choline has been researched along with Age-Related Memory Disorders in 68 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prenatal choline supplementation can protect rats against cognitive deficits induced by status epilepticus induced by the cholinergic agent pilocarpine [J." | 7.71 | Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Yang, Y, 2002) |
| "Prenatal choline supplementation can protect rats against cognitive deficits induced by status epilepticus induced by the cholinergic agent pilocarpine [J." | 3.71 | Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Yang, Y, 2002) |
| " In the crossover study, the higher dosage of citicoline was clearly associated with improved immediate and delayed logical memory." | 2.68 | Citicoline improves verbal memory in aging. ( Hochanadel, GS; Lieberman, HR; Myers, D; Spiers, PA; Wurtman, RJ, 1996) |
| "Choline is a dietary component essential for normal function of all cells." | 2.41 | Choline: needed for normal development of memory. ( Zeisel, SH, 2000) |
| "Menopause is associated with memory deficits attributed to reduced serum estrogen levels." | 1.72 | Improvement of Cognitive Function in Ovariectomized Rats by Human Neural Stem Cells Overexpressing Choline Acetyltransferase via Secretion of NGF and BDNF. ( Choi, Y; Park, D; Yoon, EJ, 2022) |
| "The cholinergic system plays a crucial role in learning and memory processes." | 1.56 | Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats. ( Hill, E; Jiang, L; Mooney, SM; Tang, S; Waddell, J; Xu, S, 2020) |
| "Choline (Ch) is an essential nutrient that acts as a cognitive facilitator when administered during perinatal periods, and it has been recognised as a 'pharmacological' agent that can ease cognitive dysfunctions provoked by exposure to damaging stimuli during early developmental stages." | 1.46 | Dietary choline during periadolescence attenuates cognitive damage caused by neonatal maternal separation in male rats. ( Carías Picón, D; de Brugada Sauras, I; Moreno Gudiño, H, 2017) |
| "Choline treatment failed to attenuate alcohol-related overactivity in the open field and deficits in Morris water maze performance." | 1.43 | Adolescent Choline Supplementation Attenuates Working Memory Deficits in Rats Exposed to Alcohol During the Third Trimester Equivalent. ( Schneider, RD; Thomas, JD, 2016) |
| "Animal models of Fetal Alcohol Spectrum Disorders (FASD) afford the unique capacity to precisely control timing of alcohol exposure and alcohol exposure amounts in the developing animal." | 1.42 | An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics. ( Barnet, RC; Hunt, PS, 2015) |
| "Many patients with systemic lupus erythematosus (SLE) have working memory deficits." | 1.39 | White matter abnormalities and working memory impairment in systemic lupus erythematosus. ( Arciniegas, DB; Brown, MS; Duggan, E; Filley, CM; Kozora, E; West, S, 2013) |
| "Choline is an essential nutrient required for early development." | 1.39 | Long-lasting effects of prenatal dietary choline availability on object recognition memory ability in adult rats. ( Carias, D; de Brugada, I; Gallo, M; Moreno, HC, 2013) |
