Page last updated: 2024-10-16

choline and Adenocarcinoma

choline has been researched along with Adenocarcinoma in 74 studies

Adenocarcinoma: A malignant epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
"A 62-year-old patient with prostate adenocarcinoma underwent PET with radiolabeled choline (18F-Fcholine) for pretreatment staging of a high-risk prostate cancer."7.81Anthracosis mimicking mediastinal lymph node metastases with 18F-FCholine in high-risk prostate cancer. ( De Clermont, H; Fernandez, P; Parrens, M; Pasticier, G; Pinaquy, JB, 2015)
"We report the results of whole body 18F-fluorocholine (FCH) PET/CT in a single patient with biochemical suspicion of prostate adenocarcinoma relapse and recent history of minor head injury."7.80Intense 18F-choline uptake after minor head injury: misleading PET/CT result in a patient with biochemical relapse of prostate adenocarcinoma. ( Imperiale, A; Leyendecker, P; Matern, JF; Namer, IJ; Noël, G, 2014)
"Choline metabolism and proliferation as assessed by PET were correlated in ER-positive breast cancer, indicating that high CHO uptake is a measure of cellular proliferation in this setting."7.77Biological basis of [¹¹C]choline-positron emission tomography in patients with breast cancer: comparison with [¹⁸F]fluorothymidine positron emission tomography. ( Aboagye, EO; Al-Nahhas, A; Challapalli, A; Contractor, KB; Coombes, RC; De Nguyen, Q; Hogben, K; Kenny, LM; Lewis, JS; Palmieri, C; Shousha, S; Stebbing, J, 2011)
"Choline is an essential nutrient for cell survival and proliferation, however, the expression and function of choline transporters have not been well identified in cancer."5.34Choline transporters in human lung adenocarcinoma: expression and functional implications. ( Chen, F; Gu, J; He, X; Li, J; Wan, D; Wang, T; Zhao, Y, 2007)
"A 62-year-old patient with prostate adenocarcinoma underwent PET with radiolabeled choline (18F-Fcholine) for pretreatment staging of a high-risk prostate cancer."3.81Anthracosis mimicking mediastinal lymph node metastases with 18F-FCholine in high-risk prostate cancer. ( De Clermont, H; Fernandez, P; Parrens, M; Pasticier, G; Pinaquy, JB, 2015)
"A 65-year-old patient with prostate adenocarcinoma was explored by 18F-fluorocholine (FCH) PET/CT for pretreatment staging because of a high risk of prostate cancer."3.81Unusual lymph node metastases of prostate cancer detected by 18F-fluorocholine PET/CT. ( Allard, JB; Cornelis, F; De Clermont, H; Pasticier, G; Pinaquy, JB, 2015)
"We report the results of whole body 18F-fluorocholine (FCH) PET/CT in a single patient with biochemical suspicion of prostate adenocarcinoma relapse and recent history of minor head injury."3.80Intense 18F-choline uptake after minor head injury: misleading PET/CT result in a patient with biochemical relapse of prostate adenocarcinoma. ( Imperiale, A; Leyendecker, P; Matern, JF; Namer, IJ; Noël, G, 2014)
"Choline metabolism and proliferation as assessed by PET were correlated in ER-positive breast cancer, indicating that high CHO uptake is a measure of cellular proliferation in this setting."3.77Biological basis of [¹¹C]choline-positron emission tomography in patients with breast cancer: comparison with [¹⁸F]fluorothymidine positron emission tomography. ( Aboagye, EO; Al-Nahhas, A; Challapalli, A; Contractor, KB; Coombes, RC; De Nguyen, Q; Hogben, K; Kenny, LM; Lewis, JS; Palmieri, C; Shousha, S; Stebbing, J, 2011)
"The aim of this study was to assess the accuracy and clinical impact of [(11)C]choline PET/CT for localizing occult relapse of prostate adenocarcinoma after radical prostatectomy."3.74[11C]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy. ( Blumstein, NM; Glatting, G; Reske, SN, 2008)
"By comparing the intensity of resonances assigned to choline, creatine, lipid, and lysine, MR spectroscopy can depict prostate carcinoma with a high degree of sensitivity and specificity."3.72Pathologic characterization of human prostate tissue with proton MR spectroscopy. ( Himmelreich, U; Khadra, M; Lean, C; McCredie, S; Mountford, C; Russell, P; Swindle, P, 2003)
"The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor of Swiss 3T3 fibroblast and BG1 ovarian adenocarcinoma cell cytosolic phosphoinositide selective phospholipase C (PIPLC) using [3H]-phosphatidylinositol-(4, 5)-bisphosphate ([3H]PIP2) as the substrate."3.68Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. ( Gratas, C; Melder, D; Modest, EJ; Powis, G; Riebow, J; Seewald, MJ, 1992)
"Lung cancers were analysed visually and semiquantitatively using the ratio of tumour-to-normal radioactivity (T/N ratio) and standardized uptake value (SUV)."2.71A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer. ( Endo, K; Higuchi, T; Inoue, T; Khan, N; Oriuchi, N; Sato, N; Tian, M; Zhang, H, 2003)
"For the diagnosis of recurrent ovarian cancer (n = 3), (11)C-choline PET and (18)F-FDG PET were true-positive in 1 patient, whereas neither tracer could detect cystic recurrent tumor and microscopic peritoneal disease in the other 2 patients."2.71Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET. ( Futatsubashi, M; Kanno, T; Maeda, M; Nakamura, F; Okada, H; Ouchi, Y; Takekuma, M; Torizuka, T; Yoshikawa, E, 2003)
