choline has been researched along with Brain Disorders in 98 studies
Excerpt | Relevance | Reference |
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"Choline is elevated in the basal ganglia and prefrontal cortical regions, suggesting regionally increased membrane turnover or glial activation in schizophrenia." | 9.41 | Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status. ( Maddock, RJ; Smucny, J; Yang, YS; Zhang, H, 2023) |
" We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3." | 7.74 | Neuroimaging findings in hyperargininemia. ( Akinci, A; Alkan, A; Firat, AK; Güngör, S; Tabel, Y, 2008) |
"Choline is elevated in the basal ganglia and prefrontal cortical regions, suggesting regionally increased membrane turnover or glial activation in schizophrenia." | 5.41 | Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status. ( Maddock, RJ; Smucny, J; Yang, YS; Zhang, H, 2023) |
" This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors." | 4.85 | Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009) |
"Higher triglyceride and lower HDL levels statistically account for the association between BMI and myo-inositol, pointing toward a potentially critical role for dyslipidemia in the development of cerebral neurochemical alterations in obesity." | 3.79 | Dyslipidemia links obesity to early cerebral neurochemical alterations. ( Gonzales, MM; Haley, AP; Tanaka, H; Tarumi, T, 2013) |
" We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3." | 3.74 | Neuroimaging findings in hyperargininemia. ( Akinci, A; Alkan, A; Firat, AK; Güngör, S; Tabel, Y, 2008) |
"Compared with healthy subjects, patients with myotonic dystrophy had elevated levels of myoinositol (+19% in the occipital region and +12." | 3.70 | Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats. ( Chang, L; Ernst, T; Leonido-Yee, M; Osborn, D; Poland, RE; Seltzer, W, 1998) |
" Spectroscopy is a reliable technique for grading of gliomas when N-acetyl-aspartate/choline and choline/creatine ratios and presence of lipids are used in combination." | 3.69 | Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995) |
"(a) Hamartomas showed higher N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios than gliomas." | 3.69 | Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation. ( Castillo, M; Green, C; Greenwood, R; Kwock, L; Schiro, S; Smith, K; Wilson, D, 1995) |
"Lipopolysaccharide (LPS)-induced encephalopathy induces neuroinflammation." | 1.51 | Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation. ( Gulej, R; Lawrence, B; McKenzie, T; Morton, KA; Saunders, D; Smith, N; Towner, RA, 2019) |
"The histological diagnosis was anaplastic oligodendroglioma (WHO grade III)." | 1.37 | [Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma]. ( Akutsu, H; Anno, I; Isobe, T; Masumoto, T; Matsumura, A; Nakai, K; Shiigai, M; Takano, S; Yamamoto, T, 2011) |
"Previous studies have shown that COPD adversely affects distant organs and body systems, including the brain." | 1.35 | Modeling the impact of COPD on the brain. ( Anzai, Y; Aylward, E; Borson, S; Fields, J; Friedman, S; Mahurin, R; Richards, T; Scanlan, J; Yeh, S; Yukawa, M; Zuhr, E, 2008) |
"The association of chorioamnionitis and noncystic white matter injury, a common brain injury in premature newborns, remains controversial." | 1.35 | Effect of chorioamnionitis on brain development and injury in premature newborns. ( Bowen-Roberts, T; Brant, R; Chau, V; McFadden, DE; Miller, SP; Poskitt, KJ; Sargent, MA; Soulikias, W; Synnes, A, 2009) |
