choline has been researched along with Amentia in 88 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the associations of dietary choline intake with the risk of incident dementia and with cognitive performance in middle-aged and older men in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study." | 9.30 | Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. ( Lönnroos, E; Salonen, JT; Tuomainen, TP; Virtanen, HEK; Virtanen, JK; Voutilainen, S; Ylilauri, MPT, 2019) |
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 7.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 7.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia." | 7.66 | Presynaptic cholinergic dysfunction in patients with dementia. ( Allen, SJ; Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC; Thomas, DJ, 1983) |
| "The cholinergic system has been found to be crucially involved in cognitive function, with cholinergic dysfunction playing a pivotal role in the pathophysiology of dementia." | 6.53 | Cholinergic imaging in dementia spectrum disorders. ( Niccolini, F; Pagano, G; Politis, M; Roy, R, 2016) |
| "We investigated the associations of dietary choline intake with the risk of incident dementia and with cognitive performance in middle-aged and older men in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study." | 5.30 | Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study. ( Lönnroos, E; Salonen, JT; Tuomainen, TP; Virtanen, HEK; Virtanen, JK; Voutilainen, S; Ylilauri, MPT, 2019) |
| "Mice with dementia were produced by mating sibling mice who had impaired memory for > 20 generations." | 5.29 | Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. ( Chung, SY; Hirata, R; Kokubu, T; Masuda, Y; Moriyama, T; Uezu, E; Uezu, K; Yamamoto, S; Yohena, N, 1995) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 5.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily." | 5.26 | [Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979) |
| "Plasmas of 12 patients currently taking part in a double-blind trial of lecithin in senile or presenile dementia of Alzheimer type were analysed for plasma choline levels at fixed intervals during lecithin treatment." | 5.05 | Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations. ( Chuaqui, P; Levy, R, 1982) |
| "We examined prospective associations of TMAO, γ-butyrobetaine, crotonobetaine, carnitine, choline, and betaine with risk of cognitive impairment and dementia among older adults aged 65 years and older in the Cardiovascular Health Study (CHS)." | 4.12 | Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study. ( de Oliveira Otto, MC; Fretts, A; Hazen, SL; Lai, HTM; Lee, Y; Lemaitre, RN; Li, XS; Lopez, O; Mozaffarian, D; Nemet, I; Newman, AB; Siscovick, DS; Tang, WHW; Wang, M; Wang, Z, 2022) |
| " Although changes in myo-inositol and creatine occur in the early stages of AD, abnormalities of N-acetyl aspartate do not occur in mild AD but progressively change with dementia severity." | 3.71 | Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. ( Alexander, GE; Chang, L; Huang, W; Krasuski, JS; Rapoport, SI; Schapiro, MB; Shetty, HU, 2001) |
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 3.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 3.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia." | 3.66 | Presynaptic cholinergic dysfunction in patients with dementia. ( Allen, SJ; Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC; Thomas, DJ, 1983) |
