choline has been researched along with Bipolar Disorder in 93 studies
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nineteen subjects with bipolar disorder in remission, who reported subjective cognitive deficits, were treated with open-label galantamine-ER 8-24 mg/day for 4 months." | 9.14 | Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept study. ( Deckersbach, T; Iosifescu, DV; Moore, CM; Nierenberg, AA; Ostacher, MJ; Sachs, GS; Tilley, CA, 2009) |
| "Eight lithium-treated patients with DSM-IV bipolar disorder, rapid cycling type were randomly assigned to 50 mg/kg/day of choline bitartrate or placebo for 12 weeks." | 9.10 | Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy. ( Ahn, KH; Demopulos, CM; Hirashima, F; Lyoo, IK; Renshaw, PF, 2003) |
| "Choline-containing compounds (Cho) were examined by proton magnetic resonance spectroscopy (1H-MRS) in the left subcortical region, including basal ganglia, in 19 euthymic patients with bipolar disorder and 19 age-matched normal controls." | 9.08 | Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. ( Hamakawa, H; Inubushi, T; Kato, T; Murashita, J; Shioiri, T; Takahashi, S; Takahashi, Y, 1996) |
| "This study examined choline augmentation of lithium for rapid-cycling bipolar disorder." | 9.08 | Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients. ( Christensen, JD; Cohen, BM; Lafer, B; Renshaw, PF; Sachs, GS; Stoll, AL, 1996) |
| "The hypotheses of relative cholinergic underactivity in Huntington's disease, tardive dyskinesia, mania, and schizophrenia were pharmacologically investigated, using physostigmine and choline chloride." | 9.04 | Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. ( Berger, PA; Davis, KL, 1978) |
| "Alterations in choline and myo-inositol metabolism have been noted in bipolar disorder, and the therapeutic efficacy of lithium in mania may be related to these effects." | 7.70 | Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. ( Babb, SM; Breeze, JL; Cohen, BM; Frederick, BB; Gruber, SA; Hennen, J; Moore, CM; Renshaw, PF; Stoll, AL; Villafuerte, RA; Yurgelun-Todd, DA, 2000) |
| "Erythrocyte choline concentrations were measured in hospitalized patients with bipolar disorder, manic phase, and control subjects." | 7.68 | Erythrocyte choline concentration in bipolar disorder: a predictor of clinical course and medication response. ( Cohen, BM; Hanin, I; Snyder, MB; Stoll, AL, 1991) |
| "Lithium treatment can affect the transport of choline and lithium ions across cell membranes, but little is known about these effects during pregnancy." | 7.66 | Lithium treatment during pregnancy: a case study of erythrocyte choline content and lithium transport. ( Erstling, C; Hanin, I; Kopp, U; Mallinger, AG; Mallinger, J; Stumpf, RL, 1983) |
| "As choline is a marker of membrane phospholipid metabolism, the elevated choline in patients may indicate increased membrane breakdown in the brain regions examined." | 5.35 | Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study. ( Hall, GB; MacQueen, GM; Milne, AM; Senaratne, R, 2009) |
| "Nineteen subjects with bipolar disorder in remission, who reported subjective cognitive deficits, were treated with open-label galantamine-ER 8-24 mg/day for 4 months." | 5.14 | Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept study. ( Deckersbach, T; Iosifescu, DV; Moore, CM; Nierenberg, AA; Ostacher, MJ; Sachs, GS; Tilley, CA, 2009) |
| "Eight lithium-treated patients with DSM-IV bipolar disorder, rapid cycling type were randomly assigned to 50 mg/kg/day of choline bitartrate or placebo for 12 weeks." | 5.10 | Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy. ( Ahn, KH; Demopulos, CM; Hirashima, F; Lyoo, IK; Renshaw, PF, 2003) |
| "Choline-containing compounds (Cho) were examined by proton magnetic resonance spectroscopy (1H-MRS) in the left subcortical region, including basal ganglia, in 19 euthymic patients with bipolar disorder and 19 age-matched normal controls." | 5.08 | Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. ( Hamakawa, H; Inubushi, T; Kato, T; Murashita, J; Shioiri, T; Takahashi, S; Takahashi, Y, 1996) |
