choline has been researched along with Acute Disease in 63 studies
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patients had significantly reduced total choline and myo-inositol in the acute phase of Graves' thyrotoxicosis compared with the healthy volunteers." | 9.10 | Reduced myo-inositol and total choline measured with cerebral MRS in acute thyrotoxic Graves' disease. ( Danielsen, ER; Elberling, TV; Feldt-Rasmussen, U; Rasmussen, AK; Thomsen, C; Waldemar, G, 2003) |
| "A multicenter double-blind placebo-controlled study of cytidine 5'-diphosphocholine (CDP-choline) was conducted to evaluate possible clinical benefits of the drug in patients with acute, moderate to severe cerebral infarction." | 9.06 | Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study. ( Fujishima, M; Kameyama, M; Kutsuzawa, T; Omae, T; Otomo, E; Sakai, F; Sakuma, A; Tazaki, Y, 1988) |
| "Weanling rats fed a choline-deficient diet develop kidney oxidative damage, tubular and cortical kidney necrosis, renal failure and animal death." | 7.79 | The protective effect of menhaden oil in the oxidative damage and renal necrosis due to dietary choline deficiency. ( Boveris, A; Monserrat, AJ; Ossani, GP; Repetto, MG, 2013) |
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 7.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| "Young female mice were fed a choline-deficient ethionine (CDE) supplemented diet to induce acute pancreatitis." | 7.72 | Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis. ( Callicutt, CS; Fukatsu, K; Gaber, AO; Gaber, L; Kotb, M; Lundberg, AH; Sabek, O; Wilcox, H, 2003) |
| " We studied the effects of verapamil on pancreatic ultrastructure and zymogen extraction during diet-induced acute pancreatitis." | 7.69 | Dose-dependent effect of continuous subcutaneous verapamil infusion on experimental acute pancreatitis in mice. ( Lake-Bakaar, G; Lyubsky, S, 1995) |
| "This study was designed to evaluate the infectious factor in the pathogenesis of acute pancreatitis and the effects of a combination therapy with a new potent protease inhibitor, E-3123, and a broad spectrum antibiotic cefmetazole (CMZ) in mice with CDE diet-induced severe acute pancreatitis." | 7.68 | Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole. ( Hirano, T; Manabe, T; Nio, Y; Ohshio, G, 1992) |
| "The influence of several factors on the development of acute hemorrhagic pancreatitis (pancreatic necrosis) with fat necrosis in mice fed DL-ethionine with a choline-deficient diet has been investigated." | 7.65 | Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate. ( Lombardi, B; Rao, NK, 1975) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 5.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 5.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| " The patients had significantly reduced total choline and myo-inositol in the acute phase of Graves' thyrotoxicosis compared with the healthy volunteers." | 5.10 | Reduced myo-inositol and total choline measured with cerebral MRS in acute thyrotoxic Graves' disease. ( Danielsen, ER; Elberling, TV; Feldt-Rasmussen, U; Rasmussen, AK; Thomsen, C; Waldemar, G, 2003) |
| "A multicenter double-blind placebo-controlled study of cytidine 5'-diphosphocholine (CDP-choline) was conducted to evaluate possible clinical benefits of the drug in patients with acute, moderate to severe cerebral infarction." | 5.06 | Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study. ( Fujishima, M; Kameyama, M; Kutsuzawa, T; Omae, T; Otomo, E; Sakai, F; Sakuma, A; Tazaki, Y, 1988) |
