Page last updated: 2024-10-17

choline and Bile Duct Obstruction

choline has been researched along with Bile Duct Obstruction in 5 studies

Research Excerpts

ExcerptRelevanceReference
"Furosemide choleresis was associated with biliary secretion of furosemide and its metabolites."1.27Furosemide choleresis in isolated perfused rat liver: partial dependency on perfusate sodium and chloride. ( Anwer, MS, 1985)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Zhang, SH1
Yu, MJ1
Yan, JL1
Xiao, JH1
Xiao, Y1
Yang, JL1
Lei, J1
Yu, X1
Chen, WL1
Chai, Y1
Kaminski, DL1
Adams, A1
Jellinek, M1
LeBlanc, MJ1
Gavino, V1
Pérea, A1
Yousef, IM1
Lévy, E1
Tuchweber, B1
Anwer, MS1
Steiner, JW1
Perz, ZM1
Taichman, LB1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Expanded Access Use of Omegaven® in the Treatment of Parenteral Nutrition Induced Liver Injury in Children[NCT02925520]0 participants Expanded AccessNo longer available
Compassionate Use of an Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants[NCT00738101]293 participants (Actual)Interventional2008-09-30Completed
Research Study of an Intravenous Fat Emulsion Comprised of Fish Oils (Omegaven) in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury[NCT01089426]90 participants (Actual)Interventional2008-09-30Completed
Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536]Phase 2110 participants (Actual)Interventional2007-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All Cause Mortality During the Study.

To describe proportion of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

InterventionParticipants (Count of Participants)
Fish Oil Emulsion Arm30

All-cause Mortality up to Hospital Discharge

To describe number and percentage of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: Anytime from initiation of study to discharge from the hospital.

InterventionParticipants (Count of Participants)
Fish Oil Emulsion Arm40

Growth Z-scores for Weight

The Z-score indicated the number of standard deviations away from the mean. A weight Z-score of 0 is equal to the mean. A weight Z-score of ≤ -2 indicates an underweight status, while a weight Z-score of ≥ 2 indicates overweight or obese status. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

Interventionz-score (Mean)
Fish Oil Emulsion Arm-1.48

Liver or Multi-visceral Transplant

To describe the number and percentage of infants who required liver or multi-visceral transplant. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

InterventionParticipants (Count of Participants)
Fish Oil Emulsion Arm2

Time to Resolution of Parenteral Nutrition Associated Cholestasis Prior to End of Study

Time in days from the initiation of fish oil emulsions (initiation of study) until resolution of cholestasis as defined by serum conjugated bilirubin≤ 2 mg/dL prior to EOS (end of study). (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

InterventionDays (Mean)
Fish Oil Emulsion Arm38.02

Other Studies

5 other studies available for choline and Bile Duct Obstruction

ArticleYear
TLR4 Knockout Attenuates BDL-induced Liver Cholestatic Injury through Amino Acid and Choline Metabolic Pathways.
    Current medical science, 2021, Volume: 41, Issue:3

    Topics: Amino Acids; Animals; Bile Ducts; Cholestasis; Choline; Humans; Ligation; Liver; Metabolic Networks

2021
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The effect of hyperalimentation on hepatic lipid content and lipogenic enzyme activity in rats and man.
    Surgery, 1980, Volume: 88, Issue:1

    Topics: Acetyl-CoA Carboxylase; Adult; Aged; Animals; Blood Proteins; Cholestasis; Choline; Diet; Fat Emulsi

1980
The role of dietary choline in the beneficial effects of lecithin on the secretion of biliary lipids in rats.
    Biochimica et biophysica acta, 1998, Aug-28, Volume: 1393, Issue:2-3

    Topics: Animals; Bile; Bile Acids and Salts; Bile Canaliculi; Cholestasis; Cholesterol; Choline; Diet; Energ

1998
Furosemide choleresis in isolated perfused rat liver: partial dependency on perfusate sodium and chloride.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Bile; Chlorides; Cholestasis; Choline; Dose-Response Relationship, Drug; Furosemide; Lithiu

1985
Cell population dynamics in the liver. A review of quantitative morphological techniques applied to the study of physiological and pathological growth.
    Experimental and molecular pathology, 1966, Volume: 5, Issue:2

    Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Cholestasis; Choline; Deficiency Dis

1966