Page last updated: 2024-10-16

choline and Aging

choline has been researched along with Aging in 337 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Postmenopausal women with deficient choline intake had worse fibrosis (P = 0."9.16Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. ( Colvin, RM; Diehl, A; Guerrerio, AL; Lavine, JE; Mohan, P; Molleston, JP; Murray, KF; Scheimann, AO; Schwartz, AK; Schwimmer, JB; Torbenson, MS, 2012)
"We established a cardiac aging model in mice through subcutaneous injection with D-galactose at a dose of 100 mg/kg/day for 6 weeks."7.88Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway. ( Chen, J; Dai, C; Fasae, MB; Jiang, Y; Liu, D; Liu, Y; Pan, W; Sun, L; Wang, L; Wang, S, 2018)
" Supplementation of choline and DHA or CTR during PMSS in rats persistently attenuates brain oxidative stress through aging."7.88Persistent attenuation of brain oxidative stress through aging in perinatal maternal separated rat pups supplemented with choline and docosahexaenoic acid or Clitoria ternatea aqueous root extract. ( Almeida, PMD; Bernhardt, LK; Kamath, SU; Kishore, A; Rai, KS; Shenoy, PR, 2018)
"Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration."7.83Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016)
" In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)."7.74Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008)
"Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population."7.74N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008)
"Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring."7.72Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003)
"The effect of aging and melatonin on 24-h rhythms in tyrosine hydroxylase activity and 3H - choline conversion into 3H - acetylcholine were examined in cervical, stellate, coeliac-mesenteric and hypogastric ganglia, and in the adrenal medulla and heart of rats."7.70Diurnal rhythms in norepinephrine and acetylcholine synthesis of sympathetic ganglia, heart and adrenals of aging rats: effect of melatonin. ( Brusco, LI; Cardinali, DP; Esquifino, AI; García-Bonacho, M, 1998)
"We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats."7.69The influence of aging on whole body choline release and clearance. ( Jenden, DJ; Li, G; Roch, M; Scremin, OU, 1996)
"It has been suggested that the activity of the enzyme responsible for the synthesis of acetylcholine, choline acetyltransferase (ChAT), is substantially reduced in the neocortex and hippocampus of Alzheimer's and other aging brains."7.68Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E. ( Govitrapong, P; Maneesub, Y; Sanvarinda, Y, 1993)
" Behavioural effects of chronic manipulations of dietary choline in rats in the early stages of aging are reported."7.68Dietary choline manipulations and behavioural modifications in rats in the early stages of aging. ( Fundarò, A; Paschero, A, 1991)
"Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging."7.67Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984)
"The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months."7.67Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989)
"We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats."7.67Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984)
"Fragile X syndrome is a learning disability caused by excess of CGG repeats in the 5' untranslated region of the Fragile X gene (FMR1) silencing its transcription and translation."5.42Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. ( Djazayeri, S; Liu, YY; Norman, KM; Roch, M; Scremin, OU, 2015)
"We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals."5.29Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995)
"All subjects with DS had a trisomy 21 karyotype, and 3 of the 6 older subjects were demented as judged from a history of mental deterioration, disorientation, and memory loss."5.28Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome. ( Atack, JR; Hanin, I; Haxby, JV; May, C; Rapoport, SI; Schapiro, MB, 1990)
" Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males."5.27The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983)
"Postmenopausal women with deficient choline intake had worse fibrosis (P = 0."5.16Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. ( Colvin, RM; Diehl, A; Guerrerio, AL; Lavine, JE; Mohan, P; Molleston, JP; Murray, KF; Scheimann, AO; Schwartz, AK; Schwimmer, JB; Torbenson, MS, 2012)
"Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)."4.76Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984)
"Patients prescribed an anticholinergic were evaluated using the Overactive Bladder Symptom Score; Medical, Epidemiologic and Social Aspects of Aging and Incontinence Questionnaire; and Incontinence Impact Questionnaire-7."3.96Evaluation of Choline and Acetylcholine Levels in Responders and Nonresponders to Anticholinergic Therapy for Overactive Bladder Syndrome. ( El-Nashar, S; Hazlett, FE; Hijaz, AK; Li, X; Mahajan, ST; Mangel, JM; Mara, E; Sheyn, D, 2020)
"We established a cardiac aging model in mice through subcutaneous injection with D-galactose at a dose of 100 mg/kg/day for 6 weeks."3.88Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway. ( Chen, J; Dai, C; Fasae, MB; Jiang, Y; Liu, D; Liu, Y; Pan, W; Sun, L; Wang, L; Wang, S, 2018)
" Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale."3.85Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017)
"Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration."3.83Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016)
"In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers."3.80APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain. ( Buthorn, JJ; Christen, E; Conejero-Goldberg, C; Davies, P; Dickinson, D; Goldberg, TE; Gomar, JJ; Gordon, ML; Huet, S; Keehlisen, L; Kingsley, PB; Koppel, J; Uluğ, AM, 2014)
"Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration."3.80Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. ( Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2014)
" In the current study, biochemical markers sensitive to Alzheimer disease (activities of high-affinity choline uptake and of nitric oxide synthases, expression of 17beta-hydroxysteroid dehydrogenase type 10) were estimated in both hemispheres of young and old male Wistar/Long Evans rats."3.76Aging and lateralization of the rat brain on a biochemical level. ( Kristofiková, Z; Ort, M; Rícný, J; Rípová, D, 2010)
" We used structural magnetic resonance imaging (sMRI) to measure the volume of the AHC, and magnetic resonance spectroscopy ((1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)."3.76Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. ( Baird, G; Bolton, P; Conroy, RM; Curran, S; Daly, E; Foy, C; Hallahan, B; Murphy, DG; Murphy, KC; O'Brien, FM; O'Gorman, RL; Page, L; Robertson, D; Sharma, A, 2010)
" In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)."3.74Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008)
"Long- and short-echo proton spectroscopic imaging were used to investigate concentrations and R2 relaxation rates of N-acetyl aspartate (NAA) + N-acetyl aspartyl glutamate (NAAG), choline (Cho), creatine (Cr), and myoinositol (mI) in the white matter of the centrum semiovale of 106 healthy volunteers aged 50-90 years; usable data were obtained from 79 subjects."3.74Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. ( Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ, 2007)
"Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population."3.74N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008)
"To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men."3.72Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. ( Breteler, MM; den Heijer, T; Hofman, A; Origgi, D; Oudkerk, M; Sijens, PE; Vermeer, SE, 2003)
"Compared with seronegative controls, HIV-positive subjects showed additional and marked increases in the concentration of glial markers, choline-containing compounds (seronegative controls +2%/decade; HIV-positive subjects +10%/decade) and myoinositol (seronegative controls +3%/decade; HIV-positive subjects +12%/decade), with aging in the frontal white matter."3.72Effect of aging on brain metabolism in antiretroviral-naive HIV patients. ( Chang, L; Ernst, T, 2004)
"Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring."3.72Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003)
"To investigate whether damages of cholinergic neurons in the brain produce aging-like changes in circadian rhythms, we examined the influences of intracerebroventricular injection of cholinergic neurotoxin ethylcholine aziridinium ion (AF64A, 5 nmol/5 microl) on circadian rhythms in rats, by measuring locomotor activity and body temperature with the automatic behavioral measurement system combined with the telemetry."3.71Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats. ( Endo, Y; Fueta, Y; Irie, M; Shinohara, K, 2001)
"Female Sprague-Dawley rats received approximately 300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (NGF) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age."3.71Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. ( Loy, R; Sandstrom, NJ; Williams, CL, 2002)
" Here, the developmental and protective effects of SNV were investigated in vivo using two models of developmental retardation, hypoxia and cholinergic blockade."3.70Protection against developmental deficiencies by a lipophilic VIP analogue. ( Bachar, M; Bardea, A; Davidson, A; Fridkin, M; Gozes, I; Rubinraut, S, 1998)
"The purpose of this investigation was to examine the effects of aging and aerobic fitness on exercise- and methylcholine-induced sweating responses during heat acclimation."3.70Exercise- and methylcholine-induced sweating responses in older and younger men: effect of heat acclimation and aerobic fitness. ( Buskirk, ER; Havenith, G; Inoue, Y; Kenney, WL; Loomis, JL, 1999)
"Supplementation with choline during pregnancy in rats causes a long-lasting improvement of visuospatial memory of the offspring."3.70Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. ( Jones, JP; Meck, WH; Swartzwelder, HS; Williams, CL; Wilson, WA, 1999)
"We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats."3.69The influence of aging on whole body choline release and clearance. ( Jenden, DJ; Li, G; Roch, M; Scremin, OU, 1996)
" In living adult rhesus monkeys, we studied the long-term effects of early mesial temporo-limbic (MTL) lesions on prefrontal cortex (PFC) neurons using proton magnetic resonance spectroscopic imaging (1H-MRSI), an in vivo neurochemical assay technique for measuring signals from metabolites such as N-acetyl-aspartate (NAA, a neuronal marker), choline-containing compounds (CHO) and creatine + phosphocreatine (CRE)."3.69Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study. ( Bachevalier, J; Bertolino, A; Frank, JA; Mattay, VS; Saunders, RC; Weinberger, DR, 1997)
"To evaluate whether any degenerative changes affect the brain cholinergic systems during natural aging, we compared various cholinergic biochemical markers (number of muscarinic receptors, mAChR; choline acetyltransferase activity, ChAT; acetylcholinesterase activity, AChE; and sodium-dependent high affinity choline uptake) in the cortical (CR) and subcortical (SS) regions of the brains of aged (24 month) and young (2 month) rats."3.69Age-related changes of cholinergic markers in the rat brain. ( Egashira, T; Yamanaka, Y; Yufu, F, 1994)
"The effect of aging was examined on cholinergically mediated contractions and acetylcholine (ACh) release in isolated colonic segments from Fischer (F344 x BN) F1 rats, 4-8 mo (postpubertal) and 22-28 mo (senescent) of age."3.69Evidence for age-associated reduction in acetylcholine release and smooth muscle response in the rat colon. ( Gelperin, D; Roberts, D; Wiley, JW, 1994)
" Behavioural effects of chronic manipulations of dietary choline in rats in the early stages of aging are reported."3.68Dietary choline manipulations and behavioural modifications in rats in the early stages of aging. ( Fundarò, A; Paschero, A, 1991)
"Normal aging has been associated with a progressive decline in hippocampal cholinergic function."3.68Effect of physical activity on hippocampal high affinity choline uptake and muscarinic binding: a comparison between young and old F344 rats. ( Farrar, RP; Fordyce, DE, 1991)
"It has been suggested that the activity of the enzyme responsible for the synthesis of acetylcholine, choline acetyltransferase (ChAT), is substantially reduced in the neocortex and hippocampus of Alzheimer's and other aging brains."3.68Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E. ( Govitrapong, P; Maneesub, Y; Sanvarinda, Y, 1993)
"Although the use of aging experimental animals for studying serotonergic neuronal changes is limited because of species differences, cholinergic neuronal deterioration does appear to be a feature common to mammalian aging brains."3.68Serotonergic ligand binding in aging brain of experimental animals. ( Yamagata, A; Yamaguchi, T, 1991)
"We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats."3.67Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984)
"Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging."3.67Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984)
"The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months."3.67Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989)
"It has been suggested that choline and/or phosphatidylcholine may be beneficial in improving the memory deficits associated with aging and Alzheimer's disease."3.67Effects of long-term dietary choline and phosphatidylcholine administration on muscarinic receptors in aged mouse brain. ( Muma, NA; Rowell, PP; Schultz, GS, 1988)
"In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices."3.67Metabolism of choline in brain of the aged CBF-1 mouse. ( Karczmar, AG; Kindel, G; Rosenberg, A; Saito, M, 1986)
"Twenty-seven patients with cervical spondylosis were evaluated."2.80Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy. ( Ellingson, BM; Hardy, AJ; Holly, LT; Salamon, N, 2015)
"Choline is an essential nutrient and can also be obtained by de novo synthesis via an oestrogen responsive pathway."2.77Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. ( Bonham, MP; Duffy, ME; McCormack, JM; McNulty, H; Molloy, AM; Robson, PJ; Scott, JM; Strain, JJ; Ueland, PM; Wallace, JM; Walsh, PM; Ward, M, 2012)
"NAA/choline ratios were significantly reduced (P<0."2.71Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate. ( Aleman, A; de Haan, EH; de Vries, R; de Winter, CF; Drent, ML; Kenemans, JL; Koppeschaar, HP; Lijffijt, M; van Dam, PS; van der Grond, J, 2005)
"Fragile X syndrome is a learning disability caused by excess of CGG repeats in the 5' untranslated region of the Fragile X gene (FMR1) silencing its transcription and translation."1.42Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. ( Djazayeri, S; Liu, YY; Norman, KM; Roch, M; Scremin, OU, 2015)
" A generalised additive regression model showed a positive dose-response relationship between the m-MMSE and choline (P=0·012 from a corresponding linear regression model)."1.39Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013)
"Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects."1.35Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009)
"Choline (Ch) plays an important role in brain neurotransmission, while Ch-deprivation (CD) has been linked to various pathophysiological states."1.35Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions. ( Al-Humadi, H; Anifantaki, F; Gkrouzman, E; Kyriakaki, A; Liapi, C; Margaritis, M; Skandali, N; Stolakis, V; Tsakiris, S; Zarros, A, 2009)
"Twenty-four patients with spastic diplegia and twenty-six healthy children were examined."1.35An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study. ( Kubas, B; Kulak, W; Otapowicz, D; Smigielska-Kuzia, J; Sobaniec, W; Zawada, B, 2009)
" Choline-stabilized orthosilicic acid (ch-OSA) was found to have a high bioavailability compared to other Si supplements."1.33Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. ( Behets, GJ; Calomme, M; D'Haese, P; Demeester, N; Geusens, P; Sindambiwe, JB; Van Hoof, V; Vanden Berghe, D, 2006)
"Cholinergic deficits in Alzheimer's disease are accompanied by a number of alterations in other transmitter systems including glutamate, noradrenaline and serotonin, suggesting the involvement also of other neurotransmitter systems in the pathogenesis of the disease."1.32Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology. ( Apelt, J; Klingner, M; Kumar, A; Sabri, O; Scheunemann, M; Schliebs, R; Sorger, D; Steinbach, J, 2003)
"Choline is an important membrane phospholipid constituent and a neurotransmitter precursor that is minimally synthesized in brain."1.30Blood-brain barrier choline transport in the senescent rat. ( Allen, DD; Smith, QR, 1999)
"The effect of transient cerebral ischemia on cholinergic metabolism was investigated in adult and young gerbils subjected to bilateral carotid artery occlusion (15 min) alone or with release."1.29Cerebral ischemia in young and adult gerbils: effects on cholinergic metabolism. ( Bertrand, N; Ishii, H; Spatz, M, 1996)
"We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals."1.29Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995)
" With regard to the hypothesis that cholinergic mechanisms play a crucial role in cognitive processes, M1- and M2-muscarinic acetylcholine receptors, choline acetyltransferase, and high-affinity choline uptake as well as benzodiazepine receptors were studied in selected cortical regions (frontal, temporal, somatosensory, visual, piriform cortex), in amygdala, hippocampus, and in the nucleus basalis of Meynert from adult rats, which received at the age of 25 days a single dosage of 11 mg/kg, s."1.28Effect of kainic acid administration to prepubescent rats on cholinergic markers in selected brain regions of adult rats. ( Guzmán-Godínez, G; Schliebs, R, 1992)
"Choline-treated old animals made more perservation errors, i."1.28Chronic dietary choline enrichment affects DRL responding of old, but not of adult CPBB rats. ( Collijn, D; Kerbusch, S; Raaijmakers, W; van der Staay, FJ, 1992)
"Choline was high at birth and declined thereafter."1.28In vivo 1H and 31P NMR spectroscopy of the developing rat brain. ( Hida, K; Kwee, IL; Nakada, T, 1992)
"All subjects with DS had a trisomy 21 karyotype, and 3 of the 6 older subjects were demented as judged from a history of mental deterioration, disorientation, and memory loss."1.28Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome. ( Atack, JR; Hanin, I; Haxby, JV; May, C; Rapoport, SI; Schapiro, MB, 1990)
"Choline was taken up by a single saturable process with apparent Km = 3."1.28Effects of hemicholinium-3 and sodium ions on choline uptake system in excised superior cervical sympathetic ganglia of rats. ( Iwata, M; Nagata, Y; Tamaru, M, 1989)
" Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males."1.27The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983)
"Biogenic amines in pons and striatum have been dosed in twenty-four months old Wistar male rats."1.27[Biochemical changes in 24-month-old Wistar rats]. ( Della Zuana, O; Duhault, J; Lonchampt, M; Roman, F; Saint Romas, G, 1984)
"Inositol incorporation was also measurable, whereas [14C]serine incorporation was low or undetectable."1.27Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism. ( Ancelin, ML; Capron, A; Torpier, G; Vial, HJ, 1985)
"RBC choline was significantly higher in Korsakoff patients compared with controls (p less than 0."1.27Red cell choline in Korsakoff psychosis. ( Aronoff, A; Barriga, C; Lal, S; Nair, NP; Suranyi-Cadotte, B; Wood, PL, 1985)
"The pharmacokinetics of two unmatched populations of asthmatic children, one from an asthmatic convalescent center in Denver and the other from an urban outpatient clinic, are compared after single and repeated dosing of a new asthma formulation, oxtriphylline syrup."1.26Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup. ( Bell, T; Danish, M; Katsampes, C; Lecks, H; Ragni, M; Rasmussen, C; Simon, T; Yaffe, S, 1980)
"Choline uptake was very low until 12 days postnatally, then the Vmax increased and approached adult values of 29 pmol/mg prot."1.26Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment. ( Krigman, MR; Morell, P; Ramsay, PB, 1980)