| "Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes." | 4.02 | Association of gut-related metabolites with outcome in acute heart failure. ( Bernieh, D; Cassambai, S; Heaney, LM; Israr, MZ; Jones, DJL; Ng, LL; Salzano, A; Suzuki, T; Yazaki, Y, 2021) |
| "Weanling rats fed a choline-deficient diet develop kidney oxidative damage, tubular and cortical kidney necrosis, renal failure and animal death." | 3.79 | The protective effect of menhaden oil in the oxidative damage and renal necrosis due to dietary choline deficiency. ( Boveris, A; Monserrat, AJ; Ossani, GP; Repetto, MG, 2013) |
| "Impaired function of the central gamma-aminobutyric acid (GABA) system, which provides the brain's major inhibitory pathways, is thought to play an important role in the pathophysiology of anxiety disorders." | 3.76 | Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy. ( Drevets, WC; Grillon, C; Hasler, G; Shen, J; van der Veen, JW, 2010) |
| "Choline and creatine are commonly used as denominators for other metabolites in ischemic stroke spectroscopy, assuming that they do not change." | 3.74 | Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. ( Armitage, PA; Bastin, ME; Cvoro, V; Marshall, I; Muñoz Maniega, S; Wardlaw, JM, 2008) |
| "Young female mice were fed a choline-deficient ethionine (CDE) supplemented diet to induce acute pancreatitis." | 3.72 | Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis. ( Callicutt, CS; Fukatsu, K; Gaber, AO; Gaber, L; Kotb, M; Lundberg, AH; Sabek, O; Wilcox, H, 2003) |
| "Hemorrhagic necrotizing pancreatitis and edematous pancreatitis were induced by the injection of taurocholic acid (TCA pancreatitis) and cerulein (cerulein pancreatitis), respectively, on male Wistar rats." | 3.72 | Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. ( Masamune, A; Nishihira, J; Sakai, Y; Satoh, A; Shimosegawa, T; Yamagiwa, T, 2003) |
| "Metabolite maps of choline-containing compounds, total creatine consisting of creatine and phosphocreatine, N-acetyl aspartate (NAA), and lactate were obtained in 23 patients with acute and subacute cerebral infarctions 1-35 days after onset of symptoms." | 3.69 | Metabolic changes in acute and subacute cerebral infarctions: findings at proton MR spectroscopic imaging. ( Heindel, W; Heiss, WD; Herholz, K; Kugel, H; Lackner, K; Lanfermann, H, 1995) |
| "Mechanism of the inhibitory effect of isoprenoid farnesol on cell proliferation has been studied in human acute leukemia CEM-C1 cells." | 3.69 | Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. ( Haug, JS; Melnykovych, G; Voziyan, PA, 1995) |
| " We studied the effects of verapamil on pancreatic ultrastructure and zymogen extraction during diet-induced acute pancreatitis." | 3.69 | Dose-dependent effect of continuous subcutaneous verapamil infusion on experimental acute pancreatitis in mice. ( Lake-Bakaar, G; Lyubsky, S, 1995) |
| "A lethal form of acute hemorrhagic necrotizing pancreatitis was induced in young female mice by feeding a choline-deficient, ethionine supplemented (CDE) diet for 72 hours." | 3.69 | Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. ( Carey, LC; Fabri, PJ; Fink, GS; Franz, MG; Gower, WR; Messina, J; Norman, JG, 1995) |
| "The effect of FUT-175, a new synthetic trypsin inhibitor, was evaluated in a lethal model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented diet (CDE diet)." | 3.68 | Effect of protease inhibitor FUT-175 on acute hemorrhagic pancreatitis in mice. ( Frey, CF; Isaji, S; Ruebner, B; Stanten, R; Suzuki, M, 1992) |