| "Recent studies have shown a defect in the cholinergic system of the cerebral cortex of patients suffering from nonvascular senile dementia." | 3.66 | Will drugs help patients with Alzheimer's disease? ( Kendall, MJ, 1979) |
| "Dementia was an independent predictor of metabolite values." | 2.73 | Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. ( Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S, 2008) |
| "Choline is a critical nutrient for cognitive development, metabolism and liver function, and regulation of homocysteine metabolism." | 2.72 | [Importance of choline in cognitive function]. ( Aparicio, A; López-Sobaler, AM; Lorenzo Mora, AM; Ortega, RMª; Peral Suárez, Á; Salas González, MªD, 2021) |
| "The cholinergic system has been found to be crucially involved in cognitive function, with cholinergic dysfunction playing a pivotal role in the pathophysiology of dementia." | 2.53 | Cholinergic imaging in dementia spectrum disorders. ( Niccolini, F; Pagano, G; Politis, M; Roy, R, 2016) |
| "We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD)." | 1.40 | Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. ( Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M, 2014) |
| "Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| "Mice with dementia were produced by mating sibling mice who had impaired memory for > 20 generations." | 1.29 | Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. ( Chung, SY; Hirata, R; Kokubu, T; Masuda, Y; Moriyama, T; Uezu, E; Uezu, K; Yamamoto, S; Yohena, N, 1995) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 1.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily." | 1.26 | [Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (62.50) | 18.7374 |
| 1990's | 9 (10.23) | 18.2507 |
| 2000's | 12 (13.64) | 29.6817 |
| 2010's | 9 (10.23) | 24.3611 |
| 2020's | 3 (3.41) | 2.80 |
| Authors | Studies |
|---|---|
| de Oliveira Otto, MC | 1 |
| Li, XS | 1 |
| Wang, Z | 1 |
| Siscovick, DS | 1 |
| Newman, AB | 1 |
| Lai, HTM | 1 |
| Nemet, I | 1 |
| Lee, Y | 1 |
| Wang, M | 1 |
| Fretts, A | 1 |
| Lemaitre, RN | 1 |
| Tang, WHW | 1 |
| Lopez, O | 1 |
| Hazen, SL | 1 |
| Mozaffarian, D | 1 |
| Shea, TB | 1 |
| Hildre, AS | 1 |
| Solvang, SH | 1 |
| Aarsland, D | 1 |
| Midtun, Ø | 1 |
| McCann, A | 1 |
| Ervik, AO | 1 |
| Nygård, O | 1 |
| Ueland, PM | 1 |
| Nordrehaug, JE | 1 |
| Giil, LM | 1 |
| López-Sobaler, AM | 1 |
| Lorenzo Mora, AM | 1 |
| Salas González, MªD | 1 |
| Peral Suárez, Á | 1 |
| Aparicio, A | 1 |
| Ortega, RMª | 1 |
| Reddan, JM | 1 |
| Macpherson, H | 1 |
| White, DJ | 1 |
| Scholey, A | 1 |
| Pipingas, A | 1 |
| Ylilauri, MPT | 1 |
| Voutilainen, S | 1 |
| Lönnroos, E | 1 |
| Virtanen, HEK | 1 |
| Tuomainen, TP | 1 |
| Salonen, JT | 1 |
| Virtanen, JK | 1 |
| Herrmann, W | 1 |
| Obeid, R | 1 |
| Kantarci, K | 2 |
| Targosz-Gajniak, MG | 1 |
| Siuda, JS | 1 |
| Wicher, MM | 1 |
| Banasik, TJ | 1 |
| Bujak, MA | 1 |
| Augusciak-Duma, AM | 1 |
| Opala, G | 1 |
| Waragai, M | 1 |
| Hata, S | 1 |
| Suzuki, T | 1 |
| Ishii, R | 1 |
| Fujii, C | 1 |
| Tokuda, T | 1 |
| Arai, H | 1 |
| Ohrui, T | 1 |
| Higuchi, S | 1 |
| Yoshida, M | 1 |
