choline has been researched along with Acrania in 23 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neural tube defects (NTDs) still occur among some women who consume 400 μg of folic acid for prevention." | 8.31 | Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recom ( Carmichael, SL; Darling, AM; Desrosiers, TA; Nestoridi, E; Parker, SE; Petersen, JM; Politis, MD; Shaw, GM; Smith-Webb, RS; Werler, MM; Yazdy, MM, 2023) |
| "Low maternal intake of dietary choline and betaine (a choline derivative) has recently been investigated as a possible risk factor for neural tube defects (NTDs)." | 7.80 | Dietary intake of choline and neural tube defects in Mexican Americans. ( Brender, JD; Canfield, MA; Felkner, M; Lavery, AM; Suarez, L; Sweeney, A; Zhao, H, 2014) |
| "Folic acid is known to reduce risk of neural tube defects (NTDs)." | 7.75 | Choline and risk of neural tube defects in a folate-fortified population. ( Blom, HJ; Carmichael, SL; Finnell, RH; Shaw, GM; Ueland, PM; Vollset, SE; Yang, W, 2009) |
| " The World Health Organisation recommends folic acid (FA) supplementation pre-conception and in early pregnancy to reduce the risk of fetal neural tube defects (NTDs)." | 5.22 | High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus. ( Arthurs, AL; Jankovic-Karasoulos, T; Roberts, CT; Smith, MD; Williamson, JM, 2022) |
| " Folates are important for normal neural tube closure in early gestation, and the efficacy of diet fortification with folic acid in reducing the incidence of neural tube defects is a major success story for public health nutrition." | 4.85 | Importance of methyl donors during reproduction. ( Zeisel, SH, 2009) |
| "Neural tube defects (NTDs) still occur among some women who consume 400 μg of folic acid for prevention." | 4.31 | Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recom ( Carmichael, SL; Darling, AM; Desrosiers, TA; Nestoridi, E; Parker, SE; Petersen, JM; Politis, MD; Shaw, GM; Smith-Webb, RS; Werler, MM; Yazdy, MM, 2023) |
| "Low maternal intake of dietary choline and betaine (a choline derivative) has recently been investigated as a possible risk factor for neural tube defects (NTDs)." | 3.80 | Dietary intake of choline and neural tube defects in Mexican Americans. ( Brender, JD; Canfield, MA; Felkner, M; Lavery, AM; Suarez, L; Sweeney, A; Zhao, H, 2014) |
| "To dissociate the effects of dietary folate and choline deficiency on Shmt1-related NTD sensitivity, we determined NTD incidence in embryos from Shmt1-null dams fed diets deficient in either folate or choline." | 3.78 | Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. ( Abarinov, EV; Beaudin, AE; Caudill, M; Malysheva, O; Perry, CA; Stover, PJ, 2012) |
| "Reduced folate and choline status resulted in severe fetal growth restriction (FGR) and impaired fertility in litters harvested from Mthfd1(gt/+) dams, but embryonic Mthfd1(gt/+) genotype did not affect fetal growth." | 3.78 | Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. ( Allen, RH; Beaudin, AE; Perry, CA; Stabler, SP; Stover, PJ, 2012) |
| "We examined whether genetic disruption of the Shmt1 gene in mice induces NTDs in response to maternal folate and choline deficiency and whether a corresponding disruption in de novo thymidylate biosynthesis underlies NTD pathogenesis." | 3.77 | Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. ( Abarinov, EV; Allen, RH; Beaudin, AE; Chu, S; Noden, DM; Perry, CA; Stabler, SP; Stover, PJ, 2011) |
