choline has been researched along with Alcohol Related Neurodevelopmental Disorder in 33 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy." | 9.27 | Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Herbert, JS; Hoyme, HE; Jacobson, JL; Jacobson, SW; Lewis, CE; Lindinger, NM; Meintjes, EM; Molteno, CD; Stanton, ME; Zeisel, SH, 2018) |
| "Our objectives were to examine whether fetal vulnerability to PAE-related growth restriction is modified by: 1) rate of gestational weight gain; or prenatal dietary intakes of 2) energy, 3) iron, or 4) choline." | 8.12 | Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Meintjes, EM; Molteno, CD; Senekal, M, 2022) |
| "Fifty-two infants born to heavy-drinking women who had participated in a choline supplementation trial during pregnancy underwent structural magnetic resonance imaging with a multi-echo FLASH protocol on a 3T Siemens Allegra MRI (median age = 2." | 5.41 | Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes. ( Carter, RC; Dodge, NC; Jacobson, JL; Jacobson, SW; Lindinger, NM; Meintjes, EM; Molteno, CD; van der Kouwe, AJW; Warton, CMR; Warton, FL; Wintermark, P; Zöllei, L, 2021) |
| "Seventy heavy drinkers, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of 2 g of choline or a placebo from time of enrollment until delivery." | 5.27 | Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Lindinger, NM; Meintjes, EM; Molteno, CD; Senekal, MS; Zeisel, SH, 2018) |
| "We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy." | 5.27 | Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Carter, RC; Dodge, NC; Duggan, CP; Herbert, JS; Hoyme, HE; Jacobson, JL; Jacobson, SW; Lewis, CE; Lindinger, NM; Meintjes, EM; Molteno, CD; Stanton, ME; Zeisel, SH, 2018) |
| "Our objectives were to examine whether fetal vulnerability to PAE-related growth restriction is modified by: 1) rate of gestational weight gain; or prenatal dietary intakes of 2) energy, 3) iron, or 4) choline." | 4.12 | Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort. ( Carter, RC; Dodge, NC; Duggan, CP; Jacobson, JL; Jacobson, SW; Meintjes, EM; Molteno, CD; Senekal, M, 2022) |
| " Women who differed in prenatal alcohol use were recruited during pregnancy and assigned to a group (No study-provided supplements, multivitamin/mineral supplement, or multivitamin/mineral supplement plus choline supplement)." | 3.81 | The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. ( Chambers, CD; Coles, CD; Jones, KL; Kable, JA; Keen, CL; Kulikovsky, Y; Pedersen, TL; Uriu-Adams, JY; Wertelecki, W; Yevtushok, L, 2015) |
| "Diagnoses were 28% fetal alcohol syndrome (FAS), 28% partial FAS, and 44% alcohol-related neurodevelopmental disorder." | 3.11 | Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes. ( Anthony, ME; Boys, CJ; de Water, E; Eckerle, JK; Ernst, AM; Fuglestad, AJ; Georgieff, MK; Gimbel, BA; Mueller, BA; Radke, JP; Roediger, DJ; Wozniak, JR; Zeisel, SH, 2022) |
| "Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits." | 2.94 | Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder. ( Boys, CJ; Brearley, AM; Eckerle, JK; Fink, BA; Fuglestad, AJ; Georgieff, MK; Lindgren, C; Miller, NC; Radke, JP; Sandness, KE; Wozniak, JR; Zeisel, SH, 2020) |
| "There are no specific biological treatments for FASDs, but rodent models have shown that prenatal or postnatal choline supplementation reduces cognitive and behavioral deficits." | 2.80 | Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial. ( Boys, CJ; Brearley, AM; Eckerle, JK; Fink, BA; Fuglestad, AJ; Georgieff, MK; Hoecker, HL; Kroupina, MG; Miller, NC; Radke, JP; Wozniak, JR; Zeisel, SH, 2015) |
| "There are no biological treatments for fetal alcohol spectrum disorders (FASDs), lifelong conditions associated with physical anomalies, brain damage, and neurocognitive abnormalities." | 2.78 | Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. ( Boys, CJ; Brearley, AM; Eckerle, JK; Fink, BA; Fuglestad, AJ; Georgieff, MK; Hoecker, HL; Kroupina, MG; Miller, NC; Wozniak, JR; Zeisel, SH, 2013) |