| "This study was designed to evaluate the infectious factor in the pathogenesis of acute pancreatitis and the effects of a combination therapy with a new potent protease inhibitor, E-3123, and a broad spectrum antibiotic cefmetazole (CMZ) in mice with CDE diet-induced severe acute pancreatitis." | 3.68 | Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole. ( Hirano, T; Manabe, T; Nio, Y; Ohshio, G, 1992) |
| "This study was performed to elucidate the role of bacterial infection in acute pancreatitis in young female mice fed a choline-deficient diet supplemented with 0." | 3.68 | Role of bacterial infection in diet-induced acute pancreatitis in mice. ( Carlson, J; Frey, CF; Isaji, S; Ruebner, B; Suzuki, M, 1992) |
| "The influence of several factors on the development of acute hemorrhagic pancreatitis (pancreatic necrosis) with fat necrosis in mice fed DL-ethionine with a choline-deficient diet has been investigated." | 3.65 | Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate. ( Lombardi, B; Rao, NK, 1975) |
| "A new experimental model has been found whereby acute hemorrhagic pancreatic necrosis with fat necrosis is induced in 100% of young female mice fed a choline-deficient diet supplemented with 0." | 3.65 | Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum. ( Lombardi, B; Rao, KN; Tuma, J, 1976) |
| "Choline was significantly elevated in acute lesions compared with controls (P < 0." | 2.70 | Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis. ( Grodd, W; Klose, U; Mader, I; Melms, A; Naegele, T; Seeger, U; Weissert, R, 2001) |
| "Severe acute pancreatitis can easily lead to systemic inflammatory response syndrome and death." | 1.72 | USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-κB Signaling in Macrophages. ( Chen, J; Hu, C; Huang, L; Liang, G; Liu, X; Luo, W; Mutsinze, RN; Wang, X; Wang, Y; Zhang, Y; Zuo, W, 2022) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 1.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "The mortality associated with acute pancreatitis (AP) is largely attributable to abnormalities that occur in distant organs and supportive care remains the only treatment for patients with these complications." | 1.34 | Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. ( Berenguer-Pina, JJ; Hernández-Espinosa, D; Mota, R; Parrilla, P; Sánchez-Bueno, F; Yélamos, J, 2007) |
| "The choline level was not changed significantly by ischaemia (from 0." | 1.33 | Myocardial interstitial choline and glutamate levels during acute myocardial ischaemia and local ouabain administration. ( Akiyama, T; Kawada, T; Mori, H; Shishido, T; Sugimachi, M; Yamazaki, T, 2005) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 1.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| "In a mouse model of acute pancreatitis induced by a choline-deficient, ethionine (0." | 1.33 | Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. ( Asai, F; Fujimoto, K; Fukushige, J; Ogawa, T; Sugidachi, A; Tanaka, N; Tani, Y, 2005) |
| "3 x 27 mg/kg (an empirical LD50 for mice) or 27 mg/kg divided by 1." | 1.31 | [Neurotoxicity in sodium azide poisoning]. ( Fujimura, T; Hara, S; Kobayashi, H; Sato, I; Suzuki, T, 2002) |
| "A completely noninvasive animal model of acute pancreatitis-associated lung injury was used to show that neutrophils, activated by pancreatitis, play a key role in mediating pancreatitis-associated lung injury." | 1.30 | The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury. ( Bhatia, M; Frossard, JL; Hofbauer, B; Lee, HS; Saluja, AK; Steer, ML, 1998) |