"Active demyelination or increased myelin turnover might contribute to the hitherto unexplained WMD of this rare disorder." | 1.33 | White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination. ( Anhuf, D; Häusler, M; Möller-Hartmann, W; Ramaekers, VT; Schüler, H; Thron, A; Zerres, K, 2005) |
"PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy." | 1.33 | Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006) |
"Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
"This elevation is unrelated to hepatic encephalopathy or a history of intravenous drug abuse, and suggests that a biological process underlies the extrahepatic symptoms in chronic HCV infection." | 1.31 | Evidence for a cerebral effect of the hepatitis C virus. ( Allsop, JM; Forton, DM; Foster, GR; Main, J; Taylor-Robinson, SD; Thomas, HC, 2001) |
"Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging." | 1.31 | Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome. ( Barker, PB; Beauchamp, NJ; Eichler, FS; Wang, P; Wityk, RJ, 2002) |
"Also, patients with Wilson disease and portosystemic shunting had lower myo-inositol-creatine ratios than did patients with Wilson disease and no portosystemic shunting (P < ." | 1.30 | Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy. ( Hoogenraad, TU; Mali, WP; Van Den Heuvel, AG; Van der Grond, J; Van Rooij, LG; Van Wassenaer-van Hall, HN, 1997) |
"The study included 12 patients with progressive supranuclear palsy, 10 with Parkinson's disease, nine with corticobasal degeneration and 11 age-matched normal control subjects." | 1.30 | Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. ( Bertolino, A; Bonavita, S; Hallett, M; Litvan, I; Lundbom, N; Patronas, NJ; Tedeschi, G, 1997) |
"Late juvenile neuronal ceroid lipofuscinosis (NCL) is a lysosomal neurodegenerative disorder caused by the accumulation of lipopigment in neurons." | 1.30 | MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis. ( Grodd, W; Klose, U; Nägele, T; Schwab, A; Seeger, U; Seitz, D, 1998) |
"Choline treatment did not change brain choline content, and was not associated with clinical or radiological improvement." | 1.30 | One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. ( Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH, 1998) |
"Choline levels were unchanged in the lesions." | 1.29 | Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions. ( Barker, PB; Bryan, RN; Conturo, TE; Oppenheimer, SM; Preziosi, TJ; Soher, BJ, 1995) |
" Further, each dosing paradigm has been evaluated with a view to experimental error and interactive variables." | 1.27 | Effects of early lead exposure on neurotransmitter systems in the brain. A review with commentary. ( Shellenberger, MK, 1984) |
"Cerebrospinal fluid from patients with Parkinson's disease and Huntington's chorea has been investigated with regard to the concentration of choline." | 1.25 | Cerebrospinal fluid choline in extrapyramidal disorders. ( Aquilonius, SM; Nyström, B; Schuberth, J; Sundwall, A, 1972) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (15.31) | 18.7374 |
1990's | 27 (27.55) | 18.2507 |
2000's | 41 (41.84) | 29.6817 |
2010's | 11 (11.22) | 24.3611 |
2020's | 4 (4.08) | 2.80 |
Authors | Studies |
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Mueller, C | 1 |
Baird, JF | 1 |
Motl, RW | 1 |
Matveeva, MV | 1 |
Samoilova, YG | 1 |
Kudlay, DA | 1 |