| Igarashi, K | 1 |
| Moriya, M | 1 |
| Iwai, N | 1 |
| Uemura, K | 1 |
| Almuqbel, M | 1 |
| Melzer, TR | 1 |
| Myall, DJ | 1 |
| MacAskill, MR | 1 |
| Pitcher, TL | 1 |
| Livingston, L | 1 |
| Wood, KL | 1 |
| Keenan, RJ | 1 |
| Dalrymple-Alford, JC | 1 |
| Anderson, TJ | 1 |
| Roy, R | 1 |
| Niccolini, F | 1 |
| Pagano, G | 1 |
| Politis, M | 1 |
| García Santos, JM | 1 |
| Gavrila, D | 1 |
| Antúnez, C | 1 |
| Tormo, MJ | 1 |
| Salmerón, D | 1 |
| Carles, R | 1 |
| Jiménez Veiga, J | 1 |
| Parrilla, G | 1 |
| Torres del Río, S | 1 |
| Fortuna, L | 1 |
| Navarro, C | 1 |
| Caserta, MT | 1 |
| Ragin, A | 1 |
| Hermida, AP | 1 |
| Ahrens, RJ | 1 |
| Wise, L | 1 |
| Pilatus, U | 1 |
| Lais, C | 1 |
| Rochmont, Adu M | 1 |
| Kratzsch, T | 1 |
| Frölich, L | 1 |
| Maurer, K | 1 |
| Zanella, FE | 1 |
| Lanfermann, H | 1 |
| Pantel, J | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Kizu, O | 1 |
| Yamada, K | 1 |
| Ito, H | 1 |
| Nishimura, T | 1 |
| Petersen, RC | 1 |
| Boeve, BF | 1 |
| Knopman, DS | 1 |
| Tang-Wai, DF | 1 |
| O'Brien, PC | 1 |
| Weigand, SD | 1 |
| Edland, SD | 1 |
| Smith, GE | 1 |
| Ivnik, RJ | 1 |
| Ferman, TJ | 1 |
| Tangalos, EG | 1 |
| Jack, CR | 1 |
| Frederick, BD | 1 |
| Lyoo, IK | 1 |
| Satlin, A | 1 |
| Ahn, KH | 1 |
| Kim, MJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Cohen, BM | 3 |
| Renshaw, PF | 2 |
| Pfefferbaum, A | 1 |
| Adalsteinsson, E | 1 |
| Sullivan, EV | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Tarducci, R | 1 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 1 |
| Pelliccioli, GP | 1 |
| Gobbi, G | 1 |
| Senin, U | 1 |
| Mecocci, P | 1 |
| Rami, L | 1 |
| Caprile, C | 1 |
| Gómez-Ansón, B | 1 |
| Sánchez-Valle, R | 1 |
| Monte, GC | 1 |
| Bosch, B | 1 |
| Molinuevo, JL | 1 |
| Xuan, X | 1 |
| Ding, M | 1 |
| Gong, X | 1 |
| Jolles, J | 1 |
| Verhoeven, WM | 1 |
| Hier, DB | 1 |
| Caplan, LR | 1 |
| Carolei, A | 1 |
| Di Piero, V | 1 |
| Squitieri, G | 1 |
| Murphy, MF | 1 |
| Davis, KL | 3 |
| McGeer, EG | 1 |
| Fisman, M | 2 |
| Pomara, N | 4 |
| Stanley, M | 2 |
| Flentge, F | 1 |
| van den Berg, CJ | 1 |
| Davies, P | 1 |
| Kameyama, M | 1 |
| Spar, JE | 1 |
| Price, DL | 1 |
| Whitehouse, PJ | 1 |
| Struble, RG | 1 |
| Coyle, JT | 1 |
| Clark, AW | 1 |
| Delong, MR | 1 |
| Cork, LC | 1 |
| Hedreen, JC | 1 |
| Banay-Schwartz, M | 1 |
| Block, R | 1 |
| Gershon, S | 2 |
| Maire, JC | 1 |
| Wurtman, RJ | 2 |
| Vatassery, GT | 1 |
| Maletta, GJ | 1 |
| Paggi, A | 1 |
| Quattrini, A | 1 |
| Ortenzi, A | 1 |
| Cianci, F | 1 |
| Silvestri, R | 1 |
| Mancini, S | 1 |
| Ball, MJ | 1 |
| Marchbanks, RM | 2 |
| Sims, NR | 1 |
| Bowen, DM | 2 |
| Allen, SJ | 1 |
| Smith, CC | 1 |
| Neary, D | 1 |
| Thomas, DJ | 1 |
| Davison, AN | 2 |
| Lamb, K | 1 |
| Bradshaw, CM | 1 |
| Szabadi, E | 1 |
| Stramba-Badiale, M | 1 |
| Scillieri, E | 1 |
| Domino, EF | 2 |
| Yoon, H | 1 |
| Brinkman, S | 1 |
| Tamminga, CA | 1 |
| Canter, NL | 1 |
| Hallett, M | 1 |
| Growdon, JH | 2 |
| Merskey, H | 1 |
| Helmes, E | 1 |
| McCready, J | 1 |
| Colhoun, EH | 1 |
| Rylett, BJ | 1 |
| Chuaqui, P | 1 |
| Levy, R | 2 |
| Barclay, LL | 1 |
| Blass, JP | 1 |
| Kopp, U | 2 |
| Hanin, I | 3 |
| Brinkman, SD | 1 |
| Goodnick, PJ | 1 |
| Barnett, N | 1 |
| Hsieh, JY | 1 |
| Levy, MI | 2 |
| Horvath, TB | 2 |
| Davis, BM | 2 |