| "Choline is an essential nutrient for animals and humans." | 1.32 | Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. ( Blusztajn, JK; Meck, WH; Mellott, TJ; Williams, CL, 2004) |
| " This study was designed to assess 1) neuroprotection after intranasal administration of ADNF-9 and NAP to rats treated with the cholinotoxin ethylcholine aziridium; and 2) bioavailability and pharmacokinetics after intranasal administration." | 1.31 | Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze. ( Bardea, A; Brenneman, DE; Giladi, E; Gozes, I; Pinhasov, A, 2000) |
| "Choline is an essential nutrient for rats and humans, and its availability during fetal development has long-lasting cognitive effects (Blusztajn, 1998)." | 1.31 | Protective effects of prenatal choline supplementation on seizure-induced memory impairment. ( Blusztajn, JK; Cermak, JM; Holmes, GL; Liu, Z; Neill, JC; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y, 2000) |
| "We investigated the effects of egg phosphatidylcholine (PC) combined with vitamin B12 on memory in the Morris water maze task, and on choline and acetylcholine (ACh) concentrations in the brain of rats." | 1.30 | EGG phosphatidylcholine combined with vitamin B12 improved memory impairment following lesioning of nucleus basalis in rats. ( Ikeda, H; Inoue, S; Kokubu, T; Masuda, Y; Yamashita, M, 1998) |
| "The effects of acute and chronic administration of MKC-231, a new choline uptake enhancer, and two other nootropic agents, linopiridine (Dup 996) and tetrahydroaminoacridine (THA) on working memory deficits and decreased hippocampal acetylcholine (ACh) content were studied in a delayed non-matching to sample task, using a T-maze, in ethylcholine aziridinium ion (AF64A)-treated mice." | 1.29 | MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. ( Abe, E; Itoh, T; Masuda, Y; Murai, S; Odashima, J; Saito, H, 1994) |
| "These findings suggest that the memory deficits induced by chronic ethanol consumption stem from a failure of some cholinergic-dependent retrieval processes." | 1.28 | Memory deficits following chronic alcohol consumption in mice: relationships with hippocampal and cortical cholinergic activities. ( Beracochea, D; Jaffard, R; Micheau, J, 1992) |
| "These findings indicate that the memory deficits resulting from intraventricular administration of AF64A are a consequence of the compound's cholinotoxic properties and in particular its interaction with the HAChT carrier." | 1.28 | Hemicholinium-3 prevents the working memory impairments and the cholinergic hypofunction induced by ethylcholine aziridinium ion (AF64A). ( Chrobak, JJ; Spates, MJ; Stackman, RW; Walsh, TJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (22.06) | 18.7374 |
| 1990's | 15 (22.06) | 18.2507 |
| 2000's | 17 (25.00) | 29.6817 |
| 2010's | 16 (23.53) | 24.3611 |
| 2020's | 5 (7.35) | 2.80 |
| Authors | Studies |
|---|---|
| Yoon, EJ | 1 |
| Choi, Y | 1 |
| Park, D | 1 |
| Zhao, Y | 1 |
| Zhao, X | 1 |
| Wang, J | 1 |
| Prabhu, GS | 1 |
| K G Rao, M | 1 |
| Rai, KS | 1 |
| Waddell, J | 1 |
| Hill, E | 1 |
| Tang, S | 1 |
| Jiang, L | 1 |
| Xu, S | 1 |
