cholecystokinin and Hepatitis

Topics: Amylases; Bicarbonates; Cholecystokinin; Chronic Disease; Clinical Trials as Topic; Enzyme Activation; Hepatitis; Humans; Lipase; Pancreas; Secretin; Time Factors; Trypsin

The motor activity of the gall bladder was studied using cholescintigraphy with 99m Tc-HIDA in 57 patients with chronic cholecystitis and chronic hepatitis and in 9 controls. A comparative analysis of the curves activity-time based upon the elements of images of the external contour and the entire zone of the gall bladder, made it possible to reveal differences in the type of reaction of the gall bladder to the use of cholagogic stimulators (cholecystokinin i.v. and cholagogic breakfast). A method of the processing of the results made it possible to determine the number of contraction phases of the gall bladder during its emptying as well as the true latent period and the period of primary reactions of the biliferous apparatus after taking a food stimulus.

Topics: Cholagogues and Choleretics; Cholecystitis; Cholecystokinin; Gallbladder; Hepatitis; Humans; Imino Acids; Peristalsis; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin

Topics: Adult; Antipyrine; Biotransformation; Cholecystokinin; Chronic Disease; Diabetes Mellitus; Hepatitis; Humans; Liver; Metabolic Clearance Rate; Pancreatitis

Size of gallbladder after overnight fasting and the kinetics of gallbladder contraction following i.v. injection of 1 I. U. of CCK was investigated in patients with chronic liver disease (liver cirrhosis: n = 26; chronic hepatitis: = 12; fatty liver: n = 5). The results were compared with those obtained in an age and sex matched control group of subjects without symptoms of diseases of the liver or gastrointestinal tract (n = 15). Ultrasound was used for continuous monitoring of gallbladder emptying. In the cirrhotics the cartographically determined initial area of the gallbladder was significantly greater than in the controls (p less than 0,01). The kinetic of gallbladder emptying following CCK-pancreozymin stimulation was similar in the groups of patients with liver diseases to that of the control subjects. However, the residual area of the gallbladder following maximal contraction was again significantly greater in the cirrhotics when compared to the control group (p less than 0.05). The area of the gallbladder in patients with chronic hepatitis exhibited similar changes of the values in the fasting state and after maximal contraction as seen in the patients with liver cirrhosis, although the differences when compared to the control group were not significant. The results show that in spite of distinct signs of a hypotonic state of the unstimulated gallbladder in patients with chronic liver disease the kinetic of contraction following an exogenous stimulus with CCK remains normal.

Topics: Adult; Aged; Cholecystokinin; Cholelithiasis; Fatty Liver; Female; Gallbladder; Hepatitis; Humans; Kinetics; Liver Cirrhosis; Liver Diseases; Male; Middle Aged; Muscle Contraction; Ultrasonography

Topics: Cholecystokinin; Chronic Disease; Drug Evaluation; Duodenal Ulcer; Hepatitis; Humans; Pancreatitis; Secretin

Topics: Cholecystokinin; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Liver Cirrhosis, Biliary; Pancreas; Pancreatic Juice; Secretin

Topics: Cholecystokinin; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Pancreas; Pancreatic Juice; Secretin; Secretory Rate

Serum lipase activity was measured in 360 patients with the clinical suspicion of chronic pancreatic disease, 60 of them also having the lipase evocation test (serum lipase activity before and after pancreatic stimulation with secretin and pancreozymin). Of 48 with chronic pancreatitis (40 confirmed at operation) the diagnosis was made by endoscopic retrograde pancretography in all but one. Serum lipase activity was abnormal in 38. Without those cases associated with pancreatic insufficency, serum lipase activity-spontaneously and after the evocation test-was abnormal in 46 patients. Nine of 10 patients with papillary stenosis had the diagnosis confirmed at surgery, the pancretographic findings co-inciding with the surgical ones in all instances. All the five patients with abnormally high serum lipase activity also had chronic pancreatitis on pancreatography. In all of the 18 patients with pancreatic neoplasm pancreatography gave the same results as operation or post-mortem findings. In eight of these serum lipase activity was spontaneously elevated. The lipase evocation test was shown to be most effective if 2 C.H.R.- U/KG-h each of pancreozymin and secretin were administered. Serum lipase results were falsely positive in 17 of 300 patients with clinical suspicion of pancreatic disease but normal pancreatographic findings.

Topics: Adult; Aged; Alcoholism; Cholecystokinin; Chronic Disease; Clinical Enzyme Tests; Duodenal Ulcer; Endoscopy; False Positive Reactions; Gallbladder Diseases; Hepatitis; Humans; Lipase; Liver Cirrhosis; Middle Aged; Pancreatic Neoplasms; Pancreatitis; Radiography; Secretin

Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Cholecystokinin; Cholesterol; Chronic Disease; Duodenum; Fasting; Female; Follow-Up Studies; Hepatitis; Humans; Hydroxysteroid Dehydrogenases; Injections, Intravenous; Liver Cirrhosis; Male; Middle Aged; Taurocholic Acid

Topics: Bile Acids and Salts; Cholecystokinin; Chronic Disease; Circadian Rhythm; Duodenum; Fasting; Female; Gallbladder; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Male; Taurocholic Acid

Topics: Acute Kidney Injury; Amylases; Biliary Tract Diseases; Cholecystokinin; Gastrointestinal Diseases; Hepatitis; Humans; Kidney Failure, Chronic; Lipase; Methods; Pancreas; Pancreatic Neoplasms; Pancreatitis; Parotitis; Secretin

Topics: Amylases; Cholecystokinin; Chronic Disease; Hepatitis; Hepatitis A; Humans; Pancreas; Pancreatic Ducts; Secretin; Trypsin

Topics: Cholecystokinin; Gastrointestinal Hormones; Hepatitis; Liver Cirrhosis; Pancreatic Diseases; Secretin