| "This study examined choline augmentation of lithium for rapid-cycling bipolar disorder." | 5.08 | Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients. ( Christensen, JD; Cohen, BM; Lafer, B; Renshaw, PF; Sachs, GS; Stoll, AL, 1996) |
| "The hypotheses of relative cholinergic underactivity in Huntington's disease, tardive dyskinesia, mania, and schizophrenia were pharmacologically investigated, using physostigmine and choline chloride." | 5.04 | Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. ( Berger, PA; Davis, KL, 1978) |
| "We conducted a Medline search for clinical trials conducted with humans, published in English from 1960 to 2012 using nutritional supplements such as n-3, chromium, inositol, choline, magnesium, folate and tryptophan alone or in combination with pharmacotherapies for the treatment of bipolar disorder." | 4.89 | Nutrient-based therapies for bipolar disorder: a systematic review. ( Deckersbach, T; Nierenberg, AA; Peters, AT; Sylvia, LG, 2013) |
| " Omega-3 fatty acids and lecithin/ choline have preliminary data indicating potential utility in the CAM treatment for bipolar disorder while S-adenosyl methionine (SAM-e) and inositol have some data supporting their efficacy in the treatment of depressive symptoms." | 4.84 | Complementary medicines in pediatric bipolar disorder. ( Bishop, JR; Bogarapu, S; Krueger, CD; Pavuluri, MN, 2008) |
| " Proton spectroscopic studies suggest that abnormalities in choline metabolism exist in bipolar disorder, particularly in the basal ganglia." | 4.80 | Neuroimaging in bipolar disorder. ( Adler, C; Cecil, DM; DelBello, MP; Sax, KW; Strakowski, SM, 2000) |
| "Response to lithium maintenance varies widely across patients with bipolar disorder (BD)." | 4.31 | Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder. ( Deep, R; Khandelwal, SK; Kumaran, SS; Mahal, P, 2023) |
| "We aimed to compare concentrations of N-acetyl aspartate, myo-inositol, and other neurometabolites in the cerebellar vermis of offspring at risk for bipolar disorder (BD) and healthy controls to examine whether changes in these neuronal metabolite concentrations occur in at-risk offspring prior to the onset of mania." | 3.77 | Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder. ( Acquaye, T; Adams, E; Chang, KD; Howe, M; Kelley, R; Libby, A; Reiss, A; Singh, MK; Spielman, D, 2011) |
| "Compared to controls, schizophrenia and bipolar patients presented decreased NAA to creatine ratios, while only the schizophrenia group showed an increase in CSF in the dorsolateral prefrontal region." | 3.74 | Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder. ( Benito, C; Desco, M; Leal, I; Molina, V; Palomo, T; Rebolledo, R; Reig, S; Sánchez, J; Sanz, J; Sarramea, F, 2007) |
| "The authors examined the levels of NAA, creatine plus phosphocreatine, and choline-containing molecules in the left dorsolateral prefrontal cortex of 14 bipolar disorder patients (mean age=15." | 3.73 | Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. ( Axelson, D; Birmaher, B; Brambilla, P; Keshavan, MS; Nicoletti, MA; Ramos, RT; Ryan, N; Sassi, RB; Soares, JC; Stanley, JA, 2005) |
| "Based on earlier structural and functional neuroimaging studies, we specifically wanted to assess N-acetylaspartate (NAA), choline-containing compounds (CHO), and creatine+phosphocreatine (CRE) levels in brain hippocampus previously demonstrated to be involved in the pathophysiology of bipolar disorder which have not been evaluated in first-episode patients." | 3.73 | Hippocampal 1H MRS in first-episode bipolar I patients. ( Atmaca, M; Ogur, E; Ozdemir, H; Poyraz, AK; Tezcan, E; Yildirim, H, 2006) |