| "Acute pancreatitis was induced in female mice fed a choline-deficient meal containing 0." | 1.28 | Changes of xanthine oxidase, lipid peroxide and superoxide dismutase in mouse acute pancreatitis. ( Asano, N; Imanishi, K; Manabe, T; Nonaka, A; Tamura, K; Tobe, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (30.16) | 18.7374 |
| 1990's | 16 (25.40) | 18.2507 |
| 2000's | 20 (31.75) | 29.6817 |
| 2010's | 5 (7.94) | 24.3611 |
| 2020's | 3 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C | 1 |
| Zhu, L | 1 |
| Dai, Y | 1 |
| Zhang, Z | 1 |
| Huang, L | 2 |
| Wang, TJ | 1 |
| Fu, P | 1 |
| Li, Y | 1 |
| Wang, J | 1 |
| Jiang, C | 1 |
| Liu, X | 1 |
| Luo, W | 1 |
| Chen, J | 1 |
| Hu, C | 1 |
| Mutsinze, RN | 1 |
| Wang, X | 2 |
| Zhang, Y | 1 |
| Zuo, W | 1 |
| Liang, G | 1 |
| Wang, Y | 2 |
| Israr, MZ | 1 |
| Bernieh, D | 1 |
| Salzano, A | 1 |
| Cassambai, S | 1 |
| Yazaki, Y | 1 |
| Heaney, LM | 1 |
| Jones, DJL | 1 |
| Ng, LL | 1 |
| Suzuki, T | 2 |
| Muñoz Maniega, S | 1 |
| Cvoro, V | 1 |
| Armitage, PA | 1 |
| Marshall, I | 2 |
| Bastin, ME | 1 |
| Wardlaw, JM | 2 |
| Gussew, A | 1 |
| Rzanny, R | 1 |
| Erdtel, M | 1 |
| Scholle, HC | 1 |
| Kaiser, WA | 1 |
| Mentzel, HJ | 1 |
| Reichenbach, JR | 1 |
| Chang, KH | 1 |
| Tsou, JC | 1 |
| Chen, ST | 1 |
| Ro, LS | 1 |
| Lyu, RK | 1 |
| Chang, HS | 1 |
| Hsu, WC | 1 |
| Chen, CM | 1 |
| Wu, YR | 1 |
| Chen, CJ | 1 |
| Hasler, G | 1 |
| van der Veen, JW | 1 |
| Grillon, C | 1 |
| Drevets, WC | 1 |
| Shen, J | 1 |
| Yong-Ping, S | 1 |
| Jin-Da, W | 1 |
| Ru-Huan, W | 1 |
| Xiang-Di, Z | 1 |
| Hai-Tao, Y | 1 |
| Hai, W | 1 |
| Ossani, GP | 1 |
| Repetto, MG | 1 |
| Boveris, A | 1 |
| Monserrat, AJ | 1 |
| Fujimura, T | 1 |
| Kobayashi, H | 1 |
| Sato, I | 1 |
| Hara, S | 1 |
| Elberling, TV | 1 |
| Danielsen, ER | 1 |
| Rasmussen, AK | 1 |
| Feldt-Rasmussen, U | 1 |
| Waldemar, G | 1 |
| Thomsen, C | 1 |
| Callicutt, CS | 1 |
| Sabek, O | 1 |
| Fukatsu, K | 1 |
| Lundberg, AH | 1 |
| Gaber, L | 1 |
| Wilcox, H | 1 |
| Kotb, M | 1 |
| Gaber, AO | 1 |
| Sakai, Y | 1 |
| Masamune, A | 1 |
| Satoh, A | 1 |
| Nishihira, J | 1 |
| Yamagiwa, T | 1 |
| Shimosegawa, T | 1 |
| Michael, N | 1 |
| Erfurth, A | 1 |
| Ohrmann, P | 1 |
| Gössling, M | 1 |
| Arolt, V | 1 |
| Heindel, W | 2 |
| Pfleiderer, B | 1 |
| Fuller, RA | 1 |
| Westmoreland, SV | 2 |
| Ratai, E | 1 |
| Greco, JB | 2 |
| Kim, JP | 1 |
| Lentz, MR | 2 |
| He, J | 2 |
| Sehgal, PK | 2 |
| Masliah, E | 2 |
| Halpern, E | 1 |
| Lackner, AA | 2 |
| González, RG | 2 |
| Brownell, AL | 1 |
| Chen, YI | 1 |
| Yu, M | 1 |
| Dedeoglu, A | 1 |
| Cicchetti, F | 1 |
| Jenkins, BG | 1 |
| Beal, MF | 1 |
| Ratai, EM | 1 |
| Sakaie, K | 1 |
| Frey, BN | 1 |
| Folgierini, M | 1 |
| Nicoletti, M | 1 |
| Machado-Vieira, R | 1 |
| Stanley, JA | 1 |
| Soares, JC | 1 |
| Kapczinski, F | 1 |
| Srinivasan, R | 1 |
| Sailasuta, N | 1 |
| Hurd, R | 1 |
| Nelson, S | 1 |
| Pelletier, D | 1 |
| Apple, FS | 1 |
| Wu, AH | 1 |
| Mair, J | 1 |
| Ravkilde, J | 1 |
| Panteghini, M | 1 |
| Tate, J | 1 |
| Pagani, F | 1 |
| Christenson, RH | 1 |
| Mockel, M | 1 |
| Danne, O | 1 |
| Jaffe, AS | 1 |
| Su, DM | 1 |
| Wang, RH | 1 |
| Liu, Y | 1 |
| Wang, H | 1 |
| Kawada, T | 1 |
| Yamazaki, T | 1 |
| Akiyama, T | 1 |
| Shishido, T | 1 |
| Mori, H | 1 |
| Sugimachi, M | 1 |
| Ogawa, T | 1 |
| Sugidachi, A | 1 |
| Tanaka, N | 1 |
