Aged; Aged, 80 and over; Biopsy; Breast Neoplasms; Choline; Discriminant Analysis; Feasibilit | 2013 |
HDAC inhibition induces increased choline uptake and elevated phosphocholine levels in MCF7 breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Choline; Enzyme Activation; Fema | 2013 |
Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI.
Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Early | 2013 |
Absolute quantification of choline-related biomarkers in breast cancer biopsies by liquid chromatography electrospray ionization mass spectrometry.
Topics: Acetonitriles; Biomarkers, Tumor; Biopsy; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Carci | 2013 |
Pubertal supplementation of lipotropes in female rats reduces mammary cancer risk by suppressing histone deacetylase 1.
Topics: Animals; Breast Neoplasms; Choline; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferase 1; DNA | 2014 |
Feasibility of MR spectroscopy for characterizing malignant breast lesions using a clinical 3-T scanner.
Topics: Adult; Aged; Breast Neoplasms; Choline; False Negative Reactions; Feasibility Studies; Female; Human | 2015 |
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Choline; Choline Kinase; Female; Gene Expression; Gene Expression Profili | 2014 |
In vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Heterografts; Humans; Imaging, Three- | 2015 |
Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Choline; Female; Fluorine Radioisotopes; Heterografts; Humans; Liver; Mic | 2014 |
Dixon imaging-based partial volume correction improves quantification of choline detected by breast 3D-MRSI.
Topics: Adipose Tissue; Body Water; Breast; Breast Neoplasms; Choline; Female; Humans; Imaging, Three-Dimens | 2015 |
Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study.
Topics: Adult; Aged; Breast Neoplasms; Choline; Female; Humans; Immunohistochemistry; Magnetic Resonance Ima | 2015 |
Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter.
Topics: Brain Neoplasms; Breast Neoplasms; Carcinoma, Lobular; Cell Hypoxia; Choline; Female; Humans; Lactic | 2015 |
Diffusion-Weighted Imaging-guided MR Spectroscopy in Breast Lesions using Readout-Segmented Echo-Planar Imaging.
Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobu | 2016 |
Comparative Investigation of Single Voxel Magnetic Resonance Spectroscopy and Dynamic Contrast Enhancement MR Imaging in Differentiation of Benign and Malignant Breast Lesions in a Sample of Iranian Women.
Topics: Adult; Breast; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Differential; Early Detection o | 2015 |
Serum betaine but not choline is inversely associated with breast cancer risk: a case-control study in China.
Topics: Adult; Aged; Betaine; Breast Neoplasms; Case-Control Studies; China; Choline; Diet; Exercise; Female | 2017 |
Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Choline; Female; Humans; Metformin; Phosphatidylcholines; Phosph | 2016 |
Multiparametric breast MRI with 3T: Effectivity of combination of contrast enhanced MRI, DWI and 1H single voxel spectroscopy in differentiation of Breast tumors.
Topics: Adolescent; Adult; Aged; Biopsy; Breast; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Diffe | 2016 |
Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism.
Topics: Animals; Breast Neoplasms; Choline; Choline-Phosphate Cytidylyltransferase; Diacylglycerol Cholineph | 2016 |
Dietary choline and betaine intake, choline-metabolising genetic polymorphisms and breast cancer risk: a case-control study in China.
Topics: Adult; Aged; Betaine; Breast Neoplasms; Case-Control Studies; China; Choline; Diet; Female; Food Ana | 2016 |
GDPD5, a choline-generating enzyme and its novel role in tumor cell migration.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Choline; Female; Gene Knockdown Techniques; Human | 2016 |
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Body Water; Breast; Breast Neoplasms; Carcinoma | 2017 |
Choline as a biomarker for cell proliferation: do the results from proton MR spectroscopy show difference between HER2/neu positive and negative breast cancers?
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Choline; Female; Humans; Magne | 2008 |
Monitoring of early response to neoadjuvant chemotherapy in breast cancer with (1)H MR spectroscopy: comparison to sequential 2-[18F]-fluorodeoxyglucose positron emission tomography.
Topics: Adult; Algorithms; Breast Neoplasms; Chemotherapy, Adjuvant; Choline; Contrast Media; Female; Fluoro | 2008 |
Breast MR.