| "Folic acid is known to reduce risk of neural tube defects (NTDs)." | 3.75 | Choline and risk of neural tube defects in a folate-fortified population. ( Blom, HJ; Carmichael, SL; Finnell, RH; Shaw, GM; Ueland, PM; Vollset, SE; Yang, W, 2009) |
| "Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998." | 2.45 | Choline: an essential nutrient for public health. ( da Costa, KA; Zeisel, SH, 2009) |
| "Choline is an essential nutrient and it is also a methyl donor critical for the maintenance of cell membrane integrity and methyl metabolism." | 1.33 | CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. ( Enaw, JO; Finnell, RH; Lammer, EJ; Lu, W; Shaw, GM; Yang, W; Zhu, H, 2006) |
| "Choline is an essential nutrient in methylation, acetylcholine and phospholipid biosynthesis, and in cell signaling." | 1.31 | Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. ( Fisher, MC; Mar, MH; Sadler, TW; Zeisel, SH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 12 (52.17) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Obeid, R | 4 |
| Derbyshire, E | 1 |
| Schön, C | 1 |
| Williamson, JM | 1 |
| Arthurs, AL | 1 |
| Smith, MD | 1 |
| Roberts, CT | 1 |
| Jankovic-Karasoulos, T | 1 |
| Holzgreve, W | 3 |
| Pietrzik, K | 3 |
| Petersen, JM | 2 |
| Smith-Webb, RS | 1 |
| Shaw, GM | 4 |
| Carmichael, SL | 3 |
| Desrosiers, TA | 1 |
| Nestoridi, E | 1 |
| Darling, AM | 1 |
| Parker, SE | 2 |
| Politis, MD | 1 |
| Yazdy, MM | 1 |
| Werler, MM | 2 |
| Wang, R | 1 |
| Sun, DG | 1 |
| Song, G | 2 |
| Guan, CY | 1 |
| Cui, Y | 2 |
| Ma, X | 2 |
| Xia, HF | 2 |
| Crider, KS | 1 |
| Tinker, SC | 1 |
| Mitchell, AA | 1 |
| Osterhues, A | 1 |
| Ali, NS | 1 |
| Michels, KB | 1 |
| Imbard, A | 1 |
| Benoist, JF | 1 |
| Blom, HJ | 2 |
| Lavery, AM | 1 |
| Brender, JD | 1 |
| Zhao, H | 1 |
| Sweeney, A | 1 |
| Felkner, M | 1 |
| Suarez, L | 1 |
| Canfield, MA | 1 |
| Mills, JL | 1 |
| Fan, R | 1 |
| Brody, LC | 1 |
| Liu, A | 1 |
| Ueland, PM | 2 |
| Wang, Y | 1 |
| Kirke, PN | 1 |
| Shane, B | 2 |
| Molloy, AM | 1 |
| Zeisel, SH | 3 |
| Finnell, RH | 2 |
| Vollset, SE | 1 |
| Yang, W | 3 |
| da Costa, KA | 1 |
| Beaudin, AE | 3 |
| Abarinov, EV | 2 |
| Noden, DM | 1 |
| Perry, CA | 3 |
| Chu, S | 1 |
| Stabler, SP | 2 |
| Allen, RH | 2 |
| Stover, PJ | 3 |
| Toriello, HV | 1 |
| Malysheva, O | 1 |
| Caudill, M | 1 |
| Han, ZJ | 1 |
| Selvin, S | 1 |
| Schaffer, DM | 1 |
| Enaw, JO | 1 |
| Zhu, H | 1 |
| Lu, W | 1 |
| Lammer, EJ | 1 |
| Glade, MJ | 1 |
| Fisher, MC | 1 |
| Mar, MH | 1 |
| Sadler, TW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)[NCT03269110] | 2,578 participants (Anticipated) | Observational | 2017-07-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for choline and Acrania
| Article | Year |
|---|---|
Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Topics: Brain; Child; Child Development; Choline; Diet; Dietary Supplements; Female; Humans; Infant, Newborn | 2022 |
High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Carbon; Choline; Diabet | 2022 |
The role of folic acid fortification in neural tube defects: a review.
