choline has been researched along with Acute Confusional Senile Dementia in 284 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Galantamine is a cholinesterase inhibitor and allosteric potentiating ligand modulating presynaptic nicotinic acetylcholine receptors that is used in the treatment of Alzheimer disease (AD)." | 9.14 | Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease. ( Bartha, R; Borrie, MJ; Penner, J; Rupsingh, R; Smith, M; Wells, JL, 2010) |
| "The purpose of this study was to measure metabolite level changes in patients with newly diagnosed Alzheimer Disease (AD) following four months of donepezil treatment." | 9.13 | High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease. ( Bartha, R; Borrie, MJ; Rupsingh, R; Rylett, J; Smith, M; Wells, JL, 2008) |
| "Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer's disease (AD)." | 8.31 | Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation. ( Alldred, MJ; Ginsberg, SD; Heguy, A; Pidikiti, H; Roussos, P, 2023) |
| " A potential therapeutic strategy emerging from the study of trisomic mouse models of DS is to supplement the maternal diet with additional choline during pregnancy and lactation." | 7.83 | Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. ( Alldred, MJ; Ash, JA; Caudill, MA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, M; Strupp, BJ; Velazquez, R, 2016) |
| "We aimed to test whether in vivo levels of magnetic resonance spectroscopy (MRS) metabolites myo-inositol (mI), N-acetylaspartate (NAA), and choline are abnormal already during preclinical Alzheimer disease (AD), relating these changes to amyloid or tau pathology, and functional connectivity." | 7.83 | Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease. ( Blennow, K; Hansson, O; Minthon, L; Strandberg, O; Sundgren, PC; Voevodskaya, O; Wahlund, LO; Westman, E; Zetterberg, H, 2016) |
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 7.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| "Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr of death and examined for indices of presynaptic cholinergic function." | 7.68 | Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. ( Bell, JM; Bissette, G; Crain, BJ; Nemeroff, CB; Seidler, FJ; Slotkin, TA, 1990) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 7.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia." | 7.66 | Presynaptic cholinergic dysfunction in patients with dementia. ( Allen, SJ; Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC; Thomas, DJ, 1983) |
| "Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences." | 5.46 | Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. ( Blusztajn, JK; Huleatt, OM; Liu, YB; Mellott, TJ; Pender, SM; Shade, BN; Slack, BE, 2017) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 5.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily." | 5.26 | [Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979) |
| "Galantamine is a cholinesterase inhibitor and allosteric potentiating ligand modulating presynaptic nicotinic acetylcholine receptors that is used in the treatment of Alzheimer disease (AD)." | 5.14 | Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease. ( Bartha, R; Borrie, MJ; Penner, J; Rupsingh, R; Smith, M; Wells, JL, 2010) |
| "The purpose of this study was to measure metabolite level changes in patients with newly diagnosed Alzheimer Disease (AD) following four months of donepezil treatment." | 5.13 | High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease. ( Bartha, R; Borrie, MJ; Rupsingh, R; Rylett, J; Smith, M; Wells, JL, 2008) |
| "Plasmas of 12 patients currently taking part in a double-blind trial of lecithin in senile or presenile dementia of Alzheimer type were analysed for plasma choline levels at fixed intervals during lecithin treatment." | 5.05 | Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations. ( Chuaqui, P; Levy, R, 1982) |
| "Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)." | 4.76 | Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984) |
| "Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer's disease (AD)." | 4.31 | Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation. ( Alldred, MJ; Ginsberg, SD; Heguy, A; Pidikiti, H; Roussos, P, 2023) |
| " A potential therapeutic strategy emerging from the study of trisomic mouse models of DS is to supplement the maternal diet with additional choline during pregnancy and lactation." | 3.83 | Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. ( Alldred, MJ; Ash, JA; Caudill, MA; Ginsberg, SD; Kelley, CM; Mufson, EJ; Powers, BE; Strawderman, M; Strupp, BJ; Velazquez, R, 2016) |
| "We aimed to test whether in vivo levels of magnetic resonance spectroscopy (MRS) metabolites myo-inositol (mI), N-acetylaspartate (NAA), and choline are abnormal already during preclinical Alzheimer disease (AD), relating these changes to amyloid or tau pathology, and functional connectivity." | 3.83 | Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease. ( Blennow, K; Hansson, O; Minthon, L; Strandberg, O; Sundgren, PC; Voevodskaya, O; Wahlund, LO; Westman, E; Zetterberg, H, 2016) |
| " In the current study, biochemical markers sensitive to Alzheimer disease (activities of high-affinity choline uptake and of nitric oxide synthases, expression of 17beta-hydroxysteroid dehydrogenase type 10) were estimated in both hemispheres of young and old male Wistar/Long Evans rats." | 3.76 | Aging and lateralization of the rat brain on a biochemical level. ( Kristofiková, Z; Ort, M; Rícný, J; Rípová, D, 2010) |
| "In this manuscript we report an integrated study to develop simple choline esters as cholinergic agents potentially useful against the Alzheimer disease." | 3.76 | Simple choline esters as potential anti-Alzheimer agents. ( Alcaro, S; Arcone, R; Costa, G; De Vita, D; Iannone, M; Ortuso, F; Pasceri, R; Procopio, A; Rotiroti, D; Scipione, L, 2010) |
| "Our paper on loss of neurons in the Nucleus Basalis of Meynert (now considered part of the cholinergic basal forebrain) in Alzheimer disease (AD) stimulated scientific interest in this little studied brain region." | 3.73 | Quality of life: the bridge from the cholinergic basal forebrain to cognitive science and bioethics. ( Whitehouse, PJ, 2006) |
| "In this study, cognitively intact chronic hypertensive older patients had a higher white matter myoinositol/creatine ratio compared with healthy older subjects, suggesting that myoinositol may be a sensitive marker of the effects of chronic hypertension on the brain." | 3.71 | Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease. ( Benedetti, C; Catani, M; Cherubini, A; Howard, R; Mariani, E; Mecocci, P; Metastasio, A; Pelliccioli, GP; Senin, U; Tarducci, R, 2002) |
| "(1)H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined." | 3.71 | Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. ( Alexander, GE; Chang, L; Huang, W; Krasuski, JS; Rapoport, SI; Schapiro, MB; Shetty, HU, 2001) |
| "The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD)." | 3.69 | Role of increased cerebral myo-inositol in the dementia of Down syndrome. ( Ross, BD; Shonk, T, 1995) |
| "Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr of death and examined for indices of presynaptic cholinergic function." | 3.68 | Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. ( Bell, JM; Bissette, G; Crain, BJ; Nemeroff, CB; Seidler, FJ; Slotkin, TA, 1990) |
| "Deficits in certain long-axon cholinergic brain neurons have been demonstrated both in senile dementia of the Alzheimer type (SDAT) and, to a lesser degree, in association with the cognitive and memory impairments sometimes seen with normal aging." | 3.67 | Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging. ( Maire, JC; Wurtman, RJ, 1984) |
| "In a prospective, double-blind study of 84 unselected persons in a dementia clinic, the red blood cell/plasma choline ratios were found to be significantly higher in 47 subjects with clinically defined Alzheimer disease (DAT) than in 37 non-DAT, nondepressed subjects (3." | 3.67 | Red blood cell abnormalities in Alzheimer disease. ( Barclay, L; Blass, JP; Hanin, I; Kopp, U; Reding, MJ, 1985) |
| "Acetylcholinesterase (AChE) and choline (Ch) in the cerebrospinal fluid (CSF) from familial and non-familial Alzheimer disease patients were studied." | 3.67 | Cerebrospinal fluid choline, and acetylcholinesterase activity in familial vs. non-familial Alzheimer's disease patients. ( Giacobini, E; Kumar, V, 1988) |
| "Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples from patients with presenile dementia." | 3.66 | Presynaptic cholinergic dysfunction in patients with dementia. ( Allen, SJ; Bowen, DM; Davison, AN; Neary, D; Sims, NR; Smith, CC; Thomas, DJ, 1983) |
