choline and Astrocytoma, Grade IV studies

Research Excerpts

Excerpt	Relevance	Reference
"The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma."	9.12	[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007)
"Glioblastomas (GBMs), the most frequent and aggressive human primary brain tumours, have altered cell metabolism, and one of the strongest indicators of malignancy is an increase in choline compounds."	8.02	Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors. ( Benfante, R; Clementi, F; Daga, A; Di Lascio, S; Fasoli, F; Gordon, TJ; Gotti, C; McIntosh, M; Moretti, M; Pucci, S; Viani, P; Zoli, M, 2021)
"Positron emission tomography (PET) and PET/computed tomography (PET-CT) studies with (11)C- or (18)F-labeled choline derivatives are used for PET imaging in glioblastoma patients."	7.80	Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs. ( Hara, N; Inazu, M; Saiki, I; Taguchi, C; Uchino, H; Yamanaka, T; Yara, M, 2014)
"A new method based on hydrophilic interaction chromatography-electrospray ionisation-tandem mass spectrometry (HILIC-ESI-MS/MS) coupled to the use of a stable isotope labelled substrate was developed to study the metabolism of choline (Cho) compounds in two human glioblastoma multiform (GBM) cell lines with different responses to ionising radiation."	7.76	Analysis of hydrophilic and lipophilic choline compounds in radioresistant and radiosensitive glioblastoma cell lines by HILIC-ESI-MS/MS. ( Balayssac, S; Claparols, C; Desoubzdanne, D; Gilard, V; Malet-Martino, M; Martino, R; Martins-Froment, N; Tercé, F; Zedde, C, 2010)
"To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)."	7.72	Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004)
"Thirteen patients with recurrent glioblastoma were enrolled in RTOG 0625/ACRIN 6677, a prospective multicenter trial in which bevacizumab was used in combination with either temozolomide or irinotecan."	5.17	Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. ( Barboriak, DP; Bokstein, F; Boxerman, JL; Gilbert, MR; McKinstry, RC; Ratai, EM; Safriel, Y; Snyder, BS; Sorensen, AG; Zhang, Z, 2013)
"The choline/N-acetyl-aspartate (Cho/NAA) ratio, obtained by the multivoxel spectroscopy with short echo time (TE), was evaluated, in the histological grading of the brain astrocytomas (grades I, II and III-IV) in comparison with the normal cerebral parenchyma."	5.12	[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. ( Aragão, Mde F; Araújo, N; Azevedo Filho, HR; Leite, Cda C; Melo, RV; Otaduy, MC; Silva, JL; Valença, MM; Victor, EG, 2007)
" This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors."	4.85	Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. ( Celda, B; Martínez-Bisbal, MC, 2009)
"Glioblastomas (GBMs), the most frequent and aggressive human primary brain tumours, have altered cell metabolism, and one of the strongest indicators of malignancy is an increase in choline compounds."	4.02	Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors. ( Benfante, R; Clementi, F; Daga, A; Di Lascio, S; Fasoli, F; Gordon, TJ; Gotti, C; McIntosh, M; Moretti, M; Pucci, S; Viani, P; Zoli, M, 2021)
"We investigated the potential of [18F]fluorodeoxyglucose ([18F]FDG) and [18F]Fluoromethylcholine ([18F]FCho) PET, compared to contrast-enhanced MRI, for the early detection of treatment response in F98 glioblastoma (GB) rats."	4.02	Assessment of the effect of therapy in a rat model of glioblastoma using [18F]FDG and [18F]FCho PET compared to contrast-enhanced MRI. ( Bolcaen, J; Boterberg, T; De Vos, F; Deblaere, K; Descamps, B; Goethals, I; Hallaert, G; Van den Broecke, C; Vanhove, C, 2021)
"In this study, we investigated fluorine-18 fluoromethylcholine (F-FCho) PET and contrast-enhanced MRI for predicting therapy response in glioblastoma (GB) patients according to the Response Assessment in Neuro-Oncology criteria."	3.85	18F-FCho PET and MRI for the prediction of response in glioblastoma patients according to the RANO criteria. ( Acou, M; Bolcaen, J; Boterberg, T; De Vos, F; Deblaere, K; Goethals, I; Van den Broecke, C; Van Holen, R; Vanhove, C, 2017)
"Purpose To determine whether regions of low apparent diffusion coefficient (ADC) with high relative cerebral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafter, Cho/NAA ratio) and whether their volumes correlated with progression-free survival (PFS) and overall survival (OS) in patients with glioblastoma (GBM)."	3.85	Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. ( Boonzaier, NR; Larkin, TJ; Matys, T; Price, SJ; van der Hoorn, A; Yan, JL, 2017)