| "Choline is an essential nutrient in humans, and is an important methyl group donor." | 2.47 | What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. ( Zeisel, SH, 2011) |
| "Individuals with fetal alcohol spectrum disorders (FASD) incur enduring brain damage and neurodevelopmental impairments from prenatal alcohol exposure (PAE)." | 1.72 | The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent. ( Carugati, M; Cudd, TA; Goodlett, CR; Washburn, SE, 2022) |
| "Choline is an essential nutrient under evaluation as a cognitive enhancing treatment for fetal alcohol spectrum disorders (FASD) in clinical trials." | 1.62 | Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus. ( Christie, BR; Fontaine, CJ; Grafe, EL; Thomas, JD, 2021) |
| "The cholinergic system plays a crucial role in learning and memory processes." | 1.56 | Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats. ( Hill, E; Jiang, L; Mooney, SM; Tang, S; Waddell, J; Xu, S, 2020) |
| "Animal models of Fetal Alcohol Spectrum Disorders (FASD) afford the unique capacity to precisely control timing of alcohol exposure and alcohol exposure amounts in the developing animal." | 1.42 | An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics. ( Barnet, RC; Hunt, PS, 2015) |
| "Choline is an essential nutrient that influences brain and behavioral development." | 1.36 | Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. ( Dominguez, HD; Idrus, NM; Monk, BR; Thomas, JD, 2010) |
| "Three of them had fetal alcohol syndrome (FAS), 3 had partial FAS (PFAS), and 4 had alcohol-related neurobehavioral disorder (ARND)." | 1.33 | Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders. ( Autti-Rämö, I; Fagerlund, A; Heikkinen, S; Korkman, M; Kuusi, T; Lundbom, N; Riley, EP; Timonen, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 16 (48.48) | 24.3611 |
| 2020's | 16 (48.48) | 2.80 |
| Authors | Studies |
|---|---|
| Grafe, EL | 1 |
| Fontaine, CJ | 1 |
| Thomas, JD | 7 |
| Christie, BR | 1 |
| Kwan, STC | 1 |
| Ricketts, DK | 1 |
| Presswood, BH | 1 |
| Smith, SM | 2 |
| Mooney, SM | 2 |
| Carugati, M | 1 |
| Goodlett, CR | 2 |
| Cudd, TA | 2 |
| Washburn, SE | 2 |
| Ernst, AM | 3 |
| Gimbel, BA | 3 |
| de Water, E | 3 |
| Eckerle, JK | 8 |
| Radke, JP | 5 |
| Georgieff, MK | 8 |
| Wozniak, JR | 8 |
| Carter, RC | 4 |
| Senekal, M | 1 |
| Duggan, CP | 3 |
| Dodge, NC | 4 |
| Meintjes, EM | 4 |
| Molteno, CD | 4 |
| Jacobson, JL | 4 |
| Jacobson, SW | 4 |
| Curioni, CC | 1 |
| Mocellin, MC | 1 |
| Tavares, MDS | 1 |
| da Silva, ACF | 1 |
| de Velasco, PC | 1 |
| Ribas, SA | 1 |
| Lamarca, F | 1 |
| André, C | 1 |
| Anthony, ME | 2 |
| Roediger, DJ | 2 |
| Boys, CJ | 6 |
| Mueller, BA | 2 |
| Fuglestad, AJ | 5 |
| Zeisel, SH | 9 |
| Baker, JA | 1 |
| Bodnar, TS | 1 |
| Breit, KR | 1 |
| Weinberg, J | 1 |
| de la Monte, SM | 1 |
| Tong, M | 1 |
| Delikkaya, B | 1 |
| Hasken, JM | 1 |
| de Vries, MM | 1 |
| Marais, AS | 1 |
| Kalberg, WO | 1 |
| Buckley, D | 1 |
| Parry, CDH | 1 |
| Seedat, S | 1 |
| May, PA | 1 |
| Bottom, RT | 1 |
| Abbott, CW | 1 |
| Huffman, KJ | 1 |
| Fink, BA | 3 |
| Sandness, KE | 2 |
| Miller, NC | 3 |
| Lindgren, C | 1 |
| Brearley, AM | 3 |
| Waddell, J | 1 |
| Hill, E | 1 |
| Tang, S | 1 |
| Jiang, L | 1 |
| Xu, S | 1 |
| Virdee, MS | 1 |
| Warton, FL | 1 |
| Warton, CMR | 1 |
| Wintermark, P | 1 |
| Lindinger, NM | 3 |
| Zöllei, L | 1 |
| van der Kouwe, AJW | 1 |
| Balaraman, S | 1 |
| Idrus, NM | 2 |
| Miranda, RC | 1 |
| Goeke, CM | 1 |
| Roberts, ML | 1 |
| Hashimoto, JG | 1 |
| Finn, DA | 1 |
| Guizzetti, M | 1 |
| Senekal, MS | 1 |
| Stanton, ME | 1 |
| Herbert, JS | 1 |
| Lewis, CE | 1 |
| Hoyme, HE | 1 |
| Sawant, OB | 1 |
| Birch, SM | 1 |
| Sarkar, DK | 1 |
| Gangisetty, O | 1 |
| Foroud, TM | 1 |
| Wetherill, L | 1 |
| Wertelecki, W | 2 |
| Chambers, CD | 3 |
| Riley, E | 1 |
| Zymak-Zakutnya, N | 1 |
| Yevtushok, L | 2 |