| "Recent studies have shown a defect in the cholinergic system of the cerebral cortex of patients suffering from nonvascular senile dementia." | 3.66 | Will drugs help patients with Alzheimer's disease? ( Kendall, MJ, 1979) |
| "Alzheimer's disease is associated with multiple risk factors and is the most common type of dementia." | 2.82 | The role of trimethylamine-N-Oxide in the development of Alzheimer's disease. ( Buawangpong, N; Chattipakorn, N; Chattipakorn, SC; Pinyopornpanish, K; Siri-Angkul, N, 2022) |
| "Synaptic loss is a major hallmark of Alzheimer's disease (AD)." | 2.79 | The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. ( de Waal, H; Kamphuis, PJ; Lansbergen, MM; Maestú, F; Scheltens, P; Stam, CJ; van Straaten, EC; Wieggers, RL, 2014) |
| "Dementia was an independent predictor of metabolite values." | 2.73 | Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. ( Antúnez, C; Carles, R; Fortuna, L; García Santos, JM; Gavrila, D; Jiménez Veiga, J; Navarro, C; Parrilla, G; Salmerón, D; Tormo, MJ; Torres del Río, S, 2008) |
| "Patients with mild to moderate Alzheimer's disease received placebo or xanomeline for 6 months." | 2.68 | Brain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist. ( Bodick, N; Offen, WW; Renshaw, PF; Satlin, A, 1997) |
| "Alzheimer's disease is currently thought to be a complex, multifactorial syndrome, unlikely to arise from a single causal factor; instead, a number of related biological alterations are thought to contribute to its pathogenesis." | 2.45 | Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease. ( Bolognesi, ML; Cavalli, A; Melchiorre, C, 2009) |
| "L-Carnitine is an essential co-factor in the metabolism of lipids and consequently in the production of cellular energy." | 2.44 | [Physiological functions of carnitine and carnitine transporters in the central nervous system]. ( Inazu, M; Matsumiya, T, 2008) |
| "myo-Inositol was raised by about 15%, again uniformly throughout the brain, but there was no evidence for changed levels of choline." | 2.41 | A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease. ( Firbank, MJ; Harrison, RM; O'Brien, JT, 2002) |
| " Excitoxins when infused directly into the Nbm destroy non-specifically cell bodies but spare axons passing the injection site, whereas the specificity of AF64A to destroy cholinergic neurons depends on both the dosage applied and the site of injection." | 2.39 | Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction. ( Bigl, V; Rossner, S; Schliebs, R, 1996) |
| "Oral tacrine treatment (80 mg daily) restore nicotinic receptors in AD patients as visualized by PET and 11C-nicotine." | 2.38 | In vivo detection of neurotransmitter changes in Alzheimer's disease. ( Nordberg, A, 1993) |
| "Alzheimer's disease is an insidious degenerative disease of the brain and is the leading cause of dementia in the U." | 2.37 | Alzheimer's disease: clinical features, pathogenesis, and treatment. ( Conner, CS; Rathmann, KL, 1984) |
| "Huntington's chorea, ataxias, Tourette's syndrome, schizophrenia, affective illness, and senile dementia of the Alzheimer type, has been implicated with a general underactivity of central cholinergic mechanisms." | 2.36 | The use of cholinergic precursors in neuropsychiatric diseases. ( Davis, KL; Rosenberg, GS, 1982) |
| "Dietary choline deficiency altered hippocampal networks associated with microtubule function and postsynaptic membrane regulation." | 1.91 | Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks. ( Bartholomew, SK; Bilal, A; Blackwood, EA; Dave, N; Decker, A; Glembotski, C; Judd, JM; Karr, T; McDonough, I; Sandler, J; Sarette, P; Tallino, S; Velazquez, R; Villarreal Espinosa, O; Winslow, W; Winstone, JK, 2023) |
| "Low choline intake was associated with increased risks of incident dementia and AD." | 1.72 | Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study. ( Ang, AF; Au, R; Auerbach, SH; Blusztajn, JK; Devine, SA; Jacques, PF; Liu, C; Liu, X; Massaro, J; Yuan, J, 2022) |
| "Brain damage associated with Alzheimer's disease (AD) occurs even decades before the symptomatic onset, raising the need to investigate its progression from prodromal stages." | 1.72 | Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. ( López-Gil, X; Muñoz-Moreno, E; Simões, RV; Soria, G; Tudela, R, 2022) |
| " In conclusion, this study indicates that the bioavailability of OST was improved by using the OST-NE via the nasal route." | 1.62 | Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration. ( Hao, J; Hao, Q; Hou, X; Song, Y; Wang, J; Wang, X, 2021) |
| "The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades." | 1.56 | Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations. ( Caccamo, A; Dave, N; Ferreira, E; Huentelman, MJ; Naymik, M; Oddo, S; Piras, IS; Tran, A; Velazquez, R; Winslow, W, 2020) |
| "Choline is a B-like vitamin nutrient found in common foods that is important in various cell functions." | 1.51 | Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. ( Ferreira, E; Fux, C; Knowles, S; Oddo, S; Rodin, A; Velazquez, R; Winslow, W, 2019) |
| "Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences." | 1.46 | Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. ( Blusztajn, JK; Huleatt, OM; Liu, YB; Mellott, TJ; Pender, SM; Shade, BN; Slack, BE, 2017) |
| "Amnestic mild cognitive impairment (aMCI) is often the prodromal stage to AD." | 1.43 | (1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease. ( Chen, W; Chen, X; Guo, Z; Hou, H; Liu, X; Shen, Y; Wei, F, 2016) |
| "We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD)." | 1.40 | Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. ( Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M, 2014) |
| "Agitation and depression are among the commonest behavioural and psychological symptoms exhibited by Alzheimer's disease patients." | 1.39 | Differences in brain metabolism associated with agitation and depression in Alzheimer's disease. ( Fuh, JL; Hung, CW; Lirng, JF; Tsai, CF; Wang, SJ, 2013) |
| "Myo-inositol (mIns) is a marker of glial cells proliferation and has been shown to increase in early Alzheimer's disease (AD) pathology." | 1.39 | MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. ( Cai, K; Crescenzi, R; Hariharan, H; Haris, M; Kogan, F; Nath, K; Reddy, R; Singh, A, 2013) |
| "Murine models of Alzheimer's disease (AD) provide means to detect and follow biomarker changes similar to those observed in humans." | 1.38 | Systematic evaluation of magnetic resonance imaging and spectroscopy techniques for imaging a transgenic model of Alzheimer's disease (AβPP/PS1). ( Alquézar, C; Antequera, D; Barrios, L; Bartolomé, F; Carro, E; Cerdán, S; Esteras, N; Martín-Requero, A, 2012) |
| "Lipidomic studies related to Alzheimer's disease have been reported on either biological fluids or large human brain samples." | 1.38 | Choline-containing phospholipids in microdissected human Alzheimer's disease brain senile plaque versus neuropil. ( Auzeil, N; Brunelle, A; Duyckaerts, C; Gaudin, M; Laprévote, O; Panchal, M; Touboul, D, 2012) |
| " Testing of conditioned passive avoidance 24 h after learning showed that chronic administration of scopolamine to rats 4-fold reduced the latency of entry into the dark chamber in comparison with controls (intact animals)." | 1.38 | Changes in activity of proline-specific peptidases in rat model for dementia of Alzheimer's type. ( Kolyasnikova, KN; Nazarova, GA; Zolotov, NN, 2012) |
| " The results showed that piperine at all dosage range used in this study significantly improved memory impairment and neurodegeneration in hippocampus." | 1.36 | Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease. ( Chonpathompikunlert, P; Muchimapura, S; Wattanathorn, J, 2010) |
| "Cholinergic neurons are a major constituent of the mammalian central nervous system." | 1.35 | Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells. ( Lahiri, DK; Ray, B; Simon, JR, 2009) |
| "Galantamine, a drug used to treat Alzheimer's disease, is a nicotinic allosteric potentiating ligand, and kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is an endogenous noncompetitive inhibitor of alpha7* nicotinic receptors (nAChRs) [the asterisk next to the nAChR subunit is intended to indicate that the exact subunit composition of the receptor is not known (Pharmacol Rev 51:397-401, 1999)]." | 1.34 | Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptors. ( Albuquerque, EX; Lopes, C; Njar, V; Pereira, EF; Purushottamachar, P; Schwarcz, R; Wu, HQ, 2007) |
| "Given the available therapies for Alzheimer's disease, early diagnosis is of paramount importance." | 1.33 | Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy. ( Fayed, N; Modrego, PJ; Pina, MA, 2005) |