Research

Studies (337)

TimeframeStudies, this research(%)All Research%
pre-1990139 (41.25)18.7374
1990's76 (22.55)18.2507
2000's56 (16.62)29.6817
2010's58 (17.21)24.3611
2020's8 (2.37)2.80

Authors

AuthorsStudies
Rodríguez-Nieto, G1
Levin, O2
Hermans, L1
Weerasekera, A1
Sava, AC1
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Shetty, AK1
White, AM1
Filippi, CG1
Deck, MD1
Zimmerman, RD1
Heier, LA1
Accolla, RS1
Gearhart, PJ1
Sigal, NH1
Cancro, MP1
Klinman, NR3
Maniscalco, WM1
Wilson, CM1
Gross, I1
Gobran, L1
Rooney, SA1
Warshaw, JB1
Vernadakis, A2
Ciaranello, RD1
Axelrod, J1
McKearn, JP1
Miller, GW1
Quintáns, J1
Rotter, A1
Field, PM1
Raisman, G1
Hruschak, K1
Horrocks, LA1
Fu, SC1
Atterwill, CK1
Prince, AK1
Miller, SL1
Ghishan, FK1
Shewayhat, W1
Dykes, W1
Abumrad, N1
Guzmán-Godínez, G1
Gomeza, J1
Aragón, C1
Giménez, C1
Raaijmakers, W1
Collijn, D1
Kerbusch, S1
Giusto, NM1
Roque, ME1
Ilincheta de Boschero, MG1
Happe, HK1
Murrin, LC1
Walsh, TJ1
Opello, KD1
Karadsheh, NS1
Rattan, AK1
Tejwani, GA1
Fitkin, JG1
Zhao, XH1
Kitamura, Y1
Nomura, Y1
Hida, K1
Kwee, IL1
Nakada, T1
Babenko, NA1
Filonenko, NS1
Vil'iasen'or, VS1
Nikitin, VN1
Sudo, S1
Murayama, F1
Kono, T1
Kudo, Y1
Goto, S1
Takayama, F1
Yamaguchi, T1
Yamagata, A1
Kostic, V1
Przedborski, S1
Jackson-Lewis, V1
Cadet, JL1
Burke, RE1
Fundarò, A1
Paschero, A1
Rao, MS1
Landis, SC1
Gilad, GM2
Gilad, VH2
Tizabi, Y1
Fordyce, DE1
Farrar, RP1
Casamenti, F2
Scali, C1
Pepeu, G2
Mistry, JS1
Abraham, DJ1
Kozikowski, AP1
Schapiro, MB1
Atack, JR1
May, C1
Haxby, JV1
Rapoport, SI1
van der Knaap, MS1
van Rijen, PC1
Faber, JA1
Valk, J1
Willemse, K1
Smith, DO2
Vannucchi, MG1
Zharhary, D2
Riley, SC1
Froscher, BG1
Linton, PJ1
Marcu, K1
Cazenave, PA1
Martinez, C1
Coutinho, A1
Walch, C1
Bigl, V1
Curti, D1
Dagani, F1
Galmozzi, MR1
Marzatico, F1
Durkin, T1
Binková, B1
Dlohozková, N1
Yavin, E1
Zigler, JS1
Gerber, V2
Ponnappan, U2
Cinader, B2
Blaser, K2
Shimon, M1
Egozi, Y1
Kloog, Y1
Sokolovsky, M1
Cohen, S1
Lorković, H1
Tamaru, M1
Iwata, M1
Nagata, Y1
Frieder, B1
Grimm, VE1
Mizumori, SJ1
Patterson, TA1
Sternberg, H1
Rosenzweig, MR1
Bennett, EL1
Timiras, PS1
Siow, BL1
Kitt, CA1
Walker, LC1
Cornford, ME1
Lieberman, HR1
Abou-Nader, TM1
Johnson, JM1
Skau, KA1
Gerald, MC1
Wallace, LJ1
Muma, NA1
Rowell, PP1
Schultz, GS1
Russell, RW1
Nordenstam, G1
Andersson, B1
Bengtsson, C1
Briles, D1
Scott, G2
Svanborg, A1
Svanborg Edén, C1
Emerit, MB1
Segovia, J1
Alho, H1
Mastrangelo, MJ1
Wise, BC1
Seoane, R2
Faro, J2
Eiras, A2
Lareo, I2
Couceiro, J1
Regueiro, BJ2
Esen Momol, A1
Baker, SP1
Hanai, H1
Ishida, M1
Liang, CT1
Sacktor, B1
Leathwood, PD1
Schlosser, B1
Fisher, A1
Mosharrof, AH1
Petkov, VD1
Petkov, VV1
Fowler, SR1
Okuyama, S1
Ikeda, Y1
Decker, MW1
Pelleymounter, MA1
Gallagher, M1
Pilch, H1
Müller, WE1
Mooradian, AD1
Sirviö, J1
Hervonen, A1
Riekkinen, PJ1
Brehm, R1
Lindmar, R1
Martin, KJ1
Vyas, S1
Briles, DE1
Gray, B1
Crain, MJ1
Blaese, M1
Nahm, M1
Scott, V1
Haber, P1
Weiler, MH1
Church, RM1
Wenk, GL1
Mervis, R1
Horrocks, L1
Demediuk, P1
Wallace, L1
Meyer, DR1
Beall, S1
Caris, K1
Naber, E1
Vial, HJ1
Torpier, G1
Ancelin, ML1
Capron, A1
Gage, FH1
Saito, M1
Kindel, G1
Karczmar, AG1
Rosenberg, A1
Wheeler, DD1
Lal, S1
Barriga, C1
Wood, PL1
Suranyi-Cadotte, B1
Nair, NP1
Aronoff, A1
Gornall, DA1
Kuksis, A1
Pinteric, L1
Mookerjea, S2
McGeer, PL1
Stanton, HC1
Phinney, G1
Mueller, RL1
Mackay, AV1
Portman, OW1
Illingworth, DR1
Alexander, M1
Blatt, JM1
Eisenberg, S1
Stein, O1
Stein, Y1
Marley, E1
Seller, TJ1
Eleftheriou, BE1
Dobson, CL1
Hochschild, R1
Diamond, I1
Fishman, RA1
Bruce, A1
Jato-Rodriguez, JJ1
Ladinsky, H1
Consolo, S1
Peri, G1
Garattini, S1
Freysz, L1
Lastennet, A1
Mandel, P1
Kratzing, CC1
Perry, JJ1
Dewhurst, SA1
McCaman, RE1
Kaplan, WD1
Weinhold, PA1
Wells, IC1
Remy, CN1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Research Network in Nonalcoholic Steatohepatitis: Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)[NCT00063635]Phase 3173 participants (Actual)Interventional2005-09-30Completed
Clinical Research Network in Nonalcoholic Steatohepatitis: Pioglitazone vs. Vitamin E vs. Placebo for the Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis (PIVENS)[NCT00063622]Phase 3247 participants (Actual)Interventional2005-01-31Completed
Feru-guard (Ferulic Acid and Angelica Archangelica Extract) for Behavioral Symptoms in Dementia[NCT03451760]Phase 270 participants (Anticipated)Interventional2018-09-30Not yet recruiting
Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180]70 participants Observational2003-06-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Body Mass Index

(NCT00063635)
Timeframe: baseline and 96 weeks

Interventionkg/m-squared (Mean)
Metformin1.3
Vitamin E2.1
Placebo1.9

Change in Nonalcoholic Fatty Liver Disease (NAFLD) Score (Histologic Feature Scores Determined by Standardized Scoring of Liver Biopsies) From Baseline at 96 Weeks of Treatment

Histological activity was assessed using the NAFLD activity score on a scale of 0 to 8, with higher scores indicating more severe disease; the components of this measure include steatosis (0-3), lobular inflammation (0-3), and hepatocellular ballooning (0-2). (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionunits on a scale (Mean)
Metformin-1.1
Vitamin E-1.8
Placebo-0.7

Change in QOL- Psychosocial Health

Change in self-reported QOL physical health Pediatric Quality of Life Inventory (version 4.0) scores were recorded to range from 0 to 100 with increasing scores indicating better quality of life. (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionunits on a scale (Mean)
Metformin4.0
Vitamin E6.0
Placebo5.6

Change in Quality of Life (QOL) Scores- Physical Health

Change in self-reported QOL physical health Pediatric Quality of Life Inventory (version 4.0) scores were recorded to range from 0 to 100 with increasing scores indicating better quality of life. (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionunits on a scale (Mean)
Metformin5.4
Vitamin E7.6
Placebo5.4

Change in Serum Aspartate Aminotransferase (AST)

(NCT00063635)
Timeframe: baseline and 96 weeks

InterventionIU/L (Mean)
Metformin-21.5
Vitamin E-22.8
Placebo-20.4

Change in Serum Vitamin E Levels

Change in alpha-Tocopherol (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionmg/L (Mean)
Metformin-0.5
Vitamin E9.4
Placebo-0.9

Number of Participants With Improvement in Ballooning Degradation Score

Ballooning is assessed on a scale of 0 to 2 with higher scores indicating more severe ballooning. This secondary outcome measure is the number of participants that experienced a decrease in ballooning score at 96 weeks compared to baseline, which indicates improvement in ballooning. (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Metformin22
Vitamin E22
Placebo10

