Page last updated: 2024-10-16

choline and Amnesia

choline has been researched along with Amnesia in 27 studies

Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)

Research Excerpts

ExcerptRelevanceReference
"Systemic (IP) and/or intraseptal (IS) administration of scopolamine (SCP) and diazepam (DZP) induce amnesia, whereas IP injection of the neuropeptide substance P (SP) and choline chloride (ChCl) produce memory facilitation."7.76Scopolamine- and diazepam-induced amnesia are blocked by systemic and intraseptal administration of substance P and choline chloride. ( Costa, JC; Costa, KM; do Nascimento, JL, 2010)
" In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)."7.74Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008)
"We investigated the interrelationship of delayed amnesia, delayed neuronal death and changes in acetylcholine concentration induced by carbon monoxide (CO)-exposure in mice."7.68Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice. ( Fukuta, T; Inari, K; Ishimaru, H; Kameyama, T; Katoh, A; Murase, K; Nabeshima, T; Ogita, K; Ohtsuka, H; Yoneda, Y, 1991)
"A number of studies have shown that cholinergic blockade of the striatum produces amnesia."7.68Retrograde amnesia produced by intrastriatal atropine and its reversal by choline. ( Prado-Alcalá, RA; Solana-Figueroa, R, 1990)
"Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily."5.26[Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979)
"Systemic (IP) and/or intraseptal (IS) administration of scopolamine (SCP) and diazepam (DZP) induce amnesia, whereas IP injection of the neuropeptide substance P (SP) and choline chloride (ChCl) produce memory facilitation."3.76Scopolamine- and diazepam-induced amnesia are blocked by systemic and intraseptal administration of substance P and choline chloride. ( Costa, JC; Costa, KM; do Nascimento, JL, 2010)
" In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)."3.74Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008)
"We investigated the interrelationship of delayed amnesia, delayed neuronal death and changes in acetylcholine concentration induced by carbon monoxide (CO)-exposure in mice."3.68Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice. ( Fukuta, T; Inari, K; Ishimaru, H; Kameyama, T; Katoh, A; Murase, K; Nabeshima, T; Ogita, K; Ohtsuka, H; Yoneda, Y, 1991)
"A number of studies have shown that cholinergic blockade of the striatum produces amnesia."3.68Retrograde amnesia produced by intrastriatal atropine and its reversal by choline. ( Prado-Alcalá, RA; Solana-Figueroa, R, 1990)
"Mice and rats trained after treatment with cycloheximide or acetoxycycloheximide in a conditioned avoidance response develop an amnesia of their training experience."3.65Cycloheximide and acetoxycycloheximide: inhibition of tyrosine hydroxylase activity and amnestic effects. ( Flexner, LB; Goodman, RH; Serota, RG, 1973)
" Testing of conditioned passive avoidance 24 h after learning showed that chronic administration of scopolamine to rats 4-fold reduced the latency of entry into the dark chamber in comparison with controls (intact animals)."1.38Changes in activity of proline-specific peptidases in rat model for dementia of Alzheimer's type. ( Kolyasnikova, KN; Nazarova, GA; Zolotov, NN, 2012)
"The effects of acute and chronic administration of MKC-231, a new choline uptake enhancer, and two other nootropic agents, linopiridine (Dup 996) and tetrahydroaminoacridine (THA) on working memory deficits and decreased hippocampal acetylcholine (ACh) content were studied in a delayed non-matching to sample task, using a T-maze, in ethylcholine aziridinium ion (AF64A)-treated mice."1.29MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. ( Abe, E; Itoh, T; Masuda, Y; Murai, S; Odashima, J; Saito, H, 1994)
"8 mg/kg as free TRH) produced a sustained increase in immunoreactive plasma TRH levels up to about 2 weeks after dosing in rats."1.29Effects of sustained release formulation of thyrotropin-releasing hormone on learning impairments caused by scopolamine and AF64A in rodents. ( Hirai, K; Kato, K; Miyamoto, M; Nagaoka, A; Nishiyama, M; Okada, H; Takahashi, H, 1993)
"Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily."1.26[Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199010 (37.04)18.7374
1990's5 (18.52)18.2507
2000's4 (14.81)29.6817
2010's8 (29.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crespo-Eguilaz, N1
Dominguez, PD1
Vaquero, M1
Narbona, J1
Pandey, S1
Garabadu, D1
Nardone, R1
Bergmann, J1
De Blasi, P1
Kronbichler, M1
Kraus, J1
Caleri, F1
Tezzon, F1
Ladurner, G1
Golaszewski, S1
Griffith, HR1
Okonkwo, OC1
den Hollander, JA1
Belue, K1
Copeland, J1
Harrell, LE1
Brockington, JC1
Clark, DG1
Marson, DC1
Costa, JC1
Costa, KM1
do Nascimento, JL1
Watanabe, T1
Shiino, A1
Akiguchi, I1
Yang, ZX1
Huo, SS1
Cheng, XF1
Xu, ZF1
Cao, Z1
Zeng, JX1
Xiao, YY1
You, KZ1
Chen, W1
Liu, YY1
Wu, RH1
Nazarova, GA1
Kolyasnikova, KN1
Zolotov, NN1
Metastasio, A1
Rinaldi, P1
Tarducci, R1
Mariani, E1
Feliziani, FT1
Cherubini, A1
Pelliccioli, GP1
Gobbi, G1
Senin, U1
Mecocci, P1
Rami, L1
Caprile, C1
Gómez-Ansón, B1
Sánchez-Valle, R1
Monte, GC1
Bosch, B1
Molinuevo, JL1
Storozheva, ZI1
Proshin, AT1
Sherstnev, VV1
Storozhevykh, TP1
Senilova, YE1
Persiyantseva, NA1
Pinelis, VG1
Semenova, NA1
Zakharova, EI1
Pomytkin, IA1
Kent, S1
Mohs, RC1
Davis, KL1
Tinklenberg, JR1
Hollister, LE1
Murai, S1
Saito, H1
Abe, E1
Masuda, Y1
Odashima, J1
Itoh, T1
Miyamoto, M1
Hirai, K1
Takahashi, H1
Kato, K1
Nishiyama, M1
Okada, H1
Nagaoka, A1
Garnett, MR1
Blamire, AM1
Rajagopalan, B1
Styles, P1
Cadoux-Hudson, TA1
Signoret, JL2
Whiteley, A2
Lhermitte, F2
Agid, Y1
Nabeshima, T2
Katoh, A1
Ishimaru, H1
Yoneda, Y1
Ogita, K1
Murase, K1
Ohtsuka, H1
Inari, K1
Fukuta, T1
Kameyama, T2
Solana-Figueroa, R1
Prado-Alcalá, RA1
Mosharrof, AH1
Petkov, VD1
Nakahara, N2
Iga, Y2
Mizobe, F2
Kawanishi, G2
Yoshida, S1
Yasumatsu, H1
Yamamoto, Y1
Takamuku, H1
Anami, K1
Takehara, S1
Setoguchi, M1
Maruyama, Y1
Spignoli, G1
Pepeu, G1
Flexner, LB1
Serota, RG1
Goodman, RH1