| "Myo-inositol (mI)/Cr was higher than normal in patients with AD and FTLD." | 1.32 | 1H MR spectroscopy in common dementias. ( Boeve, BF; Edland, SD; Ferman, TJ; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; O'Brien, PC; Petersen, RC; Smith, GE; Tang-Wai, DF; Tangalos, EG; Weigand, SD, 2004) |
| "The level in patients with Parkinson's disease, where dementia develops in up to 40% of patients, was not elevated significantly compared to that in controls." | 1.32 | Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor. ( Aasly, J; Gårseth, M; Sonnewald, U; White, LR, 2004) |
| "An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons." | 1.32 | Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia. ( Chu, CB; Jia, JM; Jia, JP; Sun, YX; Xu, M; Yan, X; Zhou, WD, 2004) |
| "Cholinergic deficits in Alzheimer's disease are accompanied by a number of alterations in other transmitter systems including glutamate, noradrenaline and serotonin, suggesting the involvement also of other neurotransmitter systems in the pathogenesis of the disease." | 1.32 | Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology. ( Apelt, J; Klingner, M; Kumar, A; Sabri, O; Scheunemann, M; Schliebs, R; Sorger, D; Steinbach, J, 2003) |
| "Murine trisomy 16 is an animal model of human Down's syndrome." | 1.31 | Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice. ( Allen, DD; Arriagada, C; Cárdenas, AM; Caviedes, P; Caviedes, R; Martín, J; Rapoport, SI, 2000) |
| "Brain cells in Alzheimer's disease (AD) exhibit a membrane defect characterized by accelerated phospholipid turnover." | 1.31 | Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. ( Blusztajn, JK; Farber, SA; Slack, BE, 2000) |
| "3, 1, 3, 10, or 30 mg/kg/day sc for 14 days) attenuated the AF64A-induced cognitive impairment in a dose-dependent manner, producing an inverted U-shaped dose-response function which was optimal at 1." | 1.30 | Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease. ( Bartolomeo, AC; Boast, CA; Morris, H, 1997) |
| " The results obtained warrant the further search for the novel types of safe neuroprotectors among the synthetic NAS/melatonin derivatives." | 1.30 | N-acetylserotonin, melatonin and their derivatives improve cognition and protect against beta-amyloid-induced neurotoxicity. ( Afanasiev, A; Bachurin, S; Beznosko, B; Lermontova, N; Mukhina, T; Oxenkrug, G; Serkova, T; Shevtzova, E; Vankin, G, 1999) |
| "Cholinergic deficits in Alzheimer's disease are typically assessed by choline acetyltransferase, the enzyme that synthesizes acetylcholine." | 1.29 | Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies. ( Bissette, G; Nemeroff, CB; Seidler, FJ; Slotkin, TA, 1994) |
| "The cholinergic deficit was also responsible for a disinhibition of the negative feedback regulation of glucocorticoids." | 1.29 | AF64A-induced brain damage and its relation to dementia. ( Hörtnagl, H, 1994) |
| " Nicotine enhanced release, with a bell-shaped dose-response curve." | 1.29 | Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function. ( Potter, PE; Thorne, B, 1995) |
| "Rats treated with a cholinergic blocker (ethylcholine aziridium) have been used as a model for cholinergic deficits." | 1.29 | Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide. ( Bardea, A; Brenneman, DE; Fridkin, M; Gozes, I; Reshef, A; Rubinraut, S; Zamostiano, R; Zhukovsky, S, 1996) |
| "Cholinergic markers were decreased in the cerebral cortex of BF-lesioned rats." | 1.28 | Cholecystokinin protects cholinergic neurons against basal forebrain lesion. ( Kubota, K; Sugaya, K; Takahashi, M, 1992) |
| "The implication is that if Alzheimer's disease is a cholinergic disorder, it may be amenable to transport-directed chemotherapies." | 1.28 | Studies on choline transport enhancement into fibroblasts from normals and Alzheimer's donors. ( Mokrasch, LC, 1991) |
| "In contrast, trisomy 21 did not affect the uptake of choline, serine or glucose." | 1.28 | Down's syndrome fibroblasts exhibit enhanced inositol uptake. ( Fruen, BR; Lester, BR, 1990) |
| " Young males showed greater responsiveness to both drugs than young females, this being reflected in higher maxima of the dose-response curves obtained for the males." | 1.27 | The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia. ( Bradshaw, CM; Lamb, K; Szabadi, E, 1983) |
| "In 10 samples from Alzheimer's disease-afflicted brains the affinity for the limiting substrate choline (Ch) was significantly higher: Michaelis constant KmCh was for these samples 1." | 1.27 | Increased affinity of choline acetyltransferase for choline in Alzheimer's disease: a steady-state kinetic study. ( Bartfai, T; Eliaz, M; Gottfries, CG; Nordström, O, 1987) |
| "Seventeen drug-free patients with Alzheimer's disease (AD) and 15 normal elderly controls, of which 13 age- and sex-matched pairs were included, participated in a study of red blood cell (RBC) and plasma choline." | 1.27 | Red blood cell choline. I: Choline in Alzheimer's disease. ( Davis, KL; Edasery, J; Greenwald, BS; Mohs, RC; Shah, N; Trigos, GG, 1985) |
| "In addition, among the patients with Alzheimer's disease, the theoretical choline uptake was strongly correlated with the severity of dementia." | 1.27 | Red blood cell choline. II: Kinetics in Alzheimer's disease. ( Davis, KL; Greenwald, BS; Kanof, PD; Mohs, RC, 1985) |
| "Eight patients with Alzheimer's disease presenting whith memory difficulties and no significant intellectual deterioration were treated with 9 grams daily." | 1.26 | [Influence of choline on amnesia in Alzheimer's disease (author's transl)]. ( Agid, Y; Lhermitte, F; Signoret, JL; Whiteley, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 97 (34.15) | 18.7374 |
| 1990's | 58 (20.42) | 18.2507 |
| 2000's | 55 (19.37) | 29.6817 |
| 2010's | 53 (18.66) | 24.3611 |
| 2020's | 21 (7.39) | 2.80 |
| Authors | Studies |
|---|---|
| Mistry, JS | 1 |
| Abraham, DJ | 1 |
| Hanin, I | 9 |
| Buawangpong, N | 1 |
| Pinyopornpanish, K | 1 |
| Siri-Angkul, N | 1 |
| Chattipakorn, N | 1 |
| Chattipakorn, SC | 1 |
| Bortz, J | 1 |
| Klatt, KC | 1 |
| Wallace, TC | 1 |
| Bilen, E | 1 |
| Özdemir Özmen, Ü | 1 |
| Çete, S | 1 |
| Alyar, S | 1 |
| Yaşar, A | 1 |
| Muñoz-Moreno, E | 1 |
| Simões, RV | 1 |
| Tudela, R | 1 |
| López-Gil, X | 1 |
| Soria, G | 1 |
| Dave, N | 2 |
| Judd, JM | 2 |
| Decker, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Swedish BioFINDER Study: Early Diagnosis of Alzheimer's Disease - a Multidisciplinary Approach[NCT01208675] | 1,150 participants (Actual) | Observational | 2010-09-30 | Active, not recruiting | |||
| In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.[NCT05753228] | 90 participants (Anticipated) | Interventional | 2022-12-09 | Recruiting | |||
| An Open-label Exploratory Study With Memantine: Correlation Between Proton Magnetic Resonance Spectroscopy, Cerebrospinal Fluid Biomarkers, and Cognition in Patients With Mild to Moderate Alzheimer's Disease[NCT00551161] | Phase 4 | 12 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Feru-guard (Ferulic Acid and Angelica Archangelica Extract) for Behavioral Symptoms in Dementia[NCT03451760] | Phase 2 | 70 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Ratios of myo-inositol (mI), N-acetylaspartate (NAA), total creatine (Cr), and choline (Cho) by single voxel 1H MRS (proton magnetic resonance spectroscopy). Mean (± SD) metabolite levels (normalized to T2-corrected water signal intensity) and metabolite ratios for Alzheimer's disease subjects at baseline (t0), after 24 weeks of ongoing monotherapy with stable-dose cholinesterase inhibitor (t1), and after another 24 weeks of combination therapy with memantine in addition to stable-dose cholinesterase inhibitor (t2). The Wilcoxon signed-rank test was used to examine whether the change between t0 and t1 differed from the change between t1 and t2 [(t2 - t1) - (t1 - t0)]. (NCT00551161)
Timeframe: Baseline, 24 weeks, and 48 weeks
| Intervention | ratio (normalized to T2-corrected water (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in NAA [(t2-t1) - (t1-t0)] | Change in Cr [(t2-t1) - (t1-t0)] | Change in Cho [(t2-t1) - (t1-t0)] | Change in mI [(t2-t1) - (t1-t0)] | Change in NAA/Cr [(t2-t1) - (t1-t0)] | Change in Cho/Cr [(t2-t1) - (t1-t0)] | Change in mI/Cr [(t2-t1) - (t1-t0)] | Change in NAA/Cho [(t2-t1) - (t1-t0)] | Change in NAA/mI [(t2-t1) - (t1-t0)] | |
| Memantine | -54 | -2 | 9 | 16 | -0.09 | 0.02 | 0.04 | -0.26 | -0.35 |
45 reviews available for choline and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
The role of trimethylamine-N-Oxide in the development of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Choline; Methylamines; Oxides | 2022 |
The Role of Butyrylcholinesterase and Iron in the Regulation of Cholinergic Network and Cognitive Dysfunction in Alzheimer's Disease Pathogenesis.