| Mohs, RC | 2 |
| Etienne, P | 2 |
| Dastoor, D | 2 |
| Gauthier, S | 2 |
| Ludwick, R | 1 |
| Collier, B | 2 |
| Friedman, E | 1 |
| Sherman, KA | 1 |
| Ferris, SH | 1 |
| Reisberg, B | 1 |
| Bartus, RT | 1 |
| Schneck, MK | 1 |
| Glen, AI | 1 |
| Yates, CM | 1 |
| Simpson, J | 1 |
| Christie, JE | 1 |
| Shering, A | 1 |
| Whalley, LJ | 1 |
| Jellinek, EH | 1 |
| Kent, S | 1 |
| Thal, LJ | 2 |
| Rosen, W | 2 |
| Sharpless, NS | 2 |
| Crystal, H | 2 |
| Richter, JA | 1 |
| Perry, EK | 1 |
| Tomlinson, BE | 1 |
| Corkin, S | 1 |
| Fovall, P | 1 |
| Dysken, MW | 1 |
| Lazarus, LW | 1 |
| Davis, JM | 1 |
| Kahn, RL | 1 |
| Jope, R | 1 |
| Finkel, S | 1 |
| Rattan, P | 1 |
| Tinklenberg, JR | 1 |
| Rosenberg, GS | 1 |
| Constans, JM | 1 |
| Meyerhoff, DJ | 1 |
| Gerson, J | 1 |
| MacKay, S | 1 |
| Norman, D | 1 |
| Fein, G | 1 |
| Weiner, MW | 1 |
| Shonk, T | 1 |
| Ross, BD | 1 |
| Stoll, AL | 2 |
| Yurgelun-Todd, D | 1 |
| Babb, SM | 1 |
| Chung, SY | 1 |
| Moriyama, T | 1 |
| Uezu, E | 1 |
| Uezu, K | 1 |
| Hirata, R | 1 |
| Yohena, N | 1 |
| Masuda, Y | 1 |
| Kokubu, T | 1 |
| Yamamoto, S | 1 |
| Bowen, BC | 1 |
| Block, RE | 1 |
| Sanchez-Ramos, J | 1 |
| Pattany, PM | 1 |
| Lampman, DA | 1 |
| Murdoch, JB | 1 |
| Quencer, RM | 1 |
| Egashira, T | 1 |
| Kanfer, JN | 1 |
| Pettegrew, JW | 1 |
| Moossy, J | 1 |
| McCartney, DG | 1 |
| Huang, W | 1 |
| Alexander, GE | 1 |
| Chang, L | 1 |
| Shetty, HU | 1 |
| Krasuski, JS | 1 |
| Rapoport, SI | 1 |
| Schapiro, MB | 1 |
| Boyd, WD | 1 |
| Graham-White, J | 1 |
| Blackwood, G | 1 |
| Glen, I | 1 |
| McQueen, J | 1 |
| Spillane, JA | 1 |
| Goodhart, MJ | 1 |
| White, P | 1 |
| Johnson, G | 1 |
| Mendis, T | 1 |
| Cole, M | 1 |
| Muller, HF | 1 |
| Smith, CM | 2 |
| Swash, M | 2 |
| Exton-Smith, AN | 1 |
| Phillips, MJ | 1 |
| Overstall, PW | 1 |
| Piper, ME | 1 |
| Bailey, MR | 1 |
| Signoret, JL | 2 |
| Whiteley, A | 2 |
| Lhermitte, F | 2 |
| Kolata, GB | 1 |
| Renvoize, EB | 1 |
| Jerram, T | 1 |
| Kendall, MJ | 1 |
| Agid, Y | 1 |
| Aquilonius, SM | 1 |
| Ceder, G | 1 |
| Lying-Tunell, U | 1 |
| Malmlund, HO | 1 |
| Schuberth, J | 1 |
| Serra, F | 1 |
| Diaspri, GP | 1 |
| Gasbarrini, A | 1 |
| Giancane, S | 1 |
| Rimondi, A | 1 |
| Tamè, MR | 1 |
| Sakellaridis, E | 1 |
| Bernardi, M | 1 |
| Gasbarrini, G | 1 |
| Ohtomo, E | 1 |
| Nakahiro, M | 1 |
| Mochizuki, D | 1 |
| Uchida, S | 1 |
| Yoshida, H | 1 |
| Houck, PR | 1 |
| Reynolds, CF | 1 |
| Bonavita, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)[NCT03221127] | 2,682 participants (Actual) | Observational | 1984-03-01 | Active, not recruiting | |||
| Open Label Study for the Use of Tyrosine Kinase Inhibitors for Treatment of Cognitive Decline Due to Degenerative Dementias[NCT02921477] | Phase 1 | 150 participants (Anticipated) | Interventional | 2016-09-30 | Enrolling by invitation | ||
| Focused Ultrasound Delivery of Exosomes for Treatment of Refractory Depression, Anxiety, and Neurodegenerative Dementias[NCT04202770] | 300 participants (Anticipated) | Interventional | 2019-12-01 | Suspended (stopped due to Pending COVID-19 pandemic; pending status of product development) | |||
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
14 reviews available for choline and Amentia
| Article | Year |
|---|---|
[Importance of choline in cognitive function].