Topics: Animals; Breast; Breast Neoplasms; Choline; Contrast Media; Female; Humans; Magnetic Resonance Imagi | 2009 |
Predicting pathologic response to neoadjuvant chemotherapy in breast cancer by using MR imaging and quantitative 1H MR spectroscopy.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chem | 2009 |
Interaction of gadolinium-based MR contrast agents with choline: implications for MR spectroscopy (MRS) of the breast.
Topics: Animals; Artifacts; Breast; Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium; Magnetic | 2009 |
Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells.
Topics: Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Choline; Choline Kinase; D | 2009 |
In vivo proton MR spectroscopy of the breast using the total choline peak integral as a marker of malignancy.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Magnet | 2009 |
High intakes of choline and betaine reduce breast cancer mortality in a population-based study.
Topics: Adult; Aged; Aged, 80 and over; Betaine; Betaine-Homocysteine S-Methyltransferase; Breast Neoplasms; | 2009 |
[11C]choline positron emission tomography in estrogen receptor-positive breast cancer.
Topics: Breast Neoplasms; Carbon Radioisotopes; Choline; Female; Humans; Ki-67 Antigen; Positron-Emission To | 2009 |
Can proton MRS provide useful information for characterizing estrogen receptor status in breast cancer?
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Spectr | 2010 |
A high spatial resolution in vivo 1H magnetic resonance spectroscopic imaging technique for the human breast at 3 T.
Topics: Breast; Breast Neoplasms; Choline; Feasibility Studies; Female; Humans; Magnetic Resonance Imaging; | 2009 |
Choline and betaine intake and risk of breast cancer among post-menopausal women.
Topics: Adult; Aged; Aged, 80 and over; Betaine; Breast Neoplasms; Choline; Female; Folic Acid; Humans; Midd | 2010 |
Quantitative multivoxel proton chemical shift imaging of the breast.
Topics: Algorithms; Biomarkers, Tumor; Breast; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted; Fema | 2010 |
Detection of synchronous primary breast and prostate cancer by F-18 fluorocholine PET/CT.
Topics: Aged; Breast Neoplasms; Choline; Humans; Male; Neoplasms, Multiple Primary; Positron-Emission Tomogr | 2010 |
Assessment of therapeutic response of locally advanced breast cancer (LABC) patients undergoing neoadjuvant chemotherapy (NACT) monitored using sequential magnetic resonance spectroscopic imaging (MRSI).
Topics: Adult; Aged; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Imaging; Magnetic Resonan | 2010 |
Predicting pathological response to neoadjuvant chemotherapy in breast cancer with quantitative 1H MR spectroscopy using the external standard method.
Topics: Adult; Algorithms; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; | 2010 |
Association of choline levels and tumor perfusion in brain metastases assessed with proton MR spectroscopy and dynamic susceptibility contrast-enhanced perfusion weighted MRI.
Topics: Blood Volume; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cerebrovascular Cir | 2010 |
Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Spectr | 2011 |
Combined DCE-MRI and single-voxel 2D MRS for differentiation between benign and malignant breast lesions.
Topics: Breast Neoplasms; Choline; Contrast Media; Female; Humans; Magnetic Resonance Imaging; Magnetic Reso | 2010 |
17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2.
Topics: Antigens, CD; Antineoplastic Agents; Benzoquinones; Biological Transport; Biomarkers, Tumor; Breast | 2010 |
Multimodal mass spectrometric imaging of small molecules reveals distinct spatio-molecular signatures in differentially metastatic breast tumor models.
Topics: Animals; Breast Neoplasms; Choline; Female; Glycerylphosphorylcholine; Humans; Magnetic Resonance Im | 2010 |
Diagnostic usefulness of water-to-fat ratio and choline concentration in malignant and benign breast lesions and normal breast parenchyma: an in vivo (1) H MRS study.
Topics: Adipose Tissue; Adult; Aged; Area Under Curve; Biomarkers; Body Water; Breast; Breast Diseases; Brea | 2011 |
Determination of choline concentration in breast lesions: quantitative multivoxel proton MR spectroscopy as a promising noninvasive assessment tool to exclude benign lesions.