"The management of prostate cancer has dramatically changed over the last decades, mainly due to improvement of diagnostic modalities and development of new therapeutic strategies."2.66Prostate imaging: Contribution of PET PSMA and MRI. ( Abecassis, JP; Ghazzar, N; Giraud, P; Peyromaure, M, 2020)
"The role of PET imaging in prostate cancer is gradually evolving but still remains within the experimental realm."2.44Is there a role for positron emission tomography imaging in the early evaluation of prostate cancer relapse? ( Cascini, GL; Greco, C; Tamburrini, O, 2008)
"multi-parametric MRI in the prostate cancer relapse."1.42(11)C-choline PET/CT and multiparametric MRI in patients with biochemical relapse of prostate cancer. ( Cozar, M; Escobar, M; Garcia, JR; Moragas, M; Romera, N; Soler, M, 2015)
"Primary therapies for prostate cancer were 19 radical prostatectomy, 18 radiotherapy, 13 radiotherapy with hormonal treatment, 3 brachytherapy."1.42[Biochemical recurrence after curative treatment for localized prostate cancer: Performance of choline PET/CT in the assessment of local recurrence]. ( Arnoux, V; Boillot, B; Carnicelli, D; Descotes, JL; Dubreuil, J; Fiard, G; Lanchon, C; Long, JA; Poncet, D; Rambeaud, JJ; Terrier, N; Verry, C, 2015)
"Nine patients with prostate cancer were scanned with an endorectal coil (ERC) on a 7-T MR scanner."1.40Temporal B0 field variation effects on MRSI of the human prostate at 7 T and feasibility of correction using an internal field probe. ( Arteaga de Castro, CS; Bhogal, A; Boer, VO; Klomp, DW; Luijten, PR; Luttje, MP; van der Heide, UA; van der Velden, TA; van Vulpen, M, 2014)
"To diagnose rectal cancer and monitor treatment response after preoperative concurrent chemoradiotherapy (CCRT) in rectal cancer patients using proton-1 magnetic resonance spectroscopy ((1)H-MRS)."1.38Detection of rectal cancer and response to concurrent chemoradiotherapy by proton magnetic resonance spectroscopy. ( Chun, HK; Kim, MJ; Kim, SH; Lee, JH; Lee, SJ; Lim, HK; Yun, SH, 2012)
"Choline is an essential nutrient that serves as a donor of metabolic methyl groups used during gestation to establish the epigenetic DNA methylation patterns that modulate tissue-specific gene expression."1.35Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. ( Blusztajn, JK; Davison, JM; Kovacheva, VP; Mellott, TJ; O'Brien, MJ; Rogers, AE; Yang, S, 2009)
"Although prostate cancer in TRAMP mice shares some metabolic features with that in humans, it differs with respect to choline phospholipid metabolism, which could impact upon the interpretation of results from biomarker or chemotherapy/chemoprevention studies."1.35Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism. ( Edwards, RE; Farmer, PB; Gant, TW; Gescher, AJ; Greaves, P; Jones, DJ; Keun, HC; Steward, WP; Teahan, O; Teichert, F; Verschoyle, RD; Wilson, ID, 2008)
"Choline is an essential nutrient for cell survival and proliferation, however, the expression and function of choline transporters have not been well identified in cancer."1.34Choline transporters in human lung adenocarcinoma: expression and functional implications. ( Chen, F; Gu, J; He, X; Li, J; Wan, D; Wang, T; Zhao, Y, 2007)
"Prostate cancer is known for its difficulties in preoperative staging of pelvic lymph nodes by conventional imaging techniques."1.32Preoperative staging of pelvic lymph nodes in prostate cancer by 11C-choline PET. ( de Jong, IJ; Elsinga, PH; Mensink, HJ; Pruim, J; Vaalburg, W, 2003)
"In specimens (Borrmann type III) with tubular adenocarcinoma, resonance peaks were observed at 1."1.32Ex vivo proton MR spectroscopy (1H-MRS) for evaluation of human gastric carcinoma. ( Cha, SS; Cho, JY; Choi, KS; Eun, CK; Kim, J; Lee, J; Lee, SY; Mun, CW; Nam, SH; Shin, WJ; Yang, YI, 2004)
"The exact staging of prostate cancer is mandatory to allow selection of the appropriate primary therapy."1.31[The (11C) acetate positron emission tomography in prostatic carcinoma. New prospects in metabolic imaging]. ( Ackermann, R; Coenen, HH; Hautzel, H; Herzog, H; Krause, BJ; Müller-Gärtner, HW; Müller-Mattheis, V; Roden, W, 2002)
"PET was performed on 10 prostate cancer patients from the level of pelvis to the lower abdomen."1.30PET imaging of prostate cancer using carbon-11-choline. ( Hara, T; Kishi, H; Kosaka, N, 1998)
"An estimate of the spatial extent of prostate cancer was determined by generating metabolite images in which this metabolite ratio significantly exceeded normal peripheral zone values in multiple contiguous sections."1.29Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution. ( Carroll, P; Hricak, H; Kurhanewicz, J; Narayan, P; Nelson, SJ; Vigneron, DB, 1996)
"Choline was not effective in inhibiting the development of lung metastases in either case."1.27Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats. ( Hoover, KL; Poirier, LA; Shivapurkar, N, 1986)