Topics: Alzheimer Disease; Animals; Brain; Butyrylcholinesterase; Choline; Cognitive Dysfunction; Humans; Ir | 2021 |
Neurochemical changes in the aging brain: A systematic review.
Topics: Aging; Alzheimer Disease; Animals; Brain; Choline; Cognition; Creatine; Humans | 2019 |
Cholinesterase inhibitors as Alzheimer's therapeutics (Review).
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Cholinesterase Inhibitors; Cognition; Dis | 2019 |
Proton MRS in mild cognitive impairment.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Cognitive Dysfunction; Creati | 2013 |
[Physiological functions of carnitine and carnitine transporters in the central nervous system].
Topics: Acetylcarnitine; Alzheimer Disease; Astrocytes; Brain; Carnitine; Choline; Energy Metabolism; Ketone | 2008 |
Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease.
Topics: Alkanes; Alzheimer Disease; Amides; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Ani | 2009 |
Use of phosphatide precursors to promote synaptogenesis.
Topics: Alzheimer Disease; Choline; Docosahexaenoic Acids; Humans; Phospholipids; Prodrugs; Synapses; Synapt | 2009 |
Nutrition and Alzheimer's disease: pre-clinical concepts.
Topics: Alzheimer Disease; Animals; Brain; Choline; Fatty Acids, Unsaturated; Humans; Malnutrition; Nerve Re | 2009 |
Choline-containing phospholipids: relevance to brain functional pathways.
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Choline; Cholinergic Neurons; Glycerylphosphorylch | 2013 |
A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Choline; Humans; Inositol; Magnetic Resonance Spectroscopy; | 2002 |
[Exploring the conformational energy landscape of acetylcholinesterase by kinetic crystallography].
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Cholinesterase Inhibitors; Crystallograph | 2007 |
[New approaches for the development of anti-Alzheimer's disease drugs based on the cholinergic hypothesis and amyloid hypothesis].
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein | 2008 |
[Treatment of Alzheimer's disease: status quo and future considerations].
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Behavioral Symptoms; Choline; Cholinesteras | 2008 |
[Psychopharmacologic treatment of cognitive function disorders in aging persons: current possibilities].
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Anticonvulsants; Brain; Catecholamines; Cholin | 1984 |
[The role of nutrition in the synthesis of neurotransmitters and in cerebral functions: clinical implications].
Topics: Alzheimer Disease; Amino Acids; Choline; Choline O-Acetyltransferase; Diabetes Mellitus; Dopa Decarb | 1981 |
An update on the neurochemistry of Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Arecoline; Brain; Choline; Choline O-Acetyltransferase; Cho | 1983 |
The use of cholinergic precursors in neuropsychiatric diseases.
Topics: Acetylcholine; Alzheimer Disease; Animals; Bipolar Disorder; Brain; Cerebellar Ataxia; Choline; Huma | 1982 |
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co | 1984 |
Alzheimer's disease: clinical features, pathogenesis, and treatment.
Topics: Acetylcholine; Alzheimer Disease; Choline; Cholinesterase Inhibitors; Humans; Parasympathomimetics; | 1984 |
Biochemistry of Alzheimer's dementia.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Cerebral Cortex; Choline; Ch | 1982 |
The cholinergic hypothesis of geriatric memory dysfunction.
Topics: Acetylcholine; Adult; Aged; Aging; Alzheimer Disease; Animals; Brain Chemistry; Choline; Choline O-A | 1982 |
Strategies to limit brain injury and promote recovery of function.
Topics: Alzheimer Disease; Animals; Aziridines; Brain Diseases; Choline; Hippocampus; Humans; Parasympatheti | 1994 |
In vivo detection of neurotransmitter changes in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Brain; Choline; Humans; Neurotransmitter Agents; Receptors, Muscar | 1993 |
High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy.
Topics: Alzheimer Disease; Binding, Competitive; Brain; Carrier Proteins; Choline; Choline O-Acetyltransfera | 1996 |
Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cerebral Co | 1996 |
Possible role of the cholinergic system and disease models.
Topics: Alzheimer Disease; Animals; Brain; Cerebrovascular Circulation; Choline; Cholinesterase Inhibitors; | 1997 |
Apolipoprotein E and neuronal plasticity following experimental de-afferentation and in Alzheimer's disease.
Topics: Afferent Pathways; Alzheimer Disease; Animals; Apolipoproteins E; Central Nervous System; Choline; H | 1998 |
Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Central Nervous System; Choline; Huma | 1998 |
Complementary and alternative medicines for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Complementary Therapies; Dietary Fats; Dietary Supplements; Female | 1998 |
[Alzheimer's disease and magnetic resonance spectroscopy of the hippocampus].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine; | 2001 |
Can drugs improve memory?
Topics: Acetylcholine; Alzheimer Disease; Animals; Choline; Cholinesterase Inhibitors; Humans; Memory; Paras | 1979 |
Neuroplasticity, the aging brain, and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Aziridines; Brain; Brain Tissue Transplantation; Choline; Ganglio | 1992 |
Cholinergic toxins and Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Humans; Neur | 1992 |
Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases.
Topics: Alzheimer Disease; Brain Diseases; Choline; Cholinergic Fibers; Humans | 1990 |
Phosphatase and phospholipase activity in Alzheimer brain tissues.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Choline; Humans; Middle Aged; Phospholip | 1987 |
Biochemistry of Alzheimer's disease: a report.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Brain Chemistry; Cats; Choline; Hum | 1985 |
Biologic markers in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Aluminum; Alzheimer Disease; Biogenic Amines; Blood Platelets; Brain; Ch | 1985 |
Neurobiological studies of transmitter systems in aging and in Alzheimer-type dementia.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Amyloid; Animals; Axons; Brain; Cerebral Cortex; Cho | 1985 |
Pathogenesis of Alzheimer's disease--beyond the cholinergic hypothesis: discussion paper.
Topics: Alzheimer Disease; Cerebral Cortex; Choline; Glutamates; Glutamic Acid; Humans; Somatostatin | 1986 |
Are the neurochemical and behavioral changes induced by lesions of the nucleus basalis in the rat a model of Alzheimer's disease?
Topics: Alzheimer Disease; Animals; Basal Ganglia; Behavior, Animal; Choline; Choline O-Acetyltransferase; D | 1986 |
[Recent drug therapy of senile dementia].
Topics: Adrenocorticotropic Hormone; Alzheimer Disease; Choline; Dementia; Dihydroergotoxine; Humans; Narcot | 1987 |
Phosphatidylcholine, choline and cholinergic function.
Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Alzheimer Disease; Animals; Avoidance Learning; Biological | 1986 |
Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity.
Topics: Aged; Aging; Aluminum; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Hapl | 1986 |
Correlative studies in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biological Transport; Brain; Cerebral Cortex; Choline; Hippocampus; Humans; | 1985 |
22 trials available for choline and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer's disease: results from a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Beverages; Brain; Choline; Docosahexaenoic Acids; Double | 2017 |
The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study.
Topics: Aged; Alzheimer Disease; Brain; Choline; Cognitive Dysfunction; Docosahexaenoic Acids; Eicosapentaen | 2014 |
3.0 T MRI arterial spin labeling and magnetic resonance spectroscopy technology in the application of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebrovascular Circulatio | 2014 |
Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea | 2008 |
Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Dementia, Vascular; Diagnosis, Differenti | 2008 |
Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cholinesterase In | 2010 |
High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cholinesterase | 2008 |
Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: a community-based study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Atrophy; Brain; Choline; Cognition Disord | 2008 |
Double blind study of lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; H | 1981 |
Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; M | 1982 |
A dose-ranging study of lecithin in the treatment of primary degenerative dementia (Alzheimer disease).