Topics: Biological Availability; Choline; Edible Grain; Female; Folic Acid; Folic Acid Antagonists; Food, Fo | 2013 |
Neural tube defects, folic acid and methylation.
Topics: Animals; Choline; Folic Acid; Homocysteine; Humans; Methylation; Neural Tube Defects; Neurulation; V | 2013 |
Importance of methyl donors during reproduction.
Topics: Brain; Choline; Female; Fetal Development; Folic Acid; Food, Fortified; Humans; Infant, Newborn; Met | 2009 |
Choline: an essential nutrient for public health.
Topics: Adolescent; Adult; Aged; Animals; Breast Neoplasms; Child; Child, Preschool; Choline; Choline Defici | 2009 |
17 other studies available for choline and Acrania
| Article | Year |
|---|---|
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
[Folate, Choline, and Vitamin B12 Supplementation for Pre-Conceptional and Pregnant Women].
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lactation; Neural Tube Defects; P | 2022 |
Periconceptional intakes of methyl donors and other micronutrients involved in one-carbon metabolism may further reduce the risk of neural tube defects in offspring: a United States population-based case-control study of women meeting the folic acid recom
Topics: Betaine; Carbon; Case-Control Studies; Choline; Female; Folic Acid; Humans; Methionine; Micronutrien | 2023 |
Choline, not folate, can attenuate the teratogenic effects ofdibutyl phthalate (DBP) during early chick embryo development.
Topics: Animals; Apoptosis; Body Fluids; Chick Embryo; Chickens; Choline; Dibutyl Phthalate; Embryonic Devel | 2019 |
One-Carbon Cofactor Intake and Risk of Neural Tube Defects Among Women Who Meet Folic Acid Recommendations: A Multicenter Case-Control Study.
Topics: Adult; Betaine; Carbon; Case-Control Studies; Choline; Dietary Supplements; Dose-Response Relationsh | 2019 |
Dietary intake of choline and neural tube defects in Mexican Americans.
Topics: Adult; Betaine; Case-Control Studies; Choline; Dietary Supplements; Female; Humans; Mexican American | 2014 |
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.
Topics: Adult; Betaine; Case-Control Studies; Choline; Dietary Supplements; Female; Folic Acid; Genome, Huma | 2014 |
Choline and risk of neural tube defects in a folate-fortified population.
Topics: Adult; California; Choline; Dietary Supplements; Female; Folic Acid; Humans; Lipotropic Agents; Neur | 2009 |
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Def | 2011 |
Policy statement on folic acid and neural tube defects.
Topics: Choline; Dietary Supplements; Female; Folic Acid; Humans; Neural Tube Defects; Pregnancy; Vitamin B | 2011 |
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Energy Intake; Folic Acid; Folic | 2012 |
Folate-responsive birth defects: of mice and women.
Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyl | 2012 |
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
Topics: Aminohydrolases; Animals; Choline; Choline Deficiency; Crosses, Genetic; Disease Models, Animal; Emb | 2012 |
Effects of choline on sodium arsenite-induced neural tube defects in chick embryos.
Topics: Animals; Apoptosis; Arsenites; bcl-2-Associated X Protein; Chick Embryo; Choline; Cricetinae; DNA Me | 2012 |
Periconceptional dietary intake of choline and betaine and neural tube defects in offspring.
Topics: Betaine; California; Case-Control Studies; Choline; Female; Humans; Infant, Newborn; Maternal Nutrit | 2004 |
CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.
Topics: California; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Female; Genotype; Human | 2006 |
Workshop on Folate, B12, and Choline. Sponsored by the Panel on Folate and other B vitamins of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Washington, D.C., March 3-4,
Topics: Biological Availability; Biomarkers; Cardiovascular Diseases; Choline; Congenital Abnormalities; Fem | 1999 |
Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Dyskinesia Agents; Choline; Deanol; Embryo, Mammalian; Em | 2001 |