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-19906 (8.11)18.7374
1990's10 (13.51)18.2507
2000's23 (31.08)29.6817
2010's30 (40.54)24.3611
2020's5 (6.76)2.80

Authors

AuthorsStudies
Liu, C3
Liu, D3
Wang, F3
Liu, Y3
Xie, J6
Xie, Y3
Fuentes-Baile, M1
Bello-Gil, D1
Pérez-Valenciano, E1
Sanz, JM1
García-Morales, P1
Maestro, B1
Ventero, MP1
Alenda, C1
Barberá, VM1
Saceda, M1
Turpin, L1
Pouliot, Q1
Zhang, J1
Glikman, M1
Gomez, F1
Talbot, JN1
Montravers, F1
Abecassis, JP1
Ghazzar, N1
Peyromaure, M1
Giraud, P1
Latge, A1
Heimburger, C1
Severac, F1
Meyer, N1
Somme, F1
Imperiale, A3
Conteduca, V1
Scarpi, E1
Caroli, P1
Salvi, S1
Lolli, C1
Burgio, SL1
Menna, C1
Schepisi, G1
Testoni, S1
Gurioli, G1
Paganelli, G1
Casadio, V1
Matteucci, F1
De Giorgi, U1
Dejust, S1
Messaoud, L1
Jallerat, P1
Marical, V1
Morland, D1
Mujukian, A1
Kay, M1
Babu, MA1
Spinner, RJ1
Dyck, PJ1
Amrami, KK1
Nathan, MA1
Kawashima, A1
Howe, BM1
Bergerat, JP1
Saussine, C1
Abu Eid, M1
Kehrli, P1
Namer, IJ2
Chang, JH1
Lim Joon, D1
Lee, ST1
Hiew, CY1
Esler, S1
Gong, SJ1
Wada, M1
Clouston, D1
O'Sullivan, R1
Goh, YP1
Tochon-Danguy, H1
Chan, JG1
Bolton, D1
Scott, AM1
Khoo, V1
Davis, ID1
Leyendecker, P1
Matern, JF1
Noël, G1
Cochet, A1
Kanoun, S1
Humbert, O1
Walker, PM1
Cormier, L1
Créhange, G1
Brunotte, F1
Arteaga de Castro, CS1
Boer, VO1
Luttje, MP1
van der Velden, TA1
Bhogal, A1
van Vulpen, M1
Luijten, PR1
van der Heide, UA1
Klomp, DW2
Trousil, S1
Lee, P1
Pinato, DJ1
Ellis, JK1
Dina, R2
Aboagye, EO2
Keun, HC3
Sharma, R1
Garcia, JR2
Romera, N1
Cozar, M1
Soler, M2
Moragas, M1
Escobar, M1
Tabrizipour, AI1
Dunne, M1
Pinaquy, JB2
Fernandez, P1
Pasticier, G2
Parrens, M1
De Clermont, H2
Allard, JB1
Cornelis, F1
Giovacchini, G1
Incerti, E1
Mapelli, P1
Kirienko, M1
Briganti, A1
Gandaglia, G1
Montorsi, F1
Gianolli, L2
Picchio, M2
Matrone, F1
Sivolella, S1
Bellavita, R1
Casciola, L1
Cristallini, EG1
Aristei, C1
Poncet, D1
Arnoux, V1
Descotes, JL1
Rambeaud, JJ1
Verry, C1
Terrier, N1
Boillot, B1
Dubreuil, J1
Lanchon, C1
Carnicelli, D1
Fiard, G1
Long, JA1
Piert, M1
Montgomery, J1
Kunju, LP1
Siddiqui, J1
Rogers, V1
Rajendiran, T1
Johnson, TD1
Shao, X1
Davenport, MS1
Jacob, M1
Delfort, F1
Heliette, C1
Renard, D1
Scalzi, P1
Baiocco, C1
Genovese, S1
Trevisan, A1
Sirotova, Z1
Poti, C1
Calabrese, C1
Pisi, A1
Di Febo, G1
Liguori, G1
Filippini, G1
Cervellera, M1
Righi, V1
Lucchi, P1
Mucci, A1
Schenetti, L1
Tonini, V1
Tosi, MR1
Tugnoli, V1
Mansilla, F1
da Costa, KA1
Wang, S1
Kruhøffer, M1
Lewin, TM1
Orntoft, TF1
Coleman, RA1
Birkenkamp-Demtröder, K1
Kovacheva, VP1
Davison, JM1
Mellott, TJ1
Rogers, AE1
Yang, S1
O'Brien, MJ1
Blusztajn, JK1
Galván-Portillo, MV1
Cantoral, A1
Oñate-Ocaña, LF1
Chen, J1
Herrera-Goepfert, R1
Torres-Sanchez, L1
Hernandez-Ramirez, RU1
Palma-Coca, O1
López-Carrillo, L1
Raina, K1
Serkova, NJ1
Agarwal, R1
Watanabe, H1
Kanematsu, M1
Kondo, H1
Kako, N1
Yamamoto, N1
Yamada, T1
Goshima, S1
Hoshi, H1
Bae, KT1
Al-Saffar, NM1
Jackson, LE1
Raynaud, FI1
Clarke, PA1
Ramírez de Molina, A1
Lacal, JC1
Workman, P1
Leach, MO1
García-Martín, ML1
Adrados, M1
Ortega, MP1
Fernández González, I1
López-Larrubia, P1
Viaño, J1
García-Segura, JM1
Budiharto, T1
Joniau, S1
Lerut, E1
Van den Bergh, L1
Mottaghy, F1
Deroose, CM1
Oyen, R1
Ameye, F1
Bogaerts, K1
Haustermans, K1
Van Poppel, H1
Contractor, KB1
Kenny, LM1
Stebbing, J1
Challapalli, A1
Al-Nahhas, A1
Palmieri, C1
Shousha, S1
Lewis, JS1
Hogben, K1
De Nguyen, Q1
Coombes, RC1
Evans-Axelsson, S1
Ulmert, D1
Örbom, A1
Peterson, P1
Nilsson, O1
Wennerberg, J1
Strand, J1
Wingårdh, K1
Olsson, T1
Hagman, Z1
Tolmachev, V1
Bjartell, A1
Lilja, H1
Strand, SE1
Kim, MJ1
Lee, SJ1
Lee, JH2
Kim, SH2
Chun, HK1
Lim, HK1
Yun, SH1
Aguilo, JJ1
Marco, V1
Valls, E1
Lomeña, F1
