choline and Aging
choline has been researched along with Aging in 337 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Postmenopausal women with deficient choline intake had worse fibrosis (P = 0." | 9.16 | Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. ( Colvin, RM; Diehl, A; Guerrerio, AL; Lavine, JE; Mohan, P; Molleston, JP; Murray, KF; Scheimann, AO; Schwartz, AK; Schwimmer, JB; Torbenson, MS, 2012) |
| "We established a cardiac aging model in mice through subcutaneous injection with D-galactose at a dose of 100 mg/kg/day for 6 weeks." | 7.88 | Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway. ( Chen, J; Dai, C; Fasae, MB; Jiang, Y; Liu, D; Liu, Y; Pan, W; Sun, L; Wang, L; Wang, S, 2018) |
| " Supplementation of choline and DHA or CTR during PMSS in rats persistently attenuates brain oxidative stress through aging." | 7.88 | Persistent attenuation of brain oxidative stress through aging in perinatal maternal separated rat pups supplemented with choline and docosahexaenoic acid or Clitoria ternatea aqueous root extract. ( Almeida, PMD; Bernhardt, LK; Kamath, SU; Kishore, A; Rai, KS; Shenoy, PR, 2018) |
| "Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration." | 7.83 | Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016) |
| " In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)." | 7.74 | Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008) |
| "Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population." | 7.74 | N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008) |
| "Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring." | 7.72 | Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003) |
| "The effect of aging and melatonin on 24-h rhythms in tyrosine hydroxylase activity and 3H - choline conversion into 3H - acetylcholine were examined in cervical, stellate, coeliac-mesenteric and hypogastric ganglia, and in the adrenal medulla and heart of rats." | 7.70 | Diurnal rhythms in norepinephrine and acetylcholine synthesis of sympathetic ganglia, heart and adrenals of aging rats: effect of melatonin. ( Brusco, LI; Cardinali, DP; Esquifino, AI; García-Bonacho, M, 1998) |
| "We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats." | 7.69 | The influence of aging on whole body choline release and clearance. ( Jenden, DJ; Li, G; Roch, M; Scremin, OU, 1996) |
| "It has been suggested that the activity of the enzyme responsible for the synthesis of acetylcholine, choline acetyltransferase (ChAT), is substantially reduced in the neocortex and hippocampus of Alzheimer's and other aging brains." | 7.68 | Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E. ( Govitrapong, P; Maneesub, Y; Sanvarinda, Y, 1993) |
| " Behavioural effects of chronic manipulations of dietary choline in rats in the early stages of aging are reported." | 7.68 | Dietary choline manipulations and behavioural modifications in rats in the early stages of aging. ( Fundarò, A; Paschero, A, 1991) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 7.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months." | 7.67 | Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989) |
| "We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats." | 7.67 | Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984) |
| "Fragile X syndrome is a learning disability caused by excess of CGG repeats in the 5' untranslated region of the Fragile X gene (FMR1) silencing its transcription and translation." | 5.42 | Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. ( Djazayeri, S; Liu, YY; Norman, KM; Roch, M; Scremin, OU, 2015) |
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 5.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| "All subjects with DS had a trisomy 21 karyotype, and 3 of the 6 older subjects were demented as judged from a history of mental deterioration, disorientation, and memory loss." | 5.28 | Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome. ( Atack, JR; Hanin, I; Haxby, JV; May, C; Rapoport, SI; Schapiro, MB, 1990) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 5.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "Postmenopausal women with deficient choline intake had worse fibrosis (P = 0." | 5.16 | Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. ( Colvin, RM; Diehl, A; Guerrerio, AL; Lavine, JE; Mohan, P; Molleston, JP; Murray, KF; Scheimann, AO; Schwartz, AK; Schwimmer, JB; Torbenson, MS, 2012) |
| "Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)." | 4.76 | Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984) |
| "Patients prescribed an anticholinergic were evaluated using the Overactive Bladder Symptom Score; Medical, Epidemiologic and Social Aspects of Aging and Incontinence Questionnaire; and Incontinence Impact Questionnaire-7." | 3.96 | Evaluation of Choline and Acetylcholine Levels in Responders and Nonresponders to Anticholinergic Therapy for Overactive Bladder Syndrome. ( El-Nashar, S; Hazlett, FE; Hijaz, AK; Li, X; Mahajan, ST; Mangel, JM; Mara, E; Sheyn, D, 2020) |
| "We established a cardiac aging model in mice through subcutaneous injection with D-galactose at a dose of 100 mg/kg/day for 6 weeks." | 3.88 | Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway. ( Chen, J; Dai, C; Fasae, MB; Jiang, Y; Liu, D; Liu, Y; Pan, W; Sun, L; Wang, L; Wang, S, 2018) |
| " Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale." | 3.85 | Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017) |
| "Down syndrome (DS), caused by trisomy of chromosome 21, is marked by intellectual disability (ID) and early onset of Alzheimer's disease (AD) neuropathology including hippocampal cholinergic projection system degeneration." | 3.83 | Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. ( Alldred, MJ; Ash, JA; Ginsberg, SD; Ikonomovic, MD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2016) |
| "In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers." | 3.80 | APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain. ( Buthorn, JJ; Christen, E; Conejero-Goldberg, C; Davies, P; Dickinson, D; Goldberg, TE; Gomar, JJ; Gordon, ML; Huet, S; Keehlisen, L; Kingsley, PB; Koppel, J; Uluğ, AM, 2014) |
| "Down syndrome (DS) is marked by intellectual disability (ID) and early-onset of Alzheimer's disease (AD) neuropathology, including basal forebrain cholinergic neuron (BFCN) degeneration." | 3.80 | Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. ( Ash, JA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strupp, BJ; Velazquez, R, 2014) |
| " In the current study, biochemical markers sensitive to Alzheimer disease (activities of high-affinity choline uptake and of nitric oxide synthases, expression of 17beta-hydroxysteroid dehydrogenase type 10) were estimated in both hemispheres of young and old male Wistar/Long Evans rats." | 3.76 | Aging and lateralization of the rat brain on a biochemical level. ( Kristofiková, Z; Ort, M; Rícný, J; Rípová, D, 2010) |
| " We used structural magnetic resonance imaging (sMRI) to measure the volume of the AHC, and magnetic resonance spectroscopy ((1)H-MRS) to measure concentrations of N-acetyl aspartate (NAA), creatine+phosphocreatine (Cr+PCr), myo-inositol (mI) and choline (Cho)." | 3.76 | Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. ( Baird, G; Bolton, P; Conroy, RM; Curran, S; Daly, E; Foy, C; Hallahan, B; Murphy, DG; Murphy, KC; O'Brien, FM; O'Gorman, RL; Page, L; Robertson, D; Sharma, A, 2010) |
| " In rats with beta-amyloid peptide-(25-35)-induced amnesia, CS enhanced passive avoidance performance and increased activity of brain choline acetyltransferase, as compared to control rats (saline)." | 3.74 | Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. ( Persiyantseva, NA; Pinelis, VG; Pomytkin, IA; Proshin, AT; Semenova, NA; Senilova, YE; Sherstnev, VV; Storozheva, ZI; Storozhevykh, TP; Zakharova, EI, 2008) |
| "Long- and short-echo proton spectroscopic imaging were used to investigate concentrations and R2 relaxation rates of N-acetyl aspartate (NAA) + N-acetyl aspartyl glutamate (NAAG), choline (Cho), creatine (Cr), and myoinositol (mI) in the white matter of the centrum semiovale of 106 healthy volunteers aged 50-90 years; usable data were obtained from 79 subjects." | 3.74 | Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain. ( Charlton, RA; Howe, FA; Markus, HS; McIntyre, DJ, 2007) |
| "Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population." | 3.74 | N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly. ( Aho, SL; Bejot, Y; Ben Salem, D; Brunotte, F; Ricolfi, F; Rouaud, O; Tavernier, B; Walker, PM, 2008) |
| "To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men." | 3.72 | Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. ( Breteler, MM; den Heijer, T; Hofman, A; Origgi, D; Oudkerk, M; Sijens, PE; Vermeer, SE, 2003) |
| "Compared with seronegative controls, HIV-positive subjects showed additional and marked increases in the concentration of glial markers, choline-containing compounds (seronegative controls +2%/decade; HIV-positive subjects +10%/decade) and myoinositol (seronegative controls +3%/decade; HIV-positive subjects +12%/decade), with aging in the frontal white matter." | 3.72 | Effect of aging on brain metabolism in antiretroviral-naive HIV patients. ( Chang, L; Ernst, T, 2004) |
| "Choline availability in the diet during pregnancy alters fetal brain biochemistry with resulting behavioral changes that persist throughout the lifetime of the offspring." | 3.72 | Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. ( Albright, CD; Craciunescu, CN; Kowall, NW; Mar, MH; Siwek, DF; Williams, CL; Zeisel, SH, 2003) |
| "To investigate whether damages of cholinergic neurons in the brain produce aging-like changes in circadian rhythms, we examined the influences of intracerebroventricular injection of cholinergic neurotoxin ethylcholine aziridinium ion (AF64A, 5 nmol/5 microl) on circadian rhythms in rats, by measuring locomotor activity and body temperature with the automatic behavioral measurement system combined with the telemetry." | 3.71 | Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats. ( Endo, Y; Fueta, Y; Irie, M; Shinohara, K, 2001) |
| "Female Sprague-Dawley rats received approximately 300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (NGF) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age." | 3.71 | Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. ( Loy, R; Sandstrom, NJ; Williams, CL, 2002) |
| " Here, the developmental and protective effects of SNV were investigated in vivo using two models of developmental retardation, hypoxia and cholinergic blockade." | 3.70 | Protection against developmental deficiencies by a lipophilic VIP analogue. ( Bachar, M; Bardea, A; Davidson, A; Fridkin, M; Gozes, I; Rubinraut, S, 1998) |
| "The purpose of this investigation was to examine the effects of aging and aerobic fitness on exercise- and methylcholine-induced sweating responses during heat acclimation." | 3.70 | Exercise- and methylcholine-induced sweating responses in older and younger men: effect of heat acclimation and aerobic fitness. ( Buskirk, ER; Havenith, G; Inoue, Y; Kenney, WL; Loomis, JL, 1999) |
| "Supplementation with choline during pregnancy in rats causes a long-lasting improvement of visuospatial memory of the offspring." | 3.70 | Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. ( Jones, JP; Meck, WH; Swartzwelder, HS; Williams, CL; Wilson, WA, 1999) |
| "We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats." | 3.69 | The influence of aging on whole body choline release and clearance. ( Jenden, DJ; Li, G; Roch, M; Scremin, OU, 1996) |
| " In living adult rhesus monkeys, we studied the long-term effects of early mesial temporo-limbic (MTL) lesions on prefrontal cortex (PFC) neurons using proton magnetic resonance spectroscopic imaging (1H-MRSI), an in vivo neurochemical assay technique for measuring signals from metabolites such as N-acetyl-aspartate (NAA, a neuronal marker), choline-containing compounds (CHO) and creatine + phosphocreatine (CRE)." | 3.69 | Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study. ( Bachevalier, J; Bertolino, A; Frank, JA; Mattay, VS; Saunders, RC; Weinberger, DR, 1997) |