Yang, YS | 1 |
Smucny, J | 1 |
Zhang, H | 1 |
Maddock, RJ | 1 |
Towner, RA | 1 |
Saunders, D | 1 |
Smith, N | 1 |
Gulej, R | 1 |
McKenzie, T | 1 |
Lawrence, B | 1 |
Morton, KA | 1 |
Wang, AP | 1 |
Suryavanshi, T | 1 |
Marcucci, M | 1 |
Fong, C | 1 |
Whitton, AC | 1 |
Reddy, KKV | 1 |
Haley, AP | 1 |
Gonzales, MM | 1 |
Tarumi, T | 1 |
Tanaka, H | 1 |
Bladowska, J | 1 |
Zimny, A | 1 |
Knysz, B | 1 |
Małyszczak, K | 1 |
Kołtowska, A | 1 |
Szewczyk, P | 1 |
Gąsiorowski, J | 1 |
Furdal, M | 1 |
Sąsiadek, MJ | 1 |
Chen, WS | 1 |
Li, JJ | 1 |
Hong, L | 1 |
Xing, ZB | 1 |
Wang, F | 1 |
Li, CQ | 1 |
Pandey, S | 1 |
Garabadu, D | 1 |
Cansev, M | 1 |
Wurtman, RJ | 4 |
Sakamoto, T | 1 |
Ulus, IH | 3 |
Borson, S | 1 |
Scanlan, J | 1 |
Friedman, S | 1 |
Zuhr, E | 1 |
Fields, J | 1 |
Aylward, E | 1 |
Mahurin, R | 1 |
Richards, T | 1 |
Anzai, Y | 1 |
Yukawa, M | 1 |
Yeh, S | 1 |
Josey, L | 1 |
Al Sayyari, A | 1 |
Buckley, R | 1 |
Coulthard, A | 1 |
Majós, C | 1 |
Aguilera, C | 1 |
Alonso, J | 1 |
Julià-Sapé, M | 1 |
Castañer, S | 1 |
Sánchez, JJ | 1 |
Samitier, A | 1 |
León, A | 1 |
Rovira, A | 1 |
Arús, C | 1 |
Chau, V | 1 |
Poskitt, KJ | 1 |
McFadden, DE | 1 |
Bowen-Roberts, T | 1 |
Synnes, A | 1 |
Brant, R | 1 |
Sargent, MA | 1 |
Soulikias, W | 1 |
Miller, SP | 1 |
Martínez-Bisbal, MC | 1 |
Celda, B | 1 |
Girard, N | 1 |
Pauletti, C | 1 |
Pujia, F | 1 |
Accorinti, M | 1 |
Pauri, F | 1 |
Tinelli, E | 1 |
Bianco, F | 1 |
Morocutti, C | 1 |
Fattapposta, F | 1 |
BORNSTEIN, MB | 1 |
Isobe, T | 1 |
Akutsu, H | 1 |
Yamamoto, T | 1 |
Shiigai, M | 1 |
Masumoto, T | 1 |
Nakai, K | 1 |
Takano, S | 1 |
Anno, I | 1 |
Matsumura, A | 1 |
Prado, PT | 1 |
Escorsi-Rosset, S | 1 |
Cervi, MC | 1 |
Santos, AC | 1 |
Wang, Y | 1 |
Jia, Y | 1 |
Xu, G | 1 |
Ling, X | 1 |
Liu, S | 1 |
Huang, L | 1 |
Porto, L | 2 |
Hattingen, E | 2 |
Stuecher, A | 1 |
Herminghaus, S | 1 |
Lanfermann, H | 2 |
Ulrich Pilatus, UP | 1 |
Gelal, F | 1 |
Callí, C | 1 |
Apaydín, M | 1 |
Erdem, G | 1 |
Eichler, FS | 2 |
Itoh, R | 1 |
Barker, PB | 5 |
Mori, S | 1 |
Garrett, ES | 1 |
van Zijl, PC | 2 |
Moser, HW | 2 |
Raymond, GV | 1 |
Melhem, ER | 1 |
Smith, JK | 1 |
Londono, A | 1 |
Castillo, M | 2 |
Kwock, L | 2 |
Baik, HM | 1 |
Choe, BY | 1 |
Son, BC | 1 |
Kim, MC | 1 |
Kim, EN | 1 |
Lee, HK | 1 |
Suh, TS | 1 |
Firbank, MJ | 1 |
Minett, T | 1 |
O'Brien, JT | 1 |
Bachert, P | 1 |
Schröder, L | 1 |
Nagae-Poetscher, LM | 1 |
Bibat, G | 1 |
Philippart, M | 1 |
Rosemberg, S | 1 |
Fatemi, A | 1 |
Lacerda, MT | 1 |
Costa, MO | 1 |
Kok, F | 1 |
Costa Leite, C | 1 |
Horská, A | 1 |
Naidu, S | 1 |
Castellino, G | 1 |
Govoni, M | 1 |
Padovan, M | 1 |
Colamussi, P | 1 |
Borrelli, M | 1 |
Trotta, F | 1 |
Häusler, M | 1 |
Anhuf, D | 1 |
Schüler, H | 1 |
Ramaekers, VT | 1 |
Thron, A | 1 |
Zerres, K | 1 |
Möller-Hartmann, W | 1 |
Chang, L | 3 |
Ernst, T | 3 |
Speck, O | 1 |
Grob, CS | 1 |
Briellmann, RS | 1 |
Wellard, RM | 1 |
Jackson, GD | 1 |
Groeschel, S | 1 |
Brockmann, K | 1 |
Dechent, P | 2 |
Wilichowski, E | 1 |
Frahm, J | 3 |
Hanefeld, F | 2 |
Ilcol, YO | 1 |
Basagan-Mogol, E | 1 |
Cengiz, M | 1 |
Koudijs, SM | 1 |
van der Grond, J | 2 |
Hoogendoorn, ML | 1 |
Hulshoff Pol, HE | 1 |
Schnack, HG | 1 |
Witkamp, TD | 1 |
Gooskens, RH | 1 |
van Nieuwenhuizen, O | 1 |
Braun, KP | 1 |
Huisman, TA | 1 |
Klein, A | 1 |
Werner, B | 1 |
Straube, T | 1 |
Boltshauser, E | 1 |
Pilatus, U | 1 |
Kieslich, M | 1 |
Yan, B | 1 |
Schwabe, D | 1 |
Zanella, FE | 1 |
Mason, GF | 1 |