Li, M1
Peng, Z1
Liu, Q2
Sun, J1
Yao, S1
Jiménez, B1
Mirnezami, R1
Kinross, J1
Cloarec, O1
Holmes, E1
Goldin, RD1
Ziprin, P1
Darzi, A1
Nicholson, JK1
Landoni, C1
Messa, C1
Matarrese, M1
De Cobelli, F1
Maschio, AD1
Fazio, F1
Hautzel, H1
Müller-Mattheis, V1
Herzog, H1
Roden, W1
Coenen, HH1
Ackermann, R1
Müller-Gärtner, HW1
Krause, BJ1
de Jong, IJ1
Pruim, J1
Elsinga, PH1
Vaalburg, W1
Mensink, HJ1
Khan, N1
Oriuchi, N1
Zhang, H1
Higuchi, T1
Tian, M1
Inoue, T1
Sato, N1
Endo, K2
Swindle, P1
McCredie, S1
Russell, P1
Himmelreich, U1
Khadra, M1
Lean, C1
Mountford, C1
Torizuka, T1
Kanno, T1
Futatsubashi, M1
Okada, H1
Yoshikawa, E1
Nakamura, F1
Takekuma, M1
Maeda, M1
Ouchi, Y1
Mahon, MM1
Cox, IJ1
Soutter, WP1
McIndoe, GA1
Williams, AD1
deSouza, NM1
Mun, CW2
Cho, JY1
Shin, WJ1
Choi, KS1
Eun, CK1
Cha, SS1
Lee, J1
Yang, YI1
Nam, SH1
Kim, J1
Lee, SY1
Guo, J1
Higashi, K1
Yokota, H1
Nagao, Y1
Ueda, Y1
Kodama, Y1
Oguchi, M1
Taki, S1
Tonami, H1
Yamamoto, I1
Taouli, B1
Maeda, T2
Tateishi, U2
Komiyama, M1
Fujimoto, H1
Watanabe, S1
Terauchi, T2
Moriyama, N2
Arai, Y1
Sugimura, K1
Kakizoe, T2
Heijmink, SW1
Scheenen, TW1
Fütterer, JJ1
Heesakkers, RA1
Hulsbergen-van de Kaa, CA1
van Lin, EN1
Heerschap, A1
Barentsz, JO1
Wang, T1
Li, J1
Chen, F1
Zhao, Y1
He, X1
Wan, D1
Gu, J1
Reske, SN1
Blumstein, NM1
Glatting, G1
Kanou, D1
Daisaki, H1
Moriya, Y1
Greco, C1
Cascini, GL1
Tamburrini, O1
Teichert, F1
Verschoyle, RD1
Greaves, P1
Edwards, RE1
Teahan, O1
Jones, DJ1
Wilson, ID1
Farmer, PB1
Steward, WP1
Gant, TW1
Gescher, AJ1
Rémy-Heintz, N1
Bali, JP1
Sénelar, R1
Gastaud, JM1
Lean, CL1
Newland, RC1
Ende, DA1
Bokey, EL1
Smith, IC1
Mountford, CE1
Kurhanewicz, J1
Vigneron, DB1
Hricak, H2
Narayan, P1
Carroll, P1
Nelson, SJ1
Nakai, T1
Ishima, R1
Sakahara, H1
Konishi, J1
Akasaka, K1
Street, JC1
Szwergold, BS1
Matei, C1
Kappler, F1
Mahmood, U1
Brown, TR1
Koutcher, JA2
Burtscher, IM1
Ståhlberg, F1
Holtås, S1
Cho, KS1
Kim, YM1
Kim, ST1
Na, JH1
Mok, JE1
Lim, TH1
Hara, T1
Kosaka, N1
Kishi, H1
Zakian, K1
Powis, G1
Seewald, MJ1
Gratas, C1
Melder, D1
Riebow, J1
Modest, EJ1
McCormack, SA1
Tague, LL1
Gragoe, EJ1
Johnson, LR1
Palmer, KC1
Mooradian, DL1
Diglio, CA1
Shivapurkar, N1
Hoover, KL1
Poirier, LA1
Sahu, AP1
Singh, KP1
Shukla, LJ1
Shanker, R1
Khaletskaia, FM1
Hillyard, LA1
Abraham, S1
Hill, DL1
Wingo, R1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Investigation of the Magnitude of Uptake, Retention, and Spatial Distribution Pattern of 18F-Choline in Comparison With MRI and Histology Obtained From Prostate Cancer Biopsies[NCT01751737]63 participants (Actual)Interventional2012-11-30Completed
Clinical Value of [18]Fluoroethylcholine Positron-Emission-Tomography Combined With Endorectal Magnetic Resonance Imaging by Software Fusion for Pre-therapeutic Staging of Prostate Cancer[NCT00520546]Phase 344 participants (Actual)Interventional2007-12-31Completed
A Multi-center, Open-label, Single Arm Phase III Clinical Trial for the Diagnostic Efficacy Assessment and Safety Evaluation by [18F]Florastamin PET/CT Imaging Examination in Patients With Suspected Recurrent or Metastatic Prostate Cancer[NCT05936658]Phase 389 participants (Anticipated)Interventional2023-05-08Recruiting
Trans-Rectal Placement of Prostatic Fiducial Markers Under MR-Guidance in Patients Receiving External Beam Radiotherapy for Prostate Cancer: A Pilot Study[NCT00061347]Phase 115 participants (Actual)Interventional2003-05-23Completed
Evaluation of 11 C-Choline PET-CT for Detection of Hepatocellular Carcinoma[NCT01377220]Phase 230 participants (Anticipated)Interventional2011-06-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Lesion Based Analysis of FEC-PET, Endorectal MRI and Combined FEC-PET/eMRI in All Patients