| "The patients with bipolar disorder showed significantly higher anterior cingulate myo-inositol/creatine-phosphocreatine and myo-inositol (mmol/liter) levels than the patients with intermittent explosive disorder and the normal comparison subjects." | 3.72 | Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. ( Barnett, S; Belin, T; Davanzo, P; McCracken, J; Mintz, J; Santoro, E; Thomas, MA; Venkatraman, TN; Yue, K, 2003) |
| " The present results are compatible with our previous report of decreased phosphocreatine measured by 31P-MRS in the left frontal lobe in bipolar disorder." | 3.70 | Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder. ( Hamakawa, H; Inubushi, T; Kato, N; Kato, T; Shioiri, T, 1999) |
| "Alterations in choline and myo-inositol metabolism have been noted in bipolar disorder, and the therapeutic efficacy of lithium in mania may be related to these effects." | 3.70 | Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. ( Babb, SM; Breeze, JL; Cohen, BM; Frederick, BB; Gruber, SA; Hennen, J; Moore, CM; Renshaw, PF; Stoll, AL; Villafuerte, RA; Yurgelun-Todd, DA, 2000) |
| "Erythrocyte choline concentrations were measured in hospitalized patients with bipolar disorder, manic phase, and control subjects." | 3.68 | Erythrocyte choline concentration in bipolar disorder: a predictor of clinical course and medication response. ( Cohen, BM; Hanin, I; Snyder, MB; Stoll, AL, 1991) |
| "Lithium treatment can affect the transport of choline and lithium ions across cell membranes, but little is known about these effects during pregnancy." | 3.66 | Lithium treatment during pregnancy: a case study of erythrocyte choline content and lithium transport. ( Erstling, C; Hanin, I; Kopp, U; Mallinger, AG; Mallinger, J; Stumpf, RL, 1983) |
| " However, the study suggests that chronic administration of sodium valproate to patients does not lead to similar changes in NAA concentrations." | 2.71 | Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients. ( Asghar, SJ; Hanstock, CC; O'Donnell, T; Silverstone, PH; Ulrich, M; Wu, RH, 2003) |
| "Huntington's chorea, ataxias, Tourette's syndrome, schizophrenia, affective illness, and senile dementia of the Alzheimer type, has been implicated with a general underactivity of central cholinergic mechanisms." | 2.36 | The use of cholinergic precursors in neuropsychiatric diseases. ( Davis, KL; Rosenberg, GS, 1982) |
| "As choline is a marker of membrane phospholipid metabolism, the elevated choline in patients may indicate increased membrane breakdown in the brain regions examined." | 1.35 | Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study. ( Hall, GB; MacQueen, GM; Milne, AM; Senaratne, R, 2009) |
| "Fourteen patients with chronic paranoid schizophrenia, 17 euthymic type I bipolar patients with no previous history of psychotic symptoms and 15 healthy controls were included, most of them were female." | 1.35 | Biochemical changes in the cingulum in patients with schizophrenia and chronic bipolar disorder. ( Albert, C; Cabaleiro, F; de Luxan, A; Galán, R; Leal, I; Luque, R; Molina, V; Osuna, MI; Prieto, D; Ruiz, M; Sarramea Crespo, F; Sau, P, 2008) |
| "Cholinergic processes were measured in plasma and red blood cells (RBC) obtained from patients with mania, depression, and schizophrenia." | 1.27 | Cholinergic processes in blood samples from patients with major psychiatric disorders. ( Alarcon, RD; Jope, RS; Lally, KM; Walter-Ryan, WG, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (29.03) | 18.7374 |
| 1990's | 9 (9.68) | 18.2507 |
| 2000's | 32 (34.41) | 29.6817 |
| 2010's | 22 (23.66) | 24.3611 |
| 2020's | 3 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Mahal, P | 3 |
| Deep, R | 3 |
| Kumaran, SS | 3 |
| Khandelwal, SK | 3 |
| Lai, S | 4 |
| Zhong, S | 5 |
| Shan, Y | 1 |
| Wang, Y | 5 |
| Chen, G | 2 |
| Luo, X | 1 |
| Chen, F | 1 |
| Zhang, Y | 3 |
| Shen, S | 1 |
| Huang, H | 1 |
| Ning, Y | 1 |
| Jia, Y | 5 |
| Chen, J | 1 |
| Zou, S | 1 |
| Qu, Y | 1 |
| Zhang, C | 1 |
| Tang, X | 1 |
| Ren, Y | 1 |