Di Costanzo, A | 2 |
Trojsi, F | 1 |
Tosetti, M | 2 |
Schirmer, T | 1 |
Lechner, SM | 1 |
Popolizio, T | 2 |
Scarabino, T | 2 |
Giannatempo, GM | 1 |
d'Alesio, V | 1 |
Esposito, F | 1 |
Di Salle, F | 1 |
Bertolino, A | 2 |
Maggialetti, A | 1 |
Salvolini, U | 1 |
Qiu, SJ | 1 |
Zhang, XL | 1 |
Zhang, Y | 1 |
Jiang, M | 1 |
Taylor, MJ | 1 |
Schweinsburg, BC | 1 |
Alhassoon, OM | 1 |
Gongvatana, A | 1 |
Brown, GG | 1 |
Young-Casey, C | 1 |
Letendre, SL | 1 |
Grant, I | 1 |
Kayabas, U | 1 |
Alkan, A | 2 |
Firat, AK | 2 |
Karakas, HM | 1 |
Bayindir, Y | 1 |
Yetkin, F | 1 |
Nitkunan, A | 1 |
Charlton, RA | 1 |
McIntyre, DJ | 1 |
Barrick, TR | 1 |
Howe, FA | 2 |
Markus, HS | 1 |
Güngör, S | 1 |
Akinci, A | 1 |
Tabel, Y | 1 |
Dezortova, M | 1 |
Hajek, M | 2 |
Emad, Y | 1 |
Ragab, Y | 1 |
Zeinhom, F | 1 |
El-Khouly, G | 1 |
Abou-Zeid, A | 1 |
Rasker, JJ | 1 |
Shellenberger, MK | 1 |
Strain, GW | 1 |
Pedata, F | 1 |
Giovannelli, L | 1 |
Pepeu, G | 1 |
Zeisel, SH | 2 |
Growdon, JH | 3 |
Magil, SG | 1 |
Logue, M | 1 |
Salvadorini, F | 1 |
Saba, P | 1 |
Forli, C | 1 |
Tusini, G | 1 |
Galeone, F | 1 |
Constans, JM | 1 |
Meyerhoff, DJ | 1 |
Gerson, J | 1 |
MacKay, S | 1 |
Norman, D | 1 |
Fein, G | 1 |
Weiner, MW | 2 |
Miller, BL | 1 |
McBride, D | 1 |
Cornford, M | 1 |
Oropilla, G | 1 |
Buchthal, S | 1 |
Chiang, F | 1 |
Aronow, H | 1 |
Beck, CK | 1 |
Poptani, H | 1 |
Gupta, RK | 1 |
Roy, R | 1 |
Pandey, R | 1 |
Jain, VK | 1 |
Chhabra, DK | 1 |
Kimura, H | 2 |
Fujii, Y | 1 |
Itoh, S | 1 |
Matsuda, T | 1 |
Iwasaki, T | 1 |
Maeda, M | 1 |
Konishi, Y | 1 |
Ishii, Y | 1 |
Tedeschi, G | 2 |
Schiffmann, R | 1 |
Barton, NW | 1 |
Shih, HH | 1 |
Gospe, SM | 1 |
Brady, RO | 1 |
Alger, JR | 1 |
Di Chiro, G | 1 |
Davie, CA | 1 |
Wenning, GK | 1 |
Barker, GJ | 1 |
Tofts, PS | 1 |
Kendall, BE | 1 |
Quinn, N | 1 |
McDonald, WI | 1 |
Marsden, CD | 1 |
Miller, DH | 1 |
Walsh, TJ | 1 |
Kelly, RM | 1 |
Stackman, RW | 1 |
Oppenheimer, SM | 1 |
Bryan, RN | 1 |
Conturo, TE | 1 |
Soher, BJ | 1 |
Preziosi, TJ | 1 |
Green, C | 1 |
Smith, K | 1 |
Wilson, D | 1 |
Schiro, S | 1 |
Greenwood, R | 1 |
Kruse, B | 1 |
Duyn, JH | 1 |
Moonen, CT | 1 |
Hejcmanová, L | 1 |
Prádný, J | 1 |
Grossman, RI | 1 |
Lenkinski, RE | 2 |
Gonzalez-Scarano, F | 1 |
Jarvik, JG | 1 |
Saykin, AJ | 1 |
Jaans, A | 1 |
Frank, I | 1 |
Tourbah, A | 1 |
Stievenart, JL | 1 |
Iba-Zizen, MT | 1 |
Zannoli, G | 1 |
Lyon-Caen, O | 1 |
Cabanis, EA | 1 |
Holshouser, BA | 1 |
Ashwal, S | 1 |
Luh, GY | 1 |
Shu, S | 1 |
Kahlon, S | 1 |
Auld, KL | 1 |
Tomasi, LG | 1 |
Perkin, RM | 1 |
Hinshaw, DB | 1 |
Jackson, EF | 1 |
Meyers, CA | 1 |
Van Den Heuvel, AG | 1 |
Van Rooij, LG | 1 |
Van Wassenaer-van Hall, HN | 1 |
Hoogenraad, TU | 1 |
Mali, WP | 1 |
Litvan, I | 1 |
Bonavita, S | 1 |
Lundbom, N | 1 |
Patronas, NJ | 1 |
Hallett, M | 1 |
Burtscher, IM | 2 |
Ståhlberg, F | 1 |
Holtås, S | 2 |
Osborn, D | 1 |
Seltzer, W | 1 |
Leonido-Yee, M | 1 |
Poland, RE | 1 |
Laubenberger, J | 1 |
Bayer, S | 1 |
Thiel, T | 1 |
Hennig, J | 1 |
Langer, M | 1 |
Seitz, D | 1 |
Grodd, W | 1 |
Schwab, A | 1 |
Seeger, U | 1 |
Klose, U | 1 |
Nägele, T | 1 |
Van Hove, JL | 1 |
Lazeyras, F | 1 |
Bottiglieri, T | 1 |
Hyland, K | 1 |
Charles, HC | 1 |
Gray, L | 1 |
Jaeken, J | 1 |
Kahler, SG | 1 |
Balse, E | 1 |
Suhr, R | 1 |
Haaf, A | 1 |
Kelche, C | 1 |
Jackisch, R | 1 |
Cassel, JC | 1 |
Blüml, S | 1 |
Seymour, KJ | 1 |
Ross, BD | 1 |
Wilken, B | 1 |
Herms, J | 1 |
Maxton, C | 1 |
Markakis, E | 1 |
Boulanger, Y | 1 |