PET positive lesions (n=128) were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative and positive predictive values were determined. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionlesions (Number)
True positiveFalse positiveTrue negativeFalse negativeTotal trueTotal false
FEC-PET592619247850
Magnetic Resonance Imaging (MRI)402718435870
PET/MRI55837289236

Lesion Based Analysis of FEC-PET, Endorectal MRI and Combined FEC-PET/eMRI in Patients With Gleason Score >6 (3+3)

PET positive lesions in patients with Gleason >6(3+3),n=43 were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative & positive predictive values were determined. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionlesions (Number)
True positiveFalse positiveTrue negativeFalse negativeTotal trueTotal false
FEC-PET27583358
Magnetic Resonance Imaging (MRI)229482617
PET/MRI271114385

Lesion Based Analysis of FEC-PET, Endorectal MRI and Combined FEC-PET/eMRI in Patients With Malignant Lesions >5mm (n=98)

PET positive lesions were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. Sensitivity, specificity, accuracy, negative and positive predictive values were determined without malign lesions <=5mm. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionlesions (Number)
True positiveFalse positiveTrue negativeFalse negativeTotal trueTotal false
FEC-PET48241886632
Magnetic Resonance Imaging (MRI)372616195345
PET/MRI48832108018

Number of Participants With Positive or Negative Results in PET, MRI or PET/MRI for Prostate Cancer Compared to Histological Findings

PET positive lesions were measured on its own and evaluated as malignant just as hypointense lesions on MRI. In PET/MRI analysis, MRI suspect lesions without FEC uptake were considered not to be malignant. PET positive lesions in central periurethral zone with inhomogenous signal intensity and sharp edges on MRI images were also considered to be benign. PET positive lesions in the peripheral zone without a hypointense correlate on MRI were considered to be malignant. At least 1 histological confirmed cancer lesion has to be detected by each of the 3 methods to be patient based true positive. (NCT00520546)
Timeframe: within < 2 weeks after PET/MRI

,,
Interventionparticipants (Number)
True PositiveFalse PositiveTrue NegativeFalse NegativeTotal TrueTotal False
[18F]Fluoroethylcholine Positron-Emission-Tomography (FEC-PET)36101362
Magnetic Resonance Imaging (MRI)2610112711
PositronEmissionTomography/MagneticResonanceImaging (PET/MRI)35012362

Reviews

5 reviews available for choline and Adenocarcinoma

ArticleYear
Prostate imaging: Contribution of PET PSMA and MRI.
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2020, Volume: 24, Issue:5

    Topics: Adenocarcinoma; Aged; Antigens, Surface; Carbon Radioisotopes; Choline; Fluorine Radioisotopes; Glut

2020
[Multimodality MRI and PET for restaging prostate cancer after biochemical failure of the treatment].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2014, Volume: 18, Issue:5-6

    Topics: Adenocarcinoma; Brachytherapy; Carbon Radioisotopes; Choline; Fluorine Radioisotopes; Fluorodeoxyglu

2014
[MR spectroscopic imaging for evaluation of prostate cancer].
    Journal de radiologie, 2006, Volume: 87, Issue:2 Pt 2

    Topics: Adenocarcinoma; Biomarkers; Biopsy; Choline; Citrates; Humans; Magnetic Resonance Imaging; Magnetic

2006
Is there a role for positron emission tomography imaging in the early evaluation of prostate cancer relapse?
    Prostate cancer and prostatic diseases, 2008, Volume: 11, Issue:2

    Topics: Adenocarcinoma; Carbon Radioisotopes; Choline; Clinical Trials as Topic; Humans; Lymphatic Metastasi

2008
Magnetic resonance spectroscopic studies of the prostate.
    Molecular urology, 2000,Fall, Volume: 4, Issue:3

    Topics: Adenocarcinoma; Choline; Citric Acid; Humans; Magnetic Resonance Spectroscopy; Male; Neoplasm Stagin

2000

Trials

5 trials available for choline and Adenocarcinoma

ArticleYear
Diffusion-weighted MRI, 11C-choline PET and 18F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma.
    European radiology, 2014, Volume: 24, Issue:3

    Topics: Adenocarcinoma; Aged; Biopsy; Carbon Radioisotopes; Choline; Diffusion Magnetic Resonance Imaging; F

2014
18F-Choline PET/MRI: The Additional Value of PET for MRI-Guided Transrectal Prostate Biopsies.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:7

    Topics: Adenocarcinoma; Aged; Choline; Humans; Image-Guided Biopsy; Magnetic Resonance Imaging; Male; Middle

2016
Preoperative detection of prostate cancer: a comparison with 11C-choline PET, 18F-fluorodeoxyglucose PET and MR imaging.
    Journal of magnetic resonance imaging : JMRI, 2010, Volume: 31, Issue:5

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Humans; Magnetic Resona

2010
A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer.
    Nuclear medicine communications, 2003, Volume: 24, Issue:4

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Choline

2003
Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003, Volume: 44, Issue:7

    Topics: Adenocarcinoma; Adult; Aged; Carbon Radioisotopes; Carcinoma, Squamous Cell; Carcinosarcoma; Choline

2003

Other Studies

64 other studies available for choline and Adenocarcinoma

ArticleYear
Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma; Animals; CD8-Positive T-Lymphocytes; Choline; Colonic Neoplasms; Endothelial Cells;

2022
Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma; Animals; CD8-Positive T-Lymphocytes; Choline; Colonic Neoplasms; Endothelial Cells;

2022
Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma; Animals; CD8-Positive T-Lymphocytes; Choline; Colonic Neoplasms; Endothelial Cells;

2022
Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Adenocarcinoma; Animals; CD8-Positive T-Lymphocytes; Choline; Colonic Neoplasms; Endothelial Cells;

2022
CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells.
    Biomolecules, 2020, 02-03, Volume: 10, Issue:2

    Topics: 3T3-L1 Cells; Adenocarcinoma; Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival;