Trials

3 trials available for choline and Amnesia

ArticleYear
Choline chloride effects on memory in the elderly.
    Neurobiology of aging, 1980,Summer, Volume: 1, Issue:1

    Topics: Acetylcholine; Aged; Amnesia; Choline; Dose-Response Relationship, Drug; Female; Humans; Male; Memor

1980
Evidence for cellular damage in normal-appearing white matter correlates with injury severity in patients following traumatic brain injury: A magnetic resonance spectroscopy study.
    Brain : a journal of neurology, 2000, Volume: 123 ( Pt 7)

    Topics: Adolescent; Adult; Aged; Amnesia; Aspartic Acid; Axons; Brain Chemistry; Brain Injuries; Cerebral Co

2000
Influence of choline on amnesia in early Alzheimer's disease.
    Lancet (London, England), 1978, Oct-14, Volume: 2, Issue:8094

    Topics: Aged; Alzheimer Disease; Amnesia; Choline; Clinical Trials as Topic; Dementia; Humans; Memory; Middl

1978

Other Studies

24 other studies available for choline and Amnesia

ArticleYear
[Developmental amnesia and early brain damage: neuropsychology and neuroimaging].
    Revista de neurologia, 2018, Mar-01, Volume: 66, Issue:S01

    Topics: Adolescent; Amnesia; Aspartic Acid; Atrophy; Cerebral Palsy; Child; Choline; Creatine; Female; Fetal

2018
Piracetam Facilitates the Anti-Amnesic but not Anti-Diabetic Activity of Metformin in Experimentally Induced Type-2 Diabetic Encephalopathic Rats.
    Cellular and molecular neurobiology, 2017, Volume: 37, Issue:5

    Topics: Amnesia; Animals; Blood Glucose; Brain Diseases; Brain-Derived Neurotrophic Factor; Choline; Diabete

2017
Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:3

    Topics: Adult; Alcoholics; Amnesia; Brain; Choline; Cholinesterase Inhibitors; Female; Humans; Korsakoff Syn

2010
Brain metabolic correlates of decision making in amnestic mild cognitive impairment.
    Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2010, Volume: 17, Issue:4

    Topics: Aged; Amnesia; Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Decision Making; Female

2010
Scopolamine- and diazepam-induced amnesia are blocked by systemic and intraseptal administration of substance P and choline chloride.
    Peptides, 2010, Volume: 31, Issue:9

    Topics: Amnesia; Animals; Avoidance Learning; Choline; Diazepam; GABA Modulators; Male; Muscarinic Antagonis