| "To evaluate whether any degenerative changes affect the brain cholinergic systems during natural aging, we compared various cholinergic biochemical markers (number of muscarinic receptors, mAChR; choline acetyltransferase activity, ChAT; acetylcholinesterase activity, AChE; and sodium-dependent high affinity choline uptake) in the cortical (CR) and subcortical (SS) regions of the brains of aged (24 month) and young (2 month) rats." | 3.69 | Age-related changes of cholinergic markers in the rat brain. ( Egashira, T; Yamanaka, Y; Yufu, F, 1994) |
| "The effect of aging was examined on cholinergically mediated contractions and acetylcholine (ACh) release in isolated colonic segments from Fischer (F344 x BN) F1 rats, 4-8 mo (postpubertal) and 22-28 mo (senescent) of age." | 3.69 | Evidence for age-associated reduction in acetylcholine release and smooth muscle response in the rat colon. ( Gelperin, D; Roberts, D; Wiley, JW, 1994) |
| " Behavioural effects of chronic manipulations of dietary choline in rats in the early stages of aging are reported." | 3.68 | Dietary choline manipulations and behavioural modifications in rats in the early stages of aging. ( Fundarò, A; Paschero, A, 1991) |
| "Normal aging has been associated with a progressive decline in hippocampal cholinergic function." | 3.68 | Effect of physical activity on hippocampal high affinity choline uptake and muscarinic binding: a comparison between young and old F344 rats. ( Farrar, RP; Fordyce, DE, 1991) |
| "It has been suggested that the activity of the enzyme responsible for the synthesis of acetylcholine, choline acetyltransferase (ChAT), is substantially reduced in the neocortex and hippocampus of Alzheimer's and other aging brains." | 3.68 | Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E. ( Govitrapong, P; Maneesub, Y; Sanvarinda, Y, 1993) |
| "Although the use of aging experimental animals for studying serotonergic neuronal changes is limited because of species differences, cholinergic neuronal deterioration does appear to be a feature common to mammalian aging brains." | 3.68 | Serotonergic ligand binding in aging brain of experimental animals. ( Yamagata, A; Yamaguchi, T, 1991) |
| "We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats." | 3.67 | Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 3.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "The effect of aging and subchronic treatment with acetyl-L-carnitine (50 mg/kg per day) was studied on mitochondrial bioenergetics and cholinergic metabolism in non-synaptic mitochondria and synaptosomes isolated from cerebral cortex, hippocampus and striatum of rats aged 4, 11 and 18 months." | 3.67 | Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. ( Curti, D; Dagani, F; Galmozzi, MR; Marzatico, F, 1989) |
| "It has been suggested that choline and/or phosphatidylcholine may be beneficial in improving the memory deficits associated with aging and Alzheimer's disease." | 3.67 | Effects of long-term dietary choline and phosphatidylcholine administration on muscarinic receptors in aged mouse brain. ( Muma, NA; Rowell, PP; Schultz, GS, 1988) |
| "In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices." | 3.67 | Metabolism of choline in brain of the aged CBF-1 mouse. ( Karczmar, AG; Kindel, G; Rosenberg, A; Saito, M, 1986) |
| "Twenty-seven patients with cervical spondylosis were evaluated." | 2.80 | Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy. ( Ellingson, BM; Hardy, AJ; Holly, LT; Salamon, N, 2015) |
| "Choline is an essential nutrient and can also be obtained by de novo synthesis via an oestrogen responsive pathway." | 2.77 | Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. ( Bonham, MP; Duffy, ME; McCormack, JM; McNulty, H; Molloy, AM; Robson, PJ; Scott, JM; Strain, JJ; Ueland, PM; Wallace, JM; Walsh, PM; Ward, M, 2012) |
| "NAA/choline ratios were significantly reduced (P<0." | 2.71 | Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate. ( Aleman, A; de Haan, EH; de Vries, R; de Winter, CF; Drent, ML; Kenemans, JL; Koppeschaar, HP; Lijffijt, M; van Dam, PS; van der Grond, J, 2005) |
| "Fragile X syndrome is a learning disability caused by excess of CGG repeats in the 5' untranslated region of the Fragile X gene (FMR1) silencing its transcription and translation." | 1.42 | Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. ( Djazayeri, S; Liu, YY; Norman, KM; Roch, M; Scremin, OU, 2015) |
| " A generalised additive regression model showed a positive dose-response relationship between the m-MMSE and choline (P=0·012 from a corresponding linear regression model)." | 1.39 | Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013) |
| "Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects." | 1.35 | Proton magnetic resonance spectroscopy of late-life major depressive disorder. ( Chen, CS; Chiang, IC; Hsieh, TJ; Kuo, YT; Li, CW; Lin, HF; Lin, WC; Liu, GC; Lu, CY, 2009) |
| "Choline (Ch) plays an important role in brain neurotransmission, while Ch-deprivation (CD) has been linked to various pathophysiological states." | 1.35 | Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions. ( Al-Humadi, H; Anifantaki, F; Gkrouzman, E; Kyriakaki, A; Liapi, C; Margaritis, M; Skandali, N; Stolakis, V; Tsakiris, S; Zarros, A, 2009) |
| "Twenty-four patients with spastic diplegia and twenty-six healthy children were examined." | 1.35 | An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study. ( Kubas, B; Kulak, W; Otapowicz, D; Smigielska-Kuzia, J; Sobaniec, W; Zawada, B, 2009) |
| " Choline-stabilized orthosilicic acid (ch-OSA) was found to have a high bioavailability compared to other Si supplements." | 1.33 | Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. ( Behets, GJ; Calomme, M; D'Haese, P; Demeester, N; Geusens, P; Sindambiwe, JB; Van Hoof, V; Vanden Berghe, D, 2006) |
| "Cholinergic deficits in Alzheimer's disease are accompanied by a number of alterations in other transmitter systems including glutamate, noradrenaline and serotonin, suggesting the involvement also of other neurotransmitter systems in the pathogenesis of the disease." | 1.32 | Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology. ( Apelt, J; Klingner, M; Kumar, A; Sabri, O; Scheunemann, M; Schliebs, R; Sorger, D; Steinbach, J, 2003) |
| "Choline is an important membrane phospholipid constituent and a neurotransmitter precursor that is minimally synthesized in brain." | 1.30 | Blood-brain barrier choline transport in the senescent rat. ( Allen, DD; Smith, QR, 1999) |
| "The effect of transient cerebral ischemia on cholinergic metabolism was investigated in adult and young gerbils subjected to bilateral carotid artery occlusion (15 min) alone or with release." | 1.29 | Cerebral ischemia in young and adult gerbils: effects on cholinergic metabolism. ( Bertrand, N; Ishii, H; Spatz, M, 1996) |
| "We suggest that choline deficiency altered the protein kinase C-mediated signal transduction within liver and this contributed to hepatic carcinogenesis in these animals." | 1.29 | Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver. ( Chang, J; da Costa, KA; Garner, SC; Zeisel, SH, 1995) |
| " With regard to the hypothesis that cholinergic mechanisms play a crucial role in cognitive processes, M1- and M2-muscarinic acetylcholine receptors, choline acetyltransferase, and high-affinity choline uptake as well as benzodiazepine receptors were studied in selected cortical regions (frontal, temporal, somatosensory, visual, piriform cortex), in amygdala, hippocampus, and in the nucleus basalis of Meynert from adult rats, which received at the age of 25 days a single dosage of 11 mg/kg, s." | 1.28 | Effect of kainic acid administration to prepubescent rats on cholinergic markers in selected brain regions of adult rats. ( Guzmán-Godínez, G; Schliebs, R, 1992) |
| "Choline-treated old animals made more perservation errors, i." | 1.28 | Chronic dietary choline enrichment affects DRL responding of old, but not of adult CPBB rats. ( Collijn, D; Kerbusch, S; Raaijmakers, W; van der Staay, FJ, 1992) |
| "Choline was high at birth and declined thereafter." | 1.28 | In vivo 1H and 31P NMR spectroscopy of the developing rat brain. ( Hida, K; Kwee, IL; Nakada, T, 1992) |
| "All subjects with DS had a trisomy 21 karyotype, and 3 of the 6 older subjects were demented as judged from a history of mental deterioration, disorientation, and memory loss." | 1.28 | Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome. ( Atack, JR; Hanin, I; Haxby, JV; May, C; Rapoport, SI; Schapiro, MB, 1990) |
| "Choline was taken up by a single saturable process with apparent Km = 3." | 1.28 | Effects of hemicholinium-3 and sodium ions on choline uptake system in excised superior cervical sympathetic ganglia of rats. ( Iwata, M; Nagata, Y; Tamaru, M, 1989) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 1.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "Biogenic amines in pons and striatum have been dosed in twenty-four months old Wistar male rats." | 1.27 | [Biochemical changes in 24-month-old Wistar rats]. ( Della Zuana, O; Duhault, J; Lonchampt, M; Roman, F; Saint Romas, G, 1984) |
| "Inositol incorporation was also measurable, whereas [14C]serine incorporation was low or undetectable." | 1.27 | Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism. ( Ancelin, ML; Capron, A; Torpier, G; Vial, HJ, 1985) |
| "RBC choline was significantly higher in Korsakoff patients compared with controls (p less than 0." | 1.27 | Red cell choline in Korsakoff psychosis. ( Aronoff, A; Barriga, C; Lal, S; Nair, NP; Suranyi-Cadotte, B; Wood, PL, 1985) |
| "The pharmacokinetics of two unmatched populations of asthmatic children, one from an asthmatic convalescent center in Denver and the other from an urban outpatient clinic, are compared after single and repeated dosing of a new asthma formulation, oxtriphylline syrup." | 1.26 | Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup. ( Bell, T; Danish, M; Katsampes, C; Lecks, H; Ragni, M; Rasmussen, C; Simon, T; Yaffe, S, 1980) |
| "Choline uptake was very low until 12 days postnatally, then the Vmax increased and approached adult values of 29 pmol/mg prot." | 1.26 | Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment. ( Krigman, MR; Morell, P; Ramsay, PB, 1980) |
Research
Studies (337)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 139 (41.25) | 18.7374 |
| 1990's | 76 (22.55) | 18.2507 |
| 2000's | 56 (16.62) | 29.6817 |
| 2010's | 58 (17.21) | 24.3611 |
| 2020's | 8 (2.37) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Rodríguez-Nieto, G | 1 |
| Levin, O | 2 |
| Hermans, L | 1 |
| Weerasekera, A | 1 |
| Sava, AC | 1 |
| Haghebaert, A | 1 |
| Huybrechts, A | 1 |
| Cuypers, K | 1 |
| Mantini, D | 1 |
| Himmelreich, U | 2 |
| Swinnen, SP | 1 |
| Vints, WAJ | 1 |
| Ziv, G | 1 |
| Katkutė, G | 1 |
| Kušleikienė, S | 1 |
| Valatkevičienė, K | 1 |
| Sheoran, S | 1 |
| Drozdova-Statkevičienė, M | 1 |
| Gleiznienė, R | 1 |
| Pääsuke, M | 1 |
| Dudonienė, V | 1 |
| Česnaitienė, VJ | 1 |
| Masiulis, N | 1 |
| Mahmoudi, N | 1 |
| Dadak, M | 2 |
| Bronzlik, P | 2 |
| Maudsley, AA | 4 |
| Sheriff, S | 1 |
| Lanfermann, H | 2 |
| Ding, XQ | 2 |
| Jadavji, NM | 1 |
| Mosnier, H | 1 |
| Kelly, E | 1 |
| Lawrence, K | 1 |
| Cruickshank, S | 1 |
| Stacey, S | 1 |
| McCall, A | 1 |
| Dhatt, S | 1 |
| Arning, E | 1 |
| Bottiglieri, T | 1 |
| Smith, PD | 1 |
| Sheyn, D | 1 |
| Hijaz, AK | 1 |
| Hazlett, FE | 1 |
| El-Nashar, S | 1 |
| Mangel, JM | 1 |
| Li, X | 2 |
| Mara, E | 1 |
| Mahajan, ST | 1 |
| Walchuk, C | 1 |
| Suh, M | 1 |
| Deelchand, DK | 2 |
| McCarten, JR | 1 |
| Hemmy, LS | 1 |
| Auerbach, EJ | 1 |
| Eberly, LE | 1 |
| Marjańska, M | 2 |
| Toan, NK | 1 |
| Tai, NC | 1 |
| Kim, SA | 1 |
| Ahn, SG | 1 |
| Gillies, NA | 1 |
| Franzke, B | 1 |
| Wessner, B | 1 |
| Schober-Halper, B | 1 |
| Hofmann, M | 1 |
| Oesen, S | 1 |
| Tosevska, A | 1 |
| Strasser, EM | 1 |
| Roy, NC | 1 |
| Milan, AM | 1 |
| Cameron-Smith, D | 1 |
| Wagner, KH | 1 |
| Nickerson, CA | 1 |
| Brown, AL | 1 |
| Yu, W | 1 |
| Chun, Y | 1 |
| Glenn, MJ | 2 |
| Matura, S | 2 |
| Fleckenstein, J | 2 |
| Deichmann, R | 2 |
| Engeroff, T | 2 |
| Füzéki, E | 2 |
| Hattingen, E | 1 |
| Hellweg, R | 2 |
| Lienerth, B | 1 |
| Pilatus, U | 3 |
| Schwarz, S | 2 |
| Tesky, VA | 1 |
| Vogt, L | 2 |
| Banzer, W | 2 |
| Pantel, J | 2 |