2020
    European journal of nuclear medicine and molecular imaging, 2020, Volume: 47, Issue:11

    Topics: Adenocarcinoma; Aged; Betacoronavirus; Choline; Convalescence; Coronavirus Infections; COVID-19; Flu

2020
Impact of pelvic dynamic acquisition on final reading of
    Journal of medical imaging and radiation oncology, 2022, Volume: 66, Issue:3

    Topics: Adenocarcinoma; Choline; Humans; Male; Positron Emission Tomography Computed Tomography; Positron-Em

2022
Circulating androgen receptor combined with 18F-fluorocholine PET/CT metabolic activity and outcome to androgen receptor signalling-directed therapies in castration-resistant prostate cancer.
    Scientific reports, 2017, Nov-14, Volume: 7, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Androstenes; Antineoplastic Combined Chemotherapy Pr

2017
Hepatic Metastases From Prostatic Adenocarcinoma Without Elevated 18F-Choline Activity.
    Clinical nuclear medicine, 2018, Volume: 43, Issue:10

    Topics: Adenocarcinoma; Aged; Biological Transport; Choline; Humans; Liver Neoplasms; Male; Positron Emissio

2018
Indeterminate single bone lesion on multimodality imaging of prostate cancer.
    BMJ case reports, 2019, Jan-07, Volume: 12, Issue:1

    Topics: Adenocarcinoma; Aged; Bone Neoplasms; Choline; Diagnosis, Differential; Diphosphonates; Disease Prog

2019
Recurrent prostatic adenocarcinoma with perineural spread to the lumbosacral plexus and sciatic nerve: comparing high resolution MRI with torso and endorectal coils and F-18 FDG and C-11 choline PET/CT.
    Abdominal imaging, 2013, Volume: 38, Issue:5

    Topics: Adenocarcinoma; Aged, 80 and over; Biopsy; Choline; Fluorodeoxyglucose F18; Humans; Lumbosacral Plex

2013
Isolated cerebellar metastasis from prostate adenocarcinoma diagnosed by 18F-fluorocholine PET/CT: a rare but not impossible complication.
    European journal of nuclear medicine and molecular imaging, 2014, Volume: 41, Issue:2

    Topics: Adenocarcinoma; Aged; Cerebellar Neoplasms; Choline; Humans; Male; Multimodal Imaging; Positron-Emis

2014
Intense 18F-choline uptake after minor head injury: misleading PET/CT result in a patient with biochemical relapse of prostate adenocarcinoma.
    Clinical nuclear medicine, 2014, Volume: 39, Issue:11

    Topics: Adenocarcinoma; Choline; Diagnostic Errors; Humans; Male; Middle Aged; Multimodal Imaging; Positron-

2014
Temporal B0 field variation effects on MRSI of the human prostate at 7 T and feasibility of correction using an internal field probe.
    NMR in biomedicine, 2014, Volume: 27, Issue:11

    Topics: Adenocarcinoma; Algorithms; Artifacts; Choline; Citrates; Feasibility Studies; Humans; Magnetic Reso

2014
Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway.
    Cancer research, 2014, Dec-01, Volume: 74, Issue:23

    Topics: Adenocarcinoma; Cell Line; Cell Line, Tumor; Choline; Choline Kinase; Endometrial Neoplasms; Female;

2014
(11)C-choline PET/CT and multiparametric MRI in patients with biochemical relapse of prostate cancer.
    Actas urologicas espanolas, 2015, Volume: 39, Issue:4

    Topics: Adenocarcinoma; Bone Neoplasms; Carbon Radioisotopes; Choline; Combined Modality Therapy; Humans; Ly

2015
The role of 18F-flourocholine PET/CT in biochemically relapsed prostate cancer: a case of osteolytic prostate metastasis.
    Clinical nuclear medicine, 2015, Volume: 40, Issue:5

    Topics: Adenocarcinoma; Bone Neoplasms; Choline; Humans; Male; Middle Aged; Multimodal Imaging; Positron-Emi

2015
Anthracosis mimicking mediastinal lymph node metastases with 18F-FCholine in high-risk prostate cancer.
    Clinical nuclear medicine, 2015, Volume: 40, Issue:4

    Topics: Adenocarcinoma; Anthracosis; Choline; False Positive Reactions; Humans; Lymphatic Metastasis; Male;

2015
Unusual lymph node metastases of prostate cancer detected by 18F-fluorocholine PET/CT.
    Clinical nuclear medicine, 2015, Volume: 40, Issue:4

    Topics: Adenocarcinoma; Aged; Choline; Humans; Lymphatic Metastasis; Male; Multimodal Imaging; Positron-Emis

2015
[¹¹C]Choline PET/CT predicts survival in hormone-naive prostate cancer patients with biochemical failure after radical prostatectomy.
    European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:6

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Choline; Humans; Male; Middle Aged; Multimodal Imaging;

2015
Use of 18F-choline positron emission tomography/CT in high-risk prostate cancer: a case of solitary adrenal metastasis.
    Tumori, 2015, Mar-20, Volume: 101, Issue:1

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Agents, Hormonal; Bioma

2015
[Biochemical recurrence after curative treatment for localized prostate cancer: Performance of choline PET/CT in the assessment of local recurrence].
    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 2015, Volume: 25, Issue:6

    Topics: Adenocarcinoma; Aged; Choline; Fluorine Radioisotopes; Humans; Male; Middle Aged; Multimodal Imaging

2015
Brain 18F-choline PET/CT in primary diffuse leptomeningeal melanomatosis.
    Acta neurologica Belgica, 2016, Volume: 116, Issue:4

    Topics: Adenocarcinoma; Choline; Humans; Male; Melanoma; Meningeal Carcinomatosis; Middle Aged; Neoplasms, M