Number of Participants With Improvement in Liver Fibrosis Score

Fibrosis is assessed on a scale of 0 to 4 with higher scores indicating more severe fibrosis. This secondary outcome measure is the number of participants that experienced a decrease in fibrosis score at 96 weeks compared to baseline, which indicates improvement in fibrosis. (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Metformin22
Vitamin E18
Placebo19

Number of Participants With Improvement in Lobular Inflammation Score

Lobular inflammation is assessed on a scale of 0 to 3 with higher scores indicating more severe lobular inflammation. This secondary outcome measure is the number of participants that experienced a decrease in lobular inflammation score at 96 weeks compared to baseline, which indicates improvement in lobular inflammation. (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Metformin23
Vitamin E22
Placebo20

Number of Participants With Improvement in Steatosis Score

Steatosis is assessed on a scale of 0 to 3 with higher scores indicating more severe steatosis. This secondary outcome measure is the number of participants that experienced a decrease in steatosis score at 96 weeks compared to baseline, which indicates improvement in steatosis. (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Metformin26
Vitamin E27
Placebo19

Number of Participants With Sustained Reduction in Alanine Aminotransferase (ALT) to Either 50% of Baseline Value or < 40 IU/L

The primary outcome was sustained reduction in ALT level, defined as 50% or less of the baseline level or 40 IU/L or less at each visit from 48 to 96 weeks of treatment. (NCT00063635)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Metformin9
Vitamin E15
Placebo10

Number of Participants With Improvement in Fibrosis

Fibrosis is assessed on a scale of 0 to 4 with higher scores indicating more severe fibrosis. This secondary outcome measure is the number of participants that experienced a decrease in fibrosis score, which indicates improvement in fibrosis. (NCT00063622)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Pioglitazone31
Vitamin E33
Placebo22

Number of Participants With Improvement in Hepatocellular Ballooning

Hepatocellular ballooning is assessed on a scale of 0 to 2 with higher scores indicating more severe hepatocellular ballooning. This secondary outcome measure is the number of participants that experienced a decrease in hepatocellular ballooning score, which indicates improvement in hepatocellular ballooning. (NCT00063622)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Pioglitazone31
Vitamin E40
Placebo21

Number of Participants With Improvement in Lobular Inflammation

Lobular inflammation is assessed on a scale of 0 to 3 with higher scores indicating more severe lobular inflammation. This secondary outcome measure is the number of participants that experienced a decrease in lobular inflammation score, which indicates improvement in lobular inflammation. (NCT00063622)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Pioglitazone41
Vitamin E43
Placebo25

Number of Participants With Improvement in Non-alcoholic Fatty Liver Disease (NAFLD) Activity Defined by Change in Standardized Scoring of Liver Biopsies at Baseline and After 96 Weeks of Treatment.

Total nonalcoholic fatty liver disease (NAFLD) activity was assessed on a scale of 0 to 8, with higher scores indicating more severe disease; the components of this measure include steatosis (assessed on a scale of 0 to 3), lobular inflammation (assessed on a scale of 0 to 3), and hepatocellular ballooning (assessed on a scale of 0 to 2). The primary outcome was an improvement in histological findings from baseline to 96 weeks, which required an improvement by 1 or more points in the hepatocellular ballooning score; no increase in the fibrosis score; and either a decrease in the activity score for nonalcoholic fatty liver disease to a score of 3 or less or a decrease in the activity score of at least 2 points, with at least a 1-point decrease in either the lobular inflammation or steatosis score. (NCT00063622)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Pioglitazone27
Vitamin E36
Placebo16

Number of Participants With Improvement in Steatosis

Steatosis is assessed on a scale of 0 to 3 with higher scores indicating more severe steatosis. This secondary outcome measure is the number of participants that experienced a decrease in steatosis score, which indicates improvement in steatosis. (NCT00063622)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Pioglitazone48
Vitamin E43
Placebo22

Number of Participants With Resolution of Definite Nonalcoholic Steatohepatitis

The criteria for nonalcoholic steatohepatitis was definite or possible steatohepatitis (assessed by a pathologist) with an activity score of 5 or more, or definite steatohepatitis (confirmed by two pathologists) with an activity score of 4. This secondary outcome measure is the number of participants who met this definition at baseline and did not meet this definition after 96 weeks of treatment and thus had a resolution of steatohepatitis. (NCT00063622)
Timeframe: baseline and 96 weeks

Interventionparticipants (Number)
Pioglitazone33
Vitamin E29
Placebo15

Reviews

29 reviews available for choline and Aging

ArticleYear
Nutrition and the aging retina: A comprehensive review of the relationship between nutrients and their role in age-related macular degeneration and retina disease prevention.
    Advances in food and nutrition research, 2020, Volume: 93

    Topics: Aging; Antioxidants; Choline; Diet; Dietary Supplements; Docosahexaenoic Acids; Fatty Acids, Unsatur

2020
Examining the relationship between nutrition and cerebral structural integrity in older adults without dementia.
    Nutrition research reviews, 2019, Volume: 32, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Brain; Choline; Cognition; Cognitive Dysfunction; Dementia; Diet; Di

2019
Neurochemical changes in the aging brain: A systematic review.
    Neuroscience and biobehavioral reviews, 2019, Volume: 98

    Topics: Aging; Alzheimer Disease; Animals; Brain; Choline; Cognition; Creatine; Humans

2019
Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan.
    Neuroscience and biobehavioral reviews, 2003, Volume: 27, Issue:4

    Topics: Aging; Animals; Attention; Behavior, Animal; Choline; Cognition; Dietary Supplements; Embryonic and

2003
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
    Advances in experimental medicine and biology, 2006, Volume: 576

    Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries;

2006
[Neurobiological and neurochemical aspects and therapeutic problems in aging and in dementia].
    La Clinica terapeutica, 1980, Oct-31, Volume: 95, Issue:2

    Topics: Age Factors; Aged; Aging; Brain Chemistry; Choline; Dementia; Humans; Nervous System; Nervous System

1980
Neurotransmitter systems in aging and senile dementia.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6

    Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g

1981
Clinical pharmacology of senile dementia.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6

    Topics: Aged; Aging; Anticoagulants; Arginine Vasopressin; Brain; Choline; Dementia; Dihydroergotoxine; Free

1981
[Aging of the nervous system--with special reference to dementia in the aged].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1983, Volume: 20, Issue:1

    Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Dementia; Humans;

1983
Chemotherapy of cognitive disorders in geriatric subjects.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:5

    Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co

1984
Intracerebral neural implants: neuronal replacement and reconstruction of damaged circuitries.
    Annual review of neuroscience, 1984, Volume: 7

    Topics: Adrenergic Fibers; Aging; Animals; Axons; Behavior, Animal; Brain; Brain Stem; Central Nervous Syste

1984
Effects of consumption of choline and lecithin on neurological and cardiovascular systems.
    Federation proceedings, 1982, Volume: 41, Issue:14

    Topics: Acetylcholine; Aging; Arteriosclerosis; Choline; Diet; Humans; Hypercholesterolemia; Memory; Movemen

1982
Alzheimer's disease: a challenging enigma.
    Archives of pathology & laboratory medicine, 1982, Volume: 106, Issue:4

    Topics: Aging; Animals; Brain; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; De

1982
The cholinergic hypothesis of geriatric memory dysfunction.
    Science (New York, N.Y.), 1982, Jul-30, Volume: 217, Issue:4558

    Topics: Acetylcholine; Adult; Aged; Aging; Alzheimer Disease; Animals; Brain Chemistry; Choline; Choline O-A

1982
Age-related changes in rodent cortical acetylcholine and cognition: main effects of age versus age as an intervening variable.
    Brain research. Brain research reviews, 1998, Volume: 27, Issue:2

    Topics: Acetylcholine; Aging; Animals; Carrier Proteins; Cerebral Cortex; Choline; Choline O-Acetyltransfera

1998
Neuroendocrinology of ageing.
    Age and ageing, 2001, Volume: 30, Issue:4

    Topics: Aging; Amino Acid Transport Systems; Animals; Carrier Proteins; Choline; Corticotropin-Releasing Hor

2001
Neuronal--glial interactions during development and aging.
    Federation proceedings, 1975, Volume: 34, Issue:1

    Topics: Acetylcholinesterase; Acetyltransferases; Aging; Animals; Blood-Brain Barrier; Brain; Brain Chemistr

1975
Neuroplasticity, the aging brain, and Alzheimer's disease.
    Neurotoxicology, 1992,Spring, Volume: 13, Issue:1

    Topics: Aging; Alzheimer Disease; Animals; Aziridines; Brain; Brain Tissue Transplantation; Choline; Ganglio

1992
Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: new findings and an interpretative review.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:6

    Topics: Aging; Animals; Binding, Competitive; Brain; Choline; Choline O-Acetyltransferase; Male; Mice; Mice,

1990
Central cholinergic pathways and learning and memory processes: presynaptic aspects.
    Comparative biochemistry and physiology. A, Comparative physiology, 1989, Volume: 93, Issue:1

    Topics: Aging; Animals; Biomechanical Phenomena; Brain; Choline; Hippocampus; Humans; Learning; Memory; Mode

1989
Neurobiological studies of transmitter systems in aging and in Alzheimer-type dementia.
    Annals of the New York Academy of Sciences, 1985, Volume: 457

    Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Amyloid; Animals; Axons; Brain; Cerebral Cortex; Cho

1985
Nutrient transport and the blood-brain barrier in developing animals.
    Federation proceedings, 1986, Volume: 45, Issue:7

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Blood-Brain Barrier; Brain; Cap

1986
Possible dietary strategies to reduce cognitive deficits in old age.
    Progress in brain research, 1986, Volume: 70

    Topics: Acetylcholine; Aging; Amino Acids; Brain; Choline; Cognition; Humans; Neurotransmitter Agents; Nutri

1986
Behavioral correlates of presynaptic events in the cholinergic neurotransmitter system.
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1988, Volume: 32

    Topics: Acetylcholine; Aging; Behavior; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Cholineste

1988
Phosphatidylcholine, choline and cholinergic function.
    International journal for vitamin and nutrition research. Supplement = Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Supplement, 1986, Volume: 29

    Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Alzheimer Disease; Animals; Avoidance Learning; Biological

1986
Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity.
    Annual review of pharmacology and toxicology, 1986, Volume: 26

    Topics: Aged; Aging; Aluminum; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Hapl

1986
Dietary choline and synaptic morphology in mice.
    Nutrition reviews, 1987, Volume: 45, Issue:1

    Topics: Aging; Animals; Choline; Diet; Mice; Mice, Inbred C57BL; Synapses

1987
Neural grafting in animal models of neurodegenerative diseases.
    Annals of the New York Academy of Sciences, 1985, Volume: 457

    Topics: Aging; Animals; Behavior, Animal; Brain; Brain Diseases; Choline; Corpus Striatum; Denervation; Dise

1985
Neurotransmitter synthetic enzymes.
    Progress in neurobiology, 1973, Volume: 2, Issue:1

    Topics: Acetylcholine; Acetyltransferases; Adenylyl Cyclases; Aging; Aminobutyrates; Animals; Brain; Brain C

1973

Trials

14 trials available for choline and Aging

ArticleYear
Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study.
    European journal of nutrition, 2022, Volume: 61, Issue:1

    Topics: Aged; Aging; Betaine; Carbon; Cardiovascular Diseases; Choline; Dietary Supplements; Female; Homocys

2022
Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial.
    Translational psychiatry, 2017, 07-18, Volume: 7, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Brain; Brain-Derived Neurotrophic Factor; Choline; Exercise; Female;

2017
Estimate of choline nutritional requirements for chicks from 1 to 21 days of age.
    Journal of animal physiology and animal nutrition, 2018, Volume: 102, Issue:3

    Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chickens; Choline; Diet; Do

2018
Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adult; Aged; Aging; Aspartic Acid; Choline; Creatinine; Diffusion Tensor Imaging; Female; Gait Disor

2015
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
    The British journal of nutrition, 2012, Volume: 108, Issue:7

    Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Dietary Supplements; Double-Blind Met

2012
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se

2012
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se

2012
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se

2012
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se

2012
The aging hippocampus: cognitive, biochemical and structural findings.
    Cerebral cortex (New York, N.Y. : 1991), 2003, Volume: 13, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Choline; Cognition; Creatine; Female; Hippocam

2003
Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate.
    Psychoneuroendocrinology, 2005, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Age of Onset; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; C

2005
Homocysteine remethylation in broilers fed surfeit choline or betaine and varying levels and sources of methionine from eight to twenty-two days of age.
    Poultry science, 2006, Volume: 85, Issue:10

    Topics: Aging; Animal Feed; Animals; Betaine; Chickens; Choline; Dose-Response Relationship, Drug; Homocyste

2006
Neurotransmitter systems in aging and senile dementia.
    Progress in neuro-psychopharmacology, 1981, Volume: 5, Issue:5-6

    Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g

1981
Proton spectroscopy of human brain: effects of age and sex.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnet

1994
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 76, Issue:2

    Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-A

2001
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
    Journal of neurochemistry, 2001, Volume: 77, Issue:1

    Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female

2001
Methylcholine-activated eccrine sweat gland density and output as a function of age.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:3

    Topics: Adult; Aged; Aging; Choline; Eccrine Glands; Humans; Male; Middle Aged; Sweat; Sweat Glands