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Drug Evaluation; Erythrocytes; Fema | 1982 |
Alzheimer disease: lack of effect of lecithin treatment for 3 months.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Humans; Middle Aged; Phosphatidylch | 1981 |
Brain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist.
Topics: Acetylcholine; Alzheimer Disease; Brain; Choline; Creatine; Dose-Response Relationship, Drug; Drug A | 1997 |
Choline therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Drug Eval | 1978 |
Influence of choline on amnesia in early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amnesia; Choline; Clinical Trials as Topic; Dementia; Humans; Memory; Middl | 1978 |
Choline in Alzheimers disease.
Topics: Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Humans; Research Design | 1978 |
Choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; H | 1979 |
The effect of long-term high dose lecithin on erythrocyte choline transport in Alzheimer patients.
Topics: Aged; Alzheimer Disease; Choline; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Lo | 1992 |
Biological and neuropsychological characterization of physostigmine responders and nonresponders in Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Double-Blind | 1990 |
Clinical and biochemical responses to therapy in Alzheimer's disease and multi-infarct dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arousal; Blood Pressure; Choline; Clinical Trials as Top | 1989 |
Early stages of late onset Alzheimer's disease. Diagnostic criteria, protein metabolism, precursor loading effects, neurochemical and neuropsychological applications.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Choline; Clinical Trials as Topic; Double-Blind M | 1989 |
A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double | 1985 |
217 other studies available for choline and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Neurochemistry of aging. 1. Toxins for an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Binding, Competitive; Biological Transport; Brain | 1986 |
Perspective: Estrogen and the Risk of Cognitive Decline: A Missing Choline(rgic) Link?
Topics: Alzheimer Disease; Choline; Cholinergic Agents; Cognitive Dysfunction; Estrogens; Female; Humans; Me | 2022 |
Bioactive sulfonyl hydrazones with alkyl derivative: Characterization, ADME properties, molecular docking studies and investigation of inhibition on choline esterase enzymes for the diagnosis of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Choline; Cholinesterase Inhibitors; | 2022 |
Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Choline; Creatine; Disease Models, Animal; Disease Progression; G | 2022 |
Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Choline; Choline | 2023 |
Licochalcone E, a β-Amyloid Aggregation Inhibitor, Regulates Microglial M1/M2 Polarization via Inhibition of CTL1-Mediated Choline Uptake.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Choline; Mice; Microglia; Organic Cation Transpor | 2023 |
Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation.
Topics: Alzheimer Disease; Animals; Basal Forebrain; Choline; Cholinergic Neurons; Dietary Supplements; Dise | 2023 |
Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study.
Topics: Adult; Alzheimer Disease; Animals; Betaine; Choline; Eating; Female; Humans; Longitudinal Studies; M | 2022 |
Inflammation and the pathological progression of Alzheimer's disease are associated with low circulating choline levels.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Choline; Humans; Inflammation; Mic | 2023 |
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy.
Topics: Alzheimer Disease; Animals; Betaine; Carbon; Choline; Dietary Supplements; Disease Models, Animal; F | 2023 |
Ex Vivo Electrochemical Monitoring of Cholinergic Signaling in the Mouse Colon Using an Enzyme-Based Biosensor.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Cholinesterase Inhibitors; | 2023 |
Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Forebrain; Choline; Choline O-Acetyltransferase; Dietary Sup | 2023 |
Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation.
Topics: Alzheimer Disease; Animals; Brain; Choline; Cognitive Dysfunction; Dietary Supplements; Longevity; M | 2019 |
Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Choline; Cognitive Dysfunction; Dementia; Female; Humans | 2020 |
Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range.
Topics: Alzheimer Disease; Animals; Aziridines; Biological Clocks; Central Nervous System Stimulants; Cholin | 2019 |
Plasma alterations in cholinergic and serotonergic systems in early Alzheimer Disease: Diagnosis utility.
Topics: Aged; Alzheimer Disease; Choline; Early Diagnosis; Female; Humans; Male; Middle Aged; Serotonin | 2020 |
Concomitant memantine and
Topics: Alzheimer Disease; Animals; Animals, Genetically Modified; Biomarkers; Choline; Cognitive Dysfunctio | 2020 |
Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Choline; Cholinergic Agents; Disease Models, Animal | 2020 |
Choline as a prevention for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Choline; Humans; Recommended Dietary Allowances | 2020 |
Causal relationships between gut metabolites and Alzheimer's disease: a bidirectional Mendelian randomization study.
Topics: Alzheimer Disease; Betaine; Carnitine; Choline; Female; Gastrointestinal Microbiome; Genetic Predisp | 2021 |
Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Antioxidants; Apoptosis; bcl-2-Associated X | 2021 |
CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation.
Topics: Aging; Alzheimer Disease; Animals; CA1 Region, Hippocampal; Choline; Dietary Supplements; Disease Mo | 2018 |
Effect of weak combined static and extremely low-frequency alternating magnetic fields on spatial memory and brain amyloid-β in two animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Choline; Disease Models, Animal; Magnetic | 2018 |
Topics: Adult; Alzheimer Disease; Brain; Choline; Creatine; Cross-Sectional Studies; Female; Glutamic Acid; | 2019 |
Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations.
Topics: Alzheimer Disease; Animals; Brain; Choline; Dietary Supplements; Disease Models, Animal; Female; Hom | 2020 |
Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
Topics: Alzheimer Disease; Animals; CA1 Region, Hippocampal; Choline; Dietary Supplements; Disease Models, A | 2019 |
Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease-Like Pathology in Transgenic APP/PS1 Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Choline; Cholinergic N | 2019 |
1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Ischemia; Choline; Cogn | 2013 |
Association of 1H-MR spectroscopy and cerebrospinal fluid biomarkers in Alzheimer's disease: diverging behavior at three different brain regions.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Biomarkers; Case-Control Studies; Cho | 2013 |
Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Di | 2013 |
Differences in brain metabolism associated with agitation and depression in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Depression; Female; Gyrus Cinguli; Humans | 2013 |
Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Br | 2014 |
Souvenaid®: a new approach to management of early Alzheimer's disease.
Topics: Alzheimer Disease; Choline; Cholinesterase Inhibitors; Disease Progression; Docosahexaenoic Acids; D | 2014 |
A nutrient combination that can affect synapse formation.
Topics: Alzheimer Disease; Brain; Choline; Fatty Acids, Omega-3; Humans; Micronutrients; Neurites; Phospholi | 2014 |
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; De | 2014 |
Proton magnetic resonance spectroscopy in mild cognitive impairment and Alzheimer's disease: a preliminary study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive | 2014 |
Catalpol regulates cholinergic nerve system function through effect on choline acetyl-transferase not M receptor affinity.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Disease Models, A | 2015 |
Streptozotocin Induced Neurotoxicity Involves Alzheimer's Related Pathological Markers: a Study on N2A Cells.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Animals; Biomarkers; Caspase 3; Cell Death; Cell L | 2016 |
Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Choline; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Hum | 2016 |
Modeling the Interaction between β-Amyloid Aggregates and Choline Acetyltransferase Activity and Its Relation with Cholinergic Dysfunction through Two-Enzyme/Two-Compartment Model.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Brain; Choline; Choline O-Acetyltransferase | 2015 |
Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amyloidogenic Proteins; Apolipoprotein E4; Aspartic Acid; Brain; Brain Mapp | 2016 |
(1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Dominance, Cerebra | 2016 |
Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Cre | 2016 |
A silk peptide fraction restores cognitive function in AF64A-induced Alzheimer disease model rats by increasing expression of choline acetyltransferase gene.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Cell Line, Tumor; Choline; Choline O-Ace | 2017 |
Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Animals, Newborn; Choline; | 2017 |
A novel assay to determine acetylcholinesterase activity: The application potential for screening of drugs against Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain Chemistry; Choline; Cholinesteras | 2017 |
[Inhibitory effects of sinapine on activity of acetylcholinesterase in cerebral homogenate and blood serum of rats].
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Choline; Cholinesterase Inhibitors; Rats | 2008 |
Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studie | 2008 |
Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition; Cognition Disorders; Creatine; De | 2009 |
Reduced hippocampal glutamate in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Choline; Creatine; Female; Glutamic Acid; Hi | 2011 |
Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells.
Topics: Acetylcholine; Alzheimer Disease; Biomarkers; Cell Line, Tumor; Choline; Choline O-Acetyltransferase | 2009 |
Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Aziridines; Benzodioxoles; Choline; Cog | 2010 |
Aging and lateralization of the rat brain on a biochemical level.