"Positron emission tomography (PET) and PET/computed tomography (PET-CT) studies with (11)C- or (18)F-labeled choline derivatives are used for PET imaging in glioblastoma patients."	3.80	Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs. ( Hara, N; Inazu, M; Saiki, I; Taguchi, C; Uchino, H; Yamanaka, T; Yara, M, 2014)
"Eighteen patients with newly diagnosed, histologically confirmed glioblastoma had 3D-MR proton spectroscopic imaging (MRSI) along with T2 and T1 gadolinium-enhanced MR images at simulation and at boost treatment planning after 17 to 20 fractions of radiation therapy."	3.80	3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. ( Anderson, CM; Bayouth, JE; Buatti, JM; Capizzano, AA; Clerkin, PP; Magnotta, V; McGuire, SM; Morris, A; Muruganandham, M; Smith, BJ; Smith, MC, 2014)
"Peritumoral N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, Cho/NAA and rCBV significantly differentiated glioblastomas from intracranial metastases."	3.78	Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T. ( Fezoulidis, I; Fountas, K; Kapsalaki, E; Kousi, E; Svolos, P; Theodorou, K; Tsougos, I, 2012)
"A new method based on hydrophilic interaction chromatography-electrospray ionisation-tandem mass spectrometry (HILIC-ESI-MS/MS) coupled to the use of a stable isotope labelled substrate was developed to study the metabolism of choline (Cho) compounds in two human glioblastoma multiform (GBM) cell lines with different responses to ionising radiation."	3.76	Analysis of hydrophilic and lipophilic choline compounds in radioresistant and radiosensitive glioblastoma cell lines by HILIC-ESI-MS/MS. ( Balayssac, S; Claparols, C; Desoubzdanne, D; Gilard, V; Malet-Martino, M; Martino, R; Martins-Froment, N; Tercé, F; Zedde, C, 2010)
"In vivo magnetic resonance spectroscopy (MRS) studies of glial brain tumours reported that higher grade of astrocytoma is associated with increased level of choline-containing compounds (Cho) and decreased levels of N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr)."	3.73	In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. ( Belan, V; Béres, A; De Riggo, J; Dobrota, D; Galanda, M; Likavcanová, K; Liptaj, T; Mlynárik, V; Prónayová, N, 2005)
"To investigate the potential value of pre-external-beam radiation therapy (XRT) choline-to-NAA (N-acetylaspartate) index (CNI), apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV) for predicting survival in newly diagnosed patients with glioblastoma multiforme (GBM)."	3.72	Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. ( Catalaa, I; Chang, S; Dillon, WP; Henry, RG; Li, X; Lu, Y; Nelson, SJ; Oh, J; Pirzkall, A, 2004)
"Seven patients responded to tamoxifen therapy (three with glioblastomas multiforme; four with anaplastic astrocytomas), and nine did not (six with glioblastomas multiforme; three with anaplastic astrocytomas)."	3.70	Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy. ( Arnold, DL; Caramanos, Z; Langleben, A; LeBlanc, R; Preul, MC; Shenouda, G; Villemure, JG, 2000)
" The spectra from meningiomas, neuroblastomas, and glioblastomas displayed, in addition to similarities-including the presence of signals from leucine, isoleucine, valine, threonine, lactate, acetate, glutamate, choline-containing compounds and glycine-certain distinguishing metabolic features."	3.69	Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours. ( Bhakoo, KK; Florian, CL; Noble, M; Preece, NE; Williams, SR, 1995)
"Thirty-nine patients after the standard treatment of a glioblastoma underwent advanced imaging by MRS and ADC at the time of suspected recurrence - median time to progression was 6."	1.43	Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging. ( Bulik, M; Jancalek, R; Kazda, T; Lakomy, R; Pospisil, P; Slampa, P; Smrcka, M, 2016)
"Cold choline was used for binding competition experiments."	1.42	Evidence of 18F-FCH Uptake in Human T98G Glioblastoma Cells. ( Aprile, C; Buroni, FE; Lodola, L; Nano, R; Pasi, F; Persico, MG, 2015)
"Glycine was detected in 24% of all studies, though with a wide range of signal amplitude and extent of the spatial distributions."	1.40	Mapping of glycine distributions in gliomas. ( Behari, S; Gupta, RK; Hussain, N; Maudsley, AA; Parra, NA; Roy, B; Sheriff, S; Stoyanova, R, 2014)