Labelle, M | 1 |
Khiat, A | 1 |
Lim, MK | 1 |
Suh, CH | 1 |
Kim, HJ | 1 |
Cho, YK | 1 |
Choi, SH | 1 |
Kang, JH | 1 |
Park, W | 1 |
Lee, JH | 1 |
Axford, JS | 1 |
Heron, C | 1 |
Griffiths, JR | 1 |
Schuff, N | 1 |
Ezekiel, F | 1 |
Gamst, AC | 1 |
Amend, DL | 1 |
Capizzano, AA | 1 |
Maudsley, AA | 1 |
Forton, DM | 1 |
Allsop, JM | 1 |
Main, J | 1 |
Foster, GR | 1 |
Thomas, HC | 1 |
Taylor-Robinson, SD | 1 |
Kimura, T | 1 |
Sako, K | 1 |
Gotoh, T | 1 |
Tanaka, K | 1 |
Tanaka, T | 1 |
Wang, P | 1 |
Wityk, RJ | 1 |
Beauchamp, NJ | 1 |
Cohen, EL | 1 |
Hanin, I | 1 |
Bertorelli, R | 1 |
Amoroso, D | 1 |
Girotti, P | 1 |
Consolo, S | 1 |
Blusztajn, JK | 1 |
Coviella, IL | 1 |
Buyukuysal, RL | 1 |
Slack, BE | 1 |
Flentge, F | 1 |
Begeer, JH | 1 |
Mulder-Hajonides van der Meulen, WR | 1 |
Teelken, AW | 1 |
Kaseda, Y | 1 |
Simon, JR | 1 |
Low, WC | 1 |
Bruhn, H | 1 |
Gyngell, ML | 1 |
Merboldt, KD | 1 |
Hänicke, W | 1 |
Sauter, R | 1 |
Hamburger, C | 1 |
DiPalma, JR | 1 |
Björklund, A | 1 |
Gage, FH | 1 |
Aquilonius, SM | 1 |
Nyström, B | 1 |
Schuberth, J | 1 |
Sundwall, A | 1 |
Tănase, I | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318] | 100 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
15 reviews available for choline and Brain Disorders
Article | Year |
---|---|
Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Topics: Aspartic Acid; Brain Diseases; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy; Schizophr | 2023 |
Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis.
Topics: Aspartic Acid; Brain Diseases; Carcinoma; Choline; Creatine; Humans; Magnetic Resonance Spectroscopy | 2016 |
Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses.
Topics: Administration, Oral; Animals; Brain; Brain Diseases; Cell Membrane; Choline; Docosahexaenoic Acids; | 2008 |
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In | 2009 |
[Magnetic resonance spectroscopy for cerebral imaging].
Topics: Apoptosis; Aspartic Acid; Asphyxia Neonatorum; Biomarkers, Tumor; Brain; Brain Diseases; Brain Disea | 2010 |
Seizure-associated abnormalities in epilepsy: evidence from MR imaging.
Topics: Adult; Aspartic Acid; Atrophy; Brain; Brain Diseases; Brain Edema; Choline; Creatine; Diffusion Magn | 2005 |
Proton MR spectroscopy of the brain at 3 T: an update.
Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Cortex; Choline; Creatine | 2007 |
(1)H MR spectroscopy in pediatrics.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Child; Child, Preschool; Choline; Creatine; G | 2008 |
Nutrition, brain function and behavior.
Topics: Adolescent; Adult; Animals; Appetite; Appetite Depressants; Avitaminosis; Behavior; Blood-Brain Barr | 1981 |
Strategies to limit brain injury and promote recovery of function.
Topics: Alzheimer Disease; Animals; Aziridines; Brain Diseases; Choline; Hippocampus; Humans; Parasympatheti | 1994 |
Introduction to hippocampal spectroscopy.
Topics: Aspartic Acid; Brain Diseases; Choline; Creatine; Hippocampus; Humans; Hydrogen; Image Enhancement; | 1997 |
Role of phospholipase A(2) on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases.
Topics: Animals; Brain Chemistry; Brain Diseases; Choline; Humans; Magnetic Resonance Spectroscopy; Phosphat | 2000 |
Proton MR spectroscopy in clinical routine.
Topics: Aspartic Acid; Brain Diseases; Choline; Creatine; Humans; Lactic Acid; Magnetic Resonance Spectrosco | 2001 |
Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases.