1988

Other Studies

295 other studies available for choline and Aging

ArticleYear
Organization of neurochemical interactions in young and older brains as revealed with a network approach: Evidence from proton magnetic resonance spectroscopy (
    NeuroImage, 2023, 02-01, Volume: 266

    Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Motor Cortex; Prefrontal Cor

2023
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
    NeuroImage. Clinical, 2023, Volume: 37

    Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P

2023
Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging.
    Clinical neuroradiology, 2023, Volume: 33, Issue:4

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Magnetic Resonance Imaging; Magnet

2023
One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.
    Neurobiology of disease, 2019, Volume: 132

    Topics: Aging; Animals; Brain; Choline; Dietary Supplements; Male; Methylenetetrahydrofolate Reductase (NADP

2019
Evaluation of Choline and Acetylcholine Levels in Responders and Nonresponders to Anticholinergic Therapy for Overactive Bladder Syndrome.
    Female pelvic medicine & reconstructive surgery, 2020, 12-01, Volume: 26, Issue:12

    Topics: Acetylcholine; Aged; Aging; Biomarkers, Pharmacological; Choline; Cholinergic Antagonists; Correlati

2020
Changes in the intracellular microenvironment in the aging human brain.
    Neurobiology of aging, 2020, Volume: 95

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Cellular M

2020
Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
    International journal of molecular sciences, 2021, Jan-02, Volume: 22, Issue:1

    Topics: Acetyl Coenzyme A; Acetylcholine; Aging; alpha-Amylases; Animals; Cell Line; Choline; Choline O-Acet

2021
Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats.
    Neuroscience, 2017, Oct-11, Volume: 361

    Topics: Aging; Animals; Choline; Dizocilpine Maleate; Doublecortin Protein; Female; Hippocampus; Male; Memor

2017
Lifespan leisure physical activity profile, brain plasticity and cognitive function in old age.
    Aging & mental health, 2019, Volume: 23, Issue:7

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspartic Acid; Attention; Brain; Brain-Derived Neurotro

2019
CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation.
    Hippocampus, 2018, Volume: 28, Issue:4

    Topics: Aging; Alzheimer Disease; Animals; CA1 Region, Hippocampal; Choline; Dietary Supplements; Disease Mo

2018
Effects of Aging on the Human Brain: A Proton and Phosphorus MR Spectroscopy Study at 3T.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2018, Volume: 28, Issue:4

    Topics: Adult; Aged; Aging; Biomarkers; Brain; Choline; Creatine; Female; Gray Matter; Humans; Magnetic Reso

2018
Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 49, Issue:3

    Topics: Aging; Animals; Caspase 1; Cells, Cultured; Choline; Down-Regulation; Galactose; Interleukin-1beta;

2018
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
    Molecular neurobiology, 2019, Volume: 56, Issue:6

    Topics: Aging; Amyloid beta-Peptides; Animals; Anxiety; Brain; Cell Survival; Cerebral Cortex; Choline; CpG

2019
Persistent attenuation of brain oxidative stress through aging in perinatal maternal separated rat pups supplemented with choline and docosahexaenoic acid or Clitoria ternatea aqueous root extract.
    Folia neuropathologica, 2018, Volume: 56, Issue:3

    Topics: Aging; Animals; Antioxidants; Brain; Choline; Clitoria; Dietary Supplements; Docosahexaenoic Acids;

2018
Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2019, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Hippoc

2019
Special issue on advances and controversies in B vitamins and choline.
    Clinical chemistry and laboratory medicine, 2013, Mar-01, Volume: 51, Issue:3

    Topics: Aging; Choline; Dementia; Dietary Supplements; Humans; Risk Factors; Vascular Diseases; Vitamin B Co

2013
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.
    Journal of magnetic resonance imaging : JMRI, 2013, Volume: 38, Issue:6

    Topics: Adult; Aging; Aspartic Acid; Choline; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus;

2013
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
    Arquivos de neuro-psiquiatria, 2013, Volume: 71, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di

2013
Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 134, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Biomarkers; Brain; Brain Stem; Cerebral Cortex;

2013
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; China; Choline; Creatine; Fem

2014
APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.
    Biological psychiatry, 2014, May-01, Volume: 75, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain; Chol

2014
Faster metabolite (1)H transverse relaxation in the elder human brain.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Adolescent; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cellular Microenvironment; Choline; Creat

2013
Brain aging, memory impairment and oxidative stress: a study in Drosophila melanogaster.
    Behavioural brain research, 2014, Feb-01, Volume: 259

    Topics: Acetylcholine; Aging; Animals; Animals, Genetically Modified; Brain; Catalase; Choline; Choline O-Ac

2014
Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs.
    American journal of veterinary research, 2014, Volume: 75, Issue:2

    Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Creatine; Dogs; Female; Lactic Acid; Magnetic Resonan

2014
High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging.
    Neurobiology of aging, 2014, Volume: 35, Issue:7

    Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Functional Neuroimaging; Glucose; Glutamic Acid; Magn

2014
Unexpected lack of deleterious effects of uranium on physiological systems following a chronic oral intake in adult rat.
    BioMed research international, 2014, Volume: 2014

    Topics: Administration, Oral; Aging; Animals; Antioxidants; Blood Cell Count; Cholesterol; Choline; Drinking

2014
Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits.
    Neurology, 2014, Jun-17, Volume: 82, Issue:24

    Topics: Adult; Aging; Apolipoprotein E4; Choline; Cognition Disorders; Cross-Sectional Studies; Female; Fron

2014
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.
    Neurobiology of disease, 2014, Volume: 70

    Topics: Aging; Animals; Basal Forebrain; Cell Count; Cell Size; Choline; Cholinergic Neurons; Dietary Supple

2014
Age related changes in metabolite concentrations in the normal spinal cord.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine;

2014
Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes.
    Neuroscience, 2015, Aug-20, Volume: 301

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Deuterium; Disease Models, Animal; Female; Fragile X

2015
Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome.
    Current Alzheimer research, 2016, Volume: 13, Issue:1

    Topics: Age Factors; Aging; Animals; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Synd

2016
MR Spectra of Normal Adult Testes and Variations with Age: Preliminary Observations.
    European radiology, 2016, Volume: 26, Issue:7

    Topics: Adult; Age Factors; Aged; Aging; Choline; Creatine; Humans; Inositol; Magnetic Resonance Spectroscop

2016
A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice.
    Disease models & mechanisms, 2015, Volume: 8, Issue:12

    Topics: Aging; Alanine Transaminase; Animals; Bile Ducts; Biomarkers; Body Weight; Cell Differentiation; Cel

2015
Effects of Ginkgo biloba Extract EGb 761, Donepezil and their Combination on Central Cholinergic Function in Aged Rats.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2015, Volume: 18, Issue:4

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitor

2015
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
    Schizophrenia research, 2016, Volume: 172, Issue:1-3

    Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin

2016
Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine.
    ACS chemical neuroscience, 2016, 07-20, Volume: 7, Issue:7

    Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Aging; Annexin A5; Apoptosis; Cell Pro

2016
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
    Neuroradiology, 2016, Volume: 58, Issue:10

    Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child,

2016
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
    Neurological research, 2017, Volume: 39, Issue:4

    Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre

2017
Dietary Choline Intake Is Directly Associated with Bone Mineral Density in the Hordaland Health Study.
    The Journal of nutrition, 2017, Volume: 147, Issue:4

    Topics: Aged; Aging; Bone Density; Choline; Diet; Female; Humans; Male; Middle Aged; Odds Ratio

2017
Can magnetic resonance spectroscopy predict neurodevelopmental outcome in very low birth weight preterm infants?
    Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:9

    Topics: Aging; Aspartic Acid; Basal Ganglia; Child Development; Choline; Cohort Studies; Follow-Up Studies;

2008
Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats.
    Brain research, 2008, Oct-27, Volume: 1237

    Topics: Acoustic Stimulation; Aging; Animals; Behavior, Animal; Choline; Dietary Supplements; Discrimination

2008
Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T.
    Magnetic resonance in medicine, 2008, Volume: 60, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spec

2008
An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study.
    Journal of child neurology, 2009, Volume: 24, Issue:1

    Topics: Adolescent; Aging; Aspartic Acid; Basal Ganglia; Case-Control Studies; Cerebral Palsy; Child; Child,

2009
Brain flexibility and balance and gait performances mark morphological and metabolic abnormalities in the elderly.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2008, Volume: 15, Issue:12

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Community Health Planning; Creatine;

2008
Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:1

    Topics: Acetylcholinesterase; Aging; Animals; Brain; Ca(2+) Mg(2+)-ATPase; Choline; Diet; Male; Rats; Rats,

2009
N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disor

2008
Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI).
    Magnetic resonance in medicine, 2009, Volume: 61, Issue:3

    Topics: Adolescent; Adult; Aging; Algorithms; Brain; Brain Injuries; Choline; Female; Humans; Image Enhancem

2009
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
    Psychiatry research, 2009, Jun-30, Volume: 172, Issue:3

    Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi

2009
Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.
    Neurobiology of aging, 2011, Volume: 32, Issue:6

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Humans; Image Processing, Co

2011
Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.
    Journal of neurotrauma, 2010, Volume: 27, Issue:3

    Topics: Adolescent; Age Factors; Aging; Anisotropy; Aspartic Acid; Axons; Biomarkers; Brain Injuries; Child;

2010
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
    Acta radiologica (Stockholm, Sweden : 1987), 2010, Volume: 51, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Fe

2010
Aging and lateralization of the rat brain on a biochemical level.
    Neurochemical research, 2010, Volume: 35, Issue:8

    Topics: 17-Hydroxysteroid Dehydrogenases; Aging; Alzheimer Disease; Animals; Biomarkers; Brain; Cerebrum; Ch

2010
Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome.
    Behavioral neuroscience, 2010, Volume: 124, Issue:3

    Topics: Aging; Animals; Attention; Choline; Cognition; Dietary Supplements; Disease Models, Animal; Down Syn

2010
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging.
    Dementia and geriatric cognitive disorders, 2010, Volume: 30, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chem

2010
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
    Psychiatry research, 2010, Nov-30, Volume: 184, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aging; Amygdala; Aspartic Acid; Asperger Syndrome; Brain Mapping; Ch

2010
Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age.
    Nutrition research (New York, N.Y.), 2010, Volume: 30, Issue:10

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline Deficiency; Diet; Dopamine; Folic Acid; Folic

2010
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:3

    Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A

2011
Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice.
    Journal of agricultural and food chemistry, 2011, Mar-09, Volume: 59, Issue:5

    Topics: Aging; Animals; Anthocyanins; Blueberry Plants; Brain Chemistry; Choline; Fruit; Galactosides; gamma

2011
Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.
    European journal of radiology, 2012, Volume: 81, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Choline; Creatine;

2012
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
    Magnetic resonance in medicine, 2012, Volume: 67, Issue:1

    Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies;

2012
Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions.
    NMR in biomedicine, 2012, Volume: 25, Issue:4

    Topics: Adult; Aged; Aging; Aspartic Acid; Body Mass Index; Brain; Choline; Female; Humans; Magnetic Resonan

2012
Daydreaming about our metaphorical tool belt.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male

2012
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:3

    Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reprodu

2012
Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats.
    Brain research, 2012, Mar-14, Volume: 1443

    Topics: Aging; Animals; Antidepressive Agents; Anxiety; Choline; Depression; Dietary Supplements; Female; Ma

2012
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
    The British journal of nutrition, 2013, Feb-14, Volume: 109, Issue:3

    Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies

2013
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
    Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin

2012
Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats.
    Brain research, 2002, Aug-23, Volume: 947, Issue:1

    Topics: Aging; Animals; Cell Size; Choline; Enzyme-Linked Immunosorbent Assay; Female; Hippocampus; Male; Me

2002
Age-dependent changes in cation transport in the chicken erythrocyte.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2002, Volume: 133, Issue:1

    Topics: Aging; Animals; Cations; Chickens; Choline; Erythrocytes; Ion Transport; Osmolar Concentration; Pota

2002
Choline in the aging brain.
    Brain research, 2002, Oct-04, Volume: 951, Issue:2

    Topics: Aging; Algorithms; Animals; Biological Transport, Active; Brain Chemistry; Cerebral Cortex; Choline;

2002
Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men.
    Radiology, 2003, Volume: 226, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Linear Mode

2003
Age- and sex-dependent effects of ethanol on hippocampal hemicholinium-3 sensitive choline carriers during postnatal development of rats.
    Neurochemical research, 2003, Volume: 28, Issue:3-4

    Topics: Aging; Animals; Animals, Newborn; Anisotropy; Binding Sites; Binding, Competitive; Biological Transp

2003
Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus.
    Nutritional neuroscience, 2003, Volume: 6, Issue:2

    Topics: Aging; Animals; Calbindin 2; Choline; Choline Deficiency; Embryonic and Fetal Development; Female; G

2003
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate

2003
Memory training alters hippocampal neurochemistry in healthy elderly.
    Neuroreport, 2003, Jul-18, Volume: 14, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; Brain Mapping; Cerebral Cortex; Chol

2003
[Treatment of arteriosclerosis in senile patients with essential choline phospholipids in ambulatory conditions and in the health resort].
    Hippokrates, 1961, Oct-15, Volume: 32

    Topics: Aged; Aged, 80 and over; Aging; Arteriosclerosis; Choline; Health Resorts; Phosphatidylcholines; Pho

1961
[Effect of arteriosclerosis therapy with essential choline phospholipids on the ballistocardiogram of senile patients in ambulatory conditions and at the health resort].
    Hippokrates, 1961, Nov-15, Volume: 32