"Primary brain tumors (PBT), in particular gliomas, are among the most difficult neoplasms to treat, necessitating good quality imaging to guide clinicians at many junctures."	1.37	Promising role of [18F] fluorocholine PET/CT vs [18F] fluorodeoxyglucose PET/CT in primary brain tumors-early experience. ( Lam, WW; Ng, DC; Ong, SC; See, SJ; Wong, WY; Yu, SW, 2011)
"We examined 120 patients with brain tumors using a 1."	1.31	In vivo proton magnetic resonance spectroscopy of brain tumors. ( Fountas, KN; Gotsis, SD; Johnston, KW; Kapsalaki, EZ; Kapsalakis, JZ; Papadakis, N; Robinson, JS; Smisson , HF, 2000)
"Aspirated pus from one patient with brain abscess was examined using ex vivo proton MR spectroscopy."	1.31	Discrimination of brain abscess and cystic tumor by in vivo proton magnetic resonance spectroscopy. ( Kadota, O; Kikuchi, K; Kohno, K; Kumon, Y; Miki, H; Ohue, S; Sakaki, S, 2001)
"In pretreated glioblastoma metabolic data of MRSI seem to be potentially helpful to differentiate tumorous and non tumorous enhancement phenomena after local immunotherapy, which might be useful for further treatment decisions."	1.31	Comparative follow-up of enhancement phenomena with MRI and Proton MR Spectroscopic Imaging after intralesional immunotherapy in glioblastoma--Report of two exceptional cases. ( Engelbrecht, V; Floeth, FW; Weber, F; Wittsack, HJ, 2002)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.09)	18.7374
1990's	11 (11.96)	18.2507
2000's	32 (34.78)	29.6817
2010's	36 (39.13)	24.3611
2020's	12 (13.04)	2.80

Authors	Studies
Feng, A	1
Yuan, P	1
Huang, T	1
Li, L	2
Lyu, J	1
Yang, C	1
Wu, Y	1
Wang, L	1
Li, S	1
Zhou, J	1
Tan, Y	2
Song, J	1
Xing, H	1
Yi, K	1
Zhan, Q	1
Zhao, J	1
Wang, Q	1
Yuan, X	1
Kang, C	1
Bhaduri, S	1
Kelly, CL	1
Lesbats, C	1
Sharkey, J	1
Ressel, L	1
Mukherjee, S	1
Platt, MD	1
Delikatny, EJ	1
Poptani, H	2
Sidibe, I	1
Tensaouti, F	2
Gilhodes, J	2
Cabarrou, B	1
Filleron, T	2
Desmoulin, F	2
Ken, S	3
Noël, G	2
Truc, G	2
Sunyach, MP	2
Charissoux, M	2
Magné, N	2
Lotterie, JA	2
Roques, M	2
Péran, P	2
Cohen-Jonathan Moyal, E	3
Laprie, A	4
Ma, Q	1
Jiang, H	1
Ma, L	1
Zhao, G	1
Xu, Q	1
Guo, D	1
He, N	1
Liu, H	2
Meng, Z	1
Liu, J	1
Zhu, L	1
Lin, Q	1
Wu, X	1
Li, M	1
Luo, S	1
Fang, J	1
Lu, Z	1
Lubrano, V	2
Fuentes-Baile, M	1
Bello-Gil, D	1
Pérez-Valenciano, E	1
Sanz, JM	1
García-Morales, P	1
Maestro, B	1
Ventero, MP	1
Alenda, C	1
Barberá, VM	1
Saceda, M	1
Flores-Alvarez, E	1
Anselmo Rios Piedra, E	1
Cruz-Priego, GA	1
Durand-Muñoz, C	1
Moreno-Jimenez, S	1
Roldan-Valadez, E	1
Zhao, JP	1
Cui, CX	1
Wang, JC	1
Su, HW	1
Duan, CF	1
Liu, XJ	1
Pucci, S	1
Fasoli, F	1
Moretti, M	1
Benfante, R	1
Di Lascio, S	1
Viani, P	1
Daga, A	1
Gordon, TJ	1
McIntosh, M	1
Zoli, M	1
Clementi, F	1
Gotti, C	1
Bolcaen, J	4
Descamps, B	3
Deblaere, K	4
De Vos, F	3
Boterberg, T	4
Hallaert, G	1
Van den Broecke, C	4
Vanhove, C	4
Goethals, I	4
Kumon, M	1
Nakae, S	1
Murayama, K	1
Kato, T	1
Ohba, S	1
Inamasu, J	1
Yamada, S	1
Abe, M	1
Sasaki, H	1
Ohno, Y	1
Hasegawa, M	1
Kurahashi, H	1
Hirose, Y	1
Chen, F	1
Li, Z	1
Weng, C	1
Li, P	1
Tu, L	1
Chen, L	1
Xie, W	1
Agliano, A	2
Balarajah, G	2
Ciobota, DM	1
Sidhu, J	1
Clarke, PA	2
Jones, C	2
Workman, P	2
Leach, MO	2
Al-Saffar, NMS	1
Pasi, F	2
Persico, MG	2
Buroni, FE	2
Aprile, C	2
Hodolic, M	1
Corbella, F	1
Nano, R	2
Facoetti, A	1
Lodola, L	2
Alongi, P	1
Vetrano, IG	1
Fiasconaro, E	1
Alaimo, V	1
Laudicella, R	1
Bellavia, M	1
Rubino, F	1
Bagnato, S	1
Galardi, G	1
Gurbani, SS	2
Sheriff, S	2
Maudsley, AA	3
Shim, H	2
Cooper, LAD	1
Ratai, EM	1
Zhang, Z	1
Snyder, BS	1
Boxerman, JL	1
Safriel, Y	1
McKinstry, RC	1
Bokstein, F	1
Gilbert, MR	1
Sorensen, AG	1
Barboriak, DP	1
Gupta, RK	2
Stoyanova, R	2
Parra, NA	2
Roy, B	2
Hussain, N	1
Behari, S	1
Taguchi, C	1
Inazu, M	1
Saiki, I	1
Yara, M	1
Hara, N	1
Yamanaka, T	1
Uchino, H	1
Muruganandham, M	1
Clerkin, PP	1
Smith, BJ	1
Anderson, CM	1
Morris, A	1
Capizzano, AA	1
Magnotta, V	1
McGuire, SM	1
Smith, MC	1
Bayouth, JE	1
Buatti, JM	1
Ishkanian, F	1
Huang, K	1
Walker, GR	1
Padgett, K	1
Panoff, J	1
Markoe, A	1
Al-Saffar, NM	1
Marshall, LV	1
Jackson, LE	1
Eykyn, TR	1
Pearson, AD	1
Deviers, A	1
Rowland, B	1
Laruelo, A	1
Catalaa, I	3
Celsis, P	1
Berry, I	2
Mogicato, G	1
De Vos Pharm, F	1
Kalala, JP	2
Decrock, E	1
Leybaert, L	1
Stadlbauer, A	1
Pichler, P	1
Karl, M	1
Brandner, S	1
Lerch, C	1
Renner, B	1
Heinz, G	1
Tang, C	1
Guo, J	1