| Alldred, MJ | 2 |
| Chao, HM | 1 |
| Lee, SH | 1 |
| Beilin, J | 1 |
| Powers, BE | 3 |
| Petkova, E | 1 |
| Strupp, BJ | 4 |
| Ginsberg, SD | 3 |
| de Lima, MB | 1 |
| da Silva, EP | 1 |
| Pereira, R | 1 |
| Romano, GG | 1 |
| de Freitas, LW | 1 |
| Dias, CTS | 1 |
| Menten, JFM | 1 |
| Schmitz, B | 1 |
| Wang, X | 1 |
| Barker, PB | 2 |
| Kahl, KG | 1 |
| Wang, S | 1 |
| Jiang, Y | 2 |
| Chen, J | 1 |
| Dai, C | 1 |
| Liu, D | 1 |
| Pan, W | 1 |
| Wang, L | 2 |
| Fasae, MB | 1 |
| Sun, L | 1 |
| Liu, Y | 1 |
| Bahous, RH | 1 |
| Cosín-Tomás, M | 1 |
| Deng, L | 1 |
| Leclerc, D | 1 |
| Malysheva, O | 1 |
| Ho, MK | 1 |
| Pallàs, M | 1 |
| Kaliman, P | 1 |
| Bedell, BJ | 1 |
| Caudill, MA | 1 |
| Rozen, R | 1 |
| Reddan, JM | 1 |
| Macpherson, H | 1 |
| White, DJ | 1 |
| Scholey, A | 2 |
| Pipingas, A | 2 |
| Almeida, PMD | 1 |
| Kamath, SU | 1 |
| Shenoy, PR | 1 |
| Bernhardt, LK | 1 |
| Kishore, A | 1 |
| Rai, KS | 1 |
| Cleeland, C | 1 |
| White, D | 1 |
| Sporn, L | 1 |
| MacMillan, EL | 1 |
| Ge, R | 1 |
| Greenway, K | 1 |
| Vila-Rodriguez, F | 1 |
| Laule, C | 1 |
| Herrmann, W | 1 |
| Obeid, R | 1 |
| Hädel, S | 1 |
| Wirth, C | 1 |
| Rapp, M | 1 |
| Gallinat, J | 1 |
| Schubert, F | 1 |
| Menezes, TL | 1 |
| Andrade-Valença, LP | 1 |
| Valença, MM | 1 |
| Lima, CS | 1 |
| Dutra-Tavares, AC | 1 |
| Nunes, F | 1 |
| Nunes-Freitas, AL | 1 |
| Ribeiro-Carvalho, A | 1 |
| Filgueiras, CC | 1 |
| Manhães, AC | 1 |
| Meyer, A | 1 |
| Abreu-Villaça, Y | 1 |
| Chiu, PW | 1 |
| Mak, HK | 1 |
| Yau, KK | 1 |
| Chan, Q | 1 |
| Chang, RC | 1 |
| Chu, LW | 1 |
| Gomar, JJ | 1 |
| Gordon, ML | 1 |
| Dickinson, D | 1 |
| Kingsley, PB | 1 |
| Uluğ, AM | 2 |
| Keehlisen, L | 1 |
| Huet, S | 1 |
| Buthorn, JJ | 1 |
| Koppel, J | 1 |
| Christen, E | 1 |
| Conejero-Goldberg, C | 1 |
| Davies, P | 1 |
| Goldberg, TE | 1 |
| Emir, UE | 1 |
| Terpstra, M | 1 |
| Haddadi, M | 1 |
| Jahromi, SR | 1 |
| Sagar, BK | 1 |
| Patil, RK | 1 |
| Shivanandappa, T | 1 |
| Ramesh, SR | 1 |
| Ono, K | 1 |
| Kitagawa, M | 1 |
| Ito, D | 1 |
| Tanaka, N | 1 |
| Watari, T | 1 |
| Harris, JL | 1 |
| Yeh, HW | 1 |
| Swerdlow, RH | 1 |
| Choi, IY | 1 |
| Lee, P | 1 |
| Brooks, WM | 3 |
| Dublineau, I | 1 |
| Souidi, M | 1 |
| Gueguen, Y | 1 |
| Lestaevel, P | 1 |
| Bertho, JM | 1 |
| Manens, L | 1 |
| Delissen, O | 1 |
| Grison, S | 1 |
| Paulard, A | 1 |
| Monin, A | 1 |
| Kern, Y | 1 |
| Rouas, C | 1 |
| Loyen, J | 1 |
| Gourmelon, P | 1 |
| Aigueperse, J | 1 |
| Chang, L | 3 |
| Jiang, C | 1 |
| Cunningham, E | 1 |
| Buchthal, S | 1 |
| Douet, V | 1 |
| Andres, M | 1 |
| Ernst, T | 3 |
| Ash, JA | 2 |
| Velazquez, R | 2 |
| Kelley, CM | 2 |
| Mufson, EJ | 2 |
| Abdel-Aziz, K | 1 |
| Solanky, BS | 1 |
| Yiannakas, MC | 1 |
| Altmann, DR | 1 |
| Wheeler-Kingshott, CA | 1 |
| Thompson, AJ | 2 |
| Ciccarelli, O | 1 |
| Scremin, OU | 3 |
| Roch, M | 2 |
| Norman, KM | 1 |
| Djazayeri, S | 1 |
| Liu, YY | 1 |
| Ikonomovic, MD | 1 |
| Ellingson, BM | 1 |
| Salamon, N | 1 |
| Hardy, AJ | 1 |
| Holly, LT | 1 |
| Tsili, AC | 1 |
| Astrakas, LG | 1 |
| Ntorkou, A | 1 |
| Giannakis, D | 1 |
| Stavrou, S | 1 |
| Maliakas, V | 1 |
| Sofikitis, N | 1 |
| Argyropoulou, MI | 1 |
| Passman, AM | 1 |
| Strauss, RP | 1 |
| McSpadden, SB | 1 |
| Finch-Edmondson, ML | 1 |
| Woo, KH | 1 |
| Diepeveen, LA | 1 |
| London, R | 1 |
| Callus, BA | 1 |
| Yeoh, GC | 1 |
| Stein, C | 1 |
| Hopfeld, J | 1 |
| Lau, H | 1 |
| Klein, J | 3 |
| Brandt, AS | 1 |
| Unschuld, PG | 1 |
| Pradhan, S | 1 |
| Lim, IA | 1 |
| Churchill, G | 1 |
| Harris, AD | 1 |
| Hua, J | 1 |
| Ross, CA | 1 |
| van Zijl, PC | 1 |
| Edden, RA | 1 |
| Margolis, RL | 1 |
| Daniele, S | 1 |
| Da Pozzo, E | 1 |
| Iofrida, C | 1 |
| Martini, C | 1 |
| Löbel, U | 1 |
| Hwang, S | 1 |
| Edwards, A | 1 |
| Li, Y | 1 |
| Broniscer, A | 1 |
| Patay, Z | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Bittšanský, M | 3 |
| Baranovičová, E | 1 |
| Hnilicová, P | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Nosáľ, V | 1 |
| Zeleňák, K | 1 |
| Kurča, E | 1 |
| Øyen, J | 1 |
| Gjesdal, CG | 1 |
| Karlsson, T | 1 |
| Svingen, GF | 1 |
| Tell, GS | 2 |
| Strand, E | 1 |
| Drevon, CA | 2 |
| Vinknes, KJ | 1 |
| Meyer, K | 1 |
| Ueland, PM | 3 |
| Nygård, O | 1 |
| Augustine, EM | 1 |
| Spielman, DM | 1 |
| Barnes, PD | 1 |
| Sutcliffe, TL | 1 |
| Dermon, JD | 1 |
| Mirmiran, M | 1 |
| Clayton, DB | 1 |
| Ariagno, RL | 1 |
| Cheng, RK | 1 |
| Scott, AC | 1 |
| Penney, TB | 1 |
| Williams, CL | 6 |
| Meck, WH | 5 |
| Kirov, II | 2 |
| Fleysher, L | 1 |
| Fleysher, R | 1 |
| Patil, V | 1 |
| Liu, S | 1 |
| Gonen, O | 2 |
| Kulak, W | 1 |
| Sobaniec, W | 1 |
| Smigielska-Kuzia, J | 1 |
| Kubas, B | 1 |
| Zawada, B | 1 |
| Otapowicz, D | 1 |
| Ben Salem, D | 2 |
| Walker, PM | 2 |
| Aho, S | 1 |
| Tavernier, B | 2 |
| Giroud, M | 1 |
| Tzourio, C | 1 |
| Ricolfi, F | 2 |
| Brunotte, F | 2 |
| Liapi, C | 1 |
| Kyriakaki, A | 1 |
| Zarros, A | 1 |
| Al-Humadi, H | 1 |
| Stolakis, V | 1 |
| Gkrouzman, E | 1 |
| Anifantaki, F | 1 |
| Skandali, N | 1 |
| Margaritis, M | 1 |
| Tsakiris, S | 1 |
| Bejot, Y | 1 |
| Aho, SL | 1 |
| Rouaud, O | 1 |
| Domenig, C | 1 |
| Govind, V | 2 |
| Darkazanli, A | 1 |
| Studholme, C | 1 |
| Arheart, K | 1 |
| Bloomer, C | 1 |
| Chen, CS | 1 |
| Chiang, IC | 1 |
| Li, CW | 1 |
| Lin, WC | 1 |
| Lu, CY | 1 |
| Hsieh, TJ | 1 |
| Liu, GC | 1 |
| Lin, HF | 1 |
| Kuo, YT | 1 |
| Ronen, I | 1 |
| Fan, X | 1 |
| Schettler, S | 1 |
| Jain, S | 1 |
| Murray, D | 1 |
| Kim, DS | 1 |
| Killiany, R | 1 |
| Rosene, D | 1 |
| Babikian, T | 1 |
| Marion, SD | 1 |
| Copeland, S | 1 |
| Alger, JR | 1 |
| O'Neill, J | 1 |
| Cazalis, F | 1 |
| Mink, R | 1 |
| Giza, CC | 1 |
| Vu, JA | 1 |
| Hilleary, SM | 1 |
| Kernan, CL | 1 |
| Newman, N | 1 |
| Asarnow, RF | 1 |
| Raininko, R | 1 |
| Mattsson, P | 1 |
| Kristofiková, Z | 5 |
| Rícný, J | 1 |
| Ort, M | 1 |
| Rípová, D | 1 |
| Moon, J | 1 |
| Chen, M | 1 |
| Gandhy, SU | 1 |
| Strawderman, M | 1 |
| Levitsky, DA | 1 |
| Maclean, KN | 1 |
| Watanabe, T | 1 |
| Shiino, A | 1 |
| Akiguchi, I | 1 |
| O'Brien, FM | 1 |
| Page, L | 1 |
| O'Gorman, RL | 1 |
| Bolton, P | 1 |
| Sharma, A | 1 |
| Baird, G | 1 |
| Daly, E | 2 |
| Hallahan, B | 1 |
| Conroy, RM | 1 |
| Foy, C | 1 |
| Curran, S | 1 |
| Robertson, D | 1 |
| Murphy, KC | 2 |
| Murphy, DG | 2 |
| Crivello, NA | 1 |
| Blusztajn, JK | 4 |
| Joseph, JA | 2 |
| Shukitt-Hale, B | 1 |
| Smith, DE | 1 |
| Alkondon, M | 1 |
| Pereira, EF | 1 |
| Eisenberg, HM | 1 |
| Kajii, Y | 1 |
| Schwarcz, R | 1 |
| Albuquerque, EX | 1 |
| Yang, H | 1 |
| Pang, W | 1 |
| Lu, H | 1 |
| Cheng, D | 1 |
| Yan, X | 1 |
| Cheng, Y | 1 |
| Reyngoudt, H | 1 |
| Claeys, T | 1 |
| Vlerick, L | 1 |
| Verleden, S | 1 |
| Acou, M | 1 |
| Deblaere, K | 1 |
| De Deene, Y | 1 |
| Audenaert, K | 1 |
| Goethals, I | 1 |
| Achten, E | 2 |
| George, IC | 1 |
| Jayawickrama, N | 1 |
| Babb, JS | 1 |
| Perry, NN | 1 |
| Arheart, KL | 1 |
| Mullins, ME | 1 |
| Zheng, DD | 1 |
| Liu, ZH | 1 |
| Fang, J | 1 |
| Wang, XY | 1 |
| Zhang, J | 1 |
| Wallace, JM | 1 |
| McCormack, JM | 1 |
| McNulty, H | 1 |
| Walsh, PM | 1 |
| Robson, PJ | 1 |
| Bonham, MP | 1 |
| Duffy, ME | 1 |
| Ward, M | 1 |
| Molloy, AM | 1 |
| Scott, JM | 1 |
| Strain, JJ | 1 |
| Adams, RS | 1 |
| McClurg, L | 1 |
| Guerrerio, AL | 1 |
| Colvin, RM | 1 |
| Schwartz, AK | 1 |
| Molleston, JP | 1 |
| Murray, KF | 1 |
| Diehl, A | 1 |
| Mohan, P | 1 |
| Schwimmer, JB | 1 |
| Lavine, JE | 1 |
| Torbenson, MS | 1 |
| Scheimann, AO | 1 |
| Nurk, E | 1 |
| Refsum, H | 1 |
| Bjelland, I | 1 |
| Vollset, SE | 1 |
| Engedal, K | 1 |
| Nygaard, HA | 1 |
| Smith, DA | 1 |
| Chen, SQ | 1 |
| Cai, Q | 1 |
| Shen, YY | 1 |
| Wang, PJ | 1 |
| Teng, GJ | 1 |
| Zhang, W | 1 |
| Zang, FC | 1 |
| Sandstrom, NJ | 1 |
| Loy, R | 2 |
| Drew, C | 1 |
| Lapaix, F | 1 |
| Egee, S | 1 |
| Thomas, S | 1 |
| Ellory, JC | 1 |
| Staines, HM | 1 |
| Katz-Brull, R | 1 |
| Koudinov, AR | 1 |
| Degani, H | 1 |
| Sijens, PE | 2 |
| den Heijer, T | 1 |
| Origgi, D | 1 |
| Vermeer, SE | 1 |
| Breteler, MM | 2 |
| Hofman, A | 2 |
| Oudkerk, M | 2 |
| Platilová, V | 1 |
| Klaschka, J | 3 |
| Albright, CD | 2 |
| Siwek, DF | 1 |
| Craciunescu, CN | 1 |
| Mar, MH | 2 |
| Kowall, NW | 1 |
| Zeisel, SH | 4 |
| Birthelmer, A | 1 |
| Lazaris, A | 1 |
| Schweizer, T | 1 |
| Jackisch, R | 1 |
| Cassel, JC | 1 |
| Valenzuela, MJ | 1 |
| Jones, M | 1 |
| Wen, W | 2 |
| Rae, C | 1 |
| Graham, S | 1 |
| Shnier, R | 1 |
| Sachdev, P | 1 |
| HASIK, J | 2 |
| KALINOWSKI, M | 2 |
| MIKOAJCZYK, Z | 1 |
| DURKALEC, J | 2 |
| MIKOLAJCZYK, Z | 1 |
| MCMURRAY, WC | 1 |
| ARVAY, A | 1 |
| TAKACS, I | 1 |
| JAKUBECZ, S | 1 |
| Klingner, M | 1 |
| Apelt, J | 1 |
| Kumar, A | 1 |
| Sorger, D | 1 |
| Sabri, O | 1 |
| Steinbach, J | 1 |
| Scheunemann, M | 1 |
| Schliebs, R | 3 |
| Driscoll, I | 1 |
| Hamilton, DA | 1 |
| Petropoulos, H | 1 |
| Yeo, RA | 1 |
| Baumgartner, RN | 1 |
| Sutherland, RJ | 1 |
| Szentkuti, A | 1 |
| Guderian, S | 1 |
| Schiltz, K | 1 |
| Kaufmann, J | 1 |
| Münte, TF | 1 |
| Heinze, HJ | 1 |
| Düzel, E | 1 |
| Almaguer-Melian, W | 1 |
| Cruz-Aguado, R | 1 |
| Riva, Cde L | 1 |
| Kendrick, KM | 1 |
| Frey, JU | 1 |
| Bergado, J | 1 |
| van Dam, PS | 1 |
| de Winter, CF | 1 |
| de Vries, R | 1 |
| van der Grond, J | 2 |
| Drent, ML | 1 |
| Lijffijt, M | 1 |
| Kenemans, JL | 1 |
| Aleman, A | 1 |
| de Haan, EH | 1 |
| Koppeschaar, HP | 1 |
| Moreno-Torres, A | 1 |
| Pujol, J | 1 |
| Soriano-Mas, C | 1 |
| Deus, J | 1 |
| Iranzo, A | 1 |
| Santamaria, J | 1 |
| Cermák, M | 1 |
| Benesová, O | 2 |
| Zach, P | 1 |
| Lopes, GS | 1 |
| Ferreira, AT | 1 |
| Oshiro, ME | 1 |
| Vladimirova, I | 1 |
| Jurkiewicz, NH | 1 |
| Jurkiewicz, A | 1 |
| Smaili, SS | 1 |
| Girard, N | 1 |
| Fogliarini, C | 1 |
| Viola, A | 1 |
| Confort-Gouny, S | 1 |
| Fur, YL | 1 |
| Viout, P | 1 |
| Chapon, F | 1 |
| Levrier, O | 1 |
| Cozzone, P | 1 |
| Ross, AJ | 1 |
| Sachdev, PS | 1 |
| Brodaty, H | 1 |
| Calomme, M | 1 |
| Geusens, P | 1 |
| Demeester, N | 1 |
| Behets, GJ | 1 |
| D'Haese, P | 1 |
| Sindambiwe, JB | 1 |
| Van Hoof, V | 1 |
| Vanden Berghe, D | 1 |
| Schuff, N | 2 |
| Meyerhoff, DJ | 2 |
| Mueller, S | 1 |
| Chao, L | 1 |
| Sacrey, DT | 1 |
| Laxer, K | 1 |
| Weiner, MW | 3 |
| Pillai, PB | 1 |
| Fanatico, AC | 1 |
| Blair, ME | 1 |
| Emmert, JL | 1 |
| Riederer, F | 2 |
| Lehner-Baumgartner, E | 1 |
| Baumgartner, C | 1 |
| Mlynárik, V | 2 |
| Gruber, S | 2 |
| Moser, E | 2 |
| Kaya, M | 1 |
| Serles, W | 2 |
| Pinker, K | 1 |
| Chmelík, M | 1 |
| Stadlbauer, A | 1 |
| Frey, R | 1 |
| Bodamer, O | 1 |
| McIntyre, DJ | 1 |
| Charlton, RA | 1 |
| Markus, HS | 1 |
| Howe, FA | 1 |
| Yiannoutsos, CT | 1 |
| Nakas, CT | 1 |
| Navia, BA | 1 |
| Storozheva, ZI | 1 |
| Proshin, AT | 1 |
| Sherstnev, VV | 1 |
| Storozhevykh, TP | 1 |
| Senilova, YE | 1 |
| Persiyantseva, NA | 1 |
| Pinelis, VG | 1 |
| Semenova, NA | 1 |
| Zakharova, EI | 1 |
| Pomytkin, IA | 1 |
| Casey, PA | 1 |
| McKenna, MC | 1 |
| Fiskum, G | 1 |
| Saraswati, M | 1 |
| Robertson, CL | 1 |
| Roman, F | 1 |
| Della Zuana, O | 1 |
| Lonchampt, M | 1 |
| Saint Romas, G | 1 |
| Duhault, J | 1 |
| Meyer, EM | 2 |
| St Onge, E | 1 |
| Crews, FT | 1 |
| Johnston, MV | 1 |
| Coyle, JT | 3 |
| Carolei, A | 1 |
| Di Piero, V | 1 |
| Squitieri, G | 1 |
| McGeer, EG | 2 |
| Fisman, M | 1 |
| Kameyama, M | 1 |
| Lai, JC | 2 |
| Leung, TK | 2 |
| Lim, L | 2 |
| Price, DL | 2 |
| Whitehouse, PJ | 2 |
| Struble, RG | 2 |
| Clark, AW | 1 |
| Delong, MR | 1 |
| Cork, LC | 2 |
| Hedreen, JC | 1 |
| Upreti, RK | 1 |
| Pilar, G | 1 |
| Tuttle, J | 1 |
| Vaca, K | 1 |
| Goodnick, P | 1 |
| Gershon, S | 1 |
| Björklund, A | 2 |
| Stenevi, U | 1 |
| de Toledo-Morrell, L | 2 |
| Morrell, F | 2 |
| Fleming, S | 1 |
| Cohen, MM | 1 |
| Maire, JC | 1 |
| Wurtman, RJ | 3 |
| Ojika, K | 1 |
| Appel, SH | 1 |
| Vatassery, GT | 1 |
| Maletta, GJ | 1 |
| Satomi, D | 1 |
| Romero, A | 1 |
| Grau, T | 1 |
| Sacristán, A | 1 |
| Ortiz, JA | 1 |
| Lozano Fernández, R | 1 |
| De Medio, GE | 1 |
| Trovarelli, G | 1 |
| Piccinin, GL | 1 |