2010
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging.
    Dementia and geriatric cognitive disorders, 2010, Volume: 30, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chem

2010
Quantitative multivoxel proton MR spectroscopy study of brain metabolites in patients with amnestic mild cognitive impairment: a pilot study.
    Neuroradiology, 2012, Volume: 54, Issue:5

    Topics: Amnesia; Aspartic Acid; Brain Chemistry; Case-Control Studies; Choline; Creatine; Female; Humans; Im

2012
Changes in activity of proline-specific peptidases in rat model for dementia of Alzheimer's type.
    Bulletin of experimental biology and medicine, 2012, Volume: 153, Issue:5

    Topics: Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Aziridines; Cerebral Cortex; Choline; Dipep

2012
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
    Neurobiology of aging, 2006, Volume: 27, Issue:7

    Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis

2006
Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases.
    Dementia and geriatric cognitive disorders, 2008, Volume: 25, Issue:3

    Topics: Aged; Amnesia; Anomia; Aspartic Acid; Choline; Cognition Disorders; Creatine; Dementia; Female; Huma

2008
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia.
    BMC pharmacology, 2008, Jan-23, Volume: 8

    Topics: Aging; Amnesia; Amyloid beta-Peptides; Animals; Cerebrovascular Circulation; Choline; Cognition Diso

2008
Can drugs halt memory loss?
    Geriatrics, 1981, Volume: 36, Issue:2

    Topics: Aged; Aging; Amnesia; Animals; Choline; Cholinergic Fibers; Female; Haplorhini; Humans; Male; Memory

1981
MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.
    Journal of neural transmission. General section, 1994, Volume: 98, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Aziridines; Choline; Choline Deficiency; Data

1994
Effects of sustained release formulation of thyrotropin-releasing hormone on learning impairments caused by scopolamine and AF64A in rodents.
    European journal of pharmacology, 1993, Jul-20, Volume: 238, Issue:2-3

    Topics: Amnesia; Animals; Avoidance Learning; Aziridines; Brain; Choline; Delayed-Action Preparations; Dose-

1993
[Influence of choline on amnesia in Alzheimer's disease (author's transl)].
    Revue neurologique, 1979, Volume: 135, Issue:8-9

    Topics: Aged; Alzheimer Disease; Amnesia; Choline; Dementia; Female; Humans; Learning; Male; Mental Recall;

1979
Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1

    Topics: Acetylcholine; Amnesia; Animals; Binding Sites; Brain; Carbon Monoxide; Cell Survival; Choline; Glut

1991
Retrograde amnesia produced by intrastriatal atropine and its reversal by choline.
    Life sciences, 1990, Volume: 46, Issue:10

    Topics: Acetylcholine; Amnesia; Amnesia, Retrograde; Analysis of Variance; Animals; Atropine; Avoidance Lear

1990
Effects of citicholine and of the combination citicholine + piracetam on the memory (experiments on mice).
    Acta physiologica et pharmacologica Bulgarica, 1990, Volume: 16, Issue:1

    Topics: Amnesia; Animals; Avoidance Learning; Choline; Cytidine Diphosphate Choline; Male; Memory; Mice; Mod

1990
Effects of intracerebroventricular injection of AF64A on learning behaviors in rats.
    Japanese journal of pharmacology, 1988, Volume: 48, Issue:1

    Topics: Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Aziridines; Azirines; Choline; Choline O-Ac

1988
Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice.
    European journal of pharmacology, 1988, Sep-23, Volume: 154, Issue:3

    Topics: Aminoquinolines; Amnesia; Animals; Avoidance Learning; Choline; Cholinesterase Inhibitors; Cyclohexi

1988
Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.
    Japanese journal of pharmacology, 1988, Volume: 48, Issue:4

    Topics: Amnesia; Animals; Arecoline; Aziridines; Choline; Male; Memory; Mice; Mice, Inbred Strains; Oxotremo

1988
[Pharmacological studies on Y-8894. (VII). Effects on transient cerebral ischemia-induced amnesia in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1987, Volume: 90, Issue:6

    Topics: Amnesia; Animals; Avoidance Learning; Brain; Choline; Energy Metabolism; Ischemic Attack, Transient;

1987
Oxiracetam prevents electroshock-induced decrease in brain acetylcholine and amnesia.
    European journal of pharmacology, 1986, Jul-31, Volume: 126, Issue:3

    Topics: Acetylcholine; Amnesia; Animals; Avoidance Learning; Brain; Cerebral Cortex; Choline; Electroshock;

1986
Cycloheximide and acetoxycycloheximide: inhibition of tyrosine hydroxylase activity and amnestic effects.
    Proceedings of the National Academy of Sciences of the United States of America, 1973, Volume: 70, Issue:2

    Topics: Acetates; Acetyltransferases; Amnesia; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain;

1973