Chen, H	1
Yao, CJ	1
Zhuang, DX	1
Wang, Y	1
Tang, WJ	1
Ren, G	1
Yao, Y	1
Wu, JS	1
Mao, Y	1
Zhou, LF	1
Fu, Y	1
Ong, LC	1
Ranganath, SH	1
Zheng, L	1
Kee, I	1
Zhan, W	1
Yu, S	1
Chow, PK	1
Wang, CH	1
Cordova, JS	1
Shu, HK	1
Liang, Z	1
Cooper, LA	1
Holder, CA	1
Olson, JJ	1
Kairdolf, B	1
Schreibmann, E	1
Neill, SG	1
Hadjipanayis, CG	1
Mohan, S	1
Chawla, S	1
Wang, S	1
Verma, G	1
Skolnik, A	1
Brem, S	1
Peters, KB	1
Kazda, T	1
Bulik, M	1
Pospisil, P	1
Lakomy, R	1
Smrcka, M	1
Slampa, P	1
Jancalek, R	1
Nelson, SJ	9
Li, Y	2
Lupo, JM	1
Olson, M	2
Crane, JC	1
Molinaro, A	2
Roy, R	2
Clarke, J	1
Butowski, N	2
Prados, M	1
Cha, S	5
Chang, SM	4
Lybaert, K	1
Moerman, L	1
Kadambi, AK	1
Park, I	1
Crane, J	1
Chang, S	5
Koch, K	1
Hartmann, R	1
Schröter, F	1
Suwala, AK	1
Maciaczyk, D	1
Krüger, AC	1
Willbold, D	1
Kahlert, UD	1
Maciaczyk, J	1
Acou, M	1
Van Holen, R	1
Boonzaier, NR	1
Larkin, TJ	1
Matys, T	1
van der Hoorn, A	1
Yan, JL	1
Price, SJ	1
Thorsen, F	1
Jirak, D	1
Wang, J	1
Sykova, E	1
Bjerkvig, R	1
Enger, PØ	1
van der Kogel, A	1
Hajek, M	1
Saraswathy, S	2
Crawford, FW	2
Lamborn, KR	2
Pirzkall, A	5
Khayal, IS	1
McGue, C	1
Berger, MS	1
Vanpouille, C	1
Le Jeune, N	1
Kryza, D	1
Clotagatide, A	1
Janier, M	1
Dubois, F	1
Perek, N	1
Martínez-Bisbal, MC	1
Celda, B	1
Srinivasan, R	1
Phillips, JJ	1
Vandenberg, SR	1
Polley, MY	1
Bourne, G	1
Au, A	1
Desoubzdanne, D	1
Claparols, C	1
Martins-Froment, N	1
Zedde, C	1
Balayssac, S	1
Gilard, V	1
Tercé, F	1
Martino, R	1
Malet-Martino, M	1
Lam, WW	1
Ng, DC	1
Wong, WY	1
Ong, SC	1
Yu, SW	1
See, SJ	1
Davila, M	1
Candiota, AP	1
Pumarola, M	1
Arus, C	1
Einstein, DB	1
Wessels, B	1
Bangert, B	1
Fu, P	1
Nelson, AD	1
Cohen, M	1
Sagar, S	1
Lewin, J	1
Sloan, A	1
Zheng, Y	1
Williams, J	1
Colussi, V	1
Vinkler, R	1
Maciunas, R	1
Zhu, M	1
Fischl, AS	1
Trowbridge, MA	1
Shannon, HE	1
Jeon, JY	1
Kovanlikaya, I	1
Boockvar, JA	1
Mao, X	1
Shin, B	1
K Burkhardt, J	1
Kesavabhotla, K	1
Christos, P	1
Riina, H	1
Shungu, DC	1
Tsiouris, AJ	1
Lima, EC	1
Otaduy, MC	2
Tsunemi, M	1
Pincerato, R	1
Cardoso, EF	1
Rosemberg, S	1
Aguiar, PH	1
Cerri, GG	1
Leite, CC	1
Tsougos, I	1
Svolos, P	1
Kousi, E	1
Fountas, K	1
Theodorou, K	1
Fezoulidis, I	1
Kapsalaki, E	1
Gmeiner, M	1
Sonnberger, M	1
Wurm, G	1
Weis, S	1
Rabinov, JD	1
Lee, PL	1
Barker, FG	1
Louis, DN	1
Harsh, GR	1
Cosgrove, GR	1
Chiocca, EA	1
Thornton, AF	1
Loeffler, JS	1
Henson, JW	1
Gonzalez, RG	2
Howe, FA	1
Barton, SJ	1
Cudlip, SA	1
Stubbs, M	1
Saunders, DE	1
Murphy, M	1
Wilkins, P	1
Opstad, KS	1
Doyle, VL	1
McLean, MA	1
Bell, BA	1
Griffiths, JR	1
Bulakbasi, N	1
Kocaoglu, M	1
Ors, F	1
Tayfun, C	1
Uçöz, T	1
Oh, J	1
Henry, RG	2
Lu, Y	1
Li, X	1
Dillon, WP	4
Kwee, SA	1
Coel, MN	1
Lim, J	1
Ko, JP	1
Chan, AA	1
Lau, A	1
Verhey, LJ	1
Larson, D	2
McDermott, MW	1
Plotkin, M	1
Eisenacher, J	1
Bruhn, H	1
Wurm, R	1
Michel, R	1
Stockhammer, F	1
Feussner, A	1
Dudeck, O	1
Wust, P	1
Felix, R	1
Amthauer, H	1
Magalhaes, A	1
Godfrey, W	1
Shen, Y	1
Hu, J	1
Smith, W	1
Pulkkinen, J	1
Häkkinen, AM	1
Lundbom, N	1
Paetau, A	1
Kauppinen, RA	1
Hiltunen, Y	1
Likavcanová, K	1
Dobrota, D	1
Liptaj, T	1
Prónayová, N	1
Mlynárik, V	1
Belan, V	1
Galanda, M	1
Béres, A	1
De Riggo, J	1
Lichy, MP	1
Bachert, P	1
Hamprecht, F	1
Weber, MA	1
Debus, J	1
Schulz-Ertner, D	1
Schlemmer, HP	1
Kauczor, HU	1
Aragão, Mde F	1
Melo, RV	1
Azevedo Filho, HR	1
Victor, EG	1
Silva, JL	1
Araújo, N	1
Leite, Cda C	1
Valença, MM	1
Nafe, R	1
Glienke, W	1
Hattingen, E	1
Schlote, W	1
Lanfermann, H	1
Zanella, F	1
Cassol, E	1
McKnight, TR	1
Berchery, D	1
Marre, D	1
Bachaud, JM	1
Moyal, EC	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284]	Phase 2	40 participants (Anticipated)	Interventional	2022-07-01	Recruiting
Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.[NCT03009318]		100 participants (Actual)	Interventional	2012-01-31	Completed
Phase II Trial of Conventional Radiotherapy With Stereotactic Radiosurgery to High Risk Tumor Regions as Determined by Functional Imaging in Patients With Glioblastoma Multiforme[NCT00253448]	Phase 2	35 participants (Actual)	Interventional	2002-12-31	Completed
Ependymomics: Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents[NCT05151718]		370 participants (Anticipated)	Observational	2021-09-30	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Followed every 3 months for 2 years, every 6 months for 3 years, and annually thereafter for at least 5 years (NCT00253448)
Timeframe: Minimum of 5 years.