| Kroupina, MG | 2 |
| Hoecker, HL | 2 |
| Young, JK | 1 |
| Giesbrecht, HE | 1 |
| Eskin, MN | 1 |
| Aliani, M | 1 |
| Suh, M | 1 |
| Hunt, PS | 1 |
| Barnet, RC | 1 |
| Kable, JA | 1 |
| Coles, CD | 1 |
| Keen, CL | 1 |
| Uriu-Adams, JY | 1 |
| Jones, KL | 1 |
| Kulikovsky, Y | 1 |
| Pedersen, TL | 1 |
| Nguyen, TT | 1 |
| Risbud, RD | 1 |
| Mattson, SN | 1 |
| Monk, BR | 2 |
| Dominguez, HD | 1 |
| Ballard, MS | 1 |
| Sun, M | 1 |
| Ko, J | 1 |
| Leslie, FM | 1 |
| Fagerlund, A | 1 |
| Heikkinen, S | 1 |
| Autti-Rämö, I | 1 |
| Korkman, M | 1 |
| Timonen, M | 1 |
| Kuusi, T | 1 |
| Riley, EP | 1 |
| Lundbom, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure[NCT01149538] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Effect on Pregnancy Outcomes, Infant Growth and Development of an Egg Intervention During Pregnancy in Indonesia[NCT04694235] | 653 participants (Anticipated) | Interventional | 2021-02-12 | Recruiting | |||
| Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders[NCT01911299] | Phase 2 | 55 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Elicited Imitation (EI) paradigm (P.J. Bauer, 1989, Dev. Psychology) was used to measure memory in the participants at baseline, 6 months, and 9 months. The measures were items recalled after a delay (delayed items) and pairs of items recalled after a delay (delayed pairs). The sample was split by age in the analysis (young vs. old) as reflected in the outcome data. Outcome data measures included here are the slopes of the regression lines reflecting change over the three timepoints, controlling for immediate memory performance on the EI task.The slopes are given, as opposed to the raw scores, because these were the values used in the growth curve analyses. Details of these analyses are included in Wozniak et al. (2015) AJCN, doi:10.3945/ajcn.114.099168. NOTE that the means presented below represent the simple slopes that estimate the change in task performance (% of items correct) per 6-month unit of time. To estimate change in task performance over 9 months, multiply by 1.5. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Slope (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Delayed-Items-Young | Delayed-Items-Old | Delayed-Pairs-Young | Delayed-Pairs-Old | Immed-Items-Young | Immed-Items-Old | Immed-Pairs-Young | Immed-Pairs-Old | |
| Choline Bitartrate | 14.24 | -.71 | 18.97 | 2.69 | 8.48 | 2.59 | 8.75 | 11.46 |
| Placebo | 4.43 | 4.23 | 10.39 | 7.79 | 13.72 | 3.89 | 20.01 | 5.50 |
Evoked Response Potential - negative component latency data are included. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Milliseconds (Mean) | ||
|---|---|---|---|
| Frontal Neg Component Latency at baseline | Frontal Neg Component at 6 months | Frontal Neg Component at 9 months | |
| Choline Bitartrate | 2.23 | 32.45 | -4.00 |
| Placebo | 5.35 | -4.28 | -3.03 |
Evoked response potentials were measured for the memory task. Frontal positive slow-wave potential negative component amplitude data are included. (NCT01149538)
Timeframe: Baseline, 6 months, and 9 months
| Intervention | Mircovolts (Mean) | |||||
|---|---|---|---|---|---|---|
| Frontal Positive Slow Wave (PSW) - Baseline | Frontal Positive Slow Wave (PSW) - 6 months | Frontal Positive Slow Wave (PSW) - 9 months | Frontal Neg Component Amplitude - Baseline | Frontal Neg Component Amplitude - 6 months | Frontal Neg Component Amplitude - 9 months | |
| Choline Bitartrate | -2.05 | -1.04 | -0.26 | -2.53 | 1.22 | 0.35 |
| Placebo | 0.57 | -1.03 | -1.41 | 0.62 | -0.84 | -1.37 |
The Mullen Scales of Early Learning is a measure of global cognitive development and is a primary outcome measure. The Early Learning Composite is the total score for this measure. It is a scaled score with a mean of 100 and a standard deviation of 15 (higher scores indicate better global cognitive status; average range is 85-115; Impaired range is 70 or below; full range is typically 50 - 150, although minimum and maximum scores are dependent on age). See the Mullen Scales reference manual for more psychometric details. (NCT01149538)