| Fujimoto, K | 1 |
| Fukushige, J | 1 |
| Tani, Y | 1 |
| Asai, F | 1 |
| Melek, E | 1 |
| Ozyer, U | 1 |
| Erol, I | 1 |
| Alehan, F | 1 |
| Muhteşem Ağildere, A | 1 |
| Mota, R | 1 |
| Sánchez-Bueno, F | 1 |
| Berenguer-Pina, JJ | 1 |
| Hernández-Espinosa, D | 1 |
| Parrilla, P | 1 |
| Yélamos, J | 1 |
| Ofek, K | 1 |
| Krabbe, KS | 1 |
| Evron, T | 1 |
| Debecco, M | 1 |
| Nielsen, AR | 1 |
| Brunnsgaad, H | 1 |
| Yirmiya, R | 1 |
| Soreq, H | 1 |
| Pedersen, BK | 1 |
| Kayabas, U | 1 |
| Alkan, A | 1 |
| Firat, AK | 1 |
| Karakas, HM | 1 |
| Bayindir, Y | 1 |
| Yetkin, F | 1 |
| Mizuma, K | 1 |
| Schröder, T | 1 |
| Kaarne, M | 1 |
| Korpela, H | 1 |
| Lempinen, M | 1 |
| Kosaka, A | 1 |
| Benzi, G | 1 |
| Arrigoni, E | 1 |
| Pastoris, O | 1 |
| Villa, RF | 1 |
| Dossena, M | 1 |
| Agnoli, A | 1 |
| Giuffrida, AM | 1 |
| Lake-Bakaar, G | 1 |
| Lyubsky, S | 1 |
| Voziyan, PA | 1 |
| Haug, JS | 1 |
| Melnykovych, G | 1 |
| Mathews, VP | 1 |
| Barker, PB | 1 |
| Blackband, SJ | 1 |
| Chatham, JC | 1 |
| Bryan, RN | 1 |
| Leach, SD | 1 |
| Bilchik, AJ | 1 |
| Karapetian, O | 1 |
| Gorelick, FS | 1 |
| Modlin, IM | 1 |
| Lanfermann, H | 1 |
| Kugel, H | 1 |
| Herholz, K | 1 |
| Heiss, WD | 1 |
| Lackner, K | 1 |
| Norman, JG | 1 |
| Franz, MG | 1 |
| Fink, GS | 1 |
| Messina, J | 1 |
| Fabri, PJ | 1 |
| Gower, WR | 1 |
| Carey, LC | 1 |
| Gideon, P | 2 |
| Henriksen, O | 3 |
| Sperling, BK | 1 |
| Christiansen, P | 3 |
| Olsen, TS | 2 |
| Jørgensen, HS | 2 |
| Arlien-Søborg, P | 2 |
| Wild, J | 1 |
| Dennis, MS | 1 |
| Cannon, J | 1 |
| Lewis, SC | 1 |
| Bhatia, M | 1 |
| Saluja, AK | 1 |
| Hofbauer, B | 1 |
| Lee, HS | 1 |
| Frossard, JL | 1 |
| Steer, ML | 1 |
| Mader, I | 1 |
| Seeger, U | 1 |
| Weissert, R | 1 |
| Klose, U | 1 |
| Naegele, T | 1 |
| Melms, A | 1 |
| Grodd, W | 1 |
| Yamada, N | 1 |
| Nakamura, K | 1 |
| Zeze, F | 1 |
| Ishii, K | 1 |
| Fujimura, I | 1 |
| Behmer, OA | 1 |
| Fujimura, MD | 1 |
| Penteado, S | 1 |
| Ferrarini, E | 1 |
| Lemos, PC | 1 |
| Tolosa, EM | 1 |
| Schneider-Reinkens, A | 1 |
| Bykov, II | 1 |
| Beliakov, KF | 1 |
| Slobodin, AK | 1 |
| Lombardi, B | 2 |
| Rao, NK | 1 |
| Rao, KN | 2 |
| Tuma, J | 1 |
| Suzuki, M | 2 |
| Isaji, S | 2 |
| Stanten, R | 1 |
| Frey, CF | 2 |
| Ruebner, B | 2 |
| Sperling, B | 1 |
| Hirano, T | 1 |
| Manabe, T | 2 |
| Ohshio, G | 1 |
| Nio, Y | 1 |
| Carlson, J | 1 |
| Arnold, DL | 1 |
| Matthews, PM | 1 |
| Francis, GS | 1 |
| O'Connor, J | 1 |
| Antel, JP | 1 |
| Larsson, HB | 1 |
| Jensen, M | 1 |
| Frederiksen, J | 1 |
| Heltberg, A | 1 |
| Olesen, J | 1 |
| Luzhnikov, EA | 1 |
| Savina, AS | 1 |
| Sukhodolova, GA | 1 |
| Nonaka, A | 1 |
| Tamura, K | 1 |
| Asano, N | 1 |
| Imanishi, K | 1 |
| Tobe, T | 1 |
| Tazaki, Y | 1 |
| Sakai, F | 1 |
| Otomo, E | 1 |
| Kutsuzawa, T | 1 |
| Kameyama, M | 1 |
| Omae, T | 1 |
| Fujishima, M | 1 |
| Sakuma, A | 1 |
| Centrone, G | 1 |
| Ragno, G | 1 |
| Calicchio, G | 1 |
| Virji, MA | 1 |
| Hashihira, S | 1 |
| Nishii, T | 1 |
| Mori, R | 1 |
| Takeda, Y | 1 |
| Tai, J | 1 |
| Szabb, L | 1 |
| Marumoto, S | 2 |
| Shiozu, N | 2 |
| Tsuda, H | 2 |
| Imai, Y | 2 |
| Shimamura, O | 2 |
| Yokoi, T | 1 |
| Uemura, T | 1 |
| Hashimoto, I | 1 |
| Taneda, T | 1 |
| Matsuyama, R | 1 |
| Orrego-Matte, H | 1 |
| Navia, E | 1 |
| Feres, A | 1 |
| Costamaillere, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
1 review available for choline and Acute Disease
| Article | Year |
|---|---|
Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome.