Intervention	months (Median)
	Entire Cohort	RTOG Glioma Recursive Partitioning Class 3 n=4	RTOG Glioma Recursive Partitioning Class 4 n=13	RTOG Glioma Recursive Partitioning Class 5 n=16	RTOG Glioma Recursive Partitioning Class 6 n=2	Patients receiving concurrent chemotherapy	Patients who were not candidates for chemotherapy
Stereotactic Radiosurgery Plus Conventional Radiotherapy	15.8	22	18.7	12.5	3.9	20.8	11

Article	Year
Progressive multifocal exophytic pontine glioblastoma: a case report with literature review. Chinese journal of cancer, 2017, Mar-27, Volume: 36, Issue:1 Topics: Aspartic Acid; Brain Stem Neoplasms; Child, Preschool; Choline; Diagnosis, Differential; Fatal Outco	2017
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2009, Volume: 53, Issue:6 Topics: Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Glioblastoma; Humans; In	2009
Glioblastoma with the appearance of arteriovenous malformation: pitfalls in diagnosis. Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:5 Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Child; Choline; Diagnosis,	2013
Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism. Journal of neuro-oncology, 1992, Volume: 13, Issue:2 Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Energy Metabolism; Glioblastoma; Humans; Lactates;	1992

Article	Year
Pseudoprogression in GBM versus true progression in patients with glioblastoma: A multiapproach analysis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2023, Volume: 181 Topics: Brain Neoplasms; Choline; Disease Progression; Glioblastoma; Humans; Magnetic Resonance Imaging; Neo	2023
Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. Neuro-oncology, 2013, Volume: 15, Issue:7 Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Be	2013
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme. International journal of radiation oncology, biology, physics, 2014, Oct-01, Volume: 90, Issue:2 Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Crea	2014
Phase II trial of radiosurgery to magnetic resonance spectroscopy-defined high-risk tumor volumes in patients with glioblastoma multiforme. International journal of radiation oncology, biology, physics, 2012, Nov-01, Volume: 84, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Combined Modality Therapy;	2012
Metabolic response of glioblastoma to superselective intra-arterial cerebral infusion of bevacizumab: a proton MR spectroscopic imaging study. AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:11 Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Aspartic Acid; Bevacizumab; Brain;	2012
[Multivoxel spectroscopy with short echo time: choline/N-acetyl-aspartate ratio and the grading of cerebral astrocytomas]. Arquivos de neuro-psiquiatria, 2007, Volume: 65, Issue:2A Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Chol	2007
Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study. International journal of radiation oncology, biology, physics, 2008, Mar-01, Volume: 70, Issue:3 Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Magnetic Resonance Ima	2008
Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study. Journal of neurosurgery, 1996, Volume: 84, Issue:3 Topics: Adolescent; Adult; Aged; Analysis of Variance; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Pr	1996

Article	Year
Distinguishing Tumor Recurrence From Radiation Necrosis in Treated Glioblastoma Using Multiparametric MRI. Academic radiology, 2022, Volume: 29, Issue:9 Topics: Brain Neoplasms; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging;	2022
Glioma-derived exosomes hijack the blood-brain barrier to facilitate nanocapsule delivery via LCN2. Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 345 Topics: Blood-Brain Barrier; Choline; Endothelial Cells; Exosomes; Glioblastoma; Glioma; Humans; Lipocalin-2	2022
Metabolic changes in glioblastomas in response to choline kinase inhibition: In vivo MRS in rodent models. NMR in biomedicine, 2023, Volume: 36, Issue:3 Topics: Animals; Brain Neoplasms; Choline; Choline Kinase; Glioblastoma; Mice; Rats; Receptors, Antigen, T-C	2023
The moonlighting function of glycolytic enzyme enolase-1 promotes choline phospholipid metabolism and tumor cell proliferation. Proceedings of the National Academy of Sciences of the United States of America, 2023, 04-11, Volume: 120, Issue:15 Topics: Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Choline; Glioblastoma; Humans; Phospholipid	2023
Is pre-radiotherapy metabolic heterogeneity of glioblastoma predictive of progression-free survival? Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2023, Volume: 183 Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magnetic Resonance Imaging;	2023
CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells. Biomolecules, 2020, 02-03, Volume: 10, Issue:2 Topics: 3T3-L1 Cells; Adenocarcinoma; Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival;	2020
Correlations between DTI-derived metrics and MRS metabolites in tumour regions of glioblastoma: a pilot study. Radiology and oncology, 2020, 09-29, Volume: 54, Issue:4 Topics: Anisotropy; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Contrast Media; Creatine; Di	2020
Multimodal MR Features of 8 Cases of Epithelioid Glioblastoma. BioMed research international, 2020, Volume: 2020 Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Cerebrovascular Circulation; Choline; Creatine; Diffusi	2020
Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors. Pharmacological research, 2021, Volume: 163 Topics: alpha7 Nicotinic Acetylcholine Receptor; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chol	2021