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Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Research Network in Nonalcoholic Steatohepatitis: Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)[NCT00063635] | Phase 3 | 173 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| Clinical Research Network in Nonalcoholic Steatohepatitis: Pioglitazone vs. Vitamin E vs. Placebo for the Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis (PIVENS)[NCT00063622] | Phase 3 | 247 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Feru-guard (Ferulic Acid and Angelica Archangelica Extract) for Behavioral Symptoms in Dementia[NCT03451760] | Phase 2 | 70 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | ||
| Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180] | 70 participants | Observational | 2003-06-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Change in Body Mass Index
(NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | kg/m-squared (Mean) |
|---|---|
| Metformin | 1.3 |
| Vitamin E | 2.1 |
| Placebo | 1.9 |
Change in Nonalcoholic Fatty Liver Disease (NAFLD) Score (Histologic Feature Scores Determined by Standardized Scoring of Liver Biopsies) From Baseline at 96 Weeks of Treatment
Histological activity was assessed using the NAFLD activity score on a scale of 0 to 8, with higher scores indicating more severe disease; the components of this measure include steatosis (0-3), lobular inflammation (0-3), and hepatocellular ballooning (0-2). (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Metformin | -1.1 |
| Vitamin E | -1.8 |
| Placebo | -0.7 |
Change in QOL- Psychosocial Health
Change in self-reported QOL physical health Pediatric Quality of Life Inventory (version 4.0) scores were recorded to range from 0 to 100 with increasing scores indicating better quality of life. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Metformin | 4.0 |
| Vitamin E | 6.0 |
| Placebo | 5.6 |
Change in Quality of Life (QOL) Scores- Physical Health
Change in self-reported QOL physical health Pediatric Quality of Life Inventory (version 4.0) scores were recorded to range from 0 to 100 with increasing scores indicating better quality of life. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Metformin | 5.4 |
| Vitamin E | 7.6 |
| Placebo | 5.4 |
Change in Serum Aspartate Aminotransferase (AST)
(NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | IU/L (Mean) |
|---|---|
| Metformin | -21.5 |
| Vitamin E | -22.8 |
| Placebo | -20.4 |
Change in Serum Vitamin E Levels
Change in alpha-Tocopherol (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | mg/L (Mean) |
|---|---|
| Metformin | -0.5 |
| Vitamin E | 9.4 |
| Placebo | -0.9 |
Number of Participants With Improvement in Ballooning Degradation Score
Ballooning is assessed on a scale of 0 to 2 with higher scores indicating more severe ballooning. This secondary outcome measure is the number of participants that experienced a decrease in ballooning score at 96 weeks compared to baseline, which indicates improvement in ballooning. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 22 |
| Vitamin E | 22 |
| Placebo | 10 |
Number of Participants With Improvement in Liver Fibrosis Score
Fibrosis is assessed on a scale of 0 to 4 with higher scores indicating more severe fibrosis. This secondary outcome measure is the number of participants that experienced a decrease in fibrosis score at 96 weeks compared to baseline, which indicates improvement in fibrosis. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 22 |
| Vitamin E | 18 |
| Placebo | 19 |
Number of Participants With Improvement in Lobular Inflammation Score
Lobular inflammation is assessed on a scale of 0 to 3 with higher scores indicating more severe lobular inflammation. This secondary outcome measure is the number of participants that experienced a decrease in lobular inflammation score at 96 weeks compared to baseline, which indicates improvement in lobular inflammation. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 23 |
| Vitamin E | 22 |
| Placebo | 20 |
Number of Participants With Improvement in Steatosis Score
Steatosis is assessed on a scale of 0 to 3 with higher scores indicating more severe steatosis. This secondary outcome measure is the number of participants that experienced a decrease in steatosis score at 96 weeks compared to baseline, which indicates improvement in steatosis. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 26 |
| Vitamin E | 27 |
| Placebo | 19 |
Number of Participants With Sustained Reduction in Alanine Aminotransferase (ALT) to Either 50% of Baseline Value or < 40 IU/L
The primary outcome was sustained reduction in ALT level, defined as 50% or less of the baseline level or 40 IU/L or less at each visit from 48 to 96 weeks of treatment. (NCT00063635)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Metformin | 9 |
| Vitamin E | 15 |
| Placebo | 10 |
Number of Participants With Improvement in Fibrosis
Fibrosis is assessed on a scale of 0 to 4 with higher scores indicating more severe fibrosis. This secondary outcome measure is the number of participants that experienced a decrease in fibrosis score, which indicates improvement in fibrosis. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 31 |
| Vitamin E | 33 |
| Placebo | 22 |
Number of Participants With Improvement in Hepatocellular Ballooning
Hepatocellular ballooning is assessed on a scale of 0 to 2 with higher scores indicating more severe hepatocellular ballooning. This secondary outcome measure is the number of participants that experienced a decrease in hepatocellular ballooning score, which indicates improvement in hepatocellular ballooning. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 31 |
| Vitamin E | 40 |
| Placebo | 21 |
Number of Participants With Improvement in Lobular Inflammation
Lobular inflammation is assessed on a scale of 0 to 3 with higher scores indicating more severe lobular inflammation. This secondary outcome measure is the number of participants that experienced a decrease in lobular inflammation score, which indicates improvement in lobular inflammation. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 41 |
| Vitamin E | 43 |
| Placebo | 25 |
Number of Participants With Improvement in Non-alcoholic Fatty Liver Disease (NAFLD) Activity Defined by Change in Standardized Scoring of Liver Biopsies at Baseline and After 96 Weeks of Treatment.
Total nonalcoholic fatty liver disease (NAFLD) activity was assessed on a scale of 0 to 8, with higher scores indicating more severe disease; the components of this measure include steatosis (assessed on a scale of 0 to 3), lobular inflammation (assessed on a scale of 0 to 3), and hepatocellular ballooning (assessed on a scale of 0 to 2). The primary outcome was an improvement in histological findings from baseline to 96 weeks, which required an improvement by 1 or more points in the hepatocellular ballooning score; no increase in the fibrosis score; and either a decrease in the activity score for nonalcoholic fatty liver disease to a score of 3 or less or a decrease in the activity score of at least 2 points, with at least a 1-point decrease in either the lobular inflammation or steatosis score. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 27 |
| Vitamin E | 36 |
| Placebo | 16 |
Number of Participants With Improvement in Steatosis
Steatosis is assessed on a scale of 0 to 3 with higher scores indicating more severe steatosis. This secondary outcome measure is the number of participants that experienced a decrease in steatosis score, which indicates improvement in steatosis. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 48 |
| Vitamin E | 43 |
| Placebo | 22 |
Number of Participants With Resolution of Definite Nonalcoholic Steatohepatitis
The criteria for nonalcoholic steatohepatitis was definite or possible steatohepatitis (assessed by a pathologist) with an activity score of 5 or more, or definite steatohepatitis (confirmed by two pathologists) with an activity score of 4. This secondary outcome measure is the number of participants who met this definition at baseline and did not meet this definition after 96 weeks of treatment and thus had a resolution of steatohepatitis. (NCT00063622)
Timeframe: baseline and 96 weeks
| Intervention | participants (Number) |
|---|---|
| Pioglitazone | 33 |
| Vitamin E | 29 |
| Placebo | 15 |
Reviews
29 reviews available for choline and Aging
| Article | Year |
|---|---|
Nutrition and the aging retina: A comprehensive review of the relationship between nutrients and their role in age-related macular degeneration and retina disease prevention.
Topics: Aging; Antioxidants; Choline; Diet; Dietary Supplements; Docosahexaenoic Acids; Fatty Acids, Unsatur | 2020 |
Examining the relationship between nutrition and cerebral structural integrity in older adults without dementia.
Topics: Aged; Aged, 80 and over; Aging; Brain; Choline; Cognition; Cognitive Dysfunction; Dementia; Diet; Di | 2019 |
Neurochemical changes in the aging brain: A systematic review.
Topics: Aging; Alzheimer Disease; Animals; Brain; Choline; Cognition; Creatine; Humans | 2019 |
Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan.
Topics: Aging; Animals; Attention; Behavior, Animal; Choline; Cognition; Dietary Supplements; Embryonic and | 2003 |
N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease.
Topics: Aging; Alcoholism; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Brain Injuries; | 2006 |
[Neurobiological and neurochemical aspects and therapeutic problems in aging and in dementia].
Topics: Age Factors; Aged; Aging; Brain Chemistry; Choline; Dementia; Humans; Nervous System; Nervous System | 1980 |
Neurotransmitter systems in aging and senile dementia.
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g | 1981 |
Clinical pharmacology of senile dementia.
Topics: Aged; Aging; Anticoagulants; Arginine Vasopressin; Brain; Choline; Dementia; Dihydroergotoxine; Free | 1981 |
[Aging of the nervous system--with special reference to dementia in the aged].
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Dementia; Humans; | 1983 |
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co | 1984 |
Intracerebral neural implants: neuronal replacement and reconstruction of damaged circuitries.
Topics: Adrenergic Fibers; Aging; Animals; Axons; Behavior, Animal; Brain; Brain Stem; Central Nervous Syste | 1984 |
Effects of consumption of choline and lecithin on neurological and cardiovascular systems.
Topics: Acetylcholine; Aging; Arteriosclerosis; Choline; Diet; Humans; Hypercholesterolemia; Memory; Movemen | 1982 |
Alzheimer's disease: a challenging enigma.
Topics: Aging; Animals; Brain; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; De | 1982 |
The cholinergic hypothesis of geriatric memory dysfunction.
Topics: Acetylcholine; Adult; Aged; Aging; Alzheimer Disease; Animals; Brain Chemistry; Choline; Choline O-A | 1982 |
Age-related changes in rodent cortical acetylcholine and cognition: main effects of age versus age as an intervening variable.
Topics: Acetylcholine; Aging; Animals; Carrier Proteins; Cerebral Cortex; Choline; Choline O-Acetyltransfera | 1998 |
Neuroendocrinology of ageing.
Topics: Aging; Amino Acid Transport Systems; Animals; Carrier Proteins; Choline; Corticotropin-Releasing Hor | 2001 |
Neuronal--glial interactions during development and aging.
Topics: Acetylcholinesterase; Acetyltransferases; Aging; Animals; Blood-Brain Barrier; Brain; Brain Chemistr | 1975 |
Neuroplasticity, the aging brain, and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Aziridines; Brain; Brain Tissue Transplantation; Choline; Ganglio | 1992 |
Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: new findings and an interpretative review.
Topics: Aging; Animals; Binding, Competitive; Brain; Choline; Choline O-Acetyltransferase; Male; Mice; Mice, | 1990 |
Central cholinergic pathways and learning and memory processes: presynaptic aspects.
Topics: Aging; Animals; Biomechanical Phenomena; Brain; Choline; Hippocampus; Humans; Learning; Memory; Mode | 1989 |
Neurobiological studies of transmitter systems in aging and in Alzheimer-type dementia.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Amyloid; Animals; Axons; Brain; Cerebral Cortex; Cho | 1985 |
Nutrient transport and the blood-brain barrier in developing animals.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Blood-Brain Barrier; Brain; Cap | 1986 |
Possible dietary strategies to reduce cognitive deficits in old age.