Topics: 17-Hydroxysteroid Dehydrogenases; Aging; Alzheimer Disease; Animals; Biomarkers; Brain; Cerebrum; Ch | 2010 |
Simple choline esters as potential anti-Alzheimer agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Butyrylcholinesterase; Choline; Cho | 2010 |
Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging.
Topics: Aged; Aging; Alzheimer Disease; Amnesia; Analysis of Variance; Aspartic Acid; Biomarkers; Brain Chem | 2010 |
Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Binding Sites; Calc | 2010 |
Hippocampal proton MR spectroscopy in early Alzheimer's disease and mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognitive | 2011 |
Using proton magnetic resonance spectroscopy to identify mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Cognitive Dysfunction; | 2012 |
Brain glutamate levels are decreased in Alzheimer's disease: a magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; | 2011 |
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; | 2011 |
Effects of Alzheimer's disease transgenes on neurochemical expression in the mouse brain determined by ¹H MRS in vitro.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Aspartic Acid; Biomarkers; Brain; Choline; Glycery | 2012 |
Systematic evaluation of magnetic resonance imaging and spectroscopy techniques for imaging a transgenic model of Alzheimer's disease (AβPP/PS1).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Brain; Cell Proliferation; Choline; C | 2012 |
Amperometric choline biosensor based on multiwalled carbon nanotubes/zirconium oxide nanoparticles electrodeposited on glassy carbon electrode.
Topics: Acetylcholinesterase; Adolescent; Adult; Alcohol Oxidoreductases; Alzheimer Disease; Biosensing Tech | 2012 |
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cholin | 2012 |
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Cre | 2012 |
Choline-containing phospholipids in microdissected human Alzheimer's disease brain senile plaque versus neuropil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Chemistry; Choline; Chromatography, High Pr | 2012 |
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Brain Mapping | 2013 |
Changes in activity of proline-specific peptidases in rat model for dementia of Alzheimer's type.
Topics: Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Aziridines; Cerebral Cortex; Choline; Dipep | 2012 |
Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.
Topics: Adaptor Proteins, Vesicular Transport; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; C | 2013 |
Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine | 2002 |
Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studie | 2002 |
Nerve growth factor and cholinergic CNS neurons studied in organotypic brain slices. Implication in Alzheimer's disease?
Topics: Acetyl Coenzyme A; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Cell Survival; Cerebral Cor | 2002 |
Cognitive impairment: assessment with brain magnetic resonance imaging and proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Choline; Cognition Disorders; Creati | 2003 |
Comparison of the effect of NT-0409 and antidementia drugs on learning and memory in rats with chronic cerebral cholinergic deficiency.
Topics: Alzheimer Disease; Animals; Aziridines; Brain; Choline; Excitatory Amino Acid Agonists; Male; Maze L | 2003 |
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Crea | 2003 |
The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognition Disorders; Creatinine; Dementia, Vascular | 2003 |
Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease.
Topics: alpha-Linolenic Acid; Alzheimer Disease; Amyloid beta-Peptides; Arachidonic Acid; Brain; Brain Chemi | 2003 |
Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology.
Topics: Acetylcholine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Choline; G | 2003 |
Posterior cingulate metabolic changes in frontotemporal lobar degeneration detected by magnetic resonance spectroscopy.
Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Creatine; Dementia; Di | 2004 |
Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aziridines; Cell Death; Choline; Choline O-Acetyl | 2004 |
Glycosaminoglycan C3 protects against AF64A-induced cholinotoxicity in a dose-dependent and time-dependent manner.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Aziridines; Cell Death; Choline; Choline O-Acetylt | 2004 |
Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Blood-Brain Barrier; Choline; Dementia, Vascular; Female; Hu | 2004 |
Cerebrospinal fluid from patients with dementia contains increased amounts of an unknown factor.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Case-Control Studi | 2004 |
1H MR spectroscopy in common dementias.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Brain Chemistry; Ch | 2004 |
In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain Mapping; Case | 2004 |
Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Cognition Disorders; Cohort Studies; Creatin | 2005 |
Proton magnetic resonance spectroscopy and magnetoencephalographic estimation of delta dipole density: a combination of techniques that may contribute to the diagnosis of Alzheimer's disease.
Topics: Acetylglucosamine; Aged; Alzheimer Disease; Brain Chemistry; Choline; Creatine; Female; Glutamic Aci | 2005 |
A comparative study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Female; Humans; Magnetic Resonance Spectr | 2005 |
[Proton spectroscopy in Alzheimer's disease and cognitive impairment not dementia: a community study].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Case-Control Studies; Choline; Cognition | 2005 |
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Choline; Cognition | 2007 |
Quality of life: the bridge from the cholinergic basal forebrain to cognitive science and bioethics.
Topics: Alzheimer Disease; Bioethics; Choline; Cognitive Science; Humans; Prosencephalon; Quality of Life | 2006 |
Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptors.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Atropine | 2007 |
Reproducibility of magnetic resonance spectroscopy in correlation with signal-to-noise ratio.
Topics: Aged; Alzheimer Disease; Artifacts; Aspartic Acid; Choline; Creatine; Female; Gyrus Cinguli; Humans; | 2007 |
Cholinergic precursors in Alzheimer's disease.
Topics: Alzheimer Disease; Choline; Dementia; Humans; Pilocarpine; Receptors, Muscarinic | 1982 |
Choline precursors and Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Choline; Dementia; Humans | 1982 |
Cortical cholinergic deficit in mentally impaired Parkinsonian patients.
Topics: Alzheimer Disease; Cerebral Cortex; Choline; Humans; Parkinson Disease | 1983 |
Alzheimer's disease and Down's syndrome.
Topics: Acetylcholinesterase; Adult; Aged; Aging; Alzheimer Disease; Animals; Axons; Brain; Choline; Choline | 1982 |
Elevation of RBC glycine and choline levels in geriatric patients treated with lithium.
Topics: Aged; Alzheimer Disease; Choline; Cognition Disorders; Dementia; Erythrocytes; Female; Glycine; Huma | 1983 |
Lithium-induced increases in red blood cell choline and memory performance in Alzheimer-type dementia.
Topics: Aged; Alzheimer Disease; Choline; Erythrocytes; Humans; Lithium; Lithium Carbonate; Memory; Middle A | 1984 |
Decay in plasma lithium and normalization in red blood cell choline following cessation of lithium treatment in two elderly individuals with Alzheimer-type dementia.
Topics: Aged; Alzheimer Disease; Choline; Erythrocytes; Humans; Lithium; Lithium Carbonate; Male; Substance | 1984 |
Do raised brain aluminium levels in Alzheimer's dementia contribute to cholinergic neuronal deficits?
Topics: Aluminum; Alzheimer Disease; Animals; Biological Transport; Brain Chemistry; Choline; Choline O-Acet | 1984 |
Plasma choline responses to lecithin-enriched soup.
Topics: Alzheimer Disease; Choline; Dyskinesia, Drug-Induced; Humans; Phosphatidylcholines | 1984 |
Choline production from choline-containing phospholipids: a hypothetical role in Alzheimer's disease and aging.
Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Cell Membrane; Choline; Cholinergic Fibers; | 1984 |
Elevated red blood cell/plasma choline ratio in dementia of the Alzheimer type: clinical and polysomnographic correlates.
Topics: Aged; Alzheimer Disease; Choline; Depressive Disorder; Erythrocytes; Female; Humans; Male; Middle Ag | 1984 |
Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease.
Topics: Acetylcholine; Aged; Alzheimer Disease; Cerebral Cortex; Choline; Female; Hippocampus; Humans; Male; | 1983 |
[Dementia syndromes and epilepsy].
Topics: Adult; Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Epilepsy; Female; Humans; | 1984 |
Presynaptic cholinergic dysfunction in patients with dementia.
Topics: Acetylcholine; Adult; Aged; Alzheimer Disease; Carbon Radioisotopes; Cerebral Cortex; Choline; Choli | 1983 |
The responsiveness of human eccrine sweat glands to choline and carbachol. Application to the study of peripheral cholinergic functioning in Alzheimer-type dementia.
Topics: Adult; Aged; Aging; Alzheimer Disease; Carbachol; Choline; Dementia; Dose-Response Relationship, Dru | 1983 |
Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Blood Pressure; Choline; Dementia; Erythrocytes; Female; Humans; Hydrocorti | 1983 |
Lecithin does not affect EEG spectral analysis or P300 in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Evoked Potentials; Female; Human | 1982 |
Stimulation of acetylcholine synthesis by blockade of presynaptic muscarinic inhibitory autoreceptors: observations in rat and human brain preparations and comparison with the effect of choline.