Topics: Acute Disease; Albumins; Biomarkers; CD40 Ligand; Chest Pain; Choline; Coronary Disease; Diagnosis, | 2005 |
4 trials available for choline and Acute Disease
| Article | Year |
|---|---|
Reduced myo-inositol and total choline measured with cerebral MRS in acute thyrotoxic Graves' disease.
Topics: Acute Disease; Adult; Brain; Choline; Female; Frontal Lobe; Graves Disease; Humans; Inositol; Magnet | 2003 |
Cholinergic status modulations in human volunteers under acute inflammation.
Topics: Acetylcholinesterase; Acute Disease; Adult; Aged; Attention; Biomarkers; Butyrylcholinesterase; Chol | 2007 |
Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Alanine; Amino Acids; Aspartic Acid; Biomarkers; Chol | 2001 |
Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Cerebral Infarction; Choline; Clinical Trials as Topi | 1988 |
58 other studies available for choline and Acute Disease
| Article | Year |
|---|---|
Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice.
Topics: Acute Disease; Animals; Astrocytes; Brain Injuries; Cerebral Hemorrhage; Choline; Diet; Disease Mode | 2022 |
USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-κB Signaling in Macrophages.
Topics: Acute Disease; Animals; Arginine; Ceruletide; Choline; Cytokines; Deubiquitinating Enzymes; Disease | 2022 |
Association of gut-related metabolites with outcome in acute heart failure.
Topics: Acetylcarnitine; Acute Disease; Aged; Aged, 80 and over; Betaine; Carnitine; Choline; Female; Gastro | 2021 |
Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Brain; Brain Ischemia; Choline; Creatine; Down-R | 2008 |
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperat | 2010 |
Temporal features of magnetic resonance imaging and spectroscopy in non-ketotic hyperglycemic chorea-ballism patients.
Topics: Acute Disease; Aged; Basal Ganglia; Choline; Chorea; Creatine; Female; Follow-Up Studies; Functional | 2010 |
Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy.
Topics: Acute Disease; Adult; Animals; Anxiety; Anxiety Disorders; Aspartic Acid; Choline; Diagnostic and St | 2010 |
Pharmacological action of choline and aspirin coadministration on acute inflammatory pain.
Topics: Acute Disease; Analgesics; Animals; Aspirin; Choline; Disease Models, Animal; Drug Combinations; Fem | 2011 |
The protective effect of menhaden oil in the oxidative damage and renal necrosis due to dietary choline deficiency.
Topics: Acute Disease; Animals; Choline; Choline Deficiency; Corn Oil; Creatinine; Diet; Dietary Supplements | 2013 |
[Neurotoxicity in sodium azide poisoning].
Topics: Acetylcholine; Acetylcholinesterase; Acute Disease; Animals; Behavior, Animal; Body Temperature; Cen | 2002 |
Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antibodies, Monoclonal; Apoptosis; Choline; Diet; Ethionine; Immun | 2003 |
Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis.
Topics: Acute Disease; Animals; Antibodies; Ascitic Fluid; Cholagogues and Choleretics; Choline; Ethionine; | 2003 |
Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex.