2016
Evaluation of bone metastases by 18F-choline PET/CT in a patient with castration-resistant prostate cancer treated with radium-223.
    Urologia, 2017, Feb-03, Volume: 84, Issue:1

    Topics: Adenocarcinoma; Aged; Bone Neoplasms; Choline; Fluorine Radioisotopes; Humans; Male; Positron Emissi

2017
Biochemical alterations from normal mucosa to gastric cancer by ex vivo magnetic resonance spectroscopy.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:6

    Topics: Adenocarcinoma; Aged; Alanine; Biomarkers, Tumor; Choline; Endoscopy, Gastrointestinal; Female; Gast

2008
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer.
    Journal of molecular medicine (Berlin, Germany), 2009, Volume: 87, Issue:1

    Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Adenocarcinoma; Adult; Aged; Animals; Cell Line, Tumo

2009
Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, Volume: 23, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Carcinogens; Choline; Choline Deficiency;

2009
Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers.
    European journal of nutrition, 2009, Volume: 48, Issue:5

    Topics: Adenocarcinoma; Case-Control Studies; Choline; Diet; DNA Methylation; Female; Folic Acid; Genotype;

2009
Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study.
    Cancer research, 2009, May-01, Volume: 69, Issue:9

    Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Choline; Citrates; Glucose; Inositol; Lipid Metabolism;

2009
The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.
    Cancer research, 2010, Jul-01, Volume: 70, Issue:13

    Topics: Adenocarcinoma; Cell Line, Tumor; Choline; Choline Kinase; Down-Regulation; Furans; HCT116 Cells; Hu

2010
Quantitative (1) H MR spectroscopic imaging of the prostate gland using LCModel and a dedicated basis-set: correlation with histologic findings.
    Magnetic resonance in medicine, 2011, Volume: 65, Issue:2

    Topics: Adenocarcinoma; Choline; Citric Acid; Creatine; Humans; In Vitro Techniques; Magnetic Resonance Spec

2011
Prospective evaluation of 11C-choline positron emission tomography/computed tomography and diffusion-weighted magnetic resonance imaging for the nodal staging of prostate cancer with a high risk of lymph node metastases.
    European urology, 2011, Volume: 60, Issue:1

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Choline; Diffusion Magnetic Resonance Imaging; Humans; L

2011
Biological basis of [¹¹C]choline-positron emission tomography in patients with breast cancer: comparison with [¹⁸F]fluorothymidine positron emission tomography.
    Nuclear medicine communications, 2011, Volume: 32, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Carbon Radioisotopes; Cell Proliferation; Choline; Ch

2011
Targeting free prostate-specific antigen for in vivo imaging of prostate cancer using a monoclonal antibody specific for unique epitopes accessible on free prostate-specific antigen alone.
    Cancer biotherapy & radiopharmaceuticals, 2012, Volume: 27, Issue:4

    Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Autoradiography; Choline; Feasibility Studies; Fluo

2012
Detection of rectal cancer and response to concurrent chemoradiotherapy by proton magnetic resonance spectroscopy.
    Magnetic resonance imaging, 2012, Volume: 30, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Chemoradiotherapy; Choline; Female; Humans; Magnetic Resonance Imaging;

2012
Diagnosis of penile metastases of prostatic origin with 11C-Choline PET/CT.
    Revista espanola de medicina nuclear e imagen molecular, 2012, Volume: 31, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Agents, Hormonal; Carbon Radioisotopes; Choline; Combined Modality Th

2012
Value of 11C-choline PET/CT for lung cancer diagnosis and the relation between choline metabolism and proliferation of cancer cells.
    Oncology reports, 2013, Volume: 29, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Carbon Radioisotopes; Carcinoma, Large Cell; Carcinoma, Neuroendocrine;

2013
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
    Journal of proteome research, 2013, Feb-01, Volume: 12, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers, Tumor; Cell Transformation,

2013
Positive [11C]choline and negative [18F]FDG with positron emission tomography in recurrence of prostate cancer.
    AJR. American journal of roentgenology, 2002, Volume: 179, Issue:2

    Topics: Adenocarcinoma; Aged; Bone Neoplasms; Choline; False Negative Reactions; Fluorodeoxyglucose F18; Hum

2002
[The (11C) acetate positron emission tomography in prostatic carcinoma. New prospects in metabolic imaging].
    Der Urologe. Ausg. A, 2002, Volume: 41, Issue:6

    Topics: Acetates; Adenocarcinoma; Amino Acids; Biopsy; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18

2002
Preoperative staging of pelvic lymph nodes in prostate cancer by 11C-choline PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003, Volume: 44, Issue:3

    Topics: Adenocarcinoma; Aged; Carbon Radioisotopes; Choline; Humans; Image Processing, Computer-Assisted; Ly

2003
Pathologic characterization of human prostate tissue with proton MR spectroscopy.
    Radiology, 2003, Volume: 228, Issue:1

    Topics: Adenocarcinoma; Biomarkers, Tumor; Choline; Citrates; Creatinine; Diagnosis, Differential; Humans; L

2003
(1)H magnetic resonance spectroscopy of preinvasive and invasive cervical cancer: in vivo-ex vivo profiles and effect of tumor load.
    Journal of magnetic resonance imaging : JMRI, 2004, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Analysis of Variance; Biomarkers, Tumor; Carcinoma, Squamous Cell; Chol

2004
Ex vivo proton MR spectroscopy (1H-MRS) for evaluation of human gastric carcinoma.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:6

    Topics: Adenocarcinoma; Alanine; Choline; Feasibility Studies; Humans; Lipid Metabolism; Magnetic Resonance

2004
In vitro proton magnetic resonance spectroscopic lactate and choline measurements, 18F-FDG uptake, and prognosis in patients with lung adenocarcinoma.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004, Volume: 45, Issue:8

    Topics: Adenocarcinoma; Aged; Choline; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Japan;