Topics: Acetylcholine; Aging; Amino Acids; Brain; Choline; Cognition; Humans; Neurotransmitter Agents; Nutri | 1986 |
Behavioral correlates of presynaptic events in the cholinergic neurotransmitter system.
Topics: Acetylcholine; Aging; Behavior; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Cholineste | 1988 |
Phosphatidylcholine, choline and cholinergic function.
Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Alzheimer Disease; Animals; Avoidance Learning; Biological | 1986 |
Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity.
Topics: Aged; Aging; Aluminum; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Hapl | 1986 |
Dietary choline and synaptic morphology in mice.
Topics: Aging; Animals; Choline; Diet; Mice; Mice, Inbred C57BL; Synapses | 1987 |
Neural grafting in animal models of neurodegenerative diseases.
Topics: Aging; Animals; Behavior, Animal; Brain; Brain Diseases; Choline; Corpus Striatum; Denervation; Dise | 1985 |
Neurotransmitter synthetic enzymes.
Topics: Acetylcholine; Acetyltransferases; Adenylyl Cyclases; Aging; Aminobutyrates; Animals; Brain; Brain C | 1973 |
Trials
14 trials available for choline and Aging
| Article | Year |
|---|---|
Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study.
Topics: Aged; Aging; Betaine; Carbon; Cardiovascular Diseases; Choline; Dietary Supplements; Female; Homocys | 2022 |
Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial.
Topics: Aged; Aged, 80 and over; Aging; Brain; Brain-Derived Neurotrophic Factor; Choline; Exercise; Female; | 2017 |
Estimate of choline nutritional requirements for chicks from 1 to 21 days of age.
Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Chickens; Choline; Diet; Do | 2018 |
Prediction of Neurological Impairment in Cervical Spondylotic Myelopathy using a Combination of Diffusion MRI and Proton MR Spectroscopy.
Topics: Adult; Aged; Aging; Aspartic Acid; Choline; Creatinine; Diffusion Tensor Imaging; Female; Gait Disor | 2015 |
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Dietary Supplements; Double-Blind Met | 2012 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Aged; Aging; Biopsy; Child; Choline; Choline Deficiency; Cohort Studies; Cross-Se | 2012 |
The aging hippocampus: cognitive, biochemical and structural findings.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Choline; Cognition; Creatine; Female; Hippocam | 2003 |
Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate.
Topics: Adolescent; Adult; Age of Onset; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; C | 2005 |
Homocysteine remethylation in broilers fed surfeit choline or betaine and varying levels and sources of methionine from eight to twenty-two days of age.
Topics: Aging; Animal Feed; Animals; Betaine; Chickens; Choline; Dose-Response Relationship, Drug; Homocyste | 2006 |
Neurotransmitter systems in aging and senile dementia.
Topics: Acetylcholine; Aged; Aging; Animals; Brain; Choline; Clinical Trials as Topic; Dementia; Dopamine; g | 1981 |
Proton spectroscopy of human brain: effects of age and sex.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Humans; Magnet | 1994 |
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-A | 2001 |
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female | 2001 |
Methylcholine-activated eccrine sweat gland density and output as a function of age.
Topics: Adult; Aged; Aging; Choline; Eccrine Glands; Humans; Male; Middle Aged; Sweat; Sweat Glands | 1988 |
Other Studies
295 other studies available for choline and Aging
| Article | Year |
|---|---|
Organization of neurochemical interactions in young and older brains as revealed with a network approach: Evidence from proton magnetic resonance spectroscopy (
Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Motor Cortex; Prefrontal Cor | 2023 |
Neurometabolic correlates of posturography in normal aging and older adults with mild cognitive impairment: Evidence from a
Topics: Aged; Aging; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Glutamine; Humans; Inositol; P | 2023 |
Microstructural and Metabolic Changes in Normal Aging Human Brain Studied with Combined Whole-Brain MR Spectroscopic Imaging and Quantitative MR Imaging.
Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Magnetic Resonance Imaging; Magnet | 2023 |
One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.
Topics: Aging; Animals; Brain; Choline; Dietary Supplements; Male; Methylenetetrahydrofolate Reductase (NADP | 2019 |
Evaluation of Choline and Acetylcholine Levels in Responders and Nonresponders to Anticholinergic Therapy for Overactive Bladder Syndrome.
Topics: Acetylcholine; Aged; Aging; Biomarkers, Pharmacological; Choline; Cholinergic Antagonists; Correlati | 2020 |
Changes in the intracellular microenvironment in the aging human brain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Cellular M | 2020 |
Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice.
Topics: Acetyl Coenzyme A; Acetylcholine; Aging; alpha-Amylases; Animals; Cell Line; Choline; Choline O-Acet | 2021 |
Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats.
Topics: Aging; Animals; Choline; Dizocilpine Maleate; Doublecortin Protein; Female; Hippocampus; Male; Memor | 2017 |
Lifespan leisure physical activity profile, brain plasticity and cognitive function in old age.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspartic Acid; Attention; Brain; Brain-Derived Neurotro | 2019 |
CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation.
Topics: Aging; Alzheimer Disease; Animals; CA1 Region, Hippocampal; Choline; Dietary Supplements; Disease Mo | 2018 |
Effects of Aging on the Human Brain: A Proton and Phosphorus MR Spectroscopy Study at 3T.
Topics: Adult; Aged; Aging; Biomarkers; Brain; Choline; Creatine; Female; Gray Matter; Humans; Magnetic Reso | 2018 |
Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway.
Topics: Aging; Animals; Caspase 1; Cells, Cultured; Choline; Down-Regulation; Galactose; Interleukin-1beta; | 2018 |
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Topics: Aging; Amyloid beta-Peptides; Animals; Anxiety; Brain; Cell Survival; Cerebral Cortex; Choline; CpG | 2019 |
Persistent attenuation of brain oxidative stress through aging in perinatal maternal separated rat pups supplemented with choline and docosahexaenoic acid or Clitoria ternatea aqueous root extract.
Topics: Aging; Animals; Antioxidants; Brain; Choline; Clitoria; Dietary Supplements; Docosahexaenoic Acids; | 2018 |
Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Hippoc | 2019 |
Special issue on advances and controversies in B vitamins and choline.
Topics: Aging; Choline; Dementia; Dietary Supplements; Humans; Risk Factors; Vascular Diseases; Vitamin B Co | 2013 |
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.
Topics: Adult; Aging; Aspartic Acid; Choline; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; | 2013 |
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di | 2013 |
Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Biomarkers; Brain; Brain Stem; Cerebral Cortex; | 2013 |
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; China; Choline; Creatine; Fem | 2014 |
APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.
Topics: Aged; Aged, 80 and over; Aging; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain; Chol | 2014 |
Faster metabolite (1)H transverse relaxation in the elder human brain.
Topics: Adolescent; Aged; Aged, 80 and over; Aging; Aspartic Acid; Cellular Microenvironment; Choline; Creat | 2013 |
Brain aging, memory impairment and oxidative stress: a study in Drosophila melanogaster.
Topics: Acetylcholine; Aging; Animals; Animals, Genetically Modified; Brain; Catalase; Choline; Choline O-Ac | 2014 |
Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs.
Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Creatine; Dogs; Female; Lactic Acid; Magnetic Resonan | 2014 |
High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging.
Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Functional Neuroimaging; Glucose; Glutamic Acid; Magn | 2014 |
Unexpected lack of deleterious effects of uranium on physiological systems following a chronic oral intake in adult rat.
Topics: Administration, Oral; Aging; Animals; Antioxidants; Blood Cell Count; Cholesterol; Choline; Drinking | 2014 |
Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits.
Topics: Adult; Aging; Apolipoprotein E4; Choline; Cognition Disorders; Cross-Sectional Studies; Female; Fron | 2014 |
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.
Topics: Aging; Animals; Basal Forebrain; Cell Count; Cell Size; Choline; Cholinergic Neurons; Dietary Supple | 2014 |
Age related changes in metabolite concentrations in the normal spinal cord.
Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; | 2014 |
Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Deuterium; Disease Models, Animal; Female; Fragile X | 2015 |
Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome.
Topics: Age Factors; Aging; Animals; Choline; Choline O-Acetyltransferase; Disease Models, Animal; Down Synd | 2016 |
MR Spectra of Normal Adult Testes and Variations with Age: Preliminary Observations.
Topics: Adult; Age Factors; Aged; Aging; Choline; Creatine; Humans; Inositol; Magnetic Resonance Spectroscop | 2016 |
A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice.
Topics: Aging; Alanine Transaminase; Animals; Bile Ducts; Biomarkers; Body Weight; Cell Differentiation; Cel | 2015 |
Effects of Ginkgo biloba Extract EGb 761, Donepezil and their Combination on Central Cholinergic Function in Aged Rats.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitor | 2015 |
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Amin | 2016 |
Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine.
Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Triphosphate; Aging; Annexin A5; Apoptosis; Cell Pro | 2016 |
Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.
Topics: Adolescent; Aging; Aspartic Acid; Biomarkers, Tumor; Brain Stem; Brain Stem Neoplasms; Child; Child, | 2016 |
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre | 2017 |
Dietary Choline Intake Is Directly Associated with Bone Mineral Density in the Hordaland Health Study.
Topics: Aged; Aging; Bone Density; Choline; Diet; Female; Humans; Male; Middle Aged; Odds Ratio | 2017 |
Can magnetic resonance spectroscopy predict neurodevelopmental outcome in very low birth weight preterm infants?
Topics: Aging; Aspartic Acid; Basal Ganglia; Child Development; Choline; Cohort Studies; Follow-Up Studies; | 2008 |
Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats.
Topics: Acoustic Stimulation; Aging; Animals; Behavior, Animal; Choline; Dietary Supplements; Discrimination | 2008 |
Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spec | 2008 |
An age and gender dependency of metabolite concentrations in basal ganglia in children with spastic diplegia: proton magnetic resonance spectroscopy study.
Topics: Adolescent; Aging; Aspartic Acid; Basal Ganglia; Case-Control Studies; Cerebral Palsy; Child; Child, | 2009 |
Brain flexibility and balance and gait performances mark morphological and metabolic abnormalities in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Community Health Planning; Creatine; | 2008 |
Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions.
Topics: Acetylcholinesterase; Aging; Animals; Brain; Ca(2+) Mg(2+)-ATPase; Choline; Diet; Male; Rats; Rats, | 2009 |
N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disor | 2008 |
Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI).
Topics: Adolescent; Adult; Aging; Algorithms; Brain; Brain Injuries; Choline; Female; Humans; Image Enhancem | 2009 |
Proton magnetic resonance spectroscopy of late-life major depressive disorder.
Topics: Aged; Aging; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Choline; Cognition; Creatine; Depressi | 2009 |
Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Humans; Image Processing, Co | 2011 |
Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.
Topics: Adolescent; Age Factors; Aging; Anisotropy; Aspartic Acid; Axons; Biomarkers; Brain Injuries; Child; | 2010 |
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Fe | 2010 |
Aging and lateralization of the rat brain on a biochemical level.
Topics: 17-Hydroxysteroid Dehydrogenases; Aging; Alzheimer Disease; Animals; Biomarkers; Brain; Cerebrum; Ch | 2010 |
Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome.
Topics: Aging; Animals; Attention; Choline; Cognition; Dietary Supplements; Disease Models, Animal; Down Syn | 2010 |
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging.
Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chem | 2010 |
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging.
Topics: Adolescent; Adult; Age Factors; Aging; Amygdala; Aspartic Acid; Asperger Syndrome; Brain Mapping; Ch | 2010 |
Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline Deficiency; Diet; Dopamine; Folic Acid; Folic | 2010 |
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A | 2011 |
Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice.
Topics: Aging; Animals; Anthocyanins; Blueberry Plants; Brain Chemistry; Choline; Fruit; Galactosides; gamma | 2011 |
Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Choline; Creatine; | 2012 |
Longitudinal inter- and intra-individual human brain metabolic quantification over 3 years with proton MR spectroscopy at 3 T.
Topics: Aging; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Humans; Inositol; Longitudinal Studies; | 2012 |
Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions.
Topics: Adult; Aged; Aging; Aspartic Acid; Body Mass Index; Brain; Choline; Female; Humans; Magnetic Resonan | 2012 |
Daydreaming about our metaphorical tool belt.
Topics: Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male | 2012 |
The effect of age and cerebral ischemia on diffusion-weighted proton MR spectroscopy of the human brain.
Topics: Adult; Aging; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Female; Humans; Male; Reprodu | 2012 |
Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats.
Topics: Aging; Animals; Antidepressive Agents; Anxiety; Choline; Depression; Dietary Supplements; Female; Ma | 2012 |
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies | 2013 |
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin | 2012 |
Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats.
Topics: Aging; Animals; Cell Size; Choline; Enzyme-Linked Immunosorbent Assay; Female; Hippocampus; Male; Me | 2002 |
Age-dependent changes in cation transport in the chicken erythrocyte.
Topics: Aging; Animals; Cations; Chickens; Choline; Erythrocytes; Ion Transport; Osmolar Concentration; Pota | 2002 |
Choline in the aging brain.
Topics: Aging; Algorithms; Animals; Biological Transport, Active; Brain Chemistry; Cerebral Cortex; Choline; | 2002 |
Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Linear Mode | 2003 |
Age- and sex-dependent effects of ethanol on hippocampal hemicholinium-3 sensitive choline carriers during postnatal development of rats.
Topics: Aging; Animals; Animals, Newborn; Anisotropy; Binding Sites; Binding, Competitive; Biological Transp | 2003 |
Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus.
Topics: Aging; Animals; Calbindin 2; Choline; Choline Deficiency; Embryonic and Fetal Development; Female; G | 2003 |
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate | 2003 |
Memory training alters hippocampal neurochemistry in healthy elderly.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain Chemistry; Brain Mapping; Cerebral Cortex; Chol | 2003 |
[Treatment of arteriosclerosis in senile patients with essential choline phospholipids in ambulatory conditions and in the health resort].