Topics: Acute Disease; Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Female; Glutamic Acid; Glu | 2003 |
A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Chronic Disease; Creat | 2004 |
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.
Topics: Acute Disease; Animals; Behavior, Animal; Body Weight; Brain; Choline; Chronic Disease; Disease Mode | 2004 |
In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS.
Topics: Acute Disease; AIDS Dementia Complex; Animals; Aspartic Acid; Brain; Choline; Creatine; Female; Fron | 2004 |
A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute mania.
Topics: Acute Disease; Adult; Antimanic Agents; Antipsychotic Agents; Aspartic Acid; Bipolar Disorder; Choli | 2005 |
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.
Topics: Acute Disease; Adult; Brain; Choline; Chronic Disease; Female; Glutamic Acid; Humans; Inositol; Magn | 2005 |
Antinociceptive effects of choline against acute and inflammatory pain.
Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflamm | 2005 |
Myocardial interstitial choline and glutamate levels during acute myocardial ischaemia and local ouabain administration.
Topics: Acetylcholine; Acute Disease; Animals; Cats; Choline; Coronary Vessels; Enzyme Inhibitors; Glutamic | 2005 |
Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Choline; Chronic Disease; Dietary Supplements; Ethioni | 2005 |
+H-proton-magnetic resonance spectroscopic findings in a patient with acute hemicerebellitis presenting without localized signs: a case report.
Topics: Acute Disease; Adolescent; Aspartic Acid; Cerebellar Diseases; Choline; Cranial Fossa, Posterior; Cr | 2006 |
Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury.
Topics: Acute Disease; Alanine Transaminase; Amylases; Animals; Aspartate Aminotransferases; Choline; Dietar | 2007 |
Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis.
Topics: Acute Disease; Adolescent; Adult; Aspartic Acid; Brain Diseases; Brucellosis; Case-Control Studies; | 2008 |
Serum phospholipase A2 in diet-induced pancreatitis.
Topics: Acute Disease; Amylases; Animals; Choline; Diet; Disease Models, Animal; Ethionine; Female; Lipase; | 1984 |
[Experimental studies on pathophysiology of acute pancreatitis, with special reference to pancreatic phospholipase A2 and the effect of CDP-choline].
Topics: Acute Disease; Animals; Choline; Cytidine Diphosphate Choline; Dogs; Liver; Pancreatitis; Phospholip | 1984 |
Drug action on the metabolic changes induced by acute hypoxia on synaptosomes from the cerebral cortex.
Topics: Acute Disease; Animals; Cerebral Cortex; Choline; Cytidine Diphosphate Choline; Dogs; Female; Hypoxi | 1982 |
Dose-dependent effect of continuous subcutaneous verapamil infusion on experimental acute pancreatitis in mice.
Topics: Acute Disease; Animals; Calcium Channel Blockers; Choline; Cytoplasmic Granules; Dose-Response Relat | 1995 |
Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death.
Topics: Acute Disease; Apoptosis; Cell Division; Choline; Diglycerides; DNA; Farnesol; Humans; Leukemia; Myr | 1995 |
Cerebral metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Cerebrovascular Dis | 1995 |
Influence of chloroquine on diet-induced pancreatitis.
Topics: Acute Disease; Amylases; Animals; Chloroquine; Choline; Diet; Ethionine; Female; Hydrogen-Ion Concen | 1993 |
Metabolic changes in acute and subacute cerebral infarctions: findings at proton MR spectroscopic imaging.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Cerebral Infarction; Choline; C | 1995 |
Decreased mortality of severe acute pancreatitis after proximal cytokine blockade.
Topics: Acute Disease; Animals; Choline; Cytokines; Ethionine; Female; Interleukin 1 Receptor Antagonist Pro | 1995 |
[Magnetic resonance spectroscopy of acute cerebral infarctions].
Topics: Acute Disease; Adult; Aged; Aspartic Acid; Cerebral Infarction; Choline; Creatine; Humans; Magnetic | 1993 |
Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: relation between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Chemistry; Brain Edema; B | 1998 |
The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury.
Topics: Acute Disease; Animals; Choline; Diet; Ethionine; Female; Immunization, Passive; Leukocyte Count; Lu | 1998 |
[Therapeutic effects of CDP-choline and premarin in acute experimental pancreatitis].