Topics: Adult; Aged; Breast Neoplasms; Choline; Diagnosis, Differential; Feasibility Studies; Female; Humans | 2011 |
Biological basis of [¹¹C]choline-positron emission tomography in patients with breast cancer: comparison with [¹⁸F]fluorothymidine positron emission tomography.
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Carbon Radioisotopes; Cell Proliferation; Choline; Ch | 2011 |
In vivo MRS of locally advanced breast cancer: characteristics related to negative or positive choline detection and early monitoring of treatment response.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Female; Humans | 2011 |
Noninvasive imaging identifies new roles for cyclooxygenase-2 in choline and lipid metabolism of human breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Choline; Choline Kinase; Cyclooxygenase 2; Female; Gene Knockdow | 2012 |
Three-dimensional proton MR spectroscopic imaging at 3 T for the differentiation of benign and malignant breast lesions.
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Needle; Breast Neoplasms; Choline; Diagnosis, Differential; | 2011 |
¹H-magnetic resonance spectroscopy of the breast at 3.0-T: comparison of results obtained before and after administration of gadolinium-based contrast agent.
Topics: Adult; Aged; Breast Neoplasms; Breast Neoplasms, Male; Choline; Contrast Media; Gadolinium DTPA; Hum | 2012 |
Association of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status with total choline concentration and tumor volume in breast cancer patients: an MRI and in vivo proton MRS study.
Topics: Aged; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Imaging, Three-Dimensional; Magn | 2012 |
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Choline; Choline Kinase; Choline-Phosphate Cytidylyl | 2012 |
Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.
Topics: Adult; Breast Neoplasms; Cell Extracts; Cell Line, Tumor; Choline; Choline Kinase; Female; Gene Expr | 2012 |
NMR metabolomics of MTLn3E breast cancer cells identifies a role for CXCR4 in lipid and choline regulation.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Choline; Cloning, Molecular; Female; | 2012 |
Evaluation of breast cancer using proton MR spectroscopy: total choline peak integral and signal-to-noise ratio as prognostic indicators.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Imagin | 2012 |
Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Choline; Endometrial Neoplasms; Female; | 2012 |
Comparative study of the value of dual tracer PET/CT in evaluating breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Choline; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; | 2012 |
Magnetic resonance spectroscopy of the breast at 3T: pre- and post-contrast evaluation for breast lesion characterization.
Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Contrast Media; Early Detection of Cancer; Female; G | 2012 |
(1)H MR spectroscopy with external reference solution at 1.5 T for differentiating malignant and benign breast lesions: comparison using qualitative and quantitative approaches.
Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Differential; Female; Gadolinium | 2013 |
Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer.
Topics: Animals; Breast Neoplasms; Choline; Endometrial Neoplasms; Female; Humans; Ovarian Neoplasms; Phosph | 2012 |
Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models.
Topics: Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Choline; Female; Humans; Lipid Metabolism; Magneti | 2012 |
1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer.
Topics: Biomarkers, Tumor; Biopsy, Fine-Needle; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted; Fem | 2013 |
L-COSY of breast cancer at 3T.
Topics: Adult; Aged; Algorithms; Biomarkers, Tumor; Breast Neoplasms; Choline; Diagnosis, Computer-Assisted; | 2012 |
Choline and betaine intake is inversely associated with breast cancer risk: a two-stage case-control study in China.
Topics: Betaine; Breast Neoplasms; Case-Control Studies; China; Choline; Diet; Eating; Female; Folic Acid; H | 2013 |
Comparative assessment of segmentation algorithms for tumor delineation on a test-retest [(11)C]choline dataset.
Topics: Algorithms; Artificial Intelligence; Breast Neoplasms; Carbon Radioisotopes; Choline; Female; Humans | 2012 |
Eliminating spurious lipid sidebands in 1H MRS of breast lesions.
Topics: Artifacts; Breast; Breast Neoplasms; Choline; Female; Humans; Lipids; Magnetic Resonance Spectroscop | 2002 |
Breast cancer: in vivo proton MR spectroscopy in the characterization of histopathologic subtypes and preliminary observations in axillary node metastases.