Topics: Adult; Aged; Aged, 80 and over; Choline; Cognition; Dementia; Diet; Female; Humans; Middle Aged; Neu | 2021 |
Examining the relationship between nutrition and cerebral structural integrity in older adults without dementia.
Topics: Aged; Aged, 80 and over; Aging; Brain; Choline; Cognition; Cognitive Dysfunction; Dementia; Diet; Di | 2019 |
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
Cholinergic imaging in dementia spectrum disorders.
Topics: Choline; Dementia; Diagnostic Imaging; Humans; Synapses | 2016 |
[Psychopharmacologic treatment of cognitive function disorders in aging persons: current possibilities].
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Anticonvulsants; Brain; Catecholamines; Cholin | 1984 |
[Neurobiological and neurochemical aspects and therapeutic problems in aging and in dementia].
Topics: Age Factors; Aged; Aging; Brain Chemistry; Choline; Dementia; Humans; Nervous System; Nervous System | 1980 |
Biological perspectives in chronic pain, depression, and organic mental disorders.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Animals; Antidepressive Agents; Antipsychotic Agents; Chol | 1981 |
Neurotransmitter systems in aging and senile dementia.
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g | 1981 |
Clinical pharmacology of senile dementia.
Topics: Aged; Aging; Anticoagulants; Arginine Vasopressin; Brain; Choline; Dementia; Dihydroergotoxine; Free | 1981 |
An update on the neurochemistry of Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Arecoline; Brain; Choline; Choline O-Acetyltransferase; Cho | 1983 |
[Aging of the nervous system--with special reference to dementia in the aged].
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Dementia; Humans; | 1983 |
Alzheimer's disease: a challenging enigma.
Topics: Aging; Animals; Brain; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; De | 1982 |
Biochemistry of Alzheimer's dementia.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Cerebral Cortex; Choline; Ch | 1982 |
[Recent drug therapy of senile dementia].
Topics: Adrenocorticotropic Hormone; Alzheimer Disease; Choline; Dementia; Dihydroergotoxine; Humans; Narcot | 1987 |
13 trials available for choline and Amentia
| Article | Year |
|---|---|
Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Topics: Adult; Apolipoprotein E4; Choline; Cognition; Dementia; Diet; Eggs; Finland; Follow-Up Studies; Huma | 2019 |
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea | 2008 |
Neurotransmitter systems in aging and senile dementia.
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g | 1981 |
Double blind study of lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; H | 1981 |
Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; M | 1982 |
A dose-ranging study of lecithin in the treatment of primary degenerative dementia (Alzheimer disease).
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Drug Evaluation; Erythrocytes; Fema | 1982 |
Alzheimer disease: lack of effect of lecithin treatment for 3 months.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Humans; Middle Aged; Phosphatidylch | 1981 |
Choline therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Drug Eval | 1978 |
Influence of choline on amnesia in early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amnesia; Choline; Clinical Trials as Topic; Dementia; Humans; Memory; Middl | 1978 |
Choline in Alzheimers disease.
Topics: Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Humans; Research Design | 1978 |
Mental disorders: a new approach to treatment?
Topics: Acetylcholine; Brain; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Dyskinesia, | 1979 |
Choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; H | 1979 |
[Effect of CDP-choline on senile mental deterioration. Multicenter experience on 237 cases].
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Choline; Cytidine Diphosphate Choline; Dementia | 1990 |
62 other studies available for choline and Amentia
| Article | Year |
|---|---|
Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study.
Topics: Animals; Betaine; Carnitine; Choline; Cognitive Dysfunction; Dementia; Medicare; Methylamines; Unite | 2022 |
Choline and phosphatidylcholine may maintain cognitive performance by multiple mechanisms.
Topics: Choline; Cognition; Dementia; Humans; Myocardial Ischemia; Phosphatidylcholines; Risk Factors | 2019 |
Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Choline; Cognitive Dysfunction; Dementia; Female; Humans | 2020 |
Special issue on advances and controversies in B vitamins and choline.