Topics: Acute Disease; Animals; Choline; Cytidine Diphosphate Choline; Estrogens, Conjugated (USP); Male; Pa | 1976 |
[Renal changes induced by the acute lack of choline in adult rats].
Topics: Acute Disease; Animals; Choline; Choline Deficiency; Diet; Female; Kidney; Liver; Liver Regeneration | 1978 |
[Therapeutic results with Hepsan in selected forms of hepatitis].
Topics: Acute Disease; Choline; Chronic Disease; Drug Combinations; Female; Hepatitis; Humans; Lipid Metabol | 1977 |
[Presystolic change in the length of the ischemic, border and distant myocardial areas in experimental coronary insufficiency and the action of inderal and metacin].
Topics: Acute Disease; Animals; Benzilates; Choline; Coronary Disease; Diastole; Dogs; Drug Evaluation, Prec | 1979 |
Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate.
Topics: Acute Disease; Adenine; Age Factors; Animals; Choline; Choline Deficiency; Diet; Ethionine; Female; | 1975 |
Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum.
Topics: Acute Disease; Adipose Tissue; Amylases; Animals; Body Weight; Choline; Disease Models, Animal; Enzy | 1976 |
Effect of protease inhibitor FUT-175 on acute hemorrhagic pancreatitis in mice.
Topics: Acute Disease; Amylases; Animals; Benzamidines; Choline; Choline Deficiency; Diet; Ethionine; Female | 1992 |
Early time course of N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline in the brain after acute stroke. A proton magnetic resonance spectroscopy study.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Chemistry; Cerebrovascular Circu | 1992 |
Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole.
Topics: Acute Disease; Animals; Cefmetazole; Chi-Square Distribution; Choline; Drug Therapy, Combination; Et | 1992 |
Role of bacterial infection in diet-induced acute pancreatitis in mice.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bacterial Infections; Choline; Choline Deficiency; Di | 1992 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis.
Topics: Acute Disease; Adult; Aspartic Acid; Brain; Choline; Chronic Disease; Female; Humans; Lipid Metaboli | 1991 |
[Acute klofelin poisoning].
Topics: Acute Disease; Adolescent; Adult; Antidotes; Atropine; Benzilates; Bradycardia; Child, Preschool; Ch | 1990 |
Changes of xanthine oxidase, lipid peroxide and superoxide dismutase in mouse acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Choline; Ethionine; Female; Free Radicals; Lipid Peroxides; Mice; | 1989 |
[Use of citicoline in high dosages in acute cerebrovascular disease].
Topics: Acute Disease; Aged; Brain Ischemia; Cerebral Hemorrhage; Choline; Coma; Consciousness; Cytidine Dip | 1986 |
Acute hemorrhagic pancreatitis in mice: A study of glucoregulatory hormones and glucose metabolism.
Topics: Acute Disease; Animals; Blood Glucose; Body Weight; Choline; Female; Glucagon; Glucose; Hemorrhage; | 1985 |
CDP-choline as a drug for pancreatitis.
Topics: Acute Disease; Adult; Choline; Cytidine Diphosphate Choline; Female; Humans; Male; Middle Aged; Panc | 1974 |
[Clinical treatment of acute and chronic liver diseases].
Topics: Acute Disease; Choline; Chronic Disease; Fatty Liver; Hepatitis; Humans; Liver Diseases; Male; Methi | 1972 |
[Effects of CDP-choline on EEG in experimental acute hypnotic poisoning].
Topics: Acute Disease; Animals; Barbiturates; Choline; Cytosine Nucleotides; Electroencephalography; Gluteth | 1968 |
[Clinical experiences with CDP-choline in the treatment of acute hypnotic intoxication].
Topics: Acute Disease; Adolescent; Choline; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged | 1968 |
[Effect of CDP-choline on electroencephalogram of acute hypnotic poisoning].
Topics: Acute Disease; Adult; Barbiturates; Choline; Electroencephalography; Female; Glutethimide; Humans; H | 1968 |
Ethanol ingestion and incorporation of 32P into phospholipids of pancreas in the rat.
Topics: Acute Disease; Alcoholic Intoxication; Alcoholism; Animals; Choline; Chronic Disease; Depression, Ch | 1969 |