| Soeiro-de-Souza, MG | 2 |
| Scotti-Muzzi, E | 1 |
| Fernandes, F | 1 |
| De Sousa, RT | 1 |
| Leite, CC | 1 |
| Otaduy, MC | 1 |
| Machado-Vieira, R | 3 |
| Liao, X | 3 |
| Huang, J | 1 |
| Zhang, S | 1 |
| Sun, Y | 1 |
| Zhao, H | 1 |
| Szulc, A | 1 |
| Wiedlocha, M | 1 |
| Waszkiewicz, N | 1 |
| Galińska-Skok, B | 1 |
| Marcinowicz, P | 1 |
| Gierus, J | 1 |
| Mosiolek, A | 1 |
| Otaduy, MCG | 1 |
| Moreno, RA | 1 |
| Nery, FG | 1 |
| Leite, C | 1 |
| Lafer, B | 5 |
| Liu, T | 2 |
| Lewandowski, KE | 1 |
| Du, F | 1 |
| Fan, X | 1 |
| Chen, X | 1 |
| Huynh, P | 1 |
| Öngür, D | 2 |
| Chu, WJ | 2 |
| Delbello, MP | 4 |
| Jarvis, KB | 1 |
| Norris, MM | 1 |
| Kim, MJ | 1 |
| Weber, W | 1 |
| Lee, JH | 1 |
| Strakowski, SM | 4 |
| Adler, CM | 2 |
| Gigante, AD | 1 |
| Yatham, LN | 1 |
| Shi, XF | 1 |
| Forrest, LN | 1 |
| Kuykendall, MD | 1 |
| Prescot, AP | 2 |
| Sung, YH | 1 |
| Huber, RS | 1 |
| Hellem, TL | 1 |
| Jeong, EK | 1 |
| Renshaw, PF | 7 |
| Kondo, DG | 1 |
| Zhao, G | 1 |
| Xiang, Q | 1 |
| Ling, X | 1 |
| Liu, S | 1 |
| Huang, L | 1 |
| Young, JW | 1 |
| Dulcis, D | 1 |
| Ehrlich, A | 1 |
| Schubert, F | 2 |
| Pehrs, C | 1 |
| Gallinat, J | 1 |
| Aydin, B | 1 |
| Yurt, A | 1 |
| Gökmen, N | 1 |
| Renshaw, P | 1 |
| Olson, D | 1 |
| Yildiz, A | 1 |
| Lotfi, M | 1 |
| Shafiee, S | 1 |
| Ghanizadeh, A | 1 |
| Sigaroudi, MO | 1 |
| Razeghian, L | 1 |
| Tan, HZ | 1 |
| Li, H | 2 |
| Liu, CF | 1 |
| Guan, JT | 1 |
| Guo, XB | 1 |
| Wen, CH | 1 |
| Ou, SM | 1 |
| Zhang, YN | 1 |
| Zhang, J | 3 |
| Xu, CT | 1 |
| Shen, ZW | 1 |
| Wu, RH | 2 |
| Wang, XQ | 1 |
| Xu, H | 1 |
| Guan, J | 1 |
| Xu, C | 1 |
| Shen, Z | 1 |
| Xiao, B | 1 |
| Liang, C | 1 |
| Chen, K | 1 |
| Wu, R | 1 |
| Wang, B | 1 |
| Scherk, H | 4 |
| Backens, M | 4 |
| Zill, P | 1 |
| Schneider-Axmann, T | 4 |
| Wobrock, T | 1 |
| Usher, J | 4 |
| Reith, W | 4 |
| Falkai, P | 4 |
| Möller, HJ | 1 |
| Bondy, B | 1 |
| Gruber, O | 4 |
| Patel, NC | 1 |
| Cecil, KM | 2 |
| Michael, N | 2 |
| Erfurth, A | 2 |
| Pfleiderer, B | 2 |
| Senaratne, R | 1 |
| Milne, AM | 1 |
| MacQueen, GM | 1 |
| Hall, GB | 1 |
| Iosifescu, DV | 1 |
| Moore, CM | 2 |
| Deckersbach, T | 2 |
| Tilley, CA | 1 |
| Ostacher, MJ | 1 |
| Sachs, GS | 3 |
| Nierenberg, AA | 2 |
| Jensen, JE | 1 |
| Rouse, ED | 1 |
| Cohen, BM | 7 |
| Olson, DP | 1 |
| Kemmer, C | 3 |
| Sumegi, A | 1 |
| Halasz, S | 1 |
| Kliment, E | 1 |
| Singh, MK | 1 |
| Spielman, D | 1 |
| Libby, A | 1 |
| Adams, E | 1 |
| Acquaye, T | 1 |
| Howe, M | 1 |
| Kelley, R | 1 |
| Reiss, A | 1 |
| Chang, KD | 1 |
| Shahana, N | 1 |
| Delbello, M | 1 |
| Jarvis, K | 1 |
| Fleck, D | 1 |
| Welge, J | 1 |
| Strakowski, S | 1 |
| Adler, C | 2 |
| Sylvia, LG | 1 |
| Peters, AT | 1 |
| Morey, R | 1 |
| Silverstone, PH | 2 |
| O'Donnell, T | 2 |
| Ulrich, M | 2 |
| Asghar, SJ | 2 |
| Hanstock, CC | 2 |
| Ohrmann, P | 1 |
| Gössling, M | 1 |
| Arolt, V | 1 |
| Heindel, W | 1 |
| Deicken, RF | 2 |
| Pegues, MP | 1 |
| Anzalone, S | 1 |
| Feiwell, R | 2 |
| Soher, B | 1 |
| Lyoo, IK | 1 |
| Demopulos, CM | 1 |
| Hirashima, F | 1 |
| Ahn, KH | 1 |
| Davanzo, P | 1 |
| Yue, K | 1 |
| Thomas, MA | 1 |
| Belin, T | 1 |
| Mintz, J | 1 |
| Venkatraman, TN | 1 |
| Santoro, E | 1 |
| Barnett, S | 1 |
| McCracken, J | 1 |
| Modica-Napolitano, JS | 1 |
| Wood, SJ | 1 |
| Berger, G | 1 |
| Velakoulis, D | 1 |
| Phillips, LJ | 1 |
| McGorry, PD | 1 |
| Yung, AR | 1 |
| Desmond, P | 1 |
| Pantelis, C | 1 |
| Blasi, G | 1 |
| Bertolino, A | 1 |
| Brudaglio, F | 1 |
| Sciota, D | 1 |
| Altamura, M | 1 |
| Antonucci, N | 1 |
| Scarabino, T | 1 |
| Weinberger, DR | 1 |
| Nardini, M | 1 |
| Frey, BN | 1 |
| Folgierini, M | 1 |
| Nicoletti, M | 1 |
| Stanley, JA | 2 |
| Soares, JC | 2 |
| Kapczinski, F | 1 |
| Sassi, RB | 1 |
| Axelson, D | 1 |
| Brambilla, P | 1 |
| Nicoletti, MA | 1 |
| Keshavan, MS | 1 |
| Ramos, RT | 1 |
| Ryan, N | 1 |
| Birmaher, B | 1 |
| Yildiz-Yesiloglu, A | 1 |
| Ankerst, DP | 1 |