| Mooney, SM | 1 |
| Johns, BE | 1 |
| Ficken, M | 1 |
| Engberg, ME | 1 |
| Wecker, L | 1 |
| Philpot, RM | 1 |
| Nickerson, CA | 1 |
| Brown, AL | 1 |
| Yu, W | 1 |
| Chun, Y | 1 |
| Glenn, MJ | 2 |
| Shan, Y | 1 |
| Jia, Y | 1 |
| Zhong, S | 1 |
| Li, X | 1 |
| Zhao, H | 1 |
| Chen, J | 1 |
| Lu, Q | 1 |
| Zhang, L | 1 |
| Li, Z | 1 |
| Lai, S | 1 |
| Wang, Y | 1 |
| Bahous, RH | 1 |
| Cosín-Tomás, M | 1 |
| Deng, L | 1 |
| Leclerc, D | 1 |
| Malysheva, O | 1 |
| Ho, MK | 1 |
| Pallàs, M | 1 |
| Kaliman, P | 1 |
| Bedell, BJ | 1 |
| Caudill, MA | 1 |
| Rozen, R | 1 |
| Kozora, E | 1 |
| Arciniegas, DB | 1 |
| Duggan, E | 1 |
| West, S | 1 |
| Brown, MS | 1 |
| Filley, CM | 1 |
| Haddadi, M | 1 |
| Jahromi, SR | 1 |
| Sagar, BK | 1 |
| Patil, RK | 1 |
| Shivanandappa, T | 1 |
| Ramesh, SR | 1 |
| Woo, DC | 1 |
| Lenkinski, RE | 1 |
| Hunt, PS | 1 |
| Barnet, RC | 1 |
| Calderón-Garcidueñas, L | 1 |
| Mora-Tiscareño, A | 1 |
| Franco-Lira, M | 1 |
| Zhu, H | 1 |
| Lu, Z | 1 |
| Solorio, E | 1 |
| Torres-Jardón, R | 1 |
| D'Angiulli, A | 1 |
| Moreno Gudiño, H | 1 |
| Carías Picón, D | 1 |
| de Brugada Sauras, I | 1 |
| Schneider, RD | 1 |
| Thomas, JD | 1 |
| Moon, CM | 1 |
| Sundaram, T | 1 |
| Choi, NG | 1 |
| Jeong, GW | 1 |
| Yu, L | 1 |
| Chen, Y | 1 |
| Wang, W | 1 |
| Xiao, Z | 1 |
| Hong, Y | 1 |
| Mantoan, MA | 1 |
| Caboclo, LO | 1 |
| de Figueiredo Ferreira Guilhoto, LM | 1 |
| Lin, K | 1 |
| da Silva Noffs, MH | 1 |
| de Souza Silva Tudesco, I | 1 |
| Belzunces, E | 1 |
| Carrete, H | 1 |
| Bussoletti, RT | 1 |
| Centeno, RS | 1 |
| Sakamoto, AC | 1 |
| Yacubian, EM | 1 |
| Wong-Goodrich, SJ | 1 |
| Mellott, TJ | 2 |
| Liu, YB | 1 |
| Blusztajn, JK | 4 |
| Williams, CL | 2 |
| Blake, MG | 1 |
| Boccia, MM | 1 |
| Krawczyk, MC | 1 |
| Delorenzi, A | 1 |
| Baratti, CM | 1 |
| Capsoni, S | 1 |
| Amato, G | 1 |
| Vignone, D | 1 |
| Criscuolo, C | 1 |
| Nykjaer, A | 1 |
| Cattaneo, A | 1 |
| Moreno, HC | 1 |
| de Brugada, I | 1 |
| Carias, D | 1 |
| Gallo, M | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Birthelmer, A | 1 |
| Lazaris, A | 1 |
| Schweizer, T | 1 |
| Jackisch, R | 1 |
| Cassel, JC | 1 |
| Meck, WH | 1 |
| Rispoli, V | 1 |
| Rotiroti, D | 1 |
| Carelli, V | 1 |
| Liberatore, F | 1 |
| Scipione, L | 1 |
| Marra, R | 1 |
| Giorgioni, G | 1 |
| Di Stefano, A | 1 |
| Hanoğlu, L | 1 |
| Ozkara, C | 1 |
| Keskinkiliç, C | 1 |
| Altin, U | 1 |
| Uzan, M | 1 |
| Tuzgen, S | 1 |
| Dinçer, A | 1 |
| Ozyurt, E | 1 |
| Mukhina, TV | 1 |
| Lermontova, NN | 1 |
| Van'kin, GI | 1 |
| Oettel, M | 1 |
| P'chev, VK | 1 |
| Bachurin, SO | 1 |
| Frederick, BD | 1 |
| Lyoo, IK | 1 |
| Satlin, A | 1 |
| Ahn, KH | 1 |
| Kim, MJ | 1 |
| Yurgelun-Todd, DA | 1 |
| Cohen, BM | 1 |
| Renshaw, PF | 1 |
| Metastasio, A | 1 |
| Rinaldi, P | 1 |
| Tarducci, R | 1 |
| Mariani, E | 1 |
| Feliziani, FT | 1 |
| Cherubini, A | 1 |
| Pelliccioli, GP | 1 |
| Gobbi, G | 1 |
| Senin, U | 1 |
| Mecocci, P | 1 |
| Takahata, K | 1 |
| Minami, A | 1 |
| Kusumoto, H | 1 |
| Shimazu, S | 1 |
| Yoneda, F | 1 |
| Jolles, J | 1 |
| Verhoeven, WM | 1 |
| Murphy, MF | 1 |
| Davis, KL | 2 |
| Ayuso-Gutierrez, JL | 1 |