2004
Distant metastasis of prostate cancer: early detection of recurrent tumor with dual-phase carbon-11 choline positron emission tomography/computed tomography in two cases.
    Japanese journal of clinical oncology, 2006, Volume: 36, Issue:9

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Hormonal; Carbon Radioisotopes; Choline; Early Diagnosi

2006
Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to detect recurrent prostate cancer after radiation therapy.
    Investigative radiology, 2007, Volume: 42, Issue:6

    Topics: Adenocarcinoma; Aged; Choline; Humans; Image Processing, Computer-Assisted; Lymph Node Excision; Lym

2007
Choline transporters in human lung adenocarcinoma: expression and functional implications.
    Acta biochimica et biophysica Sinica, 2007, Volume: 39, Issue:9

    Topics: Adenocarcinoma; Antigens, CD; Cell Line, Tumor; Choline; Gene Expression Regulation, Neoplastic; Hum

2007
[11C]choline PET/CT imaging in occult local relapse of prostate cancer after radical prostatectomy.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:1

    Topics: Adenocarcinoma; Aged; Biopsy; Carbon Radioisotopes; Choline; Follow-Up Studies; Humans; Male; Middle

2008
A case of colon cancer detected by carbon-11 choline positron emission tomography/computed tomography: an initial report.
    Japanese journal of clinical oncology, 2007, Volume: 37, Issue:10

    Topics: Adenocarcinoma; Biopsy; Carbon Radioisotopes; Choline; Colonic Neoplasms; Female; Humans; Hysterecto

2007
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
    The Prostate, 2008, Jul-01, Volume: 68, Issue:10

    Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Choline; Choline Kinase; Disease Models, Animal; Gene Ex

2008
[Effect of chlorine-methylated quaternary ammonium on human gastric cancer cell proliferation].
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1993, Volume: 316, Issue:11

    Topics: Adenocarcinoma; Cell Division; Chlorine; Choline; Dose-Response Relationship, Drug; Humans; Membrane

1993
Assessment of human colorectal biopsies by 1H MRS: correlation with histopathology.
    Magnetic resonance in medicine, 1993, Volume: 30, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids; Biopsy; Choline; Colorectal Neoplasms;

1993
Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution.
    Radiology, 1996, Volume: 198, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Choline; Citrates; Citric Acid; Creatine; Diagnosis, Differential; Huma

1996
1H-magnetic resonance spectroscopic observation of cultured malignant cells pharmacologically induced to different phenotypes.
    Academic radiology, 1996, Volume: 3, Issue:9

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Butyrates; Butyric Acid; Cho

1996
Study of the metabolism of choline and phosphatidylcholine in tumors in vivo using phosphonium-choline.
    Magnetic resonance in medicine, 1997, Volume: 38, Issue:5

    Topics: Adenocarcinoma; Animals; Choline; Female; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experi

1997
Proton (1H) MR spectroscopy for routine diagnostic evaluation of brain lesions.
    Acta radiologica (Stockholm, Sweden : 1987), 1997, Volume: 38, Issue:6

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Diseases; Brain Neo

1997
Localized in vivo 1H nuclear MR spectroscopy for evaluation of human uterine cervical carcinoma.
    AJR. American journal of roentgenology, 1998, Volume: 170, Issue:5

    Topics: Adenocarcinoma; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; Choline; Creatine; Female; Human

1998
PET imaging of prostate cancer using carbon-11-choline.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:6

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Huma

1998
PET imaging of prostate cancer using carbon-11-choline.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:6

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Huma

1998
PET imaging of prostate cancer using carbon-11-choline.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:6

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Huma

1998
PET imaging of prostate cancer using carbon-11-choline.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:6

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carbon Radioisotopes; Choline; Fluorodeoxyglucose F18; Huma

1998
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
    Cancer research, 1992, May-15, Volume: 52, Issue:10

    Topics: 3T3 Cells; Adenocarcinoma; Animals; Cell Division; Choline; Female; Mice; Ovarian Neoplasms; Phospha

1992
Regulation of ornithine decarboxylase activity in LoVo cells.
    The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 1

    Topics: Adenocarcinoma; Amiloride; Asparagine; Cell Line; Choline; Colonic Neoplasms; Culture Media; Drug Co

1990
Enhancement of differentiated type 2 cell function in the A549 cell line using mitomycin C1.
    Pathology and immunopathology research, 1987, Volume: 6, Issue:3

    Topics: Adenocarcinoma; Cell Differentiation; Cell Division; Cell Line; Choline; Choline-Phosphate Cytidylyl

1987
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
    Carcinogenesis, 1986, Volume: 7, Issue:4

    Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung N

1986
Choline and mica dust induced pulmonary lesions in rats.
    Industrial health, 1985, Volume: 23, Issue:2

    Topics: Adenocarcinoma; Aluminum Silicates; Animals; Choline; Lung; Lung Neoplasms; Male; Pulmonary Fibrosis

1985
[On the pathomorphology of tumors induced by benzocholine 69].
    Voprosy onkologii, 1969, Volume: 15, Issue:2

    Topics: Adenocarcinoma; Adenoma; Animals; Benzene; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Choline;

1969
Membrane proliferation and phosphatidylcholine synthesis in normal, preneoplastic, and neoplastic mammary gland tissues in C3H mice.
    Cancer research, 1972, Volume: 32, Issue:12

    Topics: Adenocarcinoma; Animals; Carbon Isotopes; Choline; Cytochrome c Group; DNA; Endoplasmic Reticulum; F

1972
Nonspecific inhibition of precursor uptake by alkyl-substituted purines and prednisolone.
    Chemico-biological interactions, 1974, Volume: 9, Issue:4

    Topics: Acetates; Adenine; Adenocarcinoma; Animals; Carbon Radioisotopes; Cell Division; Cell Line; Choline;

1974