Topics: Acetylcholine; Adolescent; Adult; Aged; Alzheimer Disease; Animals; Brain; Choline; Dose-Response Re | 1982 |
Cerebrospinal fluid acetylcholine, choline, and senile dementia of the Alzheimer's type.
Topics: Acetylcholine; Aged; Alzheimer Disease; Choline; Dementia; Female; Humans; Male; Middle Aged | 1982 |
Choline uptake in patients with Alzheimer pre-senile dementia.
Topics: Adolescent; Adult; Aged; Alzheimer Disease; Choline; Dementia; Erythrocytes; Female; Humans; Male; M | 1981 |
Choline chloride fails to improve cognition of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Cognition; Dementia; Diarrhea; Dose-Response Relationship, Drug; D | 1981 |
Choline chloride in Alzheimer disease.
Topics: Alzheimer Disease; Choline; Dementia; Humans | 1981 |
Acetylcholine and choline levels in post-mortem human brain tissue: preliminary observations in Alzheimer's disease.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Brain; Caudate Nucleus; Cerebral Cortex; Choline; D | 1980 |
Neurochemical approaches to the treatment of senile dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferase; Dementia; Dys | 1980 |
Choline bitartrate treatment of Alzheimer-type dementias.
Topics: Aged; Alzheimer Disease; Behavior; Choline; Cognition; Dementia; Double-Blind Method; Female; Humans | 1980 |
H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Case-Control Studies; | 1995 |
[1H-MR spectroscopic imaging in patients with clinically diagnosed Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Hippocampus; Humans; Lactates; Lac | 1995 |
Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function.
Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Electric Sti | 1995 |
Role of increased cerebral myo-inositol in the dementia of Down syndrome.
Topics: Adolescent; Adult; Alzheimer Disease; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creati | 1995 |
How to find a treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Choline; Humans; Research | 1994 |
Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer's disease: an autoradiographic study using 3H-hemicholinium-3.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Biological Transport; Case-Control Stud | 1994 |
Reduced N-acetylaspartate content in the frontal part of the brain in patients with probable Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Female; Frontal Lobe; | 1995 |
Remarkable reduction in acetylcholine concentration in the cerebrospinal fluid from patients with Alzheimer type dementia.
Topics: Acetylcholine; Age of Onset; Aged; Alzheimer Disease; Blood-Brain Barrier; Choline; Humans; Middle A | 1994 |
AF64A-induced brain damage and its relation to dementia.
Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Brain Damage, Chronic; Choline; Choline O-Ace | 1994 |
Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging.
Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Axons; Brain; Cerebral Cortex; Cerebral Ventricles; C | 1994 |
The return of the cholinergic hypothesis.
Topics: Alzheimer Disease; Choline; Humans; Parasympathetic Nervous System | 1994 |
Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Carrier Proteins; Cerebral Cortex; Choline; Cho | 1994 |
beta-Amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease.
Topics: Adrenal Gland Neoplasms; Alzheimer Disease; Amyloid beta-Peptides; Animals; Choline; Electric Conduc | 1994 |
Alterations of selected enzymes of phospholipid metabolism in Alzheimer's disease brain tissue as compared to non-Alzheimer's demented controls.
Topics: Aged; Alzheimer Disease; Brain; Choline; Choline Kinase; Dementia; Humans; Phospholipids; Phosphoric | 1993 |
In vivo proton magnetic resonance spectroscopy study on premature aging in adult Down's syndrome.
Topics: Adult; Alzheimer Disease; Aspartic Acid; Brain; Cellular Senescence; Choline; Creatinine; Down Syndr | 1993 |
Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Female; Humans; Inositol | 1993 |
Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aziridines; Cell Deat | 1996 |
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Brain Ischem | 1996 |
Evaluation of automated MR spectroscopy: application in Alzheimer disease.
Topics: Adult; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Humans; Inosito | 1995 |
[Effects of AF64A on neurons containing both nitric oxide synthase and choline acetyltransferase in the rat septal complex].
Topics: Alzheimer Disease; Animals; Aziridines; Choline; Choline O-Acetyltransferase; Hippocampus; Male; Neu | 1996 |
Age-dependent effect of AF64A on cholinergic activity in the septo-hippocampal pathway of the rat brain: decreased responsiveness in aged rats.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Aziridines; Choline; Choline O-Acetyltransf | 1996 |
Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Dementia, Vascular; Diagnosis, Dif | 1996 |
Cerebrospinal fluid acetylcholine and choline in vascular dementia of Binswanger and multiple small infarct types as compared with Alzheimer-type dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Biomarkers; Choline; Cholinergic Agents; Dementia, Multi-Inf | 1996 |
Proton magnetic resonance spectroscopy in dementia of Alzheimer type.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Female; Humans; | 1997 |
The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer's disease.
Topics: Acetylcholine; Age of Onset; Aging; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cell Membrane; | 1997 |
Beta-amyloid induced increase in choline flux across PC12 cell membranes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Membrane; Choline; Patch-Clamp Techniques; P | 1997 |
Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Arecoline; Aziridines; Brain; Brain Mapping; Cerebral Cortex; Choline; D | 1997 |
Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Artifacts; Aspartic Acid; Brain Chemistry; Choline; Crea | 1998 |
Effects of S-8510, a novel benzodiazepine receptor partial inverse agonist, on basal forebrain lesioning-induced dysfunction in rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Benzodiazepines; Choline; Choline O-Acetyltransferase; Di | 1998 |
[Clinical uses of proton magnetic resonance spectroscopy of the brain].
Topics: AIDS Dementia Complex; Alzheimer Disease; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Disea | 1998 |
Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Female; Humans; Ino | 1998 |
Acetylcholine in human CSF: methodological considerations and levels in dementia of Alzheimer type.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Choline; Chromatography, High Pressure Li | 1998 |
In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Cerebral Cortex; Choline; Creatine; Female; Humans; Mag | 1999 |
N-acetylserotonin, melatonin and their derivatives improve cognition and protect against beta-amyloid-induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Aziridines; Cells, Cultured; | 1999 |
Choline plus cytidine stimulate phospholipid production, and the expression and secretion of amyloid precursor protein in rat PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Membrane; Choline; Cytidine; Female | 2000 |
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cognition Disorde | 2000 |
Potentiation of brain acetylcholine neurons by Kami-Untan-To (KUT) in aged mice: implications for a possible antidementia drug.
Topics: Acetylcholine; Aging; Alzheimer Disease; Animals; Brain; Central Nervous System Agents; Choline; Cho | 2000 |
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cerebral Cortex; Choline; Choline O-Acetyltran | 2000 |
Dimebon improves learning in animals with experimental Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Choline; Cholinesterase Inhibitors; Dise | 2000 |
Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Choline; Cytidine Diphosphate | 2000 |
Amyloid beta(1-42) and its beta(25-35) fragment induce in vitro phosphatidylcholine hydrolysis in bovine retina capillary pericytes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arachidonic Acid; Blood-Brain Barrier; Capillarie | 2001 |
Relation between 1H MR spectroscopic imaging and regional cerebral glucose metabolism in Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Female; Glucose; Humans; Magnetic Res | 2001 |
Memory impairment and cholinergic dysfunction by centrally administered Abeta and carboxyl-terminal fragment of Alzheimer's APP in mice.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Ce | 2001 |
(1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cognitio | 2001 |
Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Brain; Choline; Cre | 2001 |
MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy | 2001 |
Effects of repeated administration of (-)-nicotine on AF64A-induced learning and memory impairment in rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Choline; Choline O-Acetyl | 2002 |
Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Creatine; Female; Hippocampus; Humans; Magnetic Res | 2002 |
Clinical effects of choline in Alzheimer senile dementia.
Topics: Administration, Oral; Aged; Alzheimer Disease; Choline; Dementia; Drug Evaluation; Female; Humans; M | 1977 |
Choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Dementia; gamma-Amin | 1977 |
Clinical effects of choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Female; Humans; Male | 1978 |
Possible biochemical basis of memory disorder in Alzheimer disease.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferas | 1978 |
Will drugs help patients with Alzheimer's disease?
Topics: Alzheimer Disease; Choline; Choline O-Acetyltransferase; Dementia; Humans | 1979 |
[Influence of choline on amnesia in Alzheimer's disease (author's transl)].