Timeframe: Baseline and 9 months
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | 9-month follow-up | |
| Choline Bitartrate | 83.2 | 87.1 |
| Placebo | 84.3 | 89.6 |
Side effects of choline bitartrate will be monitored by the study physician and the P.I. with physical examinations and telephone contact. (NCT01149538)
Timeframe: Baseline, 6 months, & 9 months
| Intervention | participants (Number) | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline energy level problems | 6 month energy level problems | 9 months energy level problems | Baseline pain | 6 month pain | 9 month pain | Baseline skin problems | 6 month skin problems | 9 month skin problems | Baseline Ear Nose Throat problems | 6 month Ear Nose Throat problems | 9 month Ear Nose Throat problems | Baseline headaches/dizziness | 6 month headaches/dizziness | 9 month headaches/dizziness | Baseline vision problems | 6 month vision problems | 9 month vision problems | Baseline cardiovascular | 6 month cardiovascular | 9 month cardiovascular | Baseline respiratory problems | 6 month respiratory problems | 9 month respiratory problems | Baseline gastrointestinal problems | 6 month gastrointestinal problems | 9 month gastrointestinal problems | Baseline genitourinary problems | 6 month genitourinary problems | 9 month genitourinary problems | Baseline musculoskeletal problems | 6 month musculoskeletal problems | 9 month musculoskeletal problems | 6 month neurologic/psychiatric problems | 9 month neurologic/psychiatric problems | Baseline neurologic/psychiatric problems | Baseline allergic problems | 6 month allergic problems | 9 month allergic problems | |
| Choline Bitartrate | 8 | 8 | 8 | 3 | 3 | 3 | 6 | 6 | 6 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 0 | 0 | 1 | 1 | 1 | 6 | 6 | 6 | 18 | 18 | 18 | 4 | 4 | 4 | 0 | 0 | 0 | 11 | 11 | 11 | 2 | 0 | 0 |
| Placebo | 10 | 9 | 9 | 4 | 4 | 4 | 6 | 5 | 5 | 0 | 0 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 6 | 6 | 6 | 14 | 11 | 11 | 9 | 8 | 8 | 1 | 1 | 1 | 9 | 9 | 9 | 3 | 3 | 3 |
4 reviews available for choline and Alcohol Related Neurodevelopmental Disorder
| Article | Year |
|---|---|
Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder.
Topics: Child; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Humans; Preg | 2022 |
Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials.
Topics: Acetylcysteine; Brain Injuries; Cerebral Palsy; Child; Choline; Docosahexaenoic Acids; Female; Fetal | 2022 |
Nutrition implications for fetal alcohol spectrum disorder.
Topics: Alcohol Drinking; Animals; Antioxidants; Brain; Choline; Dietary Supplements; Disease Models, Animal | 2014 |
What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.
Topics: Animals; Choline; Diet; Epigenesis, Genetic; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Huma | 2011 |
9 trials available for choline and Alcohol Related Neurodevelopmental Disorder
| Article | Year |
|---|---|
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Topics: Child; Child, Preschool; Choline; Corpus Callosum; Female; Fetal Alcohol Spectrum Disorders; Follow- | 2022 |
Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
Topics: Child, Preschool; Choline; Cognition; Double-Blind Method; Female; Fetal Alcohol Spectrum Disorders; | 2020 |
Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
Topics: Adult; Brain; Choline; Dietary Supplements; Double-Blind Method; Ethanol; Female; Fetal Alcohol Spec | 2021 |
Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Alcohol Drinking; Choline; Dietary Supplements; Double-Blind Method; Feasibility Studies; Female; Fe | 2018 |
Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Adult; Alcohol Drinking; Birth Weight; Blinking; Choline; Cognition; Dietary Supplements; Double-Bli | 2018 |
Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol.