    Topics: Aged; Aged, 80 and over; Aging; Arteriosclerosis; Ballistocardiography; Choline; Health Resorts; Hum

1961
METABOLISM OF PHOSPHATIDES IN DEVELOPING RAT BRAIN--I. INCORPORATION OF RADIOACTIVE PRECURSORS.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aging; Animals; Animals, Newborn; Brain; Choline; Lecithins; Lipid Metabolism; Phosphates; Phosphati

1964
EXPERIMENTS FOR THE CONTROL OF BIOLOGICAL SENESCENCE.
    Therapia Hungarica (English edition), 1965, Volume: 13

    Topics: Aging; Anabolic Agents; Choline; Rats; Steroids; Testosterone Congeners; Vitamin A; Vitamins

1965
Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2003, Volume: 21, Issue:7

    Topics: Acetylcholine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Choline; G

2003
Effect of aging on brain metabolism in antiretroviral-naive HIV patients.
    AIDS (London, England), 2004, Jan-01, Volume: 18 Suppl 1

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Female; Frontal

2004
Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging.
    Journal of neurology, 2004, Volume: 251, Issue:11

    Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Attention; Brain Chemistry; Ch

2004
Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats.
    Biochemical and biophysical research communications, 2005, Feb-18, Volume: 327, Issue:3

    Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Choline; Dentate Gyrus; Glutamic Acid; Glycine; Hydrox

2005
Age-related metabolic changes in the upper brainstem tegmentum by MR spectroscopy.
    Neurobiology of aging, 2005, Volume: 26, Issue:7

    Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Mapping; Choline; Creatine; Female; H

2005
Exposure of postnatal rats to a static magnetic field of 0.14 T influences functional laterality of the hippocampal high-affinity choline uptake system in adulthood; in vitro test with magnetic nanoparticles.
    Neurochemical research, 2005, Volume: 30, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Choline; Drug Carriers; Electromagnetic Fields; Functional Lateral

2005
Aging-related changes of intracellular Ca2+ stores and contractile response of intestinal smooth muscle.
    Experimental gerontology, 2006, Volume: 41, Issue:1

    Topics: Aging; Animals; Calcium; Calcium-Transporting ATPases; Carbonyl Cyanide p-Trifluoromethoxyphenylhydr

2006
MRS of normal and impaired fetal brain development.
    European journal of radiology, 2006, Volume: 57, Issue:2

    Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric

2006
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Chi-Square Distribution;

2006
Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid.
    Calcified tissue international, 2006, Volume: 78, Issue:4

    Topics: Absorptiometry, Photon; Aging; Animals; Bone Density; Calcium; Choline; Dietary Supplements; Female;

2006
Decrease of NAA with aging outside the seizure focus in mesial temporal lobe epilepsy--a proton-MRS study at 3 Tesla.
    Brain research, 2007, Nov-07, Volume: 1179

    Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Drug Resistance; Epilepsy, Temporal Lobe

2007
Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy.
    European journal of radiology, 2008, Volume: 68, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Imaging, Th

2008
Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
    Journal of magnetic resonance imaging : JMRI, 2007, Volume: 26, Issue:6

    Topics: Aged; Aged, 80 and over; Aging; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Fema

2007
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
    NeuroImage, 2008, Mar-01, Volume: 40, Issue:1

    Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr

2008
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia.
    BMC pharmacology, 2008, Jan-23, Volume: 8

    Topics: Aging; Amnesia; Amyloid beta-Peptides; Animals; Cerebrovascular Circulation; Choline; Cognition Diso

2008
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
    Journal of neurotrauma, 2008, Volume: 25, Issue:6

    Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C

2008
[Biochemical changes in 24-month-old Wistar rats].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1984, Volume: 178, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholinesterase; Aging; Animals; Choline; Choline O-Acetyltrans

1984
Effects of aging on rat cortical presynaptic cholinergic processes.
    Neurobiology of aging, 1984,Winter, Volume: 5, Issue:4

    Topics: Acetylcholine; Aging; Animals; Atropine; Cerebral Cortex; Choline; Culture Techniques; Dose-Response

1984
Lecithin and memory.
    Lancet (London, England), 1980, Feb-09, Volume: 1, Issue:8163

    Topics: Acetylcholine; Aging; Animals; Choline; Humans; Memory; Paired-Associate Learning; Phosphatidylcholi

1980
Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate.
    Journal of neurochemistry, 1980, Volume: 34, Issue:6

    Topics: Acetylcholine; Aging; Animals; Azo Compounds; Cerebral Cortex; Choline; Choline O-Acetyltransferase;

1980
Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy.
    Neurotoxicology, 1984,Spring, Volume: 5, Issue:1

    Topics: Acetylcholinesterase; Aging; Animals; Brain Chemistry; Choline; Chronic Disease; Disease Models, Ani

1984
Alzheimer's disease and Down's syndrome.
    Annals of the New York Academy of Sciences, 1982, Volume: 396

    Topics: Acetylcholinesterase; Adult; Aged; Aging; Alzheimer Disease; Animals; Axons; Brain; Choline; Choline

1982
Age dependent variations in choline and ethanolamine phosphorylating activities of rodents.
    Biochemistry and experimental biology, 1980, Volume: 16, Issue:3

    Topics: Aging; Animals; Choline; Choline Kinase; Ethanolamine; Ethanolamines; Kidney; Liver; Mice; Phosphory

1980
Functional maturation of motor nerve terminals in the avian iris: ultrastructure, transmitter metabolism and synaptic reliability.
    The Journal of physiology, 1981, Volume: 321

    Topics: Acetylcholine; Aging; Animals; Chick Embryo; Choline; Iris; Membrane Potentials; Microscopy, Electro

1981
Pentoxifylline reverses age-related deficits in spatial memory.
    Behavioral and neural biology, 1984, Volume: 42, Issue:1

    Topics: Aging; Animals; Choline; Cues; Discrimination Learning; Male; Memory; Mental Recall; Orientation; Pe

1984
Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6

    Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Cell Membrane; Choline; Cholinergic Fibers;

1984
Neurotrophic effects of hippocampal extracts on medial septal nucleus in vitro.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:8

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Ganglia, Spinal; Hippoca

1984
Relationship between nutrition and dementia in the elderly.
    Psychiatric medicine, 1983, Volume: 1, Issue:4

    Topics: Acetylcholine; Aged; Aged, 80 and over; Aging; Aluminum; Choline; Cognition; Dementia; Folic Acid; H

1983
Uptake and metabolism of choline in the organotypic culture of newborn mouse cerebellum.
    Journal of biochemistry, 1983, Volume: 94, Issue:3

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Biological Transport; Brain; Carbon Radioisotopes;

1983
Study of subacute toxicity of CDP-choline after 30 days of oral administration to rats.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:7A

    Topics: Administration, Oral; Aging; Animals; Choline; Cytidine Diphosphate Choline; Diet; Eating; Female; M

1983
Efficacy and safety of oral CDP-choline. Drug surveillance study in 2817 cases.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:7A

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aging; Cerebrovascular Disorders; Child; Choline; Cyt

1983
The effect of cytidine-diphosphate choline (CDP-choline) on brain lipid changes during aging.
    Journal of neuroscience research, 1984, Volume: 11, Issue:1

    Topics: Aging; Animals; Brain; Carbon Radioisotopes; Choline; Cytidine Diphosphate Choline; Lipid Metabolism

1984
Effects of chronic manipulations of dietary choline on locomotor activity, discrimination learning and cortical acetylcholine release in aging adult Fisher 344 rats.
    Neurobiology of aging, 1984,Spring, Volume: 5, Issue:1

    Topics: Acetylcholine; Aging; Animals; Cerebral Cortex; Choline; Discrimination Learning; Male; Motor Activi

1984
Expression of a distinct B cell clonotype profile after recovery from antigen-induced unresponsiveness.
    European journal of immunology, 1982, Volume: 12, Issue:6

    Topics: Aging; Animals; Antibody-Producing Cells; Antigens; B-Lymphocytes; Choline; Clone Cells; Hemolytic P

1982
Metabolic studies of N-bases of phospholipids and long chain bases of sphingolipids in two-weeks-old mouse brain tissue in comparison with one-month-old mouse visceral tissues.
    The Japanese journal of experimental medicine, 1980, Volume: 50, Issue:4

    Topics: Aging; Animals; Brain; Choline; Decarboxylation; Ethanolamines; Mice; Phospholipids; Serine; Sphingo

1980
Can drugs halt memory loss?
    Geriatrics, 1981, Volume: 36, Issue:2

    Topics: Aged; Aging; Amnesia; Animals; Choline; Cholinergic Fibers; Female; Haplorhini; Humans; Male; Memory

1981
The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:1

    Topics: Adult; Aged; Aging; Alzheimer Disease; Carbachol; Choline; Dementia; Dose-Response Relationship, Dru

1983
Effects of postnatal trimethyltin or triethyltin treatment on CNS catecholamine, GABA, and acetylcholine systems in the rat.
    Journal of neurochemistry, 1983, Volume: 40, Issue:5

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Dopamine; gamma-Aminobutyric Acid; Norepinephrine; Or

1983
Calcium-dependent [3H]acetylcholine release and muscarinic autoreceptors in rat cortical synaptosomes during development.
    Neurochemical research, 1983, Volume: 8, Issue:5

    Topics: Acetylcholine; Aging; Animals; Calcium; Cerebral Cortex; Choline; Kinetics; Rats; Rats, Inbred Strai

1983
Metabolic activity of developing rat lung.
    Biology of the neonate, 1981, Volume: 39, Issue:3-4

    Topics: Aging; Animals; Animals, Newborn; Choline; Female; Glucosamine; Glycoproteins; Lung; Palmitic Acids;

1981
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
    Drug-nutrient interactions, 1982, Volume: 1, Issue:4

    Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; R

1982
Developmental changes in rat blood choline concentration.
    The Biochemical journal, 1981, Sep-15, Volume: 198, Issue:3

    Topics: Aging; Alcohol Oxidoreductases; Animals; Animals, Newborn; Choline; Diet; Female; Kinetics; Liver; M

1981
Surfactant phosphatidylcholine source, fluxes, and turnover times in 3-day-old, 10-day-old, and adult rabbits.
    The Journal of biological chemistry, 1982, Feb-25, Volume: 257, Issue:4

    Topics: Aging; Animals; Carbon Radioisotopes; Choline; Kinetics; Mathematics; Palmitic Acid; Palmitic Acids;

1982
The effects of chronic manganese chloride treatment expressed as age-dependent, transient changes in rat brain synaptosomal uptake of amines.
    Journal of neurochemistry, 1982, Volume: 38, Issue:3

    Topics: Aging; Animals; Biological Transport; Brain; Chlorides; Choline; Dopamine; Male; Manganese; Manganes

1982
Phosphorylcholine and phosphorylethanolamine concentrations in the lens.
    Experimental eye research, 1982, Volume: 34, Issue:2

    Topics: Aging; Animals; Cataract; Chickens; Choline; Culture Techniques; Ethanolamines; Female; Humans; Lens

1982
Developmental modulations of blood-brain barrier permeability as an indicator of changing nutritional requirements in the brain.
    Pediatric research, 1982, Volume: 16, Issue:4 Pt 1

    Topics: Adenine; Aging; Animals; Animals, Newborn; Arginine; Blood-Brain Barrier; Brain; Butanols; Choline;

1982
Plasma choline and blood cholinesterases in aged rats.
    Gerontology, 1982, Volume: 28, Issue:2

    Topics: Aging; Animals; Choline; Cholinesterases; Erythrocytes; Male; Rats; Rats, Inbred F344; Rats, Inbred

1982
Control of phosphatidylcholine biosynthesis in myopathic hamster hearts.
    The Journal of biological chemistry, 1982, Sep-25, Volume: 257, Issue:18

    Topics: Aging; Animals; Cardiomyopathies; Choline; Cricetinae; Cytidine Diphosphate Choline; Cytidine Tripho

1982
Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments.
    Neurobiology of aging, 1981,Summer, Volume: 2, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Choline; Choline O-Acetyltransferase; Hippoca

1981
Immune response to phosphorylcholine. VIII. The response CBA/N mice to PC-LPS.
    Journal of immunology (Baltimore, Md. : 1950), 1981, Volume: 126, Issue:5

    Topics: Aging; Animals; Antibody Formation; Antibody Specificity; Choline; Female; Immunoglobulin G; Immunog

1981
Carrier mediated transport of choline in rat lens.
    Experimental eye research, 1981, Volume: 32, Issue:6

    Topics: Aging; Animals; Biological Transport, Active; Choline; Culture Techniques; Ethanolamines; Lens, Crys

1981
Brain acetylcholine synthesis declines with senescence.
    Science (New York, N.Y.), 1981, Aug-07, Volume: 213, Issue:4508

    Topics: Acetylcholine; Aging; Animals; Behavior, Animal; Brain; Choline; Glucose; Lactates; Mice

1981
Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.
    Neurobiology of aging, 1981,Summer, Volume: 2, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Choline; Male; Memory; Parasympathetic Nervous Syste

1981
Development and aging of cholinergic synapses. VI. Mechanisms of acetylcholine biosynthesis in the chick iris.
    Developmental neuroscience, 1981, Volume: 4, Issue:6

    Topics: Acetylcholine; Aging; Animals; Chick Embryo; Chickens; Choline; Cholinesterase Inhibitors; Cold Temp

1981
Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup.
    Annals of allergy, 1980, Volume: 44, Issue:2

