cholesterol-alpha-oxide and Cell-Transformation--Neoplastic

cholesterol-alpha-oxide has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for cholesterol-alpha-oxide and Cell-Transformation--Neoplastic

Article	Year
Effect of cholesterol alpha and beta epoxides on cell killing and transformation. Biochemical pharmacology, 1987, Jul-15, Volume: 36, Issue:14 V-79 Chinese hamster lung fibroblasts and C3H-10T1/2 mouse embryo cells were used to study the toxicity and transformation effects of the 5 alpha,6 alpha, and 5 beta,6 beta-epoxy derivatives of cholesterol. Both epoxides were found to be carcinogenic, and the transformation frequency increased with epoxide concentration and exposure time. The 5 beta,6 beta-epoxide caused a higher level of transformation than the alpha-isomer, and this is consistent with its greater toxicity. Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cholesterol; Cricetinae; Cricetulus; Embryo, Mammalian; Fibroblasts; Lung; Male; Mice; Mice, Inbred C3H; Stereoisomerism	1987

Article

Year

Effect of cholesterol alpha and beta epoxides on cell killing and transformation.

Biochemical pharmacology, 1987, Jul-15, Volume: 36, Issue:14

V-79 Chinese hamster lung fibroblasts and C3H-10T1/2 mouse embryo cells were used to study the toxicity and transformation effects of the 5 alpha,6 alpha, and 5 beta,6 beta-epoxy derivatives of cholesterol. Both epoxides were found to be carcinogenic, and the transformation frequency increased with epoxide concentration and exposure time. The 5 beta,6 beta-epoxide caused a higher level of transformation than the alpha-isomer, and this is consistent with its greater toxicity.

Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cholesterol; Cricetinae; Cricetulus; Embryo, Mammalian; Fibroblasts; Lung; Male; Mice; Mice, Inbred C3H; Stereoisomerism

1987