Assessment of the effect of therapy in a rat model of glioblastoma using [18F]FDG and [18F]FCho PET compared to contrast-enhanced MRI. PloS one, 2021, Volume: 16, Issue:3 Topics: Animals; Cell Line, Tumor; Choline; Contrast Media; Female; Fluorodeoxyglucose F18; Glioblastoma; Ma	2021
Myoinositol to Total Choline Ratio in Glioblastomas as a Potential Prognostic Factor in Preoperative Magnetic Resonance Spectroscopy. Neurologia medico-chirurgica, 2021, Aug-15, Volume: 61, Issue:8 Topics: Brain Neoplasms; Choline; Glioblastoma; Humans; Inositol; Isocitrate Dehydrogenase; Magnetic Resonan	2021
Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy. Oncotarget, 2017, Jul-18, Volume: 8, Issue:29 Topics: Adult; Animals; Biomarkers; Cell Line, Tumor; Cell Survival; Child; Choline; Energy Metabolism; Fema	2017
Uptake of Contrast media & molecular imaging, 2017, Volume: 2017 Topics: Carbon; Cell Line, Tumor; Choline; Diagnosis, Differential; Glioblastoma; Humans; Ions; Neoplasm Met	2017
Choline-PET/CT in the Differential Diagnosis Between Cystic Glioblastoma and Intraparenchymal Hemorrhage. Current radiopharmaceuticals, 2019, Volume: 12, Issue:1 Topics: Brain Neoplasms; Cerebral Hemorrhage; Choline; Diagnosis, Differential; Glioblastoma; Humans; Magnet	2019
Incorporation of a spectral model in a convolutional neural network for accelerated spectral fitting. Magnetic resonance in medicine, 2019, Volume: 81, Issue:5 Topics: Algorithms; Artifacts; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Computer Graphics; Cr	2019
Mapping of glycine distributions in gliomas. AJNR. American journal of neuroradiology, 2014, Volume: 35, Issue:6 Suppl Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Mapping; Brain Neoplasms; Choline; Diffusion Magn	2014
Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs. Biochemical pharmacology, 2014, Apr-01, Volume: 88, Issue:3 Topics: Antigens, CD; Antineoplastic Agents; Astrocytes; Cell Line, Tumor; Cell Survival; Central Nervous Sy	2014
3-Dimensional magnetic resonance spectroscopic imaging at 3 Tesla for early response assessment of glioblastoma patients during external beam radiation therapy. International journal of radiation oncology, biology, physics, 2014, Sep-01, Volume: 90, Issue:1 Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; C	2014
Volumetric spectroscopic imaging of glioblastoma multiforme radiation treatment volumes. International journal of radiation oncology, biology, physics, 2014, Oct-01, Volume: 90, Issue:2 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Edema; Brain Mapping; Brain Neoplasms; Choline; Creatine; F	2014
Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma. PloS one, 2014, Volume: 9, Issue:8 Topics: Cell Line, Tumor; Choline; Flow Cytometry; Glioblastoma; Humans; Immunoblotting; Lactic Acid; Magnet	2014
(18)F-fluoromethylcholine (FCho), (18)F-fluoroethyltyrosine (FET), and (18)F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: a PET study. Nuclear medicine and biology, 2015, Volume: 42, Issue:1 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Diagnosis, Differential; Female; Fluorodeoxyglu	2015
Quantification of serial changes in cerebral blood volume and metabolism in patients with recurrent glioblastoma undergoing antiangiogenic therapy. European journal of radiology, 2015, Volume: 84, Issue:6 Topics: Angiogenesis Inhibitors; Aspartic Acid; Bevacizumab; Blood Volume; Brain; Brain Mapping; Brain Neopl	2015
Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:5 Topics: Adolescent; Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Codon, Nonsense; DNA	2015
Evidence of 18F-FCH Uptake in Human T98G Glioblastoma Cells. Anticancer research, 2015, Volume: 35, Issue:12 Topics: Brain Neoplasms; Cell Line, Tumor; Choline; Fluorodeoxyglucose F18; Glioblastoma; Humans; Radionucli	2015
A Dual Tracer 18F-FCH/18F-FDG PET Imaging of an Orthotopic Brain Tumor Xenograft Model. PloS one, 2016, Volume: 11, Issue:2 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Disease Models, Animal; Fluorodeoxyglucose F18;	2016
Whole-brain spectroscopic MRI biomarkers identify infiltrating margins in glioblastoma patients. Neuro-oncology, 2016, Volume: 18, Issue:8 Topics: Aminolevulinic Acid; Aspartic Acid; Biomarkers; Brain; Brain Neoplasms; Cell Count; Choline; Disease	2016
Assessment of early response to tumor-treating fields in newly diagnosed glioblastoma using physiologic and metabolic MRI: initial experience. CNS oncology, 2016, Volume: 5, Issue:3 Topics: Anisotropy; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Blood Volume; Choline; Crea	2016
Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging. NeuroImage. Clinical, 2016, Volume: 11 Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Cohort Studies; Diffusion Magnetic Resonance I	2016
Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab. Journal of neuro-oncology, 2016, Volume: 130, Issue:1 Topics: Adult; Aged; Antineoplastic Agents, Immunological; Aspartic Acid; Bevacizumab; Brain Neoplasms; Chol	2016
Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats. PloS one, 2016, Volume: 11, Issue:8 Topics: Animals; Brain; Cell Line, Tumor; Choline; Diagnosis, Differential; Disease Models, Animal; Female;	2016
Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro-oncology, 2017, 03-01, Volume: 19, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cho	2017
Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget, 2016, Nov-08, Volume: 7, Issue:45 Topics: Brain Neoplasms; Cell Line, Tumor; Cell Survival; Choline; Choline Kinase; Dacarbazine; Energy Metab	2016
18F-FCho PET and MRI for the prediction of response in glioblastoma patients according to the RANO criteria. Nuclear medicine communications, 2017, Volume: 38, Issue:3 Topics: Adult; Aged; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Image Processing, Computer-Assi	2017
Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. Radiology, 2017, Volume: 284, Issue:1 Topics: Adult; Aged; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Contrast Media; Diffusion Tensor I	2017
Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics. NMR in biomedicine, 2008, Volume: 21, Issue:8 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Choline; Glioblastoma; Glutamic Acid; Magnetic Resonance	2008
Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy. Journal of neuro-oncology, 2009, Volume: 91, Issue:1 Topics: Adult; Aged; Asparagine; Brain Mapping; Brain Neoplasms; Choline; Contrast Media; Creatine; Drug The	2009
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM. Journal of neuro-oncology, 2009, Volume: 91, Issue:3 Topics: Adult; Aged; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti	2009
Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model. European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:8 Topics: Animals; Biological Transport; Cell Line, Tumor; Choline; Choline Kinase; Drug Resistance, Multiple;	2009
Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM. Neuro-oncology, 2010, Volume: 12, Issue:11 Topics: Biomarkers, Tumor; Brain Neoplasms; Choline; Glioblastoma; Humans; Image Interpretation, Computer-As	2010
Analysis of hydrophilic and lipophilic choline compounds in radioresistant and radiosensitive glioblastoma cell lines by HILIC-ESI-MS/MS. Analytical and bioanalytical chemistry, 2010, Volume: 398, Issue:6 Topics: Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Choline; Chromatography, Liquid; Gliobla	2010
Promising role of [18F] fluorocholine PET/CT vs [18F] fluorodeoxyglucose PET/CT in primary brain tumors-early experience. Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:2 Topics: Brain Neoplasms; Choline; Fatal Outcome; Female; Fluorine Radioisotopes; Glioblastoma; Glioma; Human	2011
Minimization of spectral pattern changes during HRMAS experiments at 37 degrees celsius by prior focused microwave irradiation. Magma (New York, N.Y.), 2012, Volume: 25, Issue:5 Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Choline; Glioblastoma; Humans; Lipids; Magnetic R	2012
Reproducibility of total choline/water ratios in mouse U87MG xenograft tumors by 1H-MRS. Journal of magnetic resonance imaging : JMRI, 2012, Volume: 36, Issue:2 Topics: Animals; Biomarkers, Tumor; Body Water; Cell Line, Tumor; Choline; Glioblastoma; Humans; Magnetic Re	2012
The effect of paramagnetic contrast in choline peak in patients with glioblastoma multiforme might not be significant. AJNR. American journal of neuroradiology, 2013, Volume: 34, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Neoplasms; Choline; Contrast Media; Electron Spin Reson	2013
Differentiation of glioblastoma multiforme from metastatic brain tumor using proton magnetic resonance spectroscopy, diffusion and perfusion metrics at 3 T. Cancer imaging : the official publication of the International Cancer Imaging Society, 2012, Oct-26, Volume: 12 Topics: Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Diagnosis, D	2012
In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology, 2002, Volume: 225, Issue:3 Topics: Adult; Astrocytoma; Biopsy; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Female; Gliobl	2002
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy. Magnetic resonance in medicine, 2003, Volume: 49, Issue:2 Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi	2003
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors. AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2 Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat	2003
Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume. Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:5 Topics: Adolescent; Adult; Aged; Aspartic Acid; Blood Volume; Brain Neoplasms; Choline; Glioblastoma; Humans	2004
Combined use of F-18 fluorocholine positron emission tomography and magnetic resonance spectroscopy for brain tumor evaluation. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2004, Volume: 14, Issue:3 Topics: Adult; Brain; Brain Neoplasms; Choline; Demyelinating Diseases; Female; Fluorine Radioisotopes; Glio	2004
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma. Journal of neurosurgery, 2004, Volume: 101, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor	2004
123I-IMT SPECT and 1H MR-spectroscopy at 3.0 T in the differential diagnosis of recurrent or residual gliomas: a comparative study. Journal of neuro-oncology, 2004, Volume: 70, Issue:1 Topics: Adult; Aged; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Female; Glioblastoma; Huma	2004
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology. Academic radiology, 2005, Volume: 12, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatin	2005
Independent component analysis to proton spectroscopic imaging data of human brain tumours. European journal of radiology, 2005, Volume: 56, Issue:2 Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio	2005
In vitro study of astrocytic tumour metabolism by proton magnetic resonance spectroscopy. General physiology and biophysics, 2005, Volume: 24, Issue:3 Topics: Aspartic Acid; Astrocytes; Astrocytoma; Brain; Brain Neoplasms; Choline; Chromium; Creatine; Gliobla	2005
[Application of (1)H MR spectroscopic imaging in radiation oncology: choline as a marker for determining the relative probability of tumor progression after radiation of glial brain tumors]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2006, Volume: 178, Issue:6 Topics: Adult; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Choline; Combined	2006