Topics: Aged; Aged, 80 and over; Aging; Arteriosclerosis; Choline; Health Resorts; Phosphatidylcholines; Pho | 1961 |
[Effect of arteriosclerosis therapy with essential choline phospholipids on the ballistocardiogram of senile patients in ambulatory conditions and at the health resort].
Topics: Aged; Aged, 80 and over; Aging; Arteriosclerosis; Ballistocardiography; Choline; Health Resorts; Hum | 1961 |
METABOLISM OF PHOSPHATIDES IN DEVELOPING RAT BRAIN--I. INCORPORATION OF RADIOACTIVE PRECURSORS.
Topics: Aging; Animals; Animals, Newborn; Brain; Choline; Lecithins; Lipid Metabolism; Phosphates; Phosphati | 1964 |
EXPERIMENTS FOR THE CONTROL OF BIOLOGICAL SENESCENCE.
Topics: Aging; Anabolic Agents; Choline; Rats; Steroids; Testosterone Congeners; Vitamin A; Vitamins | 1965 |
Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology.
Topics: Acetylcholine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Choline; G | 2003 |
Effect of aging on brain metabolism in antiretroviral-naive HIV patients.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Basal Ganglia; Brain; Choline; Creatinine; Female; Frontal | 2004 |
Quantitative MR analyses of the hippocampus: unspecific metabolic changes in aging.
Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Aspartic Acid; Attention; Brain Chemistry; Ch | 2004 |
Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats.
Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Choline; Dentate Gyrus; Glutamic Acid; Glycine; Hydrox | 2005 |
Age-related metabolic changes in the upper brainstem tegmentum by MR spectroscopy.
Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Mapping; Choline; Creatine; Female; H | 2005 |
Exposure of postnatal rats to a static magnetic field of 0.14 T influences functional laterality of the hippocampal high-affinity choline uptake system in adulthood; in vitro test with magnetic nanoparticles.
Topics: Aging; Animals; Animals, Newborn; Choline; Drug Carriers; Electromagnetic Fields; Functional Lateral | 2005 |
Aging-related changes of intracellular Ca2+ stores and contractile response of intestinal smooth muscle.
Topics: Aging; Animals; Calcium; Calcium-Transporting ATPases; Carbonyl Cyanide p-Trifluoromethoxyphenylhydr | 2006 |
MRS of normal and impaired fetal brain development.
Topics: Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Fetal Development; Fetus; gamma-Aminobutyric | 2006 |
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Chi-Square Distribution; | 2006 |
Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid.
Topics: Absorptiometry, Photon; Aging; Animals; Bone Density; Calcium; Choline; Dietary Supplements; Female; | 2006 |
Decrease of NAA with aging outside the seizure focus in mesial temporal lobe epilepsy--a proton-MRS study at 3 Tesla.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Drug Resistance; Epilepsy, Temporal Lobe | 2007 |
Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Imaging, Th | 2008 |
Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain.
Topics: Aged; Aged, 80 and over; Aging; Artifacts; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Fema | 2007 |
Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injury.
Topics: Adult; Aging; AIDS Dementia Complex; Algorithms; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistr | 2008 |
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia.
Topics: Aging; Amnesia; Amyloid beta-Peptides; Animals; Cerebrovascular Circulation; Choline; Cognition Diso | 2008 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
[Biochemical changes in 24-month-old Wistar rats].
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholinesterase; Aging; Animals; Choline; Choline O-Acetyltrans | 1984 |
Effects of aging on rat cortical presynaptic cholinergic processes.
Topics: Acetylcholine; Aging; Animals; Atropine; Cerebral Cortex; Choline; Culture Techniques; Dose-Response | 1984 |
Lecithin and memory.
Topics: Acetylcholine; Aging; Animals; Choline; Humans; Memory; Paired-Associate Learning; Phosphatidylcholi | 1980 |
Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate.
Topics: Acetylcholine; Aging; Animals; Azo Compounds; Cerebral Cortex; Choline; Choline O-Acetyltransferase; | 1980 |
Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy.
Topics: Acetylcholinesterase; Aging; Animals; Brain Chemistry; Choline; Chronic Disease; Disease Models, Ani | 1984 |
Alzheimer's disease and Down's syndrome.
Topics: Acetylcholinesterase; Adult; Aged; Aging; Alzheimer Disease; Animals; Axons; Brain; Choline; Choline | 1982 |
Age dependent variations in choline and ethanolamine phosphorylating activities of rodents.
Topics: Aging; Animals; Choline; Choline Kinase; Ethanolamine; Ethanolamines; Kidney; Liver; Mice; Phosphory | 1980 |
Functional maturation of motor nerve terminals in the avian iris: ultrastructure, transmitter metabolism and synaptic reliability.
Topics: Acetylcholine; Aging; Animals; Chick Embryo; Choline; Iris; Membrane Potentials; Microscopy, Electro | 1981 |
Pentoxifylline reverses age-related deficits in spatial memory.
Topics: Aging; Animals; Choline; Cues; Discrimination Learning; Male; Memory; Mental Recall; Orientation; Pe | 1984 |
Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging.
Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Cell Membrane; Choline; Cholinergic Fibers; | 1984 |
Neurotrophic effects of hippocampal extracts on medial septal nucleus in vitro.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Ganglia, Spinal; Hippoca | 1984 |
Relationship between nutrition and dementia in the elderly.
Topics: Acetylcholine; Aged; Aged, 80 and over; Aging; Aluminum; Choline; Cognition; Dementia; Folic Acid; H | 1983 |
Uptake and metabolism of choline in the organotypic culture of newborn mouse cerebellum.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Biological Transport; Brain; Carbon Radioisotopes; | 1983 |
Study of subacute toxicity of CDP-choline after 30 days of oral administration to rats.
Topics: Administration, Oral; Aging; Animals; Choline; Cytidine Diphosphate Choline; Diet; Eating; Female; M | 1983 |
Efficacy and safety of oral CDP-choline. Drug surveillance study in 2817 cases.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aging; Cerebrovascular Disorders; Child; Choline; Cyt | 1983 |
The effect of cytidine-diphosphate choline (CDP-choline) on brain lipid changes during aging.
Topics: Aging; Animals; Brain; Carbon Radioisotopes; Choline; Cytidine Diphosphate Choline; Lipid Metabolism | 1984 |
Effects of chronic manipulations of dietary choline on locomotor activity, discrimination learning and cortical acetylcholine release in aging adult Fisher 344 rats.
Topics: Acetylcholine; Aging; Animals; Cerebral Cortex; Choline; Discrimination Learning; Male; Motor Activi | 1984 |
Expression of a distinct B cell clonotype profile after recovery from antigen-induced unresponsiveness.
Topics: Aging; Animals; Antibody-Producing Cells; Antigens; B-Lymphocytes; Choline; Clone Cells; Hemolytic P | 1982 |
Metabolic studies of N-bases of phospholipids and long chain bases of sphingolipids in two-weeks-old mouse brain tissue in comparison with one-month-old mouse visceral tissues.
Topics: Aging; Animals; Brain; Choline; Decarboxylation; Ethanolamines; Mice; Phospholipids; Serine; Sphingo | 1980 |
Can drugs halt memory loss?
Topics: Aged; Aging; Amnesia; Animals; Choline; Cholinergic Fibers; Female; Haplorhini; Humans; Male; Memory | 1981 |
The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia.
Topics: Adult; Aged; Aging; Alzheimer Disease; Carbachol; Choline; Dementia; Dose-Response Relationship, Dru | 1983 |
Effects of postnatal trimethyltin or triethyltin treatment on CNS catecholamine, GABA, and acetylcholine systems in the rat.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Dopamine; gamma-Aminobutyric Acid; Norepinephrine; Or | 1983 |
Calcium-dependent [3H]acetylcholine release and muscarinic autoreceptors in rat cortical synaptosomes during development.
Topics: Acetylcholine; Aging; Animals; Calcium; Cerebral Cortex; Choline; Kinetics; Rats; Rats, Inbred Strai | 1983 |
Metabolic activity of developing rat lung.
Topics: Aging; Animals; Animals, Newborn; Choline; Female; Glucosamine; Glycoproteins; Lung; Palmitic Acids; | 1981 |
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; R | 1982 |
Developmental changes in rat blood choline concentration.
Topics: Aging; Alcohol Oxidoreductases; Animals; Animals, Newborn; Choline; Diet; Female; Kinetics; Liver; M | 1981 |
Surfactant phosphatidylcholine source, fluxes, and turnover times in 3-day-old, 10-day-old, and adult rabbits.
Topics: Aging; Animals; Carbon Radioisotopes; Choline; Kinetics; Mathematics; Palmitic Acid; Palmitic Acids; | 1982 |
The effects of chronic manganese chloride treatment expressed as age-dependent, transient changes in rat brain synaptosomal uptake of amines.
Topics: Aging; Animals; Biological Transport; Brain; Chlorides; Choline; Dopamine; Male; Manganese; Manganes | 1982 |
Phosphorylcholine and phosphorylethanolamine concentrations in the lens.
Topics: Aging; Animals; Cataract; Chickens; Choline; Culture Techniques; Ethanolamines; Female; Humans; Lens | 1982 |
Developmental modulations of blood-brain barrier permeability as an indicator of changing nutritional requirements in the brain.
Topics: Adenine; Aging; Animals; Animals, Newborn; Arginine; Blood-Brain Barrier; Brain; Butanols; Choline; | 1982 |
Plasma choline and blood cholinesterases in aged rats.
Topics: Aging; Animals; Choline; Cholinesterases; Erythrocytes; Male; Rats; Rats, Inbred F344; Rats, Inbred | 1982 |
Control of phosphatidylcholine biosynthesis in myopathic hamster hearts.
Topics: Aging; Animals; Cardiomyopathies; Choline; Cricetinae; Cytidine Diphosphate Choline; Cytidine Tripho | 1982 |
Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments.
Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Choline; Choline O-Acetyltransferase; Hippoca | 1981 |
Immune response to phosphorylcholine. VIII. The response CBA/N mice to PC-LPS.
Topics: Aging; Animals; Antibody Formation; Antibody Specificity; Choline; Female; Immunoglobulin G; Immunog | 1981 |
Carrier mediated transport of choline in rat lens.
Topics: Aging; Animals; Biological Transport, Active; Choline; Culture Techniques; Ethanolamines; Lens, Crys | 1981 |
Brain acetylcholine synthesis declines with senescence.
Topics: Acetylcholine; Aging; Animals; Behavior, Animal; Brain; Choline; Glucose; Lactates; Mice | 1981 |
Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.
Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Choline; Male; Memory; Parasympathetic Nervous Syste | 1981 |
Development and aging of cholinergic synapses. VI. Mechanisms of acetylcholine biosynthesis in the chick iris.
Topics: Acetylcholine; Aging; Animals; Chick Embryo; Chickens; Choline; Cholinesterase Inhibitors; Cold Temp | 1981 |
Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup.
Topics: Administration, Oral; Aging; Body Height; Body Weight; Child; Choline; Female; Humans; Kinetics; Mal | 1980 |
Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment.
Topics: Aging; Animals; Biological Transport; Body Weight; Brain; Cerebral Cortex; Choline; Corpus Striatum; | 1980 |
Age-related changes in passive avoidance retention: modulation with dietary choline.
Topics: Administration, Oral; Aging; Animals; Avoidance Learning; Choline; Mice; Mice, Inbred Strains; Time | 1980 |
Age dependent changes in choline uptake of the chick iris.
Topics: Acetylcholine; Aging; Animals; Chickens; Choline; Iris; Kinetics; Sodium; Temperature | 1980 |
Development and aging of cholinergic synapses. II. Continuous growth of acetylcholine and choline levels in autonomic ganglia and iris of the chick.
Topics: Acetylcholine; Aging; Animals; Chickens; Choline; Ganglia, Autonomic; Ganglia, Parasympathetic; Gang | 1980 |
Newborn rabbit blood-brain barrier is selectively permeable and differs substantially from the adult.
Topics: Adenine; Adenosine; Aging; Amino Acids; Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Carbo | 1980 |
Development and aging of cholinergic synapses. III. Choline uptake in the developing iris of the chick.
Topics: Aging; Animals; Biological Transport; Chick Embryo; Chickens; Choline; Cholinergic Fibers; Iris; Kin | 1980 |
Food for thought.
Topics: Aging; Brain Chemistry; Choline; Diet; Humans; Magnetic Resonance Spectroscopy; Neurons | 1995 |
Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood-Brain Barrier; Brain | 1995 |
Effects of prolonged (1 year) choline deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver.
Topics: Aging; Animals; Cell Membrane; Choline; Choline Deficiency; Diglycerides; Fatty Acids; gamma-Glutamy | 1995 |
Nicotine improves cognitive disturbance in senescence-accelerated mice.
Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Body Weight; Brain Chemistry; Choline; Cognition | 1994 |
Age-related changes of cholinergic markers in the rat brain.
Topics: Acetylcholinesterase; Aging; Animals; Binding, Competitive; Biomarkers; Cerebral Cortex; Choline; Ch | 1994 |
Evidence for age-associated reduction in acetylcholine release and smooth muscle response in the rat colon.
Topics: Acetylcholine; Aging; Animals; Choline; Colon; Electric Stimulation; Gastrointestinal Motility; In V | 1994 |
[Experimental techniques for developing new drugs acting on dementia (4)--Aged rats].
Topics: Acetylcholinesterase; Aging; Animals; Choline; Choline O-Acetyltransferase; Dementia; Female; Male; | 1994 |
Changes in the cholinergic neurochemical parameters in regional brain areas of Wistar rats aged 3 (weanling), 10 (mature) and 119 (old age) weeks.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Ma | 1994 |
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging.
Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Axons; Brain; Cerebral Cortex; Cerebral Ventricles; C | 1994 |
Nerve growth factor affects the cholinergic neurochemistry and behavior of aged rats.
Topics: Acetylcholine; Aging; Animals; Behavior, Animal; Biomarkers; Choline; Choline O-Acetyltransferase; C | 1993 |
Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats.
Topics: Acetylcholine; Aging; Animals; Biomarkers; Brain; Cerebral Ventricles; Choline; Choline O-Acetyltran | 1993 |
The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Magnetic Res | 1993 |
Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats.
