choline has been researched along with Acidosis, Lactic in 5 studies
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Congenital lactic acidosis form a large group of disorders that are commonly associated with profound neurological dysfunction." | 7.68 | Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. ( Connelly, A; Cross, JH; Gadian, DG; Leonard, JV, 1993) |
| " Inhibition of mitochondrial respiration likely explains lactate formation in the brain during metformin infusion which may cause lactic acidosis during metformin intoxication." | 4.02 | Cholinergic and metabolic effects of metformin in mouse brain. ( Klein, J; Lau, H; Lehto, A; Piechotta, C; Thinnes, A; Westenberger, M; Wirth, F, 2021) |
| " Mutation carriers included 45 patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); 11 participants who would develop the MELAS syndrome during follow-up (converters); and 79 participants who would not develop the MELAS syndrome during follow-up (nonconverters)." | 3.80 | Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers. ( De Vivo, D; DiMauro, S; Engelstad, KM; Hinton, V; Kaufmann, P; Mao, X; Shungu, D; Weiduschat, N, 2014) |
| "The effects of iron-induced lipid peroxidation and of lactic acidosis on [3H]choline uptake were investigated on crude synaptosomes prepared from rat cerebral cortices." | 3.69 | Effects of iron-induced lipid peroxidation and of acidosis on choline uptake by synaptosomes. ( Beley, A; Bralet, J; Cancela, JM, 1994) |
| "Congenital lactic acidosis form a large group of disorders that are commonly associated with profound neurological dysfunction." | 3.68 | Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. ( Connelly, A; Cross, JH; Gadian, DG; Leonard, JV, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thinnes, A | 1 |
| Westenberger, M | 1 |
| Piechotta, C | 1 |
| Lehto, A | 1 |
| Wirth, F | 1 |
| Lau, H | 1 |
| Klein, J | 1 |
| Weiduschat, N | 1 |
| Kaufmann, P | 1 |
| Mao, X | 1 |
| Engelstad, KM | 1 |
| Hinton, V | 1 |
| DiMauro, S | 1 |
| De Vivo, D | 1 |
| Shungu, D | 1 |
| Cancela, JM | 1 |
| Bralet, J | 1 |
| Beley, A | 1 |
| Cross, JH | 1 |
| Gadian, DG | 1 |
| Connelly, A | 1 |
| Leonard, JV | 1 |
| White, EJ | 1 |
| Juchniewicz, HJ | 1 |
| Clark, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mitochondrial Encephalomyopathies and Mental Retardation: Investigations of Clinical Syndromes Associated With MtDNA Point Mutations[NCT01532791] | 300 participants (Anticipated) | Observational | 2004-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for choline and Acidosis, Lactic
| Article | Year |
|---|---|
Cholinergic and metabolic effects of metformin in mouse brain.
Topics: Acetylcholine; Acidosis, Lactic; Animals; Choline; Glucose; Hypoglycemic Agents; Hypothalamus; Lacti | 2021 |
Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers.
Topics: Acidosis, Lactic; Adult; Aged; Aspartic Acid; Cerebral Cortex; Choline; Creatine; DNA, Mitochondrial | 2014 |
Effects of iron-induced lipid peroxidation and of acidosis on choline uptake by synaptosomes.
Topics: Acidosis, Lactic; Animals; Choline; Ferrous Compounds; Free Radicals; Kinetics; Lipid Peroxidation; | 1994 |
Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders.
Topics: Acidosis, Lactic; Aspartic Acid; Brain; Child; Child, Preschool; Choline; Creatine; Female; Humans; | 1993 |
Effects of lactic acidosis on the function of cerebral cortical synaptosomes.
Topics: Acetylcholine; Acidosis, Lactic; Animals; Calcium; Cerebral Cortex; Choline; Hydrogen Peroxide; Hydr | 1989 |