| Saiz-Ruiz, J | 1 |
| Kent, S | 1 |
| Bartus, RT | 2 |
| Dean, RL | 2 |
| Beer, B | 1 |
| Lippa, AS | 1 |
| Sherman, KA | 1 |
| Kuster, JE | 1 |
| Friedman, E | 1 |
| Dixon, CE | 1 |
| Bao, J | 1 |
| Bergmann, JS | 1 |
| Johnson, KM | 1 |
| Murai, S | 3 |
| Saito, H | 3 |
| Abe, E | 2 |
| Masuda, Y | 4 |
| Odashima, J | 2 |
| Itoh, T | 3 |
| Buckley, PF | 1 |
| Moore, C | 1 |
| Long, H | 1 |
| Larkin, C | 1 |
| Thompson, P | 1 |
| Mulvany, F | 1 |
| Redmond, O | 1 |
| Stack, JP | 1 |
| Ennis, JT | 1 |
| Waddington, JL | 1 |
| Zhi, QX | 1 |
| Yi, FH | 1 |
| XI, CT | 1 |
| Spiers, PA | 1 |
| Myers, D | 1 |
| Hochanadel, GS | 1 |
| Lieberman, HR | 1 |
| Wurtman, RJ | 1 |
| Takagi, N | 1 |
| Miyake, K | 1 |
| Taguchi, T | 1 |
| Tamada, H | 1 |
| Takagi, K | 1 |
| Sugita, N | 1 |
| Takeo, S | 1 |
| Weinstock, M | 1 |
| Kokubu, T | 1 |
| Yamashita, M | 1 |
| Ikeda, H | 1 |
| Inoue, S | 1 |
| Suzuki, T | 1 |
| Hirooka, K | 1 |
| Kanda, K | 1 |
| Hirooka, H | 1 |
| Furusawa, K | 1 |
| Giordano, M | 1 |
| Salado-Castillo, R | 1 |
| Sánchez-Alvarez, M | 1 |
| Prado-Alcalá, RA | 1 |
| Gozes, I | 1 |
| Giladi, E | 1 |
| Pinhasov, A | 1 |
| Bardea, A | 1 |
| Brenneman, DE | 1 |
| Ende, G | 1 |
| Braus, DF | 1 |
| Walter, S | 1 |
| Weber-Fahr, W | 1 |
| Henn, FA | 1 |
| Zeisel, SH | 1 |
| Yang, Y | 2 |
| Liu, Z | 2 |
| Cermak, JM | 2 |
| Tandon, P | 1 |
| Sarkisian, MR | 2 |
| Stafstrom, CE | 2 |
| Neill, JC | 2 |
| Holmes, GL | 2 |
| Lin, A | 1 |
| Nguy, CH | 1 |
| Shic, F | 1 |
| Ross, BD | 1 |
| Hiramatsu, M | 1 |
| Yamatsu, T | 1 |
| Kameyama, T | 1 |
| Nabeshima, T | 1 |
| Smith, CM | 1 |
| Swash, M | 1 |
| Mohs, RC | 1 |
| Tinklenberg, JR | 1 |
| Hollister, LE | 1 |
| Yesavage, JA | 1 |
| Kopell, BS | 1 |
| Beracochea, D | 2 |
| Micheau, J | 1 |
| Jaffard, R | 2 |
| Li, YJ | 1 |
| Simon, JR | 1 |
| Low, WC | 1 |
| Arendt, T | 1 |
| Schugens, MM | 1 |
| Bigl, V | 1 |
| Chrobak, JJ | 2 |
| Spates, MJ | 1 |
| Stackman, RW | 1 |
| Walsh, TJ | 2 |
| Siow, BL | 1 |
| DiPalma, JR | 1 |
| Leathwood, PD | 1 |
| Schlosser, B | 1 |
| Hanin, I | 1 |
| Schmechel, DE | 1 |
| Durkin, TP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Feru-guard (Ferulic Acid and Angelica Archangelica Extract) for Behavioral Symptoms in Dementia[NCT03451760] | Phase 2 | 70 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | ||
| A Multicenter Ascending Dose, Double Blind, Placebo-controlled Study of NAP (AL-108) in Chronic Schizophrenia[NCT00505765] | Phase 2 | 63 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
The MATRICS Consensus Cognitive Battery (MCCB) measures functioning across various cognitive domains and is comprised of ten tests that assess seven cognitive domains (speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition) Its measurements are based on timed paper-and-pencil, computerized, and orally-administered tests, as well as spatial tests using geometric cubes. MCCB composite T scores are between 40 and 60 (normal range) and < 40 (below normal range). (NCT00505765)
Timeframe: Baseline, 12 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| AL-108, 30 mg/Day | 3.9 |
| AL-108, 5 mg/Day | 4.6 |