Topics: Adult; Aged; Aged, 80 and over; Axilla; Biopsy, Needle; Breast Neoplasms; Carcinoma, Ductal, Breast; | 2002 |
Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Choline; Epithelial Cells; Female; Humans | 2002 |
[11C]Choline as a potential PET marker for imaging of breast cancer athymic mice.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon Radioisotopes; Choline; Feasibility Studies; Mi | 2002 |
In vivo quantification of choline compounds in the breast with 1H MR spectroscopy.
Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Female; Humans; Image Processing, Computer-Assisted; | 2003 |
In vivo 1H-MRS evaluation of malignant and benign breast diseases.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Diagnosis, Differenti | 2003 |
Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study.
Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Diagnosis, Differential; Female; Gadolinium | 2004 |
Molecular causes of the aberrant choline phospholipid metabolism in breast cancer.
Topics: Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; Cell Membrane; Choline; Choline Kinase; Humans; | 2004 |
Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1H MRS at 1.5 T.
Topics: Adult; Aged; Breast Neoplasms; Case-Control Studies; Choline; Female; Humans; Magnetic Resonance Ima | 2005 |
Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study.
Topics: Breast; Breast Neoplasms; Choline; Contrast Media; Feasibility Studies; Female; Gadolinium DTPA; Hum | 2005 |
[methyl-3H]Choline incorporation into MCF7 tumour cells: correlation with proliferation.
Topics: Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Cell Proliferation; Choline; Humans; Metab | 2005 |
Choline and phosphatidylcholine fluorescent derivatives localization in carcinoma cells studied by laser scanning confocal fluorescence microscopy.
Topics: Breast Neoplasms; Choline; Female; Fluorescence; Humans; Microscopy, Confocal; Microscopy, Fluoresce | 2005 |
An improved 1H magnetic resonance spectroscopic imaging technique for the human breast: preliminary results.
Topics: Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium DTPA; Humans; Magnetic Resonance Spect | 2005 |
Evaluation of 1H-magnetic resonance spectroscopy of breast cancer pre- and postgadolinium administration.
Topics: Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium; Humans; Image Enhancement; Magnetic R | 2005 |
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation.
Topics: Breast Neoplasms; Cell Differentiation; Cell Growth Processes; Cell Line, Tumor; Choline; Choline Ki | 2005 |
Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study.
Topics: Adult; Aged; Biomarkers, Tumor; Biopsy; Breast Neoplasms; Choline; Female; Humans; Magnetic Resonanc | 2006 |
Quantification of choline-containing compounds in malignant breast tumors by 1H MR spectroscopy using water as an internal reference at 1.5 T.
Topics: Breast Neoplasms; Choline; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance S | 2006 |
Comparison of choline and pharmacokinetic parameters in breast cancer measured by MR spectroscopic imaging and dynamic contrast enhanced MRI.
Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Female; Humans; Image Interpretation, Comput | 2006 |
Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Choline; Disease Progre | 2006 |
Evaluation of spectral selected press sequence in breast lesion characterization.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Female; Fibroa | 2006 |
Quantitative correlation between (1)H MRS and dynamic contrast-enhanced MRI of human breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Choline; Contrast Media; Diffusion; Female; Humans | 2008 |
Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women.
Topics: Adult; Betaine; Breast Neoplasms; Choline; Diet; Female; Food; Humans; Metabolic Networks and Pathwa | 2007 |
Choline metabolism and risk of breast cancer in a population-based study.
Topics: Betaine; Breast Neoplasms; Case-Control Studies; Choline; Choline Dehydrogenase; Diet; Female; Genot | 2008 |
Proton MR spectroscopy for monitoring early treatment response of breast cancer to neo-adjuvant chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Ca | 2008 |
Estrogen receptor and breast MR imaging features: a correlation study.
Topics: Adult; Aged; Axilla; Breast Neoplasms; Carcinoma, Ductal, Breast; Choline; Female; Humans; Lymphatic | 2008 |
Detection of choline signal in human breast lesions with chemical-shift imaging.
Topics: Adult; Aged; Breast Neoplasms; Choline; Contrast Media; Female; Gadolinium DTPA; Humans; Magnetic Re | 2008 |
Correlation between choline level and Gd-DTPA enhancement in patients with brain metastases of mammary carcinoma.