Topics: Aging; Animals; Choline; Choline O-Acetyltransferase; Corpus Striatum; Frontal Lobe; Hippocampus; Le | 1993 |
Improving effect of acetylcholine receptor agonists on a deficit of 2-deoxyglucose uptake in cerebral cortical and hippocampal slices in aged and AF64A-treated rats.
Topics: Acetylcholine; Aging; Animals; Aziridines; Cerebral Cortex; Cerebral Ventricles; Choline; Deoxygluco | 1993 |
Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E.
Topics: Aging; Animals; Aziridines; Brain; Choline; Choline O-Acetyltransferase; Corpus Striatum; Frontal Lo | 1993 |
Spatial learning impairment in aged rats: comparing between aged basal forebrain lesioned and normal aged rats.
Topics: Acetylcholinesterase; Aging; Animals; Aziridines; Cerebral Cortex; Choline; Choline O-Acetyltransfer | 1995 |
Cholinergic changes in the hippocampus of stroke-prone spontaneously hypertensive rats.
Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Cerebral Cortex; Cerebrovascular Disorders; Choli | 1996 |
Cholinergic and Related Mechanisms in Aging and Disease: a Tribute to Donald J. Jenden, M.D. Los Angeles, California, November 17-18, 1995.
Topics: Acetylcholine; Aging; Animals; Choline; History, 20th Century; Humans; Receptors, Cholinergic | 1996 |
The influence of aging on whole body choline release and clearance.
Topics: Aging; Animals; Choline; Hypoxia; Male; Rats | 1996 |
Cholinergic control of cerebral blood flow in stroke, trauma and aging.
Topics: Acetylcholine; Aging; Animals; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Choline; | 1996 |
In vivo proton magnetic resonance spectroscopy of the normal aging human brain.
Topics: Adult; Aged; Aging; Body Water; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Inositol | 1996 |
Modulation of cholinergic synaptic functions by sialylcholesterol.
Topics: Acetylcholine; Aging; Animals; Calcium; Cerebral Cortex; Cholesterol Esters; Choline; Female; Gangli | 1996 |
Effects of nicotinamide on central cholinergic transmission and on spatial learning in rats.
Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Choline; Cognition; Extracellular Space; Hippocampus | 1996 |
Cerebral ischemia in young and adult gerbils: effects on cholinergic metabolism.
Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Choline; Gerbillinae; Ischemic Attack, Transi | 1996 |
Age-dependent effect of AF64A on cholinergic activity in the septo-hippocampal pathway of the rat brain: decreased responsiveness in aged rats.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Aziridines; Choline; Choline O-Acetyltransf | 1996 |
Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Age Factors; Aging; Aspartic Acid; Choline; Creatine; Female; Functional Laterali | 1996 |
The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer's disease.
Topics: Acetylcholine; Age of Onset; Aging; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cell Membrane; | 1997 |
Age-related variations in hepatic biosynthesis of phosphatidylcholine: a study of choline metabolism with perfused rat liver.
Topics: Aging; Animals; Bile; Choline; Lipoproteins, VLDL; Liver; Male; Perfusion; Phosphatidylcholines; Rat | 1997 |
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly.
Topics: Aged; Aging; Aspartic Acid; Brain; Choline; Creatine; Humans; Intracranial Arteriosclerosis; Magneti | 1997 |
Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study.
Topics: Aging; Amygdala; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Choline; Creatine; Entorhinal | 1997 |
Protection against developmental deficiencies by a lipophilic VIP analogue.
Topics: Aging; Animals; Aziridines; Choline; Hypoxia; Intellectual Disability; Male; Maze Learning; Memory; | 1998 |
Choline availability modulates the expression of TGFbeta1 and cytoskeletal proteins in the hippocampus of developing rat brain.
Topics: Aging; Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Biomarkers; Brain; Choline; | 1998 |
GM1 and the aged brain.
Topics: Acetylcholine; Aging; Animals; Biological Transport; Brain; Choline; Choline O-Acetyltransferase; G( | 1998 |
Gangliosides and sialylcholesterol as modulators of synaptic functions.
Topics: Acetylcholine; Aging; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carrier Proteins | 1998 |
Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition; Creatine; Female; Inosito | 1998 |
Effects of K+-depolarization, arachidonic acid, ethanol, and aging on the high-affinity choline transport in rat hippocampus.
Topics: Aging; Animals; Arachidonic Acid; Biological Transport; Choline; Ethanol; Female; Hemicholinium 3; H | 1998 |
Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models.
Topics: Aging; Aniline Compounds; Animals; Avoidance Learning; Aziridines; Bridged Bicyclo Compounds; Cholin | 1998 |
Choline, a vital amine.
Topics: Acetylcholine; Aging; Animals; Apoptosis; Brain; Cell Division; Choline; Choline Deficiency; Cogniti | 1998 |
Diurnal rhythms in norepinephrine and acetylcholine synthesis of sympathetic ganglia, heart and adrenals of aging rats: effect of melatonin.
Topics: Acetylcholine; Adrenal Glands; Aging; Animals; Choline; Circadian Rhythm; Ganglia, Sympathetic; Hear | 1998 |
In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Magnetic Reso | 1999 |
Exercise- and methylcholine-induced sweating responses in older and younger men: effect of heat acclimation and aerobic fitness.
Topics: Adaptation, Physiological; Adult; Aged; Aging; Choline; Exercise; Hot Temperature; Humans; Male; Mid | 1999 |
MR image segmentation and tissue metabolite contrast in 1H spectroscopic imaging of normal and aging brain.
Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Choline; Creatine; | 1999 |
Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.
Topics: Aging; Alkaloids; Animals; Axons; Azocines; Carbachol; Choline; Excitatory Postsynaptic Potentials; | 1999 |
1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Energy Metab | 1999 |
Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus.
Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Choline; Choline Deficiency; Corpus Striatum | 1999 |
Developmental changes in choline- and ethanolamine-containing compounds measured with proton-decoupled (31)P MRS in in vivo human brain.
Topics: Adolescent; Adult; Aged; Aging; Brain; Brain Chemistry; Brain Diseases; Child; Child, Preschool; Cho | 1999 |
Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.
Topics: Aging; Animals; Animals, Newborn; Choline; Electric Stimulation; Female; Fetus; Hippocampus; In Vitr | 1999 |
Blood-brain barrier choline transport in the senescent rat.
Topics: Aging; Animals; Biological Transport; Blood-Brain Barrier; Choline; Hemicholinium 3; Neurotransmitte | 1999 |
A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; I | 2000 |
Potentiation of brain acetylcholine neurons by Kami-Untan-To (KUT) in aged mice: implications for a possible antidementia drug.
Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Central Nervous System Agents; Choline; Cho | 2000 |
Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study.
Topics: Adult; Aging; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; Magnetic Resonance Spectrosco | 2001 |
Development and aging of the cerebrum: assessment with proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Ch | 2001 |
Recovery of water maze performance in aged versus young rats after brain injury with the impact acceleration model.
Topics: Acceleration; Aging; Animals; Binding, Competitive; Brain; Brain Injuries; Choline; Male; Maze Learn | 2000 |
Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Anesthetics, Inhalation; Animals; Choline; Cholinesteras | 2001 |
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Diseases; Choline; | 2001 |
A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations.
Topics: Adult; Aged; Aging; Aspartic Acid; Cerebrospinal Fluid; Choline; Creatinine; Frontal Lobe; Humans; M | 2001 |
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio | 2001 |
Quantitative evaluation of cerebral metabolites and cerebral blood flow in patients with carotid stenosis.
Topics: Adult; Aged; Aging; Aspartic Acid; Basal Ganglia; Brain Ischemia; Carotid Stenosis; Cerebral Cortex; | 2001 |
Phosphatidylcholine molecular species in lung surfactant: composition in relation to respiratory rate and lung development.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Aging; Animals; Animals, Newborn; Bronchoalveolar Lavage Fluid; | 2001 |
Effects of estrogen replacement therapy on human brain aging: an in vivo 1H MRS study.
Topics: Adult; Aged; Aging; Brain; Choline; Estrogen Replacement Therapy; Female; Hippocampus; Humans; Long- | 2001 |
Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats.
Topics: Acetylcholine; Aging; Animals; Aziridines; Body Temperature Regulation; Choline; Cholinergic Fibers; | 2001 |
Prenatal choline supplementation protects against postnatal neurotoxicity.
Topics: Aging; Animals; Cell Count; Choline; Cytoprotection; Dietary Supplements; Dizocilpine Maleate; Excit | 2002 |
Developmental delay in children: assessment with proton MR spectroscopy.
Topics: Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Developmental Disabilities; | 2002 |
Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells.
Topics: Aging; Animals; Animals, Newborn; Antibody Formation; B-Lymphocytes; Choline; Clone Cells; Epitopes; | 1977 |
Development of glycogen and phospholipid metabolism in fetal and newborn rat lung.
Topics: Aging; Animals; Animals, Newborn; Choline; Fetus; Gestational Age; Glucose; Glycogen; Glycogen Synth | 1978 |
Effects of dexamethasone of neurotransmitter enzymes in chromaffin tissue of the newborn rat.
Topics: Acetyltransferases; Adrenal Glands; Adrenocorticotropic Hormone; Aging; Animals; Aorta; Basal Gangli | 1975 |
The immune response in NZB mice of different ages to thymus-dependent and thymus-independent phosphorylcholine antigens.
Topics: Aging; Animals; Antibody Formation; Antigens; Choline; Female; Haptens; Hemolytic Plaque Technique; | 1978 |
Muscarinic receptofs in the central nervous system of the rat. III. Postnatal development of binding of [3H]propylbenzilylcholine mustard.
Topics: Aging; Animals; Autoradiography; Brain; Choline; Female; Propylbenzilylcholine Mustard; Rats; Recept | 1979 |
Development and aging of cholinergic synapses. I. Endogenous levels of acetylcholine and choline in developing autonomic ganglia and iris of the chick.
Topics: Acetylcholine; Aging; Animals; Chickens; Choline; Ganglia, Autonomic; Ganglia, Parasympathetic; Gang | 1979 |
Pathway for hydrolysis of plasmalogens in brain.
Topics: Aging; Animals; Brain; Choline; Ethanolamines; Hydrolases; Kinetics; Plasmalogens; Rats; Species Spe | 1978 |
Multiple forms of choline acetyltransferase and the high affinity uptake of choline in brain of developing and adult rats.
Topics: Aging; Animals; Biological Transport, Active; Brain; Choline; Choline O-Acetyltransferase; Isoelectr | 1978 |
Turnover of phosphatidylcholine in microsomes and myelin in brains of young and adult rats.
Topics: Aging; Animals; Brain; Choline; Female; Glycerol; Male; Microsomes; Myelin Sheath; Phosphatidylcholi | 1978 |
Ontogeny of glutamine transport by rat liver plasma membrane vesicles.
Topics: Aging; Amino Acids; Analysis of Variance; Animals; Animals, Suckling; Biological Transport, Active; | 1992 |
Effect of kainic acid administration to prepubescent rats on cholinergic markers in selected brain regions of adult rats.
Topics: Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Flunitrazepam; Kainic Acid; Male; Organ | 1992 |
High-affinity transport of choline and amino acid neurotransmitters in synaptosomes from brain regions after lesioning the nucleus basalis magnocellularis of young and aged rats.
Topics: Aging; Amino Acids; Animals; Biological Transport; Brain; Choline; Male; Neurotransmitter Agents; Ra | 1992 |
Chronic dietary choline enrichment affects DRL responding of old, but not of adult CPBB rats.
Topics: Aging; Animals; Appetitive Behavior; Choline; Extinction, Psychological; Female; Rats; Rats, Inbred | 1992 |
Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Choline; Fatty Acids; Medulla Oblongata; Palmiti | 1992 |
Development of high-affinity choline transport sites in rat forebrain: a quantitative autoradiography study with [3H]hemicholinium-3.
Topics: Acetylcholine; Aging; Animals; Atropine; Autoradiography; Binding, Competitive; Biological Transport | 1992 |
GM1 ganglioside enhances cholinergic parameters in the brain of senescent rats.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Brain; Brain Chemistry; Choline; Choline O-Acet | 1992 |
Age-related changes in NMDA-induced [3H]acetylcholine release from brain slices of senescence-accelerated mouse.
Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Calcium; Choline; Hemicholinium 3; In Vitro Techniqu | 1992 |
In vivo 1H and 31P NMR spectroscopy of the developing rat brain.
Topics: Adenosine Triphosphate; Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Hy | 1992 |
[Stimulation of phospholipase D by thyroid hormones in hepatocytes of rats of various ages and thyroid status].
Topics: Aging; Animals; Cell Membrane; Choline; Diglycerides; Enzyme Activation; Hypothyroidism; Liver; Male | 1991 |
[Effects of kamikihi-to, a Chinese traditional medicine, on various cholinergic biochemical markers in the brains of aged rats].
Topics: Acetylcholinesterase; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Drugs, Chinese He | 1991 |
Serotonergic ligand binding in aging brain of experimental animals.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Aging; Animals; Brain; Cell Membrane; Cerebel | 1991 |
Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on striatal muscarinic cholinergic receptors and high-affinity choline uptake sites: a quantitative autoradiographic study.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain Ischemia; Choline; Co | 1991 |
Dietary choline manipulations and behavioural modifications in rats in the early stages of aging.
Topics: Aging; Animals; Behavior, Animal; Choline; Choline Deficiency; Conditioning, Operant; Diet; Discrimi | 1991 |
Characterization of a target-derived neuronal cholinergic differentiation factor.
Topics: Aging; Animals; Cell Differentiation; Cells, Cultured; Choline; Choline O-Acetyltransferase; Glycopr | 1990 |
Aging and stress-induced changes in choline and glutamate uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors.
Topics: Aging; Animals; Brain; Choline; Glutamates; Glutamic Acid; Hippocampus; Longevity; Male; Rats; Rats, | 1990 |
Effect of physical activity on hippocampal high affinity choline uptake and muscarinic binding: a comparison between young and old F344 rats.
Topics: Adrenal Glands; Aging; Animals; Binding, Competitive; Body Weight; Choline; Hippocampus; Male; Musca | 1991 |
Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study.
Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Choline; Chromatography, Hig | 1991 |
Neurochemistry of aging. 2. Design, synthesis, and biological evaluation of halomethyl analogues of choline with high affinity choline transport inhibitory activity.
