choline has been researched along with Acute Onset Vascular Dementia in 18 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons." | 1.32 | Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. ( Chu, CB; Jia, JM; Jia, JP; Sun, YX; Xu, M; Yan, X; Zhou, WD, 2004) |
| "The level in patients with Parkinson's disease, where dementia develops in up to 40% of patients, was not elevated significantly compared to that in controls." | 1.32 | Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor. ( Aasly, J; Gårseth, M; Sonnewald, U; White, LR, 2004) |
| "Choline (Cho)/Cr was higher than normal in patients with AD, FTLD, and DLB." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gasparovic, C | 1 |
| Prestopnik, J | 1 |
| Thompson, J | 1 |
| Taheri, S | 1 |
| Huisa, B | 1 |
| Schrader, R | 1 |
| Adair, JC | 1 |
| Rosenberg, GA | 2 |
| Liu, CL | 1 |
| Chen, H | 1 |
| Jiang, Y | 1 |
| Tu, PF | 1 |
| Zhong, M | 1 |
| Ma, JY | 1 |
| Ding, H | 1 |
| Zhang, WX | 1 |
| Jin, XM | 1 |
| Watanabe, T | 1 |
| Shiino, A | 1 |
| Akiguchi, I | 1 |
| Algin, O | 1 |
| Hakyemez, B | 1 |
| Parlak, M | 1 |
| Bender, B | 1 |
| Bornemann, A | 1 |
| Reimold, M | 1 |
| Ernemann, U | 1 |
| Horger, M | 1 |
| Weiss, U | 1 |
| Bacher, R | 1 |
| Vonbank, H | 1 |
| Kemmler, G | 1 |
| Lingg, A | 1 |
| Marksteiner, J | 1 |
| Waldman, AD | 1 |
| Rai, GS | 1 |
| Marszał, E | 1 |
| Jamroz, E | 1 |
| Paprocka, J | 1 |
| Kluczewska, E | 1 |
| Sokół, M | 1 |
| Jia, JP | 1 |
| Jia, JM | 1 |
| Zhou, WD | 1 |
| Xu, M | 1 |
| Chu, CB | 1 |
| Yan, X | 1 |
| Sun, YX | 1 |
| White, LR | 1 |
| Gårseth, M | 1 |
| Aasly, J | 1 |
| Sonnewald, U | 1 |
| Kantarci, K | 1 |
| Petersen, RC | 1 |
| Boeve, BF | 1 |
| Knopman, DS | 1 |
| Tang-Wai, DF | 1 |
| O'Brien, PC | 1 |
| Weigand, SD | 1 |
| Edland, SD | 1 |
| Smith, GE | 1 |
| Ivnik, RJ | 1 |
| Ferman, TJ | 1 |
| Tangalos, EG | 1 |
| Jack, CR | 1 |
| Ross, AJ | 1 |
| Sachdev, PS | 1 |
| Wen, W | 1 |
| Valenzuela, MJ | 1 |
| Brodaty, H | 1 |
| Constans, JM | 2 |
| Meyerhoff, DJ | 2 |
| Gerson, J | 1 |
| MacKay, S | 2 |
| Norman, D | 2 |
| Fein, G | 2 |
| Weiner, MW | 2 |
| Kattapong, VJ | 1 |
| Brooks, WM | 1 |
| Wesley, MH | 1 |
| Kodituwakku, PW | 1 |
| Tohgi, H | 1 |
| Abe, T | 1 |
| Kimura, M | 1 |
| Saheki, M | 1 |
| Takahashi, S | 1 |
| Kimura, S | 1 |
| Saito, H | 1 |
| Minami, M | 1 |
| Togashi, H | 1 |
| Nakamura, N | 1 |
| Nemoto, M | 1 |
| Parvez, HS | 1 |
| Palleschi, M | 1 |
| Capobianco, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
2 trials available for choline and Acute Onset Vascular Dementia
| Article | Year |
|---|---|
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Dementia, Vascular; Diagnosis, Differenti | 2008 |
1H MRS in stroke patients with and without cognitive impairment.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Cerebral Cortex; Choline; Cognition Disorders; C | 2005 |
16 other studies available for choline and Acute Onset Vascular Dementia
| Article | Year |
|---|---|
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cogn | 2013 |
[Effects of echinacoside on extracellular acetylcholine and choline levels of hippocampus and striatum of cerebral ischemia rats].
Topics: Acetylcholine; Animals; Choline; Corpus Striatum; Dementia, Vascular; Glycosides; Hippocampus; Male; | 2013 |
Proton MR spectroscopy and white matter hyperintensities in idiopathic normal pressure hydrocephalus and other dementias.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Dementia, Vascular; Diagnosis, Differential; Female; | 2010 |
[Imaging findings in autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) - CADASIL - the most frequent familial stroke syndrome].
Topics: Aged; Brain; CADASIL; Choline; Chromosome Aberrations; Dementia, Vascular; Diffusion Magnetic Resona | 2012 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognition Disorders; Creatinine; Dementia, Vascular | 2003 |
Leukoencephalopathy with macrocephaly and mild clinical course.
Topics: Abnormalities, Multiple; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatinine; Dementi | 2004 |
Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Blood-Brain Barrier; Choline; Dementia, Vascular; Female; Hu | 2004 |
Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Case-Control Studi | 2004 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Brain Ischem | 1996 |
Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Dementia, Vascular; Diagnosis, Dif | 1996 |
Cerebrospinal fluid acetylcholine and choline in vascular dementia of Binswanger and multiple small infarct types as compared with Alzheimer-type dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Biomarkers; Choline; Cholinergic Agents; Dementia, Multi-Inf | 1996 |
Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats.
Topics: Acetylcholine; Aged; Animals; Behavior, Animal; Brain; Brain Chemistry; Cerebral Infarction; Choline | 2000 |
[Pathological aging of the brain. Personal observations on the use of citicoline].
Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Choline; Chronic Disease; Cytidine Diphosphate C | 1988 |