Topics: Adult; Aspartic Acid; Brain Neoplasms; Breast Neoplasms; Carcinoma; Choline; Contrast Media; Creatin | 1994 |
Fine-needle biopsy specimens of benign breast lesions distinguished from invasive cancer ex vivo with proton MR spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Needle; Breast; Breast Neoplasms; Carcinoma in Situ; Carcino | 1997 |
Phorbol ester stimulation of phosphatidylcholine synthesis requires expression of both protein kinase C-alpha and phospholipase D.
Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Choline; Choline Kinase; Dig | 1998 |
TNF-induced modulations of phospholipid metabolism in human breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Choline; Choline-Phosphate Cytidylyltransfer | 1998 |
Human breast lesions: characterization with proton MR spectroscopy.
Topics: Adult; Aged; Breast; Breast Neoplasms; Choline; Diagnosis, Differential; Female; Humans; Magnetic Re | 1998 |
Choline metabolism in breast cancer; 2H-, 13C- and 31P-NMR studies of cells and tumors.
Topics: Animals; Breast Neoplasms; Carbon Isotopes; Choline; Deuterium; Female; Humans; Male; Mice; Mice, Nu | 1998 |
Magnetic resonance spectroscopy and breast cancer.
Topics: Biopsy, Needle; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; Choline; Creatine; F | 1998 |
Characterization of neoplastic and normal human breast tissues with in vivo (1)H MR spectroscopy.
Topics: Adult; Aged; Breast; Breast Neoplasms; Carcinoma; Choline; Diagnosis, Differential; Female; Humans; | 1999 |
Overexpression of phospholipase D1 in human breast cancer tissues.
Topics: ADP-Ribosylation Factors; Adult; Aged; Blotting, Western; Breast; Breast Neoplasms; Choline; Female; | 2000 |
Differential routing of choline in implanted breast cancer and normal organs.
Topics: Animals; Breast Neoplasms; Carbon Isotopes; Choline; Female; Humans; Magnetic Resonance Spectroscopy | 2001 |
External standard method for the in vivo quantification of choline-containing compounds in breast tumors by proton MR spectroscopy at 1.5 Tesla.
Topics: Breast Neoplasms; Choline; Female; Humans; Magnetic Resonance Spectroscopy; Phantoms, Imaging | 2001 |
The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, | 2001 |
Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.
Topics: Adult; Aged; Animals; Brain Neoplasms; Breast Neoplasms; Choline; Female; Fluorine Radioisotopes; Hu | 2001 |
Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis.
Topics: Betaine; Biomarkers, Tumor; Breast; Breast Neoplasms; Carbon Isotopes; Choline; Epithelial Cells; Hu | 2002 |
[Directed internal after care following breast cancer surgery. Combined hyperergic treatment].
Topics: Aftercare; Antineoplastic Agents; Breast Neoplasms; Choline; Female; Humans; Mastectomy; Postoperati | 1976 |
Lipid metabolism in large T47D human breast cancer spheroids: 31P- and 13C-NMR studies of choline and ethanolamine uptake.
Topics: Breast Neoplasms; Cell Division; Choline; Ethanolamine; Ethanolamines; Humans; Magnetic Resonance Sp | 1992 |
Lipid metabolism in T47D human breast cancer cells: 31P and 13C-NMR studies of choline and ethanolamine uptake.
Topics: Breast Neoplasms; Choline; Choline-Phosphate Cytidylyltransferase; Ethanolamine; Ethanolamines; Glyc | 1991 |
Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Choline; Drug Screening Assays, Antitumor; Female; | 1989 |
Hexadecylphosphocholine (D 18506) in the topical treatment of skin metastases: a phase-I trial.
Topics: Administration, Topical; Breast Neoplasms; Choline; Drug Evaluation; Female; Humans; Neoplasm Recurr | 1988 |
Phospholipid metabolism in cancer cells monitored by 31P NMR spectroscopy.
Topics: Breast Neoplasms; Cell Line; Choline; Ethanolamine; Ethanolamines; Female; Hemicholinium 3; Humans; | 1987 |