| Atmaca, M | 1 |
| Yildirim, H | 1 |
| Ozdemir, H | 1 |
| Poyraz, AK | 1 |
| Tezcan, E | 1 |
| Ogur, E | 1 |
| Amaral, JA | 1 |
| Tamada, RS | 1 |
| Issler, CK | 1 |
| Caetano, SC | 1 |
| Cerri, GG | 1 |
| de Castro, CC | 1 |
| Malhi, GS | 1 |
| Ivanovski, B | 1 |
| Wen, W | 1 |
| Lagopoulos, J | 1 |
| Moss, K | 1 |
| Sachdev, P | 1 |
| Molina, V | 2 |
| Sánchez, J | 1 |
| Sanz, J | 1 |
| Reig, S | 1 |
| Benito, C | 1 |
| Leal, I | 2 |
| Sarramea, F | 1 |
| Rebolledo, R | 1 |
| Palomo, T | 1 |
| Desco, M | 1 |
| Kraft, S | 1 |
| Meyer, J | 1 |
| Bogarapu, S | 1 |
| Bishop, JR | 1 |
| Krueger, CD | 1 |
| Pavuluri, MN | 1 |
| Colla, M | 1 |
| Bubner, M | 1 |
| Heidenreich, JO | 1 |
| Bajbouj, M | 1 |
| Seifert, F | 1 |
| Luborzewski, A | 1 |
| Heuser, I | 1 |
| Kronenberg, G | 1 |
| Sarramea Crespo, F | 1 |
| Luque, R | 1 |
| Prieto, D | 1 |
| Sau, P | 1 |
| Albert, C | 1 |
| de Luxan, A | 1 |
| Osuna, MI | 1 |
| Ruiz, M | 1 |
| Galán, R | 1 |
| Cabaleiro, F | 1 |
| Haag, M | 2 |
| Haag, H | 2 |
| Eisenried, F | 1 |
| Greil, W | 2 |
| Gerner, RH | 1 |
| Fairbanks, L | 1 |
| Anderson, GM | 1 |
| Young, JG | 1 |
| Scheinin, M | 1 |
| Linnoila, M | 1 |
| Hare, TA | 1 |
| Shaywitz, BA | 1 |
| Cohen, DJ | 1 |
| Rosenberg, GS | 1 |
| Davis, KL | 2 |
| Kuchel, PW | 5 |
| Hunt, GE | 3 |
| Johnson, GF | 3 |
| Beilharz, GR | 3 |
| Chapman, BE | 1 |
| Jones, AJ | 2 |
| Singh, BS | 1 |
| Wood, PL | 1 |
| Suranyi-Cadotte, B | 1 |
| Schwartz, G | 1 |
| Nair, NP | 1 |
| Middlehurst, CR | 2 |
| Deutsch, SI | 1 |
| Stanley, M | 1 |
| Peselow, ED | 1 |
| Banay-Schwartz, M | 1 |
| Mallinger, AG | 3 |
| Hanin, I | 6 |
| Stumpf, RL | 1 |
| Mallinger, J | 1 |
| Kopp, U | 4 |
| Erstling, C | 1 |
| Domino, EF | 2 |
| Lipper, S | 2 |
| Landau, SG | 1 |
| Domino, SE | 1 |
| Jope, RS | 4 |
| Jenden, DJ | 1 |
| Ehrlich, BE | 2 |
| Diamond, JM | 2 |
| Gosenfeld, LF | 1 |
| Lipinski, JF | 1 |
| Himmelhoch, JM | 1 |
| Neil, JF | 1 |
| Johnson, G | 1 |
| Kato, T | 3 |
| Hamakawa, H | 3 |
| Shioiri, T | 2 |
| Murashita, J | 2 |
| Takahashi, Y | 1 |
| Takahashi, S | 1 |
| Inubushi, T | 2 |
| Stoll, AL | 5 |
| Christensen, JD | 1 |
| Kato, N | 2 |
| Ohara, K | 2 |
| Isoda, H | 1 |
| Suzuki, Y | 1 |
| Takehara, Y | 1 |
| Ochiai, M | 1 |
| Takeda, H | 1 |
| Igarashi, Y | 1 |
| Castillo, M | 1 |
| Kwock, L | 1 |
| Courvoisie, H | 1 |
| Hooper, SR | 1 |
| Eliaz, Y | 1 |
| Schuff, N | 1 |
| Breeze, JL | 1 |
| Gruber, SA | 1 |
| Babb, SM | 1 |
| Frederick, BB | 1 |
| Villafuerte, RA | 1 |
| Hennen, J | 1 |
| Yurgelun-Todd, DA | 1 |
| Cecil, DM | 1 |
| Sax, KW | 1 |
| Berger, PA | 1 |
| Sharma, R | 1 |
| Venkatasubramanian, PN | 1 |
| Bárány, M | 1 |
| Davis, JM | 1 |
| Guimaraes, AR | 1 |
| Miller, C | 1 |
| Gonzalez, RG | 1 |
| Snyder, MB | 1 |
| Granzow, L | 1 |
| Wright, SM | 2 |
| Walter-Ryan, WG | 2 |
| Alarcon, RD | 2 |
| Uney, JB | 1 |
| Duggan, C | 1 |
| Marchbanks, RM | 1 |
| Jacoby, R | 1 |
| Pleul, O | 1 |
| Müller-Oerlinghausen, B | 1 |
| Lerer, B | 1 |
| Tolbert, LC | 1 |
| Walter-Ryan, W | 1 |
| Lally, KM | 1 |
| Sharp, RR | 1 |
| Ballast, CL | 1 |
| Delidow, B | 1 |
| Bronzo, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [NCT00181636] | 25 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
11 reviews available for choline and Bipolar Disorder
| Article | Year |
|---|---|
Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Topics: Antimanic Agents; Aspartic Acid; Bipolar Disorder; Brain; Choline; Cross-Sectional Studies; gamma-Am | 2018 |
Investigating the mechanism(s) underlying switching between states in bipolar disorder.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Catecholamines; Choline; Disease Models, Animal; Humans | 2015 |
Nutrient-based therapies for bipolar disorder: a systematic review.
Topics: Antidepressive Agents, Second-Generation; Bipolar Disorder; Choline; Chromium; Dietary Supplements; | 2013 |
Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients.