Topics: Alzheimer Disease; Brain Diseases; Choline; Cholinergic Fibers; Humans | 1990 |
Neural grafting in animal models of neurodegenerative diseases.
Topics: Aging; Animals; Behavior, Animal; Brain; Brain Diseases; Choline; Corpus Striatum; Denervation; Dise | 1985 |
1 trial available for choline and Brain Disorders
Article | Year |
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Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Cross-Sectional St | 2003 |
82 other studies available for choline and Brain Disorders
Article | Year |
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Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Topics: Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Inositol; Magnetic Resonance | 2022 |
[Blood pressure variability and brain neuroimaging in patients with type 2 diabetes].
Topics: Blood Pressure; Brain; Brain Diseases; Choline; Creatine; Diabetes Mellitus, Type 2; Humans; Neuroim | 2022 |
Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Benzenesulfonates; Brain Diseases; Cerebral Cortex | 2019 |
Radiation Necrosis Following Stereotactic Radiosurgery for Trigeminal Neuralgia.
Topics: Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnostic Err | 2020 |
Dyslipidemia links obesity to early cerebral neurochemical alterations.
Topics: Adult; Aspartic Acid; Blood Glucose; Blood Pressure; Body Mass Index; Brain; Brain Diseases; Cholest | 2013 |
Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: a pilot study.
Topics: Adult; Aspartic Acid; Blood Volume; Brain; Brain Diseases; Case-Control Studies; Cerebrovascular Cir | 2013 |
Piracetam Facilitates the Anti-Amnesic but not Anti-Diabetic Activity of Metformin in Experimentally Induced Type-2 Diabetic Encephalopathic Rats.
Topics: Amnesia; Animals; Blood Glucose; Brain Diseases; Brain-Derived Neurotrophic Factor; Choline; Diabete | 2017 |
Modeling the impact of COPD on the brain.
Topics: Affect; Aged; Brain; Brain Diseases; Choline; Cognition; Cognition Disorders; Disease Progression; F | 2008 |
Usefulness of susceptibility-weighted imaging for voxel placement in MR spectroscopy.
Topics: Artifacts; Aspartic Acid; Brain Diseases; Choline; Creatine; Electromagnetic Fields; Gadolinium; Hum | 2009 |
Proton MR spectroscopy improves discrimination between tumor and pseudotumoral lesion in solid brain masses.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Diagnosis, Differe | 2009 |
Effect of chorioamnionitis on brain development and injury in premature newborns.
Topics: Anisotropy; Aspartic Acid; Brain; Brain Diseases; Choline; Chorioamnionitis; Diffusion Magnetic Reso | 2009 |
An atypical case of neuro-Whipple: Clinical presentation, magnetic resonance spectroscopy and follow-up.
Topics: Brain Diseases; Choline; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Magnetic Resonance S | 2010 |
Presence and action of acetylcholine in experimental brain trauma.
Topics: Acetylcholine; Brain; Brain Diseases; Brain Injuries; Choline | 1946 |
[Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma].
Topics: Adult; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; F | 2011 |
Image evaluation of HIV encephalopathy: a multimodal approach using quantitative MR techniques.
Topics: Brain; Brain Diseases; Child; Child, Preschool; Choline; Creatine; Female; HIV Infections; Humans; M | 2011 |
Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Choline; Creatine; Depressive Dis | 2012 |
Cutoff value of choline concentration reliably reveals high-grade brain tumors among other contrast-enhancing brain lesions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Diseases; Brain Infarction; Brain Neoplasms; Centr | 2012 |
van der Knaap's leukoencephalopathy: report of five new cases with emphasis on diffusion-weighted MRI findings.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Child, Preschool; Choline; Creatine; C | 2002 |
Proton MR spectroscopic and diffusion tensor brain MR imaging in X-linked adrenoleukodystrophy: initial experience.
Topics: Adolescent; Adrenoleukodystrophy; Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Chil | 2002 |
Proton magnetic resonance spectroscopy of brain-stem lesions.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neoplasms; Choline; Cr | 2002 |
Feasibility of proton chemical shift imaging with a stereotactic headframe.
Topics: Adult; Biopsy, Needle; Brain; Brain Diseases; Choline; Creatine; Feasibility Studies; Female; Humans | 2003 |
[Magnetic resonance imaging spectroscopy. Part 1: Basics].
Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Energy Metabolism; Humans; Image Enh | 2003 |
Leukoencephalopathy, cerebral calcifications, and cysts: new observations.
Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Calcinosis; Central Nervous System Cysts; Child; C | 2004 |
Proton magnetic resonance spectroscopy may predict future brain lesions in SLE patients: a functional multi-imaging approach and follow up.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Choline; Creatine; Female; | 2005 |
White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination.
Topics: Aspartic Acid; Brain Diseases; Choline; Chromosome Deletion; Chromosomes, Human, Pair 18; Demyelinat | 2005 |
Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities.