Topics: Aging; Choline; Dementia; Dietary Supplements; Humans; Risk Factors; Vascular Diseases; Vitamin B Co | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Cognitive Dysfunction; Creatine; Dementia; D | 2013 |
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; De | 2014 |
Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson's disease in a clinical setting.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Bayes Theorem; Case-Control Studies; Choline; Cognitive Dysf | 2016 |
Single voxel magnetic resonance spectroscopy at 3 Tesla in a memory disorders clinic: early right hippocampal NAA/Cr loss in mildly impaired subjects.
Topics: Aged; Aspartic Acid; Choline; Creatine; Dementia; Female; Functional Laterality; Hippocampus; Humans | 2008 |
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De | 2009 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Posterior cingulate metabolic changes in frontotemporal lobar degeneration detected by magnetic resonance spectroscopy.
Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dementia; Di | 2004 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
Cortical NAA deficits in HIV infection without dementia: influence of alcoholism comorbidity.
Topics: Adult; Alcoholism; Aspartic Acid; Brain Mapping; Case-Control Studies; Cerebral Cortex; Choline; Com | 2005 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases.
Topics: Aged; Amnesia; Anomia; Aspartic Acid; Choline; Cognition Disorders; Creatine; Dementia; Female; Huma | 2008 |
Proton magnetic resonance spectroscopy detects a relative decrease of N-acetylaspartate in the hippocampus of patients with dementia with Lewy bodies.
Topics: Aged; Aspartic Acid; Chi-Square Distribution; Choline; Creatine; Dementia; Female; Hippocampus; Huma | 2008 |
Drugs for senile dementia.
Topics: Aged; Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Choline; Dementia; Dihydr | 1980 |
Cholinergic precursors in Alzheimer's disease.
Topics: Alzheimer Disease; Choline; Dementia; Humans; Pilocarpine; Receptors, Muscarinic | 1982 |
Choline precursors and Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Choline; Dementia; Humans | 1982 |
Dementia in the aged.
Topics: Aged; Cerebral Infarction; Choline; Creutzfeldt-Jakob Syndrome; Dementia; Depressive Disorder; Diagn | 1982 |
Alzheimer's disease and Down's syndrome.
Topics: Acetylcholinesterase; Adult; Aged; Aging; Alzheimer Disease; Animals; Axons; Brain; Choline; Choline | 1982 |
Elevation of RBC glycine and choline levels in geriatric patients treated with lithium.
Topics: Aged; Alzheimer Disease; Choline; Cognition Disorders; Dementia; Erythrocytes; Female; Glycine; Huma | 1983 |
Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging.
Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Cell Membrane; Choline; Cholinergic Fibers; | 1984 |
Relationship between nutrition and dementia in the elderly.
Topics: Acetylcholine; Aged; Aged, 80 and over; Aging; Aluminum; Choline; Cognition; Dementia; Folic Acid; H | 1983 |
[Dementia syndromes and epilepsy].
Topics: Adult; Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Epilepsy; Female; Humans; | 1984 |
Presynaptic cholinergic dysfunction in patients with dementia.
Topics: Acetylcholine; Adult; Aged; Alzheimer Disease; Carbon Radioisotopes; Cerebral Cortex; Choline; Choli | 1983 |
The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia.
Topics: Adult; Aged; Aging; Alzheimer Disease; Carbachol; Choline; Dementia; Dose-Response Relationship, Dru | 1983 |
[Citicoline activity in senile mental decay].
Topics: Aged; Choline; Cytidine Diphosphate Choline; Dementia; Drug Evaluation; Female; Humans; Injections, | 1983 |
Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Blood Pressure; Choline; Dementia; Erythrocytes; Female; Humans; Hydrocorti | 1983 |
Lecithin does not affect EEG spectral analysis or P300 in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Evoked Potentials; Female; Human | 1982 |
Red-cell/plasma choline ratio in dementia.
Topics: Choline; Dementia; Erythrocytes; Humans; Plasma | 1982 |
Cerebrospinal fluid acetylcholine, choline, and senile dementia of the Alzheimer's type.
Topics: Acetylcholine; Aged; Alzheimer Disease; Choline; Dementia; Female; Humans; Male; Middle Aged | 1982 |
Clinical response to choline plus piracetam in senile dementia: relation to red-cell choline levels.