Topics: Acetylcholinesterase; Aging; Animals; Biological Transport, Active; Choline; Drug Interactions; Guin | 1991 |
Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome.
Topics: Adult; Aged; Aging; Choline; Down Syndrome; Female; Humans; Male; Middle Aged | 1990 |
Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain.
Topics: Adenosine Triphosphate; Adolescent; Aging; Aspartic Acid; Brain; Child; Child, Preschool; Choline; F | 1990 |
Acetylcholine synthesis and release in the extensor digitorum longus muscle of mature and aged rats.
Topics: Acetylcholine; Aging; Animals; Choline; Choline O-Acetyltransferase; Electric Stimulation; Humans; I | 1990 |
Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats.
Topics: Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Corpus Striatum; Frontal Lobe; Hemichol | 1990 |
Decrease of acetylcholine release from cortical slices in aged rats: investigations into its reversal by phosphatidylserine.
Topics: Acetylcholine; Aging; Animals; Avoidance Learning; Cerebral Cortex; Choline; Chromatography, High Pr | 1990 |
A selective increase in the generation of phosphorylcholine-specific B cells associated with aging.
Topics: Aging; Animals; Antibodies, Monoclonal; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Choline; Epit | 1986 |
Altered VH gene segment utilization in the response to phosphorylcholine by aged mice.
Topics: Aging; Animals; Antibody Specificity; Bone Marrow; Cells, Cultured; Choline; Clone Cells; Epitopes; | 1989 |
Differential L chain expression in the antibody responses to phosphorylcholine of adult bone marrow or peritoneum-derived B lymphocytes.
Topics: Aging; Animals; Antibody Formation; B-Lymphocytes; Bone Marrow; Bone Marrow Transplantation; Choline | 1989 |
Effect of early visual pattern deprivation on development and laminar distribution of cholinergic markers in rat visual cortex.
Topics: Aging; Animals; Biological Transport; Choline; Choline O-Acetyltransferase; Hemicholinium 3; Ocular | 1989 |
Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions.
Topics: Acetylcarnitine; Acetylcholinesterase; Aging; Animals; Brain; Carnitine; Choline; Choline O-Acetyltr | 1989 |
Neurobiochemical alterations in the brain of aging rats.
Topics: Aging; Animals; Biogenic Monoamines; Brain; Choline; Lipid Metabolism; Lipid Peroxidation; Neurotran | 1989 |
Phospholipid-derived choline intermediates and acetylcholine synthesis in mouse brain synaptosomes.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Female; Hemicholinium 3; Mice; Mice, Inbred C57BL; Ph | 1989 |
Phosphorylcholine and phosphorylethanolamine in human and rhesus monkey lenses.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Child; Child, Preschool; Choline; Cultur | 1989 |
Age-dependent changes of isotype and idiotype expression in the antibody response to the phosphorylcholine hapten in BALB/c mice.
Topics: Aging; Animals; Choline; Female; Haptens; Immunoglobulin A; Immunoglobulin E; Immunoglobulin G; Immu | 1989 |
Vascular cholinesterases and choline uptake in isolated rat forebrain microvessels: a possible link.
Topics: Aging; Animals; Blood Vessels; Choline; Cholinesterases; Diencephalon; In Vitro Techniques; Male; Mi | 1989 |
Sensitivity of rodent skeletal muscles to dicholines: dependence on innervation and age.
Topics: Aging; Animals; Choline; Membrane Potentials; Mice; Muscles; Rats; Rats, Inbred Strains; Succinylcho | 1989 |
Effects of hemicholinium-3 and sodium ions on choline uptake system in excised superior cervical sympathetic ganglia of rats.
Topics: Aging; Animals; Biological Transport; Choline; Denervation; Female; Ganglia, Sympathetic; Hemicholin | 1989 |
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus | 1985 |
Effects of dietary choline on memory and brain chemistry in aged mice.
Topics: Aging; Animals; Anisomycin; Avoidance Learning; Brain Chemistry; Cerebral Cortex; Choline; Choline O | 1985 |
Cerebral ageing, neurotransmitters and therapeutic implications.
Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Brain; Choline; Choline O-Acetyltransferase; Dihydroe | 1985 |
Regional noradrenergic and cholinergic neurochemistry in the rat urinary bladder: effects of age.
Topics: Acetylcholine; Acetylcholinesterase; Aging; alpha-Methyltyrosine; Animals; Choline; Choline O-Acetyl | 1988 |
Effects of long-term dietary choline and phosphatidylcholine administration on muscarinic receptors in aged mouse brain.
Topics: Aging; Animals; Body Weight; Brain; Choline; Diet; Mice; Phosphatidylcholines; Quinuclidinyl Benzila | 1988 |
Age-related change in anti-carbohydrate antibody levels.
Topics: ABO Blood-Group System; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Choline; Female; Humans; | 1989 |
Hippocampal membranes contain a neurotrophic activity that stimulates cholinergic properties of fetal rat septal neurons cultured under serum-free conditions.
Topics: Aging; Animals; Cell Membrane; Cells, Cultured; Cerebellum; Choline; Choline O-Acetyltransferase; Ch | 1989 |
Effects of antigen and internal environment on anti-phosphorylcholine immune responses of autoimmune aged NZB/W F1 mice.
Topics: Aging; Animals; Antibody Formation; Antigens; B-Lymphocytes; Choline; Female; Hemolytic Plaque Techn | 1986 |
Age-related reductions in rat atrial high affinity choline uptake, ACh synthesis, and ACh release. A brief note.
Topics: Acetylcholine; Aging; Animals; Choline; Heart Atria; Male; Rats; Rats, Inbred F344; Synaptic Transmi | 1985 |
Parathyroid hormone increases sodium/calcium exchange activity in renal cells and the blunting of the response in aging.
Topics: Aging; Animals; Calcium; Choline; Colforsin; Cyclic AMP; Kidney; Male; Parathyroid Glands; Parathyro | 1986 |
[Anti-phosphorylcholine response of autoimmune NZB/W mice: variations with age of serum titers and homogeneity].
Topics: Aging; Animals; Antibody Affinity; Antigens, Bacterial; Choline; Female; Hemocyanins; Immune Sera; M | 1987 |
Effects of meclofenoxate and citicholine on learning and memory in aged rats.
Topics: Aging; Animals; Choline; Cytidine Diphosphate Choline; Glycolates; Learning; Male; Meclofenoxate; Me | 1987 |
Determination of acetylcholine and choline in human cerebrospinal fluid using high-performance liquid chromatography combined with an immobilized enzyme reactor: ageing-induced change of acetylcholine level.
Topics: Acetylcholine; Adult; Aged; Aging; Choline; Chromatography, High Pressure Liquid; Enzymes, Immobiliz | 1988 |
Effects of training on a spatial memory task on high affinity choline uptake in hippocampus and cortex in young adult and aged rats.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Conditioning, Psychological; Cues; Hipp | 1988 |
Chronic treatment with choline or scopolamine indicates the presence of muscarinic cholinergic receptor plasticity in the frontal cortex of young but not of aged mice.
Topics: Aging; Alzheimer Disease; Animals; Choline; Female; Frontal Lobe; Humans; Mice; Models, Biological; | 1988 |
Blood-brain barrier transport of choline is reduced in the aged rat.
Topics: Aging; Animals; Blood-Brain Barrier; Choline; Male; Rats; Rats, Inbred F344 | 1988 |
Sodium dependent uptake of 3H-choline in the cerebral cortex of ageing male rats.
Topics: Aging; Aluminum; Animals; Cerebral Cortex; Choline; Hemicholinium 3; Male; Rats; Rats, Inbred WKY; S | 1988 |
Muscarinic mobilization of choline in rat brain in vivo as shown by the cerebral arterio-venous difference of choline.
Topics: Aging; Animals; Arteries; Brain; Cerebrovascular Circulation; Choline; Diet; Muscarine; Osmolar Conc | 1987 |
Increase in acetylcholine concentrations in the brain of 'old' rats following treatment with pyrithioxin (Encephabol).
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Male; Pyridines; Pyrithi | 1987 |
Naturally occurring antibodies to phosphocholine as a potential index of antibody responsiveness to polysaccharides.
Topics: ABO Blood-Group System; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antibodies; Antibodies, B | 1987 |
Age-related reductions in brain cholinergic and dopaminergic indices in two rat strains differing in longevity.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Dopamine; Longevity; Mal | 1987 |
Acetylcholine metabolism and choline availability at the neuromuscular junction of mature adult and aged rats.
Topics: Acetylcholine; Aging; Animals; Choline; Electric Stimulation; Neuromuscular Junction; Rats; Rats, In | 1987 |
Age- and strain-dependent polymorphism in IgE antibody against the phosphorylcholine hapten.
Topics: Aging; Animals; Choline; Crosses, Genetic; Female; Haptens; Immunoglobulin E; Immunoglobulin G; Immu | 1986 |
Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory.
Topics: Aging; Animals; Arginine Vasopressin; Brain Chemistry; Choline; Male; Memory; Rats; Rats, Inbred Str | 1986 |
Electrophysiological markers of aging and memory loss in rats.
Topics: Aging; Animals; Brain; Choline; Discrimination Learning; Electroencephalography; Hippocampus; Kindli | 1985 |
Neurobehavioral effects of chronic choline-containing diets on the adult and aging C57BL/6NNIA mouse brain.
Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Brain; Choline; Mental Recall; Mice; Mice, Inb | 1985 |
Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism.
Topics: Aging; Animals; Biomphalaria; Carbon Radioisotopes; Choline; Ethanolamine; Ethanolamines; Female; Gl | 1985 |
Metabolism of choline in brain of the aged CBF-1 mouse.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Chromatography, Thin Layer; Male; Mice; Mice, Inbred | 1986 |
Aging of membrane transport mechanisms in the central nervous system--high affinity choline transport in rat cortical synaptosomes.
Topics: Aging; Animals; Cerebral Cortex; Choline; Male; Mathematics; Models, Biological; Rats; Sodium; Synap | 1985 |
Red cell choline in Korsakoff psychosis.
Topics: Aged; Aging; Alcohol Amnestic Disorder; Choline; Erythrocytes; Humans; Male; Middle Aged | 1985 |
N-Acetylglucosaminyltransferase activity in liver, serum, and ovaries of domestic fowl.
Topics: Acetates; Aging; Animals; Cell Fractionation; Centrifugation, Density Gradient; Chickens; Choline; C | 1971 |
Ontogenesis of choline acetyltransferase, tyrosine hydroxylase, monoamine oxidase and catechol-O-methyl transferase in the superior cervical ganglion of swine.
Topics: Acetyltransferases; Aging; Animals; Animals, Newborn; Body Weight; Catechol O-Methyltransferase; Cho | 1974 |
The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: role of ganglionic noradrenaline content.
Topics: Acetylesterase; Aging; Animals; Animals, Newborn; Bucladesine; Carbachol; Choline; Cyclic AMP; Cyclo | 1974 |
Lysolecithin and sphingosinephosphoryl-choline in the metabolism of brain phospholipids of the rhesus monkey (Macaca mulatta): effects of development.
Topics: Aging; Animals; Animals, Newborn; Brain; Carbon Isotopes; Cerebral Cortex; Choline; Chromatography, | 1973 |
Phospholipases in arterial tissue. V. Comparison of the activity of phosphatide acyl-hydrolase and sphingomyelin choline phosphohydrolase in aortae of male, female and ovariectomized rats.
Topics: Aging; Amino Alcohols; Animals; Aorta; Benzoates; Body Weight; Carbon Isotopes; Castration; Choline; | 1971 |
Effects of cholinomimetic agents given into the brain of fowls.
Topics: Acetylcholine; Aging; Animals; Behavior, Animal; Benzoates; Body Temperature; Carbachol; Cerebral Ve | 1974 |
Effects of neonatal and adult treatments with gonadal hormones on choline acetylase activity in brain regions of male mice after fighting.
Topics: Acetyltransferases; Aggression; Aging; Animals; Animals, Newborn; Brain; Castration; Cerebral Cortex | 1972 |
Effect of dimethylaminoethanol on the life span of senile male A-J mice.
Topics: Acetamides; Aging; Animals; Benzoates; Body Weight; Cell Membrane; Choline; Ethanolamines; Longevity | 1973 |
Development of Na+-stimulated glucose oxidation in synaptosomes.
Topics: Aging; Animals; Brain; Carbon Dioxide; Carbon Radioisotopes; Choline; Deoxy Sugars; Dinitrophenols; | 1973 |
Comparative studies of neurotransmitter substances in the maturing and aging central nervous system of the chicken.
Topics: Acetylcholinesterase; Acetyltransferases; Aging; Animals; Brain; Brain Chemistry; Chick Embryo; Chic | 1973 |
Skeletal muscle lipids. 3. Changes in fatty acid composition of individual phosphoglycerides in man from fetal to middle age.
Topics: Adolescent; Adult; Aging; Cardiolipins; Child; Child, Preschool; Choline; Chromatography, Gas; Chrom | 1974 |
UDP-galactose:glycoprotein galactosyltransferase activity in tissues of developing rat.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Choline; Cyto | 1974 |
Changes in acetylcholine and choline concentrations and choline acetyltransferase activity in the developing rat brain: effect of propylthiouracil.
Topics: Acetylcholine; Acyltransferases; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Br | 1972 |
Phosphocholine diglyceride transferase activity during development of the chicken brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Brain Chemistry; Carbon Isotopes; Chick Embryo; Chickens; C | 1972 |
Hypertension in young rats following choline deficiency in maternal diets.
Topics: Age Factors; Aging; Animals; Blood Pressure Determination; Choline; Choline Deficiency; Female; Feta | 1971 |
The time course of development of acetylcholinesterase and choline acetyltransferase in Drosophila melanogaster.
Topics: Acetylcholinesterase; Acyltransferases; Aging; Aldehydes; Animals; Choline; Drosophila; Larva; Oxido | 1970 |
Phospholipid metabolism in the developing liver. I. The biosynthesis of choline glycerophosphatides by liver slices from fetal, newborn and adult rats.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Choline; Chromatography, Thin Layer; Female; Fetu | 1969 |
Choline metabolism in normal and choline-deficient rats of different ages.
Topics: Aging; Animals; Body Weight; Choline; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Me | 1965 |