Topics: Antipsychotic Agents; Bipolar Disorder; Brain; Choline; Creatine; Dextroamphetamine; Female; Humans; | 2004 |
Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain Chemistry; Child; Choline; Creatine; Glutamic Acid; Gl | 2006 |
Complementary medicines in pediatric bipolar disorder.
Topics: Adolescent; Bipolar Disorder; Child; Choline; Complementary Therapies; Drug Therapy, Combination; Fa | 2008 |
The use of cholinergic precursors in neuropsychiatric diseases.
Topics: Acetylcholine; Alzheimer Disease; Animals; Bipolar Disorder; Brain; Cerebellar Ataxia; Choline; Huma | 1982 |
Glycine: a possible role in lithium's action and affective illness.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Autistic Disorder; Bipolar Disorder; Brain Chemistry; | 1983 |
Lithium, membranes, and manic-depressive illness.
Topics: Adenylyl Cyclases; Animals; Biological Transport; Bipolar Disorder; Blood-Brain Barrier; Calcium; Ca | 1980 |
Neuroimaging in bipolar disorder.
Topics: Basal Ganglia; Bipolar Disorder; Brain; Cerebrovascular Circulation; Choline; Frontal Lobe; Humans; | 2000 |
Alternative therapies for bipolar disorder.
Topics: Ascorbic Acid; Bipolar Disorder; Bupropion; Carbamazepine; Choline; Clonazepam; Clonidine; Clorgylin | 1985 |
7 trials available for choline and Bipolar Disorder
| Article | Year |
|---|---|
A Magnetic Resonance Spectroscopy Study of Lovastatin for Treating Bipolar Mood Disorder: A 4-Week Randomized Double-Blind, Placebo- Controlled Clinical Trial.
Topics: Adolescent; Adult; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Brain; Choline; Creatine; Doub | 2017 |
Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept study.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Bipolar Disorder; Brain Mapping; Choline; Cholinesterase Inh | 2009 |
Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients.
Topics: Adult; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Cerebral Cortex; Ch | 2003 |
Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy.
Topics: Administration, Oral; Antipsychotic Agents; Bipolar Disorder; Brain; Choline; Creatine; Diagnostic a | 2003 |
Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder.
Topics: Adult; Antimanic Agents; Basal Ganglia; Bipolar Disorder; Choline; Female; Humans; Lithium Chloride; | 1996 |
Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients.
Topics: Adult; Affect; Antimanic Agents; Basal Ganglia; Bipolar Disorder; Choline; Drug Resistance; Drug The | 1996 |
Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis.
Topics: Acetylcholine; Adult; Aged; Bipolar Disorder; Brain; Choline; Clinical Trials as Topic; Double-Blind | 1978 |
75 other studies available for choline and Bipolar Disorder
| Article | Year |
|---|---|
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dorsolateral Prefrontal Cortex; Humans; L | 2023 |
Altered biochemical metabolism and its lateralization in the cortico-striato-cerebellar circuit of unmedicated bipolar II depression.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Cerebellum; Choline; Creatine; Cross-Sectiona | 2019 |
Neurometabolic alterations in bipolar disorder with anxiety symptoms: A proton magnetic resonance spectroscopy study of the prefrontal whiter matter.
Topics: Anxiety; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Humans; Proton Magnetic Resonance Spect | 2021 |
Anterior cingulate cortex neuro-metabolic changes underlying lithium-induced euthymia in bipolar depression: A longitudinal
Topics: Aspartic Acid; Bipolar Disorder; Brain; Choline; Creatine; Gyrus Cinguli; Humans; Inositol; Lithium; | 2021 |
Biochemical abnormalities in basal ganglia and executive dysfunction in acute- and euthymic-episode patients with bipolar disorder: A proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Basal Ganglia; Biomarkers; Bipolar Disorder; Brain; Brain Chemistry; Case-Cont | 2018 |
Lithium-associated anterior cingulate neurometabolic profile in euthymic Bipolar I disorder: A
Topics: Adult; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Brain; Brain Chemistry; Choline; Cyclothym | 2018 |
Associations between executive function impairment and biochemical abnormalities in bipolar disorder with suicidal ideation.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain; Case-Control Studies; Cerebral Cortex; Choline; Corpu | 2018 |
Role of glia in prefrontal white matter abnormalities in first episode psychosis or mania detected by diffusion tensor spectroscopy.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Diffusion Tensor Im | 2019 |
Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Female; | 2013 |
(1)H-MRS of hippocampus in patients after first manic episode.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Glutamic Acid; Glutamine; Hip | 2014 |
Anterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: a potential new tool for diagnosis.
Topics: Adolescent; Analysis of Variance; Bipolar Disorder; Choline; Creatine; Cross-Sectional Studies; Depr | 2014 |
Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Brain; Choline; Creatine; Depressive Disorder, M | 2014 |
Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; | 2015 |
Trait-related alterations of N-acetylaspartate in euthymic bipolar patients: A longitudinal proton magnetic resonance spectroscopy study.
Topics: Adult; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Choline; Cyclothymic Disorder; Female; Fro | 2016 |
Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders.