Topics: Adolescent; Adult; Case-Control Studies; Central Nervous System Depressants; Child; Child, Preschool | 2019 |
Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability.
Topics: Alcohol Drinking; Child, Preschool; Choline; Dietary Supplements; Double-Blind Method; Female; Fetal | 2013 |
Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial.
Topics: Behavioral Symptoms; Child, Preschool; Choline; Dietary Supplements; Double-Blind Method; Feasibilit | 2015 |
Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders.
Topics: Child; Child, Preschool; Choline; Cognition; Dietary Supplements; Dose-Response Relationship, Drug; | 2016 |
20 other studies available for choline and Alcohol Related Neurodevelopmental Disorder
| Article | Year |
|---|---|
Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus.
Topics: Animals; Central Nervous System Depressants; Choline; Dentate Gyrus; Disease Models, Animal; Ethanol | 2021 |
Prenatal choline supplementation during mouse pregnancy has differential effects in alcohol-exposed fetal organs.
Topics: Animals; Animals, Newborn; Choline; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders | 2021 |
Choline supplementation as an intervention for fetal alcohol spectrum disorders: A commentary.
Topics: Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Humans; Pregnancy | 2021 |
The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent.
Topics: Animals; Choline; Dietary Supplements; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disord | 2022 |
Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort.
Topics: Alcohol Drinking; Animals; Birth Cohort; Child; Choline; Diet; Ethanol; Female; Fetal Alcohol Spectr | 2022 |
Choline Supplementation Alters Hippocampal Cytokine Levels in Adolescence and Adulthood in an Animal Model of Fetal Alcohol Spectrum Disorders.
Topics: Adolescent; Animals; Animals, Newborn; Choline; Cytokines; Dietary Supplements; Ethanol; Female; Fet | 2023 |
Differential Early Mechanistic Frontal Lobe Responses to Choline Chloride and Soy Isoflavones in an Experimental Model of Fetal Alcohol Spectrum Disorder.
Topics: Animals; Choline; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Frontal Lobe; Humans; Insulin; | 2023 |
Maternal dietary intake among alcohol-exposed pregnancies is linked to early infant physical outcomes in South Africa.
Topics: Calcium; Choline; Diet; Eating; Ethanol; Fatty Acids; Female; Fetal Alcohol Spectrum Disorders; Foli | 2023 |
Rescue of ethanol-induced FASD-like phenotypes via prenatal co-administration of choline.
Topics: Animals; Animals, Newborn; Anxiety; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol Spe | 2020 |
Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats.
Topics: Age Factors; Animals; Animals, Newborn; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol | 2020 |
Polymorphisms in SLC44A1 are associated with cognitive improvement in children diagnosed with fetal alcohol spectrum disorder: an exploratory study of oral choline supplementation.
Topics: Administration, Oral; Antigens, CD; Child, Preschool; Choline; Cognition; Dietary Supplements; Femal | 2021 |
Postnatal choline supplementation selectively attenuates hippocampal microRNA alterations associated with developmental alcohol exposure.
Topics: Animals; Animals, Newborn; Blood Alcohol Content; Choline; Disease Models, Animal; Ethanol; Female; | 2017 |
Neonatal Ethanol and Choline Treatments Alter the Morphology of Developing Rat Hippocampal Pyramidal Neurons in Opposite Directions.
Topics: Animals; Animals, Newborn; CA1 Region, Hippocampal; Cell Size; Choline; Dendrites; Disease Models, A | 2018 |
Maternal choline supplementation mitigates alcohol-induced fetal cranio-facial abnormalities detected using an ultrasonographic examination in a sheep model.
Topics: Animals; Choline; Craniofacial Abnormalities; Disease Models, Animal; Ethanol; Female; Fetal Alcohol | 2019 |
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics.
Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Central Nervo | 2015 |
The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants.
Topics: Adult; Central Nervous System Depressants; Choline; Dietary Supplements; Ethanol; Female; Fetal Alco | 2015 |
Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Bulimia; Choline; Dietary Supplements; Eth | 2010 |
Vitamin A, folate, and choline as a possible preventive intervention to fetal alcohol syndrome.
Topics: Animals; Avitaminosis; Choline; Epigenesis, Genetic; Female; Fetal Alcohol Spectrum Disorders; Folic | 2012 |
The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt.
Topics: Acetylcholine; Animals; Animals, Newborn; Behavior, Animal; Choline; Dietary Supplements; Ethanol; F | 2012 |
Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Case-Control Studies; Central Nervous System Depressants; C | 2006 |