Correlation between amplification of the gene for the epidermal growth factor receptor (EGFR), data from preoperative proton-MR-spectroscopy (1HMRS) and histomorphometric data of glioblastomas. Analytical and quantitative cytology and histology, 2007, Volume: 29, Issue:4 Topics: Adult; Aged; Brain Neoplasms; Cell Nucleus; Choline; Creatine; ErbB Receptors; Gene Amplification; G	2007
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification. Magnetic resonance in medicine, 1995, Volume: 34, Issue:2 Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan	1995
Analysis of brain tumors using 1H magnetic resonance spectroscopy. Surgical neurology, 1995, Volume: 44, Issue:2 Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Glioblastoma; Humans; Lactates; Magneti	1995
Imaging brain tumors -- beyond three dimensions. Nature medicine, 1996, Volume: 2, Issue:3 Topics: Aged; Alanine; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Lactates; Lactic Acid; Magnet	1996
Single-voxel proton brain spectroscopy exam (PROBE/SV) in patients with primary brain tumors. AJR. American journal of roentgenology, 1996, Volume: 167, Issue:1 Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain Chemistry; Brain Neoplasms; Choline; Crea	1996
Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours. NMR in biomedicine, 1995, Volume: 8, Issue:6 Topics: Alanine; Amino Acids; Brain Neoplasms; Choline; Chromatography, High Pressure Liquid; Creatine; Glio	1995
Immortalization and transformation are associated with specific alterations in choline metabolism. Cancer research, 1996, Oct-15, Volume: 56, Issue:20 Topics: Animals; Antigens, Viral, Tumor; Cell Division; Cell Line, Transformed; Choline; Glioblastoma; Human	1996
Serial proton magnetic resonance spectroscopy imaging of glioblastoma multiforme after brachytherapy. Journal of neurosurgery, 1997, Volume: 87, Issue:4 Topics: Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Contrast Media; Creatine; Disease Pro	1997
Proton MR spectroscopy of delayed cerebral radiation in monkeys and humans after brachytherapy. AJNR. American journal of neuroradiology, 1997, Volume: 18, Issue:9 Topics: Adult; Animals; Aspartic Acid; Brachytherapy; Brain; Brain Neoplasms; Choline; Cranial Irradiation;	1997
Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy. AJNR. American journal of neuroradiology, 1999, Volume: 20, Issue:1 Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Astrocytoma; Biopsy; Body Water; Brain Neoplasms;	1999
Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy. Neurosurgery, 2000, Volume: 46, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Astro	2000
A preliminary study of the prognostic value of proton magnetic resonance spectroscopic imaging in gamma knife radiosurgery of recurrent malignant gliomas. Neurosurgery, 2000, Volume: 46, Issue:2 Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Choline; Creatine; Female; Glioblastoma; Humans; Lactic Aci	2000
Effect of voxel position on single-voxel MR spectroscopy findings. AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:2 Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio	2000
Correlation of myo-inositol levels and grading of cerebral astrocytomas. AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:9 Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Child; Chil	2000
In vivo proton magnetic resonance spectroscopy of brain tumors. Stereotactic and functional neurosurgery, 2000, Volume: 74, Issue:2 Topics: Adult; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Brain; Brain Abscess; Brain Neoplasms; Choline	2000
Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy. Neuro-oncology, 2000, Volume: 2, Issue:2 Topics: Adult; Biopsy; Brain Neoplasms; Choline; Glioblastoma; Gliosis; Humans; Lactates; Lipids; Magnetic R	2000
Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice. Cancer research, 2001, May-15, Volume: 61, Issue:10 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined	2001
Discrimination of brain abscess and cystic tumor by in vivo proton magnetic resonance spectroscopy. Neurologia medico-chirurgica, 2001, Volume: 41, Issue:3 Topics: Acetates; Aged; Amino Acids; Aspartic Acid; Astrocytoma; Bacteria; Biomarkers; Brain Abscess; Child;	2001
An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery. Journal of magnetic resonance imaging : JMRI, 2001, Volume: 14, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Biopsy; Brain; Brain Mapping; Brain Neop	2001
Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy. European radiology, 2001, Volume: 11, Issue:9 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chil	2001
In vivo single-voxel proton MR spectroscopy in brain lesions with ring-like enhancement. NMR in biomedicine, 2001, Volume: 14, Issue:6 Topics: Adult; Aged; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; Cerebral Infarction; Choline; Cr	2001
[1H-MR Spectroscopy of brain tumors in the course of radiation therapy: Use of fast spectroscopic imaging and single-voxel spectroscopy for diagnosing recurrence]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2002, Volume: 174, Issue:1 Topics: Adult; Aged; Brain; Brain Neoplasms; Choline; Combined Modality Therapy; Cranial Irradiation; Energy	2002
Comparative follow-up of enhancement phenomena with MRI and Proton MR Spectroscopic Imaging after intralesional immunotherapy in glioblastoma--Report of two exceptional cases. Zentralblatt fur Neurochirurgie, 2002, Volume: 63, Issue:1 Topics: Adult; Brain Neoplasms; Choline; Fatal Outcome; Female; Glioblastoma; Humans; Image Processing, Comp	2002
Choline uptake in glial cell cultures. Brain research, 1974, Dec-06, Volume: 81, Issue:2 Topics: Animals; Brain Neoplasms; Cells, Cultured; Choline; Clone Cells; Cricetinae; Glioblastoma; Neuroglia	1974

choline and Astrocytoma, Grade IV

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