Topics: Adult; Amphetamine-Related Disorders; Aspartic Acid; Basal Ganglia; Brain; Brain Diseases; Choline; | 2005 |
Magnetic resonance imaging and proton magnetic resonance spectroscopy of megalencephaly and dilated Virchow-Robin spaces.
Topics: Aspartic Acid; Brain Diseases; Child; Child, Preschool; Choline; Creatine; Dilatation, Pathologic; D | 2006 |
Elevation of serum cerebral injury markers correlates with serum choline decline after coronary artery bypass grafting surgery.
Topics: Adult; Aged; Biomarkers; Brain Diseases; Choline; Cognition Disorders; Coronary Artery Bypass; Femal | 2006 |
MRI, volumetry, 1H spectroscopy, and cerebropetal blood flowmetry in childhood idiopathic anatomic megalencephaly.
Topics: Aspartic Acid; Blood Flow Velocity; Brain; Brain Diseases; Case-Control Studies; Cerebrovascular Cir | 2006 |
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion | 2006 |
Proton magnetic resonance spectroscopy in childhood brainstem lesions.
Topics: Adolescent; Amino Acids; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Stem; Brain Stem Neop | 2007 |
Get sober; stay sober.
Topics: Alcoholism; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Humans; Magnetic Resonance Spec | 2007 |
3.0-T functional brain imaging: a 5-year experience.
Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Arteries; Cerebral Cortex | 2007 |
Proton magnetic resonance spectroscopy for radiation encephalopathy induced by radiotherapy for nasopharyngeal carcinoma.
Topics: Adult; Aged; Aspartic Acid; Brain Diseases; Choline; Creatine; Female; Humans; Magnetic Resonance Sp | 2007 |
Effects of human immunodeficiency virus and methamphetamine on cerebral metabolites measured with magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Brain Diseases; CD4 Lymphocyte Count; Central Nervous Sy | 2007 |
Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis.
Topics: Acute Disease; Adolescent; Adult; Aspartic Acid; Brain Diseases; Brucellosis; Case-Control Studies; | 2008 |
Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease.
Topics: Aged; Aspartic Acid; Brain Diseases; Brain Ischemia; Case-Control Studies; Cerebrovascular Circulati | 2008 |
Neuroimaging findings in hyperargininemia.
Topics: Arginine; Aspartic Acid; Atrophy; Basal Ganglia Cerebrovascular Disease; Brain Diseases; Cerebellum; | 2008 |
Hippocampus dysfunction may explain symptoms of fibromyalgia syndrome. A study with single-voxel magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Female; Fibromyalgia; | 2008 |
Effects of early lead exposure on neurotransmitter systems in the brain. A review with commentary.
Topics: Acetylcholine; Amino Acids; Animals; Animals, Newborn; Brain; Brain Diseases; Catecholamines; Cholin | 1984 |
GM1 ganglioside facilitates the recovery of high-affinity choline uptake in the cerebral cortex of rats with a lesion of the nucleus basalis magnocellularis.
Topics: Animals; Basal Ganglia; Brain Diseases; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Front | 1984 |
Normal plasma choline responses to ingested lecithin.
Topics: Adolescent; Adult; Brain Diseases; Choline; Diet; Humans; Male; Phosphatidylcholines | 1980 |
Effect of cytidine diphosphate choline on growth hormone secretion in patients with brain or pituitary lesions.
Topics: Adolescent; Adult; Aged; Brain Diseases; Brain Neoplasms; Child; Choline; Cytidine Diphosphate Choli | 1980 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Brain lesions in patients with AIDS: H-1 MR spectroscopy.
Topics: Abscess; Adult; AIDS Dementia Complex; Aspartic Acid; Brain Diseases; Brain Neoplasms; Choline; Crea | 1995 |
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea | 1995 |
Metabolic alterations in the neonate and infant brain during development: evaluation with proton MR spectroscopy.
Topics: Aspartic Acid; Brain; Brain Diseases; Choline; Creatinine; Developmental Disabilities; Humans; Infan | 1995 |
Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination.
Topics: Aspartic Acid; Ataxia; Brain; Brain Diseases; Child, Preschool; Choline; Creatine; Female; Gaucher D | 1995 |
Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Basal Ganglia; Brain Diseases; Choline; Creatine; Diagnosis, Di | 1995 |
Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Cerebrovascular Circulation; Cer | 1995 |
Proton MR spectroscopy in patients with neurofibromatosis type 1: evaluation of hamartomas and clinical correlation.
Topics: Adolescent; Adult; Aspartic Acid; Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Cerebellar Di | 1995 |
Multislice proton magnetic resonance spectroscopic imaging in X-linked adrenoleukodystrophy.