Topics: Choline; Dementia; Drug Therapy, Combination; Erythrocytes; Humans; Piracetam; Pyrrolidinones | 1981 |
Choline uptake in patients with Alzheimer pre-senile dementia.
Topics: Adolescent; Adult; Aged; Alzheimer Disease; Choline; Dementia; Erythrocytes; Female; Humans; Male; M | 1981 |
Preventing senile dementia: hope for the future.
Topics: Aged; Choline; Dementia; Dihydroergotoxine; Female; Humans; Male; Memory; Middle Aged; Piracetam | 1981 |
Choline chloride fails to improve cognition of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Cognition; Dementia; Diarrhea; Dose-Response Relationship, Drug; D | 1981 |
Choline chloride in Alzheimer disease.
Topics: Alzheimer Disease; Choline; Dementia; Humans | 1981 |
Choline, acetylcholine and dementia.
Topics: Acetylcholine; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Dementia; Humans | 1980 |
Acetylcholine and choline levels in post-mortem human brain tissue: preliminary observations in Alzheimer's disease.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Brain; Caudate Nucleus; Cerebral Cortex; Choline; D | 1980 |
Neurochemical approaches to the treatment of senile dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferase; Dementia; Dys | 1980 |
Choline bitartrate treatment of Alzheimer-type dementias.
Topics: Aged; Alzheimer Disease; Behavior; Choline; Cognition; Dementia; Double-Blind Method; Female; Humans | 1980 |
Human memory and the effects of physostigmine and choline chloride [proceedings].
Topics: Adolescent; Adult; Aged; Choline; Dementia; Double-Blind Method; Humans; Memory; Middle Aged; Physos | 1980 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Role of increased cerebral myo-inositol in the dementia of Down syndrome.
Topics: Adolescent; Adult; Alzheimer Disease; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creati | 1995 |
Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood-Brain Barrier; Brain | 1995 |
Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Cerebral Cortex; Choline; Dementia; Female; Hippocam | 1995 |
Proton MR spectroscopy of the brain in 14 patients with Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Choline; Creatine; Dementia; Energy Metabolism | 1995 |
[Experimental techniques for developing new drugs acting on dementia (4)--Aged rats].
Topics: Acetylcholinesterase; Aging; Animals; Choline; Choline O-Acetyltransferase; Dementia; Female; Male; | 1994 |
Alterations of selected enzymes of phospholipid metabolism in Alzheimer's disease brain tissue as compared to non-Alzheimer's demented controls.
Topics: Aged; Alzheimer Disease; Brain; Choline; Choline Kinase; Dementia; Humans; Phospholipids; Phosphoric | 1993 |
Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Choline; Cre | 2001 |
Clinical effects of choline in Alzheimer senile dementia.
Topics: Administration, Oral; Aged; Alzheimer Disease; Choline; Dementia; Drug Evaluation; Female; Humans; M | 1977 |
Choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Dementia; gamma-Amin | 1977 |
Clinical effects of choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Female; Humans; Male | 1978 |
Possible biochemical basis of memory disorder in Alzheimer disease.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferas | 1978 |
Will drugs help patients with Alzheimer's disease?
Topics: Alzheimer Disease; Choline; Choline O-Acetyltransferase; Dementia; Humans | 1979 |
[Influence of choline on amnesia in Alzheimer's disease (author's transl)].
Topics: Aged; Alzheimer Disease; Amnesia; Choline; Dementia; Female; Humans; Learning; Male; Mental Recall; | 1979 |
The arteriovenous difference of choline across the brain of man.
Topics: Adult; Aged; Brain; Choline; Dementia; Female; Humans; Male; Middle Aged | 1975 |
Erythrocyte choline concentrations in psychiatric disorders.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Bipolar Disorder; Choline; Dementia; Depressi | 1991 |
Effect of the 'antidementia drug' pantoyl-GABA on high affinity transport of choline and on the contents of choline and acetylcholine in rat brain.
Topics: Acetylcholine; Animals; Biological Transport, Active; Brain; Choline; Dementia; gamma-Aminobutyric A | 1988 |
Red blood cell/plasma choline ratio in elderly depressed and demented patients.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Depressive Disorder; Electroencephalography; Erythrocyte | 1988 |
[Neuropsychological study of the senile brain during and after single and combined treatment with deanol and citicoline].
Topics: Aged; Choline; Cytidine Diphosphate Choline; Deanol; Dementia; Double-Blind Method; Drug Evaluation; | 1986 |