cholecalciferol and Vitamin-A-Deficiency

To detect risk factors that may be related to chalazia in children in southwest China.. Prospective case-control study.. The case group, 88 children with chalazia, was divided into 2 subgroups. One had