Topics: Adolescent; Adrenoleukodystrophy; Adult; Aged; Aspartic Acid; Brain Diseases; Child; Child, Preschoo | 1994 |
Proton in vivo spectroscopy of patients with hyperphenylalaninaemia.
Topics: Adult; Aspartic Acid; Biopterins; Brain; Brain Chemistry; Brain Diseases; Child; Choline; Creatine; | 1993 |
Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: correlative findings of active versus irreversible plaque disease.
Topics: Adult; Aspartic Acid; Brain; Brain Diseases; Brain Edema; Choline; Chronic Disease; Creatine; Demyel | 1996 |
Proton spectroscopy in asymptomatic HIV-infected adults: initial results in a prospective cohort study.
Topics: Adult; Amino Acids; Brain; Brain Diseases; CD4 Lymphocyte Count; Choline; Creatine; Female; HIV Infe | 1996 |
In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; Clinical Trials as Topic | 1996 |
Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children.
Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Brain Injuries; Child; Choline; Discriminant Analy | 1997 |
Differentiation between portal-systemic encephalopathy and neurodegenerative disorders in patients with Wilson disease: H-1 MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Choline; Creatinine; Diagnosis, Differential; Fem | 1997 |
Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Diseases; Choline; Creatine; Female; Humans; Ma | 1997 |
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo | 1997 |
Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats.
Topics: Adult; Brain Chemistry; Brain Diseases; Choline; Creatinine; Female; Humans; Inositol; Magnetic Reso | 1998 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis.
Topics: Aspartic Acid; Brain; Brain Diseases; Case-Control Studies; Cerebellum; Cerebral Ventricles; Child; | 1998 |
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; | 1998 |
The potentiation of amphetamine-induced hyperlocomotion by fimbria-fornix lesions in rats is abolished by intrahippocampal grafts rich in serotonergic neurons.
Topics: Amphetamine; Animals; Brain Diseases; Choline; Drug Synergism; Electric Stimulation; Female; Frontal | 1999 |
Developmental changes in choline- and ethanolamine-containing compounds measured with proton-decoupled (31)P MRS in in vivo human brain.
Topics: Adolescent; Adult; Aged; Aging; Brain; Brain Chemistry; Brain Diseases; Child; Child, Preschool; Cho | 1999 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
Systemic lupus erythematosus: brain MR imaging and single-voxel hydrogen 1 MR spectroscopy.
Topics: Adolescent; Adult; Brain Diseases; Case-Control Studies; Choline; Creatinine; Female; Humans; Image | 2000 |
Sensitivity of quantitative (1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Diseases; Case-Control Studies; Choline; Creatine; Fem | 2001 |
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; | 2001 |
Evidence for a cerebral effect of the hepatitis C virus.
Topics: Adult; Basal Ganglia; Basal Ganglia Diseases; Biopsy; Brain; Brain Diseases; Choline; Creatine; Fati | 2001 |
In vivo single-voxel proton MR spectroscopy in brain lesions with ring-like enhancement.
Topics: Adult; Aged; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; Cerebral Infarction; Choline; Cr | 2001 |
Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome.
Topics: Adult; Aspartic Acid; Brain Diseases; Choline; Confusion; Creatine; Female; Headache; Humans; Magnet | 2002 |
Treatment of brain disease with dietary precursors of neurotransmitters.
Topics: Acetylcholine; Brain; Brain Diseases; Choline; Dietary Proteins; Humans; Neurotransmitter Agents; Se | 1977 |
Choline and lecithin in the treatment of neurologic disorders.
Topics: Acetylcholine; Animals; Brain; Brain Diseases; Choline; Humans; Phosphatidylcholines; Rats | 1979 |
Effect of tianeptine on the central cholinergic system: involvement of serotonin.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Antidepressive Agents, Tricyclic; Brain; Brain Disease | 1992 |
CSF choline levels in neurologically disturbed children.
Topics: Adolescent; Brain Diseases; Child; Child, Preschool; Choline; Female; Humans; Infant; Male; Movement | 1989 |
Restoration of high affinity choline uptake in the hippocampal formation following septal cell suspension transplants in rats with fimbria-fornix lesions.
Topics: Animals; Brain Diseases; Choline; Hippocampus; Male; Nerve Tissue Proteins; Picrotoxin; Potassium; Q | 1989 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |
Nutritional pharmacology.
Topics: Amino Acids, Branched-Chain; Brain Diseases; Choline; Diet; Dyskinesia, Drug-Induced; Hepatic Enceph | 1985 |
Cerebrospinal fluid choline in extrapyramidal disorders.
Topics: Acetylcholine; Adolescent; Adult; Aged; Basal Ganglia Diseases; Brain; Brain Diseases; Brain Neoplas | 1972 |
[Excretion of amino acids, keto acids, pentoses and choline in cerebral anomalies in children].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Brain; Brain Diseases; Child; Child, Preschool; C | 1972 |