    Topics: Administration, Oral; Aging; Body Height; Body Weight; Child; Choline; Female; Humans; Kinetics; Mal

1980
Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment.
    Brain research, 1980, Apr-14, Volume: 187, Issue:2

    Topics: Aging; Animals; Biological Transport; Body Weight; Brain; Cerebral Cortex; Choline; Corpus Striatum;

1980
Age-related changes in passive avoidance retention: modulation with dietary choline.
    Science (New York, N.Y.), 1980, Jul-11, Volume: 209, Issue:4453

    Topics: Administration, Oral; Aging; Animals; Avoidance Learning; Choline; Mice; Mice, Inbred Strains; Time

1980
Age dependent changes in choline uptake of the chick iris.
    Brain research, 1980, Aug-18, Volume: 195, Issue:2

    Topics: Acetylcholine; Aging; Animals; Chickens; Choline; Iris; Kinetics; Sodium; Temperature

1980
Development and aging of cholinergic synapses. II. Continuous growth of acetylcholine and choline levels in autonomic ganglia and iris of the chick.
    Developmental neuroscience, 1980, Volume: 3, Issue:1

    Topics: Acetylcholine; Aging; Animals; Chickens; Choline; Ganglia, Autonomic; Ganglia, Parasympathetic; Gang

1980
Newborn rabbit blood-brain barrier is selectively permeable and differs substantially from the adult.
    Journal of neurochemistry, 1980, Volume: 34, Issue:1

    Topics: Adenine; Adenosine; Aging; Amino Acids; Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Carbo

1980
Development and aging of cholinergic synapses. III. Choline uptake in the developing iris of the chick.
    Developmental neuroscience, 1980, Volume: 3, Issue:4-6

    Topics: Aging; Animals; Biological Transport; Chick Embryo; Chickens; Choline; Cholinergic Fibers; Iris; Kin

1980
Food for thought.
    Nature medicine, 1995, Volume: 1, Issue:10

    Topics: Aging; Brain Chemistry; Choline; Diet; Humans; Magnetic Resonance Spectroscopy; Neurons

1995
Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.
    JAMA, 1995, Sep-20, Volume: 274, Issue:11

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood-Brain Barrier; Brain

1995
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.
    Carcinogenesis, 1995, Volume: 16, Issue:2

    Topics: Aging; Animals; Cell Membrane; Choline; Choline Deficiency; Diglycerides; Fatty Acids; gamma-Glutamy

1995
Nicotine improves cognitive disturbance in senescence-accelerated mice.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3

    Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Body Weight; Brain Chemistry; Choline; Cognition

1994
Age-related changes of cholinergic markers in the rat brain.
    Japanese journal of pharmacology, 1994, Volume: 66, Issue:2

    Topics: Acetylcholinesterase; Aging; Animals; Binding, Competitive; Biomarkers; Cerebral Cortex; Choline; Ch

1994
Evidence for age-associated reduction in acetylcholine release and smooth muscle response in the rat colon.
    The American journal of physiology, 1994, Volume: 267, Issue:4 Pt 1

    Topics: Acetylcholine; Aging; Animals; Choline; Colon; Electric Stimulation; Gastrointestinal Motility; In V

1994
[Experimental techniques for developing new drugs acting on dementia (4)--Aged rats].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1994, Volume: 14, Issue:4

    Topics: Acetylcholinesterase; Aging; Animals; Choline; Choline O-Acetyltransferase; Dementia; Female; Male;

1994
Changes in the cholinergic neurochemical parameters in regional brain areas of Wistar rats aged 3 (weanling), 10 (mature) and 119 (old age) weeks.
    Laboratory animal science, 1994, Volume: 44, Issue:4

    Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Ma

1994
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging.
    Annals of neurology, 1994, Volume: 36, Issue:1

    Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Axons; Brain; Cerebral Cortex; Cerebral Ventricles; C

1994
Nerve growth factor affects the cholinergic neurochemistry and behavior of aged rats.
    Progress in brain research, 1993, Volume: 98

    Topics: Acetylcholine; Aging; Animals; Behavior, Animal; Biomarkers; Choline; Choline O-Acetyltransferase; C

1993
Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:9

    Topics: Acetylcholine; Aging; Animals; Biomarkers; Brain; Cerebral Ventricles; Choline; Choline O-Acetyltran

1993
The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium.
    Magnetic resonance imaging, 1993, Volume: 11, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Magnetic Res

1993
Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats.
    Brain research, 1993, Feb-26, Volume: 604, Issue:1-2

    Topics: Aging; Animals; Choline; Choline O-Acetyltransferase; Corpus Striatum; Frontal Lobe; Hippocampus; Le

1993
Improving effect of acetylcholine receptor agonists on a deficit of 2-deoxyglucose uptake in cerebral cortical and hippocampal slices in aged and AF64A-treated rats.
    Brain research, 1993, Feb-19, Volume: 603, Issue:2

    Topics: Acetylcholine; Aging; Animals; Aziridines; Cerebral Cortex; Cerebral Ventricles; Choline; Deoxygluco

1993
Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E.
    Neurochemistry international, 1993, Volume: 22, Issue:5

    Topics: Aging; Animals; Aziridines; Brain; Choline; Choline O-Acetyltransferase; Corpus Striatum; Frontal Lo

1993
Spatial learning impairment in aged rats: comparing between aged basal forebrain lesioned and normal aged rats.
    Behavioural brain research, 1995, Volume: 70, Issue:1

    Topics: Acetylcholinesterase; Aging; Animals; Aziridines; Cerebral Cortex; Choline; Choline O-Acetyltransfer

1995
Cholinergic changes in the hippocampus of stroke-prone spontaneously hypertensive rats.
    Stroke, 1996, Volume: 27, Issue:3

    Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Cerebral Cortex; Cerebrovascular Disorders; Choli

1996
Cholinergic and Related Mechanisms in Aging and Disease: a Tribute to Donald J. Jenden, M.D. Los Angeles, California, November 17-18, 1995.
    Life sciences, 1996, Volume: 58, Issue:22

    Topics: Acetylcholine; Aging; Animals; Choline; History, 20th Century; Humans; Receptors, Cholinergic

1996
The influence of aging on whole body choline release and clearance.
    Life sciences, 1996, Volume: 58, Issue:22

    Topics: Aging; Animals; Choline; Hypoxia; Male; Rats

1996
Cholinergic control of cerebral blood flow in stroke, trauma and aging.
    Life sciences, 1996, Volume: 58, Issue:22

    Topics: Acetylcholine; Aging; Animals; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Choline;

1996
In vivo proton magnetic resonance spectroscopy of the normal aging human brain.
    Life sciences, 1996, Volume: 58, Issue:22

    Topics: Adult; Aged; Aging; Body Water; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Inositol

1996
Modulation of cholinergic synaptic functions by sialylcholesterol.
    Glycoconjugate journal, 1996, Volume: 13, Issue:2

    Topics: Acetylcholine; Aging; Animals; Calcium; Cerebral Cortex; Cholesterol Esters; Choline; Female; Gangli

1996
Effects of nicotinamide on central cholinergic transmission and on spatial learning in rats.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:4

    Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Choline; Cognition; Extracellular Space; Hippocampus

1996
Cerebral ischemia in young and adult gerbils: effects on cholinergic metabolism.
    Neurochemistry international, 1996, Volume: 28, Issue:3

    Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Choline; Gerbillinae; Ischemic Attack, Transi

1996
Age-dependent effect of AF64A on cholinergic activity in the septo-hippocampal pathway of the rat brain: decreased responsiveness in aged rats.
    Neuroscience letters, 1996, Jan-19, Volume: 203, Issue:2

    Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Aziridines; Choline; Choline O-Acetyltransf

1996
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
    Schizophrenia research, 1996, Oct-18, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterali

1996
The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer's disease.
    Biophysical journal, 1997, Volume: 73, Issue:3

    Topics: Acetylcholine; Age of Onset; Aging; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cell Membrane;

1997
Age-related variations in hepatic biosynthesis of phosphatidylcholine: a study of choline metabolism with perfused rat liver.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1997, Volume: 216, Issue:1

    Topics: Aging; Animals; Bile; Choline; Lipoproteins, VLDL; Liver; Male; Perfusion; Phosphatidylcholines; Rat

1997
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly.
    Stroke, 1997, Volume: 28, Issue:10

    Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Intracranial Arteriosclerosis; Magneti

1997
Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study.
    Cerebral cortex (New York, N.Y. : 1991), 1997, Volume: 7, Issue:8

    Topics: Aging; Amygdala; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Choline; Creatine; Entorhinal

1997
Protection against developmental deficiencies by a lipophilic VIP analogue.
    Neurochemical research, 1998, Volume: 23, Issue:5

    Topics: Aging; Animals; Aziridines; Choline; Hypoxia; Intellectual Disability; Male; Maze Learning; Memory;

1998
Choline availability modulates the expression of TGFbeta1 and cytoskeletal proteins in the hippocampus of developing rat brain.
    Neurochemical research, 1998, Volume: 23, Issue:5

    Topics: Aging; Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Biomarkers; Brain; Choline;

1998
GM1 and the aged brain.
    Annals of the New York Academy of Sciences, 1998, Jun-19, Volume: 845

    Topics: Acetylcholine; Aging; Animals; Biological Transport; Brain; Choline; Choline O-Acetyltransferase; G(

1998
Gangliosides and sialylcholesterol as modulators of synaptic functions.
    Annals of the New York Academy of Sciences, 1998, Jun-19, Volume: 845

    Topics: Acetylcholine; Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carrier Proteins

1998
Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
    Neuroreport, 1998, Jun-22, Volume: 9, Issue:9

    Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Creatine; Female; Inosito

1998
Effects of K+-depolarization, arachidonic acid, ethanol, and aging on the high-affinity choline transport in rat hippocampus.
    Neurochemical research, 1998, Volume: 23, Issue:7

    Topics: Aging; Animals; Arachidonic Acid; Biological Transport; Choline; Ethanol; Female; Hemicholinium 3; H

1998
Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:7

    Topics: Aging; Aniline Compounds; Animals; Avoidance Learning; Aziridines; Bridged Bicyclo Compounds; Cholin

1998
Choline, a vital amine.
    Science (New York, N.Y.), 1998, Aug-07, Volume: 281, Issue:5378

    Topics: Acetylcholine; Aging; Animals; Apoptosis; Brain; Cell Division; Choline; Choline Deficiency; Cogniti

1998
Diurnal rhythms in norepinephrine and acetylcholine synthesis of sympathetic ganglia, heart and adrenals of aging rats: effect of melatonin.
    Journal of the autonomic nervous system, 1998, Nov-25, Volume: 74, Issue:1

    Topics: Acetylcholine; Adrenal Glands; Aging; Animals; Choline; Circadian Rhythm; Ganglia, Sympathetic; Hear

1998
In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging.
    Magnetic resonance in medicine, 1999, Volume: 41, Issue:2

    Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Reso

1999
Exercise- and methylcholine-induced sweating responses in older and younger men: effect of heat acclimation and aerobic fitness.
    International journal of biometeorology, 1999, Volume: 42, Issue:4

    Topics: Adaptation, Physiological; Adult; Aged; Aging; Choline; Exercise; Hot Temperature; Humans; Male; Mid

1999
MR image segmentation and tissue metabolite contrast in 1H spectroscopic imaging of normal and aging brain.
    Magnetic resonance in medicine, 1999, Volume: 41, Issue:4

    Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Choline; Creatine;

1999
Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.
    Neuroscience, 1999, Volume: 91, Issue:2

    Topics: Aging; Alkaloids; Animals; Axons; Azocines; Carbachol; Choline; Excitatory Postsynaptic Potentials;

1999
1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men.
    Magnetic resonance in medicine, 1999, Volume: 42, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Energy Metab

1999
Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus.
    Developmental neuroscience, 1999, Volume: 21, Issue:2

    Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Choline; Choline Deficiency; Corpus Striatum

1999
Developmental changes in choline- and ethanolamine-containing compounds measured with proton-decoupled (31)P MRS in in vivo human brain.
    Magnetic resonance in medicine, 1999, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Brain; Brain Chemistry; Brain Diseases; Child; Child, Preschool; Cho

1999
Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.
    Brain research. Developmental brain research, 1999, Dec-10, Volume: 118, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Choline; Electric Stimulation; Female; Fetus; Hippocampus; In Vitr

1999
Blood-brain barrier choline transport in the senescent rat.
    Neuroscience letters, 1999, Dec-31, Volume: 277, Issue:3

    Topics: Aging; Animals; Biological Transport; Blood-Brain Barrier; Choline; Hemicholinium 3; Neurotransmitte

1999
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
    Magnetic resonance imaging, 2000, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I

2000
Potentiation of brain acetylcholine neurons by Kami-Untan-To (KUT) in aged mice: implications for a possible antidementia drug.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2000, Volume: 7, Issue:4

    Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Central Nervous System Agents; Choline; Cho

2000
Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:1

    Topics: Adult; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectrosco

2001
Development and aging of the cerebrum: assessment with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2001, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Ch

2001
Recovery of water maze performance in aged versus young rats after brain injury with the impact acceleration model.
    Journal of neurotrauma, 2000, Volume: 17, Issue:12

    Topics: Acceleration; Aging; Animals; Binding, Competitive; Brain; Brain Injuries; Choline; Male; Maze Learn

2000
Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.
    Journal of neurochemistry, 2001, Volume: 77, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Aging; Anesthetics, Inhalation; Animals; Choline; Cholinesteras

