cholecystokinin and Tremor

cholecystokinin has been researched along with Tremor* in 2 studies

Reviews

1 review(s) available for cholecystokinin and Tremor

ArticleYear
Neuropharmacological profile of cholecystokinin-like peptides.
    Annals of the New York Academy of Sciences, 1985, Volume: 448

    Topics: Analgesics; Animals; Anticonvulsants; Blepharoptosis; Body Temperature; Brain; Catalepsy; Cholecystokinin; Conditioning, Psychological; Humans; Hypnotics and Sedatives; Self Stimulation; Stereotyped Behavior; Structure-Activity Relationship; Tremor

1985

Other Studies

1 other study(ies) available for cholecystokinin and Tremor

ArticleYear
Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: effects on tremors induced by oxotremorine, harmine and ibogaine. A comparison with prolyl-leucylglycine amide (MIF), anti-Parkinsonian drugs and clonazepam.
    Neuropharmacology, 1983, Volume: 22, Issue:6

    Cholecystokinin octapeptide (CCK-8), ceruletide (caerulein, CER) and 10 analogues of ceruletide, were studied in mice for antagonism of the tremors induced by harmine (5 mg/kg, s.c.), ibogaine (20 mg/kg, s.c.) and oxotremorine (0.2 mg/kg, s.c.). The following reference drugs were tested for comparison: prolyl-leucylglycine amide (MIF), atropine, haloperidol, biperiden, ethopropazine, trihexyphenidyl, methixene and clonazepam. All treatments were subcutaneous, the antagonists being given 10 min (in some trials 30 min) before the tremorogen. Tremorolytic potency (ED50) was calculated from dose-response curves. Against the tremors induced by either harmine or ibogaine, CCK-8 and ceruletide, as well as many of the analogues of ceruletide had greater tremorolytic potency than the reference drugs. Against oxotremorine, however, ceruletide and its most potent analogue, Nle8-CER (other analogues were not tested) were inactive and MIF showed very little effectiveness. Additional experiments on hypothermia and sedation as well as evaluation of previous studies on other central actions suggested that the tremorolytic effect of CCK-like peptides is independent of other central effects. The CCK-like peptides may play a physiological role in the regulation of extrapyramidal motor activity.

    Topics: Alkaloids; Animals; Antiparkinson Agents; Benzodiazepinones; Ceruletide; Cholecystokinin; Clonazepam; Drug Antagonism; Harmine; Hypnotics and Sedatives; Ibogaine; Male; Mice; Mice, Inbred Strains; Oligopeptides; Oxotremorine; Peptide Fragments; Sincalide; Structure-Activity Relationship; Tremor

1983