| Placebo | 3.2 |
The MATRICS Consensus Cognitive Battery (MCCB) measures functioning across various cognitive domains and is comprised of ten tests that assess seven cognitive domains (speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition) Its measurements are based on timed paper-and-pencil, computerized, and orally-administered tests, as well as spatial tests using geometric cubes. MCCB composite T scores are between 40 and 60 (normal range) and < 40 (below normal range). (NCT00505765)
Timeframe: Baseline, week 6
| Intervention | units on a scale (Mean) |
|---|---|
| AL-108, 30 mg/Day | 1.3 |
| AL-108, 5 mg/Day | 2.3 |
| Placebo | -0.2 |
Schizophrenia Cognition Rating Scale (SCoRS) assessed functional capacity by completing a 20-question rating scale via interviews with the subject and an informant, focusing on cognitive impairment and its impact on daily functioning. After the interview, the interviewer rated subject's overall difficulty on a Global Scale of 1-10. Higher scores indicate greater cognitive impairment. (NCT00505765)
Timeframe: Baseline, 12 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| AL-108, 30 mg/Day | -0.4 |
| AL-108, 5 mg/Day | -1.2 |
| Placebo | -0.3 |
Schizophrenia Cognition Rating Scale (SCoRS) assessed functional capacity by completing a 20-question rating scale via interviews with the subject and an informant, focusing on cognitive impairment and its impact on daily functioning. After the interview, the interviewer rated subject's overall difficulty on a Global Scale of 1-10. Higher scores indicate greater cognitive impairment. (NCT00505765)
Timeframe: Baseline, 6 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| AL-108, 30 mg/Day | 0.1 |
| AL-108, 5 mg/Day | -0.6 |
| Placebo | -0.1 |
UPSA includes 5 skill areas (subscales) with scores that each range from 0-20. The UPSA yields an overall total score which is the sum of the five subscales and ranges from 0-100. Higher scores are associated with more independent living. (NCT00505765)
Timeframe: Baseline, 12 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| AL-108, 30 mg/Day | 4.9 |
| AL-108, 5 mg/Day | 8.9 |
| Placebo | 0.3 |
UPSA includes 5 skill areas (subscales) with scores that each range from 0-20. The UPSA yields an overall total score which is the sum of the five subscales and ranges from 0-100. Higher scores are associated with more independent living. (NCT00505765)
Timeframe: Baseline, week 6
| Intervention | units on a scale (Mean) |
|---|---|
| AL-108, 30 mg/Day | 2.9 |
| AL-108, 5 mg/Day | 7.2 |
| Placebo | -0.9 |
6 reviews available for choline and Age-Related Memory Disorders
| Article | Year |
|---|---|
[Psychopharmacologic treatment of cognitive function disorders in aging persons: current possibilities].
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Anticonvulsants; Brain; Catecholamines; Cholin | 1984 |
Biological perspectives in chronic pain, depression, and organic mental disorders.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Animals; Antidepressive Agents; Antipsychotic Agents; Chol | 1981 |
The cholinergic hypothesis of geriatric memory dysfunction.