2001
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging.
    Magnetic resonance in medicine, 2001, Volume: 45, Issue:5

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline;

2001
A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations.
    Cerebral cortex (New York, N.Y. : 1991), 2001, Volume: 11, Issue:7

    Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Choline; Creatinine; Frontal Lobe; Humans; M

2001
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
    Neuroreport, 2001, Aug-08, Volume: 12, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio

2001
Quantitative evaluation of cerebral metabolites and cerebral blood flow in patients with carotid stenosis.
    Neurological research, 2001, Volume: 23, Issue:6

    Topics: Adult; Aged; Aging; Aspartic Acid; Basal Ganglia; Brain Ischemia; Carotid Stenosis; Cerebral Cortex;

2001
Phosphatidylcholine molecular species in lung surfactant: composition in relation to respiratory rate and lung development.
    American journal of respiratory cell and molecular biology, 2001, Volume: 25, Issue:6

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Aging; Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid;

2001
Effects of estrogen replacement therapy on human brain aging: an in vivo 1H MRS study.
    Neurology, 2001, Dec-11, Volume: 57, Issue:11

    Topics: Adult; Aged; Aging; Brain; Choline; Estrogen Replacement Therapy; Female; Hippocampus; Humans; Long-

2001
Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats.
    Neuroscience research, 2001, Volume: 41, Issue:4

    Topics: Acetylcholine; Aging; Animals; Aziridines; Body Temperature Regulation; Choline; Cholinergic Fibers;

2001
Prenatal choline supplementation protects against postnatal neurotoxicity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jan-01, Volume: 22, Issue:1

    Topics: Aging; Animals; Cell Count; Choline; Cytoprotection; Dietary Supplements; Dizocilpine Maleate; Excit

2002
Developmental delay in children: assessment with proton MR spectroscopy.
    AJNR. American journal of neuroradiology, 2002, Volume: 23, Issue:5

    Topics: Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Developmental Disabilities;

2002
Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells.
    European journal of immunology, 1977, Volume: 7, Issue:12

    Topics: Aging; Animals; Animals, Newborn; Antibody Formation; B-Lymphocytes; Choline; Clone Cells; Epitopes;

1977
Development of glycogen and phospholipid metabolism in fetal and newborn rat lung.
    Biochimica et biophysica acta, 1978, Sep-28, Volume: 530, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Choline; Fetus; Gestational Age; Glucose; Glycogen; Glycogen Synth

1978
Effects of dexamethasone of neurotransmitter enzymes in chromaffin tissue of the newborn rat.
    Journal of neurochemistry, 1975, Volume: 24, Issue:4

    Topics: Acetyltransferases; Adrenal Glands; Adrenocorticotropic Hormone; Aging; Animals; Aorta; Basal Gangli

1975
The immune response in NZB mice of different ages to thymus-dependent and thymus-independent phosphorylcholine antigens.
    Immunology, 1978, Volume: 34, Issue:6

    Topics: Aging; Animals; Antibody Formation; Antigens; Choline; Female; Haptens; Hemolytic Plaque Technique;

1978
Muscarinic receptofs in the central nervous system of the rat. III. Postnatal development of binding of [3H]propylbenzilylcholine mustard.
    Brain research, 1979, Volume: 180, Issue:2

    Topics: Aging; Animals; Autoradiography; Brain; Choline; Female; Propylbenzilylcholine Mustard; Rats; Recept

1979
Development and aging of cholinergic synapses. I. Endogenous levels of acetylcholine and choline in developing autonomic ganglia and iris of the chick.
    Developmental neuroscience, 1979, Volume: 2, Issue:5

    Topics: Acetylcholine; Aging; Animals; Chickens; Choline; Ganglia, Autonomic; Ganglia, Parasympathetic; Gang

1979
Pathway for hydrolysis of plasmalogens in brain.
    Advances in experimental medicine and biology, 1978, Volume: 101

    Topics: Aging; Animals; Brain; Choline; Ethanolamines; Hydrolases; Kinetics; Plasmalogens; Rats; Species Spe

1978
Multiple forms of choline acetyltransferase and the high affinity uptake of choline in brain of developing and adult rats.
    Journal of neurochemistry, 1978, Volume: 31, Issue:3

    Topics: Aging; Animals; Biological Transport, Active; Brain; Choline; Choline O-Acetyltransferase; Isoelectr

1978
Turnover of phosphatidylcholine in microsomes and myelin in brains of young and adult rats.
    Journal of neurochemistry, 1978, Volume: 31, Issue:4

    Topics: Aging; Animals; Brain; Choline; Female; Glycerol; Male; Microsomes; Myelin Sheath; Phosphatidylcholi

1978
Ontogeny of glutamine transport by rat liver plasma membrane vesicles.
    Journal of developmental physiology, 1992, Volume: 18, Issue:1

    Topics: Aging; Amino Acids; Analysis of Variance; Animals; Animals, Suckling; Biological Transport, Active;

1992
Effect of kainic acid administration to prepubescent rats on cholinergic markers in selected brain regions of adult rats.
    Neurochemistry international, 1992, Volume: 21, Issue:3

    Topics: Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Flunitrazepam; Kainic Acid; Male; Organ

1992
High-affinity transport of choline and amino acid neurotransmitters in synaptosomes from brain regions after lesioning the nucleus basalis magnocellularis of young and aged rats.
    Neurochemical research, 1992, Volume: 17, Issue:4

    Topics: Aging; Amino Acids; Animals; Biological Transport; Brain; Choline; Male; Neurotransmitter Agents; Ra

1992
Chronic dietary choline enrichment affects DRL responding of old, but not of adult CPBB rats.
    Physiology & behavior, 1992, Volume: 52, Issue:6

    Topics: Aging; Animals; Appetitive Behavior; Choline; Extinction, Psychological; Female; Rats; Rats, Inbred

1992
Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system.
    Lipids, 1992, Volume: 27, Issue:11

    Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Choline; Fatty Acids; Medulla Oblongata; Palmiti

1992
Development of high-affinity choline transport sites in rat forebrain: a quantitative autoradiography study with [3H]hemicholinium-3.
    The Journal of comparative neurology, 1992, Jul-22, Volume: 321, Issue:4

    Topics: Acetylcholine; Aging; Animals; Atropine; Autoradiography; Binding, Competitive; Biological Transport

1992
GM1 ganglioside enhances cholinergic parameters in the brain of senescent rats.
    Neuroscience, 1992, Volume: 46, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Brain; Brain Chemistry; Choline; Choline O-Acet

1992
Age-related changes in NMDA-induced [3H]acetylcholine release from brain slices of senescence-accelerated mouse.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1992, Volume: 10, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Calcium; Choline; Hemicholinium 3; In Vitro Techniqu

1992
In vivo 1H and 31P NMR spectroscopy of the developing rat brain.
    Magnetic resonance in medicine, 1992, Volume: 23, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Hy

1992
[Stimulation of phospholipase D by thyroid hormones in hepatocytes of rats of various ages and thyroid status].
    Doklady Akademii nauk SSSR, 1991, Volume: 320, Issue:3

    Topics: Aging; Animals; Cell Membrane; Choline; Diglycerides; Enzyme Activation; Hypothyroidism; Liver; Male

1991
[Effects of kamikihi-to, a Chinese traditional medicine, on various cholinergic biochemical markers in the brains of aged rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1991, Volume: 98, Issue:4

    Topics: Acetylcholinesterase; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Drugs, Chinese He

1991
Serotonergic ligand binding in aging brain of experimental animals.
    Neurochemical research, 1991, Volume: 16, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Aging; Animals; Brain; Cell Membrane; Cerebel

1991
Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on striatal muscarinic cholinergic receptors and high-affinity choline uptake sites: a quantitative autoradiographic study.
    Journal of neurochemistry, 1991, Volume: 57, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain Ischemia; Choline; Co

1991
Dietary choline manipulations and behavioural modifications in rats in the early stages of aging.
    Progress in neuro-psychopharmacology & biological psychiatry, 1991, Volume: 15, Issue:5

    Topics: Aging; Animals; Behavior, Animal; Choline; Choline Deficiency; Conditioning, Operant; Diet; Discrimi

1991
Characterization of a target-derived neuronal cholinergic differentiation factor.
    Neuron, 1990, Volume: 5, Issue:6

    Topics: Aging; Animals; Cell Differentiation; Cells, Cultured; Choline; Choline O-Acetyltransferase; Glycopr

1990
Aging and stress-induced changes in choline and glutamate uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:6

    Topics: Aging; Animals; Brain; Choline; Glutamates; Glutamic Acid; Hippocampus; Longevity; Male; Rats; Rats,

1990
Effect of physical activity on hippocampal high affinity choline uptake and muscarinic binding: a comparison between young and old F344 rats.
    Brain research, 1991, Feb-08, Volume: 541, Issue:1

    Topics: Adrenal Glands; Aging; Animals; Binding, Competitive; Body Weight; Choline; Hippocampus; Male; Musca

1991
Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study.
    European journal of pharmacology, 1991, Feb-26, Volume: 194, Issue:1

    Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Choline; Chromatography, Hig

1991
Neurochemistry of aging. 2. Design, synthesis, and biological evaluation of halomethyl analogues of choline with high affinity choline transport inhibitory activity.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:7

    Topics: Acetylcholinesterase; Aging; Animals; Biological Transport, Active; Choline; Drug Interactions; Guin

1991
Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome.
    Archives of neurology, 1990, Volume: 47, Issue:9

    Topics: Adult; Aged; Aging; Choline; Down Syndrome; Female; Humans; Male; Middle Aged

1990
Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.
    Radiology, 1990, Volume: 176, Issue:2

    Topics: Adenosine Triphosphate; Adolescent; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; F

1990
Acetylcholine synthesis and release in the extensor digitorum longus muscle of mature and aged rats.
    Journal of neurochemistry, 1990, Volume: 54, Issue:4

    Topics: Acetylcholine; Aging; Animals; Choline; Choline O-Acetyltransferase; Electric Stimulation; Humans; I

1990
Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats.
    Journal of neurochemistry, 1990, Volume: 55, Issue:3

    Topics: Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Corpus Striatum; Frontal Lobe; Hemichol

1990
Decrease of acetylcholine release from cortical slices in aged rats: investigations into its reversal by phosphatidylserine.
    Journal of neurochemistry, 1990, Volume: 55, Issue:3

    Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Cerebral Cortex; Choline; Chromatography, High Pr

1990
A selective increase in the generation of phosphorylcholine-specific B cells associated with aging.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Volume: 136, Issue:2

    Topics: Aging; Animals; Antibodies, Monoclonal; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Choline; Epit

1986
Altered VH gene segment utilization in the response to phosphorylcholine by aged mice.
    Journal of immunology (Baltimore, Md. : 1950), 1989, Dec-01, Volume: 143, Issue:11

    Topics: Aging; Animals; Antibody Specificity; Bone Marrow; Cells, Cultured; Choline; Clone Cells; Epitopes;

1989
Differential L chain expression in the antibody responses to phosphorylcholine of adult bone marrow or peritoneum-derived B lymphocytes.
    Journal of immunology (Baltimore, Md. : 1950), 1989, Jan-01, Volume: 142, Issue:1

    Topics: Aging; Animals; Antibody Formation; B-Lymphocytes; Bone Marrow; Bone Marrow Transplantation; Choline

1989
Effect of early visual pattern deprivation on development and laminar distribution of cholinergic markers in rat visual cortex.
    EXS, 1989, Volume: 57

    Topics: Aging; Animals; Biological Transport; Choline; Choline O-Acetyltransferase; Hemicholinium 3; Ocular

1989
Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions.
    Mechanisms of ageing and development, 1989, Volume: 47, Issue:1

    Topics: Acetylcarnitine; Acetylcholinesterase; Aging; Animals; Brain; Carnitine; Choline; Choline O-Acetyltr

1989
Neurobiochemical alterations in the brain of aging rats.
    Activitas nervosa superior, 1989, Volume: 31, Issue:3

    Topics: Aging; Animals; Biogenic Monoamines; Brain; Choline; Lipid Metabolism; Lipid Peroxidation; Neurotran

1989
Phospholipid-derived choline intermediates and acetylcholine synthesis in mouse brain synaptosomes.
    Journal of neuroscience research, 1989, Volume: 24, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Female; Hemicholinium 3; Mice; Mice, Inbred C57BL; Ph

1989
Phosphorylcholine and phosphorylethanolamine in human and rhesus monkey lenses.
    Experimental eye research, 1989, Volume: 49, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Child; Child, Preschool; Choline; Cultur

1989
Age-dependent changes of isotype and idiotype expression in the antibody response to the phosphorylcholine hapten in BALB/c mice.
    International archives of allergy and applied immunology, 1989, Volume: 88, Issue:1-2

    Topics: Aging; Animals; Choline; Female; Haptens; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immu

1989
Vascular cholinesterases and choline uptake in isolated rat forebrain microvessels: a possible link.
    Journal of neurochemistry, 1989, Volume: 53, Issue:2

    Topics: Aging; Animals; Blood Vessels; Choline; Cholinesterases; Diencephalon; In Vitro Techniques; Male; Mi

1989
Sensitivity of rodent skeletal muscles to dicholines: dependence on innervation and age.
    Neuropharmacology, 1989, Volume: 28, Issue:4

    Topics: Aging; Animals; Choline; Membrane Potentials; Mice; Muscles; Rats; Rats, Inbred Strains; Succinylcho