Topics: Adult; Aspartic Acid; Biomarkers; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Depress | 2016 |
Differential neurometabolite alterations in brains of medication-free individuals with bipolar disorder and those with unipolar depression: a two-dimensional proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Female; Gyrus Cingul | 2016 |
A comparison of neurometabolites between remitted bipolar disorder and depressed bipolar disorder: A proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Creatine; Female; Humans; Mal | 2017 |
SNAP-25 genotype influences NAA/Cho in left hippocampus.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; DNA; Female; Genotype; Hippocampus; Humans; Magneti | 2008 |
Neurochemical alterations in adolescent bipolar depression: a proton magnetic resonance spectroscopy pilot study of the prefrontal cortex.
Topics: Adolescent; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Aspartic Acid; Bipolar Dis | 2008 |
Elevated metabolites within dorsolateral prefrontal cortex in rapid cycling bipolar disorder.
Topics: Adult; Aspartic Acid; Biomarkers; Bipolar Disorder; Brain; Choline; Creatine; Female; Functional Lat | 2009 |
Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Female; | 2009 |
T2 relaxation time abnormalities in bipolar disorder and schizophrenia.
Topics: Adult; Aspartic Acid; Biomarkers; Bipolar Disorder; Brain; Choline; Creatine; Female; Humans; Magnet | 2010 |
Cortical neurochemistry in euthymic patients with bipolar I disorder.
Topics: Adult; Affect; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dominance, Cere | 2009 |
[Application of lamotrigine in bipolar disorder--3T MR spectroscopy follow up (part 1)].
Topics: Antimanic Agents; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Excitatory Amino Acid Antagoni | 2010 |
Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder.
Topics: Adolescent; Aspartic Acid; Bipolar Disorder; Brain Chemistry; Cerebellum; Child; Choline; Female; Hu | 2011 |
Neurochemical alteration in the caudate: implications for the pathophysiology of bipolar disorder.
Topics: Adolescent; Adult; Antidepressive Agents; Aspartic Acid; Bipolar Disorder; Brain Mapping; Caudate Nu | 2011 |
Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Choline; Female; Frontal Lobe; Humans; Magnetic | 2002 |
Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex.
Topics: Acute Disease; Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Female; Glutamic Acid; Glu | 2003 |
Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder.
Topics: Adult; Ambulatory Care; Aspartic Acid; Axons; Bipolar Disorder; Choline; Creatine; Family; Functiona | 2003 |
Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents.
Topics: Adolescent; Age Factors; Aspartic Acid; Bipolar Disorder; Child; Choline; Creatine; Diagnosis, Diffe | 2003 |
Ethanolamine and phosphoethanolamine inhibit mitochondrial function in vitro: implications for mitochondrial dysfunction hypothesis in depression and bipolar disorder.
Topics: Animals; Bipolar Disorder; Choline; Depressive Disorder; Dose-Response Relationship, Drug; Ethanolam | 2004 |
Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Brain Mapping; Choline; Creatine; Depressive Dis | 2003 |
Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging study.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Cerebral Cortex; Choline; Creatine; Depressive D | 2004 |
A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute mania.
Topics: Acute Disease; Adult; Antimanic Agents; Antipsychotic Agents; Aspartic Acid; Bipolar Disorder; Choli | 2005 |
Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients.
Topics: Adolescent; Adult; Age Factors; Aspartic Acid; Bipolar Disorder; Child; Choline; Creatine; Female; H | 2005 |
Hippocampal 1H MRS in first-episode bipolar I patients.
Topics: Adult; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Creatin | 2006 |
A 1HMRS study of the anterior cingulate gyrus in euthymic bipolar patients.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Female; Gyrus Cinguli; Humans; Lithium; M | 2006 |
Measuring mania metabolites: a longitudinal proton spectroscopy study of hypomania.
Topics: Adult; Affect; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Brain Mapping; Choline; Energy Metabo | 2007 |
Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Cerebrospinal Fluid; Choline; Chronic Disease; Creatine; Fou | 2007 |
Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dominance, Cerebral; Dopamine Plasma Memb | 2009 |
Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Dysthymic Disorder; Female; Hippocampus; | 2008 |
Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol.
Topics: Adult; Aged; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Circa | 2009 |
Biochemical changes in the cingulum in patients with schizophrenia and chronic bipolar disorder.
Topics: Adult; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Choline; Chronic Disease; Creatine; Fe | 2008 |
RBC-choline: changes by lithium and relation to prophylactic response.
Topics: Age Factors; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Choline; Depressive Diso | 1984 |
CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls.
Topics: Adolescent; Adult; Age Factors; Aged; Bipolar Disorder; Calcium; Choline; Depressive Disorder; Femal | 1984 |
Lithium, red blood cell choline and clinical state. A prospective study in manic-depressive patients.
Topics: Adult; Bipolar Disorder; Choline; Ergothioneine; Erythrocytes; Female; Humans; Lithium; Magnetic Res | 1984 |
Platelet 3H-imipramine binding and red blood cell choline in affective disorders: indications of heterogeneous pathogenesis.
Topics: Bipolar Disorder; Blood Platelets; Carrier Proteins; Choline; Depressive Disorder; Humans; Imipramin | 1983 |
Determination of choline in erythrocytes using high-resolution proton nuclear magnetic resonance spectroscopy: comparison with a choline oxidase method.