Topics: Acetylcholine; Adult; Aged; Aging; Alzheimer Disease; Animals; Brain Chemistry; Choline; Choline O-A | 1982 |
Possible role of the cholinergic system and disease models.
Topics: Alzheimer Disease; Animals; Brain; Cerebrovascular Circulation; Choline; Cholinesterase Inhibitors; | 1997 |
Choline: needed for normal development of memory.
Topics: Animals; Brain; Choline; Choline Deficiency; Diet; Eggs; Female; Humans; Infant, Newborn; Lactation; | 2000 |
Phosphatidylcholine, choline and cholinergic function.
Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Alzheimer Disease; Animals; Avoidance Learning; Biological | 1986 |
4 trials available for choline and Age-Related Memory Disorders
| Article | Year |
|---|---|
The value of cytidine-5-diphosphate-choline in the prevention of impairment of memory function after electric convulsive therapy. A double-blind study.
Topics: Adult; Choline; Clinical Trials as Topic; Cytidine Diphosphate Choline; Double-Blind Method; Electro | 1982 |
Citicoline improves verbal memory in aging.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Choline; Cross-Over Studies; Cytidine Diphosphate Cho | 1996 |
Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy.
Topics: Administration, Oral; Adult; Aged; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Dimethy | 2001 |
Good memories or mere sieves?
Topics: Aged; Animals; Choline; Clinical Trials as Topic; Humans; Male; Memory; Memory Disorders; Memory, Sh | 1979 |
58 other studies available for choline and Age-Related Memory Disorders
| Article | Year |
|---|---|
Improvement of Cognitive Function in Ovariectomized Rats by Human Neural Stem Cells Overexpressing Choline Acetyltransferase via Secretion of NGF and BDNF.
Topics: Acetylcholine; Animals; Brain-Derived Neurotrophic Factor; Choline; Choline O-Acetyltransferase; Cho | 2022 |
Choline alleviated perinatal fluoride exposure-induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice.
Topics: Animals; Choline; Female; Fluorides; Hippocampus; Memory Disorders; Mice; Pregnancy | 2023 |
Hippocampal neural cell degeneration and memory deficit in high-fat diet-induced postnatal obese rats- exploring the comparable benefits of choline and DHA or environmental enrichment.
Topics: Animals; Animals, Newborn; Behavior, Animal; Choline; Diet, High-Fat; Disease Models, Animal; Docosa | 2021 |
Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats.
Topics: Age Factors; Animals; Animals, Newborn; Choline; Dietary Supplements; Ethanol; Female; Fetal Alcohol | 2020 |
Increasing dietary choline attenuates spatial memory deficits resulting from exposure to the chemotherapeutic agents cyclophosphamide and doxorubicin.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Choline; Cognitive Dysfunct | 2021 |
Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats.
Topics: Aging; Animals; Choline; Dizocilpine Maleate; Doublecortin Protein; Female; Hippocampus; Male; Memor | 2017 |
Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine; Depressive Disorder, | 2018 |
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Topics: Aging; Amyloid beta-Peptides; Animals; Anxiety; Brain; Cell Survival; Cerebral Cortex; Choline; CpG | 2019 |
White matter abnormalities and working memory impairment in systemic lupus erythematosus.
Topics: Choline; Cognition Disorders; Creatinine; Frontal Lobe; Humans; Leukoencephalopathies; Lupus Erythem | 2013 |
Brain aging, memory impairment and oxidative stress: a study in Drosophila melanogaster.
Topics: Acetylcholine; Aging; Animals; Animals, Genetically Modified; Brain; Catalase; Choline; Choline O-Ac | 2014 |
Neurochemical changes observed by in vivo proton magnetic resonance spectroscopy in the mouse brain postadministration of scopolamine.
Topics: Adjuvants, Anesthesia; Animals; Choline; Cholinergic Agents; Hippocampus; Male; Memory Disorders; Mi | 2014 |
An animal model of fetal alcohol spectrum disorder: Trace conditioning as a window to inform memory deficits and intervention tactics.
Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Central Nervo | 2015 |
Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution.
Topics: Adolescent; Age Factors; Air Pollution; Analysis of Variance; Apolipoprotein E4; Aspartic Acid; Brai | 2015 |
Dietary choline during periadolescence attenuates cognitive damage caused by neonatal maternal separation in male rats.
Topics: Animals; Animals, Newborn; Choline; Choline Deficiency; Cognition Disorders; Dietary Supplements; Ma | 2017 |
Adolescent Choline Supplementation Attenuates Working Memory Deficits in Rats Exposed to Alcohol During the Third Trimester Equivalent.
Topics: Age Factors; Animals; Animals, Newborn; Choline; Dietary Supplements; Ethanol; Female; Male; Maze Le | 2016 |
Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creati | 2016 |
Multi-Vitamin B Supplementation Reverses Hypoxia-Induced Tau Hyperphosphorylation and Improves Memory Function in Adult Mice.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Choline; Dietary Supplements; Disease Models, Animal; | 2016 |
Correlation between memory, proton magnetic resonance spectroscopy, and interictal epileptiform discharges in temporal lobe epilepsy related to mesial temporal sclerosis.
Topics: Adult; Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Functional Laterality; Hum | 2009 |
Water maze experience and prenatal choline supplementation differentially promote long-term hippocampal recovery from seizures in adulthood.
Topics: Animals; Choline; Female; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Hum | 2011 |
Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation.
Topics: Animals; Avoidance Learning; Choline; Hippocampus; Male; Memory; Memory Disorders; Mice; Muscarinic | 2012 |
Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.
Topics: Adaptor Proteins, Vesicular Transport; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; C | 2013 |
Long-lasting effects of prenatal dietary choline availability on object recognition memory ability in adult rats.
Topics: Animals; Behavior, Animal; Choline; Choline Deficiency; Dietary Supplements; Female; Male; Maternal | 2013 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate | 2003 |
Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.
Topics: Animals; Choline; Choline Deficiency; Cues; Cyclic AMP Response Element-Binding Protein; Female; Glu | 2004 |
Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Basal Nucleus of Meynert; Cell Count; Choline; | 2004 |
Correlation between 1H MRS and memory before and after surgery in mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Choline; Creatinine; Electroencephalography; Epilep | 2004 |
The effects of estrogens on learning in rats with chronic brain cholinergic deficiency in a Morris water test. Identification of the "passive swimming" component.
Topics: Adrenal Glands; Animals; Aziridines; Brain; Castration; Choline; Cholinergic Antagonists; Estradiol; | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.
Topics: Aged; Amnesia; Aspartic Acid; Cerebral Cortex; Choline; Cognition Disorders; Creatine; Dementia; Dis | 2006 |
Effects of selegiline alone or with donepezil on memory impairment in rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Aziridines; Behavior, Animal; Choline; Cholines | 2005 |
Can drugs halt memory loss?
Topics: Aged; Aging; Amnesia; Animals; Choline; Cholinergic Fibers; Female; Haplorhini; Humans; Male; Memory | 1981 |
Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments.
Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Choline; Choline O-Acetyltransferase; Hippoca | 1981 |
Traumatic brain injury reduces hippocampal high-affinity [3H]choline uptake but not extracellular choline levels in rats.
Topics: Acetylcholine; Animals; Biological Transport; Brain Injuries; Choline; Craniotomy; Extracellular Spa | 1994 |
MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Aziridines; Choline; Choline Deficiency; Data | 1994 |
AF64A disrupts retrieval processes in long-term memory of mice.
Topics: Animals; Aziridines; Choline; Male; Maze Learning; Memory Disorders; Mental Processes; Mice; Mice, I | 1995 |
1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates.
Topics: Adult; Choline; Cognition Disorders; Creatine; Female; Frontal Lobe; Humans; Magnetic Resonance Spec | 1994 |
Huperzine A ameliorates the spatial working memory impairments induced by AF64A.