1989
Effects of hemicholinium-3 and sodium ions on choline uptake system in excised superior cervical sympathetic ganglia of rats.
    Neurochemical research, 1989, Volume: 14, Issue:7

    Topics: Aging; Animals; Biological Transport; Choline; Denervation; Female; Ganglia, Sympathetic; Hemicholin

1989
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
    Journal of neurochemistry, 1985, Volume: 45, Issue:1

    Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus

1985
Effects of dietary choline on memory and brain chemistry in aged mice.
    Neurobiology of aging, 1985,Spring, Volume: 6, Issue:1

    Topics: Aging; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Cerebral Cortex; Choline; Choline O

1985
Cerebral ageing, neurotransmitters and therapeutic implications.
    Singapore medical journal, 1985, Volume: 26, Issue:2

    Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Brain; Choline; Choline O-Acetyltransferase; Dihydroe

1985
Regional noradrenergic and cholinergic neurochemistry in the rat urinary bladder: effects of age.
    The Journal of urology, 1988, Volume: 139, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Aging; alpha-Methyltyrosine; Animals; Choline; Choline O-Acetyl

1988
Effects of long-term dietary choline and phosphatidylcholine administration on muscarinic receptors in aged mouse brain.
    Neurological research, 1988, Volume: 10, Issue:3

    Topics: Aging; Animals; Body Weight; Brain; Choline; Diet; Mice; Phosphatidylcholines; Quinuclidinyl Benzila

1988
Age-related change in anti-carbohydrate antibody levels.
    American journal of epidemiology, 1989, Volume: 129, Issue:1

    Topics: ABO Blood-Group System; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Choline; Female; Humans;

1989
Hippocampal membranes contain a neurotrophic activity that stimulates cholinergic properties of fetal rat septal neurons cultured under serum-free conditions.
    Journal of neurochemistry, 1989, Volume: 52, Issue:3

    Topics: Aging; Animals; Cell Membrane; Cells, Cultured; Cerebellum; Choline; Choline O-Acetyltransferase; Ch

1989
Effects of antigen and internal environment on anti-phosphorylcholine immune responses of autoimmune aged NZB/W F1 mice.
    Immunology, 1986, Volume: 58, Issue:2

    Topics: Aging; Animals; Antibody Formation; Antigens; B-Lymphocytes; Choline; Female; Hemolytic Plaque Techn

1986
Age-related reductions in rat atrial high affinity choline uptake, ACh synthesis, and ACh release. A brief note.
    Mechanisms of ageing and development, 1985, May-13, Volume: 30, Issue:2

    Topics: Acetylcholine; Aging; Animals; Choline; Heart Atria; Male; Rats; Rats, Inbred F344; Synaptic Transmi

1985
Parathyroid hormone increases sodium/calcium exchange activity in renal cells and the blunting of the response in aging.
    The Journal of biological chemistry, 1986, Apr-25, Volume: 261, Issue:12

    Topics: Aging; Animals; Calcium; Choline; Colforsin; Cyclic AMP; Kidney; Male; Parathyroid Glands; Parathyro

1986
[Anti-phosphorylcholine response of autoimmune NZB/W mice: variations with age of serum titers and homogeneity].
    Revista espanola de fisiologia, 1987, Volume: 43, Issue:2

    Topics: Aging; Animals; Antibody Affinity; Antigens, Bacterial; Choline; Female; Hemocyanins; Immune Sera; M

1987
Effects of meclofenoxate and citicholine on learning and memory in aged rats.
    Acta physiologica et pharmacologica Bulgarica, 1987, Volume: 13, Issue:4

    Topics: Aging; Animals; Choline; Cytidine Diphosphate Choline; Glycolates; Learning; Male; Meclofenoxate; Me

1987
Determination of acetylcholine and choline in human cerebrospinal fluid using high-performance liquid chromatography combined with an immobilized enzyme reactor: ageing-induced change of acetylcholine level.
    Journal of chromatography, 1988, Oct-14, Volume: 431, Issue:2

    Topics: Acetylcholine; Adult; Aged; Aging; Choline; Chromatography, High Pressure Liquid; Enzymes, Immobiliz

1988
Effects of training on a spatial memory task on high affinity choline uptake in hippocampus and cortex in young adult and aged rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1988, Volume: 8, Issue:1

    Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Conditioning, Psychological; Cues; Hipp

1988
Chronic treatment with choline or scopolamine indicates the presence of muscarinic cholinergic receptor plasticity in the frontal cortex of young but not of aged mice.
    Journal of neural transmission, 1988, Volume: 71, Issue:1

    Topics: Aging; Alzheimer Disease; Animals; Choline; Female; Frontal Lobe; Humans; Mice; Models, Biological;

1988
Blood-brain barrier transport of choline is reduced in the aged rat.
    Brain research, 1988, Feb-09, Volume: 440, Issue:2

    Topics: Aging; Animals; Blood-Brain Barrier; Choline; Male; Rats; Rats, Inbred F344

1988
Sodium dependent uptake of 3H-choline in the cerebral cortex of ageing male rats.
    Pharmacology & toxicology, 1988, Volume: 62, Issue:4

    Topics: Aging; Aluminum; Animals; Cerebral Cortex; Choline; Hemicholinium 3; Male; Rats; Rats, Inbred WKY; S

1988
Muscarinic mobilization of choline in rat brain in vivo as shown by the cerebral arterio-venous difference of choline.
    Journal of neurochemistry, 1987, Volume: 48, Issue:5

    Topics: Aging; Animals; Arteries; Brain; Cerebrovascular Circulation; Choline; Diet; Muscarine; Osmolar Conc

1987
Increase in acetylcholine concentrations in the brain of 'old' rats following treatment with pyrithioxin (Encephabol).
    British journal of pharmacology, 1987, Volume: 90, Issue:3

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Male; Pyridines; Pyrithi

1987
Naturally occurring antibodies to phosphocholine as a potential index of antibody responsiveness to polysaccharides.
    The Journal of infectious diseases, 1987, Volume: 155, Issue:6

    Topics: ABO Blood-Group System; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Antibodies, B

1987
Age-related reductions in brain cholinergic and dopaminergic indices in two rat strains differing in longevity.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Dopamine; Longevity; Mal

1987
Acetylcholine metabolism and choline availability at the neuromuscular junction of mature adult and aged rats.
    The Journal of physiology, 1987, Volume: 383

    Topics: Acetylcholine; Aging; Animals; Choline; Electric Stimulation; Neuromuscular Junction; Rats; Rats, In

1987
Age- and strain-dependent polymorphism in IgE antibody against the phosphorylcholine hapten.
    European journal of immunology, 1986, Volume: 16, Issue:6

    Topics: Aging; Animals; Choline; Crosses, Genetic; Female; Haptens; Immunoglobulin E; Immunoglobulin G; Immu

1986
Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory.
    European journal of pharmacology, 1986, Nov-04, Volume: 130, Issue:3

    Topics: Aging; Animals; Arginine Vasopressin; Brain Chemistry; Choline; Male; Memory; Rats; Rats, Inbred Str

1986
Electrophysiological markers of aging and memory loss in rats.
    Annals of the New York Academy of Sciences, 1985, Volume: 444

    Topics: Aging; Animals; Brain; Choline; Discrimination Learning; Electroencephalography; Hippocampus; Kindli

1985
Neurobehavioral effects of chronic choline-containing diets on the adult and aging C57BL/6NNIA mouse brain.
    Annals of the New York Academy of Sciences, 1985, Volume: 444

    Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Brain; Choline; Mental Recall; Mice; Mice, Inb

1985
Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism.
    Molecular and biochemical parasitology, 1985, Volume: 17, Issue:2

    Topics: Aging; Animals; Biomphalaria; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Female; Gl

1985
Metabolism of choline in brain of the aged CBF-1 mouse.
    Journal of neuroscience research, 1986, Volume: 15, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain; Choline; Chromatography, Thin Layer; Male; Mice; Mice, Inbred

1986
Aging of membrane transport mechanisms in the central nervous system--high affinity choline transport in rat cortical synaptosomes.
    Experimental gerontology, 1985, Volume: 20, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; Choline; Male; Mathematics; Models, Biological; Rats; Sodium; Synap

1985
Red cell choline in Korsakoff psychosis.
    Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:5-6

    Topics: Aged; Aging; Alcohol Amnestic Disorder; Choline; Erythrocytes; Humans; Male; Middle Aged

1985
N-Acetylglucosaminyltransferase activity in liver, serum, and ovaries of domestic fowl.
    Canadian journal of biochemistry, 1971, Volume: 49, Issue:6

    Topics: Acetates; Aging; Animals; Cell Fractionation; Centrifugation, Density Gradient; Chickens; Choline; C

1971
Ontogenesis of choline acetyltransferase, tyrosine hydroxylase, monoamine oxidase and catechol-O-methyl transferase in the superior cervical ganglion of swine.
    Biochemical pharmacology, 1974, Dec-15, Volume: 23, Issue:24

    Topics: Acetyltransferases; Aging; Animals; Animals, Newborn; Body Weight; Catechol O-Methyltransferase; Cho

1974
The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: role of ganglionic noradrenaline content.
    British journal of pharmacology, 1974, Volume: 51, Issue:4

    Topics: Acetylesterase; Aging; Animals; Animals, Newborn; Bucladesine; Carbachol; Choline; Cyclic AMP; Cyclo

1974
Lysolecithin and sphingosinephosphoryl-choline in the metabolism of brain phospholipids of the rhesus monkey (Macaca mulatta): effects of development.
    Journal of neurochemistry, 1973, Volume: 20, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Brain; Carbon Isotopes; Cerebral Cortex; Choline; Chromatography,

1973
Phospholipases in arterial tissue. V. Comparison of the activity of phosphatide acyl-hydrolase and sphingomyelin choline phosphohydrolase in aortae of male, female and ovariectomized rats.
    Biochimica et biophysica acta, 1971, Mar-16, Volume: 231, Issue:2

    Topics: Aging; Amino Alcohols; Animals; Aorta; Benzoates; Body Weight; Carbon Isotopes; Castration; Choline;

1971
Effects of cholinomimetic agents given into the brain of fowls.
    British journal of pharmacology, 1974, Volume: 51, Issue:3

    Topics: Acetylcholine; Aging; Animals; Behavior, Animal; Benzoates; Body Temperature; Carbachol; Cerebral Ve

1974
Effects of neonatal and adult treatments with gonadal hormones on choline acetylase activity in brain regions of male mice after fighting.
    Psychopharmacologia, 1972, Volume: 27, Issue:1

    Topics: Acetyltransferases; Aggression; Aging; Animals; Animals, Newborn; Brain; Castration; Cerebral Cortex

1972
Effect of dimethylaminoethanol on the life span of senile male A-J mice.
    Experimental gerontology, 1973, Volume: 8, Issue:4

    Topics: Acetamides; Aging; Animals; Benzoates; Body Weight; Cell Membrane; Choline; Ethanolamines; Longevity

1973
Development of Na+-stimulated glucose oxidation in synaptosomes.
    Journal of neurochemistry, 1973, Volume: 21, Issue:5

    Topics: Aging; Animals; Brain; Carbon Dioxide; Carbon Radioisotopes; Choline; Deoxy Sugars; Dinitrophenols;

1973
Comparative studies of neurotransmitter substances in the maturing and aging central nervous system of the chicken.
    Progress in brain research, 1973, Volume: 40, Issue:0

    Topics: Acetylcholinesterase; Acetyltransferases; Aging; Animals; Brain; Brain Chemistry; Chick Embryo; Chic

1973
Skeletal muscle lipids. 3. Changes in fatty acid composition of individual phosphoglycerides in man from fetal to middle age.
    Journal of lipid research, 1974, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aging; Cardiolipins; Child; Child, Preschool; Choline; Chromatography, Gas; Chrom

1974
UDP-galactose:glycoprotein galactosyltransferase activity in tissues of developing rat.
    Archives of biochemistry and biophysics, 1974, Volume: 162, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Choline; Cyto

1974
Changes in acetylcholine and choline concentrations and choline acetyltransferase activity in the developing rat brain: effect of propylthiouracil.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 196

    Topics: Acetylcholine; Acyltransferases; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Br

1972
Phosphocholine diglyceride transferase activity during development of the chicken brain.
    Journal of neurochemistry, 1972, Volume: 19, Issue:11

    Topics: Aging; Animals; Animals, Newborn; Brain; Brain Chemistry; Carbon Isotopes; Chick Embryo; Chickens; C

1972
Hypertension in young rats following choline deficiency in maternal diets.
    The Journal of nutrition, 1971, Volume: 101, Issue:12

    Topics: Age Factors; Aging; Animals; Blood Pressure Determination; Choline; Choline Deficiency; Female; Feta

1971
The time course of development of acetylcholinesterase and choline acetyltransferase in Drosophila melanogaster.
    Biochemical genetics, 1970, Volume: 4, Issue:4

    Topics: Acetylcholinesterase; Acyltransferases; Aging; Aldehydes; Animals; Choline; Drosophila; Larva; Oxido

1970
Phospholipid metabolism in the developing liver. I. The biosynthesis of choline glycerophosphatides by liver slices from fetal, newborn and adult rats.
    Biochimica et biophysica acta, 1969, Jul-29, Volume: 187, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Choline; Chromatography, Thin Layer; Female; Fetu

1969
Choline metabolism in normal and choline-deficient rats of different ages.
    Archives of biochemistry and biophysics, 1965, Volume: 112, Issue:1

    Topics: Aging; Animals; Body Weight; Choline; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Me

1965