Topics: Aged; Alzheimer Disease; Amnesia; Choline; Dementia; Female; Humans; Learning; Male; Mental Recall; | 1979 |
Evidence for a membrane defect in Alzheimer disease brain.
Topics: Aged; Alzheimer Disease; Brain; Brain Chemistry; Choline; Down Syndrome; Glycerylphosphorylcholine; | 1992 |
Cholecystokinin protects cholinergic neurons against basal forebrain lesion.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Ch | 1992 |
High-affinity choline uptake carrier in Alzheimer's disease: implications for the cholinergic hypothesis of dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Biological Transport; Brain; Caudate Nucl | 1991 |
Studies on choline transport enhancement into fibroblasts from normals and Alzheimer's donors.
Topics: Aged; Alzheimer Disease; Biological Transport; Caffeine; Cell Line; Cells, Cultured; Choline; Dexame | 1991 |
Global in vivo replacement of choline by N-aminodeanol. Testing a hypothesis about progressive degenerative dementia: I. Dynamics of choline replacement.
Topics: Acetylation; Acetylcholinesterase; Alzheimer Disease; Animals; Brain Chemistry; Butyrylcholinesteras | 1990 |
Global in vivo replacement of choline by N-aminodeanol. Testing a hypothesis about progressive degenerative dementia: II. Physiological and behavioral effects.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Body Temperature; Body Weight; Bra | 1990 |
Down's syndrome fibroblasts exhibit enhanced inositol uptake.
Topics: Alzheimer Disease; Biological Transport; Cell Line; Choline; Chromosome Mapping; Chromosomes, Human, | 1990 |
Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.
Topics: Alzheimer Disease; Autopsy; Brain; Choline; Choline O-Acetyltransferase; Humans; Organ Specificity; | 1990 |
From the National Institutes of Health.
Topics: Air Pollutants, Radioactive; Alzheimer Disease; Child; China; Choline; Cyclophosphamide; Female; Hum | 1990 |
Changes of acetylcholine and choline concentrations in cerebrospinal fluids of normal subjects and patients with dementia of Alzheimer-type.
Topics: Acetylcholine; Adult; Aged; Alzheimer Disease; Choline; Female; Humans; Male; Middle Aged; Osmolar C | 1990 |
Clinical studies of the cholinergic deficit in Alzheimer's disease. I. Neurochemical and neuroendocrine studies.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Choline; Choline Deficiency; Cognition; Female; Gas C | 1985 |
CSF choline and acetylcholinesterase in early-onset vs. late-onset Alzheimer's disease patients.
Topics: Acetylcholinesterase; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Choline; Humans; Midd | 1989 |
[Study on Alzheimer's disease and the animal disease model--special reference to acetylcholinergic system].
Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Di | 1989 |
Monoclonal antibody Tor 23 binds a subset of neural cells in the human cortex and displays an altered binding distribution in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Antigens, Surface; Cell | 1989 |
Intracortical AF64A: memory impairments and recovery from cholinergic hypofunction.
Topics: Acetylcholine; Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Biological Transport; Cer | 1989 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine (AF102B): a new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats.
Topics: Alzheimer Disease; Animals; Aziridines; Behavior, Animal; Choline; Cognition Disorders; Disease Mode | 1989 |
Cerebral ageing, neurotransmitters and therapeutic implications.
Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Brain; Choline; Choline O-Acetyltransferase; Dihydroe | 1985 |
Neurotransmitter and receptor deficits in senile dementia of the Alzheimer type.
Topics: Alzheimer Disease; Binding Sites; Brain; Choline; Choline O-Acetyltransferase; Humans; Neuropeptide | 1986 |
Choline increases acetylcholine release.
Topics: Acetylcholine; Alzheimer Disease; Animals; Choline; Humans; Rats | 1987 |
Functional and neurochemical cortical cholinergic impairment following neurotoxic lesions of the nucleus basalis magnocellularis in the rat.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Basal Ganglia; Cerebral Cortex; Cho | 1985 |
"Autocannibalism" of membrane choline-phospholipids: physiology and pathology.
Topics: Acetylcholine; Alzheimer Disease; Brain; Choline; Humans; Membrane Lipids; Synaptic Membranes; Synap | 1986 |
Effects of intracerebroventricular injection of AF64A on learning behaviors in rats.
Topics: Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Aziridines; Azirines; Choline; Choline O-Ac | 1988 |
Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Autoantibodies; Cerebral Cortex; Choline; Choli | 1988 |
Effects of training on a spatial memory task on high affinity choline uptake in hippocampus and cortex in young adult and aged rats.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Choline; Conditioning, Psychological; Cues; Hipp | 1988 |
Chronic treatment with choline or scopolamine indicates the presence of muscarinic cholinergic receptor plasticity in the frontal cortex of young but not of aged mice.
Topics: Aging; Alzheimer Disease; Animals; Choline; Female; Frontal Lobe; Humans; Mice; Models, Biological; | 1988 |
Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carbachol; Cerebral Cortex; Cholin | 1988 |
Red blood cell/plasma choline ratio in elderly depressed and demented patients.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Depressive Disorder; Electroencephalography; Erythrocyte | 1988 |
Cerebrospinal fluid choline, and acetylcholinesterase activity in familial vs. non-familial Alzheimer's disease patients.
Topics: Acetylcholinesterase; Aged; Agraphia; Alzheimer Disease; Choline; Humans; Middle Aged | 1988 |
Neurochemical effects following AF64A injection into the basal nuclei of rats.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Aziridines; Azirines; Basal Ganglia; Choline; Chol | 1987 |
A model hypocholinergic syndrome produced by a false choline analog, N-aminodeanol.
Topics: Alzheimer Disease; Animals; Choline; Disease Models, Animal; Rats | 1987 |
Ethylcholine mustard aziridinium ion lesions of the rat cortex result in retrograde degeneration of basal forebrain cholinergic neurons: implications for animal models of neurodegenerative disease.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Basal Ganglia; Cerebral Cortex; Choline; Choline O | 1987 |
Increased affinity of choline acetyltransferase for choline in Alzheimer's disease: a steady-state kinetic study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Caudate Nucleus; Choline; Choline O-Acetyltransferase; F | 1987 |
The "antidementia drug" pantoyl-gamma-aminobutyric acid increases high affinity uptake of choline by slices of rat brain.
Topics: Alzheimer Disease; Animals; Brain; Calcium; Cerebral Cortex; Choline; Corpus Striatum; gamma-Aminobu | 1986 |
Immunohistochemical evidence for degeneration of cholinergic neurons in the forebrain of the rat following injection of AF64A-picrylsulfonate into the dorsal hippocampus.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Choline; Choline O-Acetyltransferase; Cholinergic | 1986 |
Reduced phosphorylcholine hydrolysis by homogenates of temporal regions of Alzheimer's brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Choline; Humans; Hydrogen-Ion Concentration; Hydr | 1986 |
[Cholinergic treatment strategies in Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Brain; Choline; Cholinesterase Inhibitors; Drug Therapy, Combinati | 1986 |
An attempt to produce cholinergic hypofunction in rat brain using choline mustard aziridinium ion: neurochemical and histological parameters.
Topics: Alzheimer Disease; Animals; Brain; Choline; Disease Models, Animal; Hippocampus; Male; Nerve Degener | 1986 |
Qualitative abnormalities of choline acetyltransferase in Alzheimer type dementia.
Topics: Acetyl Coenzyme A; Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Choline; Choline O-A | 1986 |
Intracerebral injections of AF64A: an animal model of Alzheimer's disease?
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Brain; Choline; Cholinergic Fibers; Disease Models | 1985 |
Rational drug treatment of dementia?
Topics: Alzheimer Disease; Choline; Humans; Phosphatidylcholines | 1985 |
Abnormal erythrocyte choline and influx in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Erythrocytes; Humans; Middle Aged | 1986 |
Red blood cell choline. I: Choline in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Erythrocytes; Female; Humans; Male; Middle Aged | 1985 |
Red blood cell choline. II: Kinetics in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Erythrocytes; Female; Humans; Kinetics; Male; Middle Aged | 1985 |
Red blood cell abnormalities in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Choline; Double-Blind Method; Erythrocytes; Female; Humans; Male; Prospecti | 1985 |
Evidence for an increased rate of choline efflux across erythrocyte membranes in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biological Transport, Active; Choline; Choline O-Acetyltransferase; Choline | 1985 |