Topics: Alkaloids; Analysis of Variance; Animals; Aziridines; Choline; Cholinesterase Inhibitors; Injections | 1995 |
Failure in learning task and loss of cortical cholingergic fibers in microsphere-embolized rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Avoidance Learning; Cerebral Cortex; Choline; Choline | 1997 |
EGG phosphatidylcholine combined with vitamin B12 improved memory impairment following lesioning of nucleus basalis in rats.
Topics: Acetylcholine; Animals; Behavior, Animal; Choline; Eggs; Male; Memory Disorders; Phosphatidylcholine | 1998 |
Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models.
Topics: Aging; Aniline Compounds; Animals; Avoidance Learning; Aziridines; Bridged Bicyclo Compounds; Cholin | 1998 |
Striatal transplants prevent AF64A-induced retention deficits.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Aziridines; Brain Tissue Transplantation; Choline | 1998 |
Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze.
Topics: Administration, Intranasal; Animals; Aziridines; Biological Availability; Choline; Choline O-Acetylt | 2000 |
The hippocampus in patients treated with electroconvulsive therapy: a proton magnetic resonance spectroscopic imaging study.
Topics: Adult; Aspartic Acid; Cell Death; Choline; Creatine; Electroconvulsive Therapy; Female; Hippocampus; | 2000 |
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cell Count; Choline; Choline O-Acetyltransfe | 2000 |
Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.
Topics: Animals; Choline; Choline Deficiency; Dietary Supplements; Female; Hippocampus; Male; Maze Learning; | 2002 |
Effects of repeated administration of (-)-nicotine on AF64A-induced learning and memory impairment in rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Choline; Choline O-Acetyl | 2002 |
Possible biochemical basis of memory disorder in Alzheimer disease.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferas | 1978 |
Choline chloride treatment of memory deficits in the elderly.
Topics: Aged; Choline; Female; Humans; Male; Memory Disorders; Mental Recall; Middle Aged; Retention, Psycho | 1979 |
Reversal by 3,3',5-triido-L-thyronine of the working memory deficit, and the decrease in acetylcholine, glutamate and gamma-aminobutyric acid induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Animals; Aspartic Acid; Aziridines; Behavior, Animal; Brain; Choline; gamma-Aminobuty | 1992 |
Memory deficits following chronic alcohol consumption in mice: relationships with hippocampal and cortical cholinergic activities.
Topics: Acetylcholine; Animals; Brain Chemistry; Cerebral Cortex; Choline; Ethanol; Exploratory Behavior; Hi | 1992 |
Intrahippocampal grafts of cholinergic-rich striatal tissue ameliorate spatial memory deficits in rats with fornix lesions.
Topics: Animals; Atropine; Behavior, Animal; Brain Tissue Transplantation; Choline; Corpus Striatum; Efferen | 1992 |
The cholinergic system and memory: amelioration of ethanol-induced memory deficiency by physostigmine in rat.
Topics: Acetylcholine; Acetylcholinesterase; Alcoholism; Animals; Brain; Choline; Choline O-Acetyltransferas | 1990 |
Hemicholinium-3 prevents the working memory impairments and the cholinergic hypofunction induced by ethylcholine aziridinium ion (AF64A).
Topics: Animals; Aziridines; Choline; Cholinergic Fibers; Hemicholinium 3; Hippocampus; Injections, Intraven | 1989 |
Cerebral ageing, neurotransmitters and therapeutic implications.
Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Brain; Choline; Choline O-Acetyltransferase; Dihydroe | 1985 |
Nutritional pharmacology.
Topics: Amino Acids, Branched-Chain; Brain Diseases; Choline; Diet; Dyskinesia, Drug-Induced; Hepatic Enceph | 1985 |
AF64A-induced working memory impairment: behavioral, neurochemical and histological correlates.
Topics: Animals; Aziridines; Azirines; Brain; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Hipp | 1988 |
On the involvement of the central cholinergic system in memory deficits induced by long term ethanol consumption in mice.
Topics: Alcoholism; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Choline; Energy Intake; Hippoca | 1986 |