Topics: Alcohol Oxidoreductases; Bipolar Disorder; Choline; Erythrocytes; Humans; Magnetic Resonance Spectro | 1984 |
Lithium treatment during pregnancy: a case study of erythrocyte choline content and lithium transport.
Topics: Adult; Bipolar Disorder; Choline; Erythrocytes; Female; Fetal Blood; Humans; Lithium; Lithium Carbon | 1983 |
Erythrocyte choline transport in drug-free and lithium-treated individuals.
Topics: Bipolar Disorder; Choline; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Lithium | 1984 |
Levels of red blood cell choline after discontinuation of lithium therapy.
Topics: Adult; Bipolar Disorder; Choline; Erythrocytes; Humans; Lithium; Lithium Carbonate; Male; Substance | 1982 |
Erythrocyte choline concentrations are elevated in manic patients.
Topics: Affective Disorders, Psychotic; Animals; Bipolar Disorder; Choline; Erythrocytes; Humans; Lithium; M | 1980 |
Erythrocyte and plasma choline in bipolar psychiatric patients: a followup study.
Topics: Adolescent; Adult; Bipolar Disorder; Choline; Erythrocytes; Follow-Up Studies; Humans; Middle Aged; | 1982 |
Mechanism of lithium-induced elevation in red blood cell choline content: an in vitro analysis.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Choline; Erythrocyte Membrane; Erythrocytes; Humans; In V | 1980 |
Measurement of choline concentration and transport in human erythrocytes by 1H NMR: comparison of normal blood and that from lithium-treated psychiatric patients.
Topics: Biological Transport; Bipolar Disorder; Choline; Erythrocytes; Humans; Lithium; Magnetic Resonance S | 1980 |
Red-cell choline in manic-depressive patients taking lithium.
Topics: Bipolar Disorder; Choline; Erythrocytes; Humans; Lithium | 1980 |
Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Femal | 1998 |
Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder.
Topics: Adult; Aged; Bipolar Disorder; Choline; Female; Frontal Lobe; Functional Laterality; Humans; Magneti | 1999 |
Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar I affective disorder.
Topics: Adult; Age Factors; Aspartic Acid; Bipolar Disorder; Brain Mapping; Cell Survival; Choline; Corpus S | 1998 |
Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations.
Topics: Aspartic Acid; Basal Ganglia; Bipolar Disorder; Child; Choline; Creatine; Energy Metabolism; Frontal | 2000 |
Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Humans; Hypertrophy; Magnetic Resonance S | 2001 |
Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex.
Topics: Adult; Affect; Bipolar Disorder; Brain Mapping; Choline; Dominance, Cerebral; Female; Gyrus Cinguli; | 2000 |
Adrenergic-cholinergic imbalance in affective disorders.
Topics: Animals; Bipolar Disorder; Choline; Depression; Humans; Physostigmine; Receptors, Adrenergic; Recept | 1976 |
Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients.
Topics: Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Choline; Creatine; Depressive Disorder; Energ | 1992 |
The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain; Choline; Corpus Callosum; Humans; Lithium Carbonate; | 1992 |
Erythrocyte choline concentration in bipolar disorder: a predictor of clinical course and medication response.
Topics: Adolescent; Adult; Bipolar Disorder; Choline; Erythrocytes; Female; Humans; Male; Predictive Value o | 1991 |
Erythrocyte choline concentrations in psychiatric disorders.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Bipolar Disorder; Choline; Dementia; Depressi | 1991 |
RBC-choline: a biological marker of the outcome of lithium prophylaxis?
Topics: Alcoholism; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Choline; Erythrocytes; Hu | 1987 |
An experimental study and computer simulation of the turnover of choline in erythrocytes of patients treated with lithium carbonate.
Topics: Barium; Bipolar Disorder; Calcium; Choline; Erythrocyte Aging; Erythrocytes; Humans; Kinetics; Lithi | 1986 |
Effects of bipolar affective disorder and lithium administration on the cholinergic system in human blood.
Topics: Acetylcholinesterase; Bipolar Disorder; Choline; Cholinesterases; Erythrocytes; Humans; Lithium | 1986 |
A pilot study of erythrocyte choline flux and content in affective disorders.
Topics: Adult; Age Factors; Bipolar Disorder; Cell Membrane Permeability; Choline; Depressive Disorder; Eryt | 1986 |
Lithium therapy and the turnover of phosphatidylcholine in human erythrocytes.
Topics: Adult; Aged; Bipolar Disorder; Choline; Erythrocytes; Fatty Acids, Nonesterified; Female; Humans; In | 1986 |
Biochemical RBC abnormalities in drug-free and lithium-treated manic patients.
Topics: Adult; Biological Transport; Bipolar Disorder; Choline; Erythrocytes; Female; Humans; Lithium; Male; | 1985 |
Cholinergic processes in blood samples from patients with major psychiatric disorders.
Topics: Acetylcholinesterase; Bipolar Disorder; Choline; Cholinesterases; Depressive Disorder; Erythrocytes; | 1985 |
NMR chemistry analysis of red blood cell constituents in normal subjects and lithium-treated psychiatric patients.
Topics: Bipolar Disorder; Choline; Erythrocytes; Female; Glycine; Humans; Lactates; Lactic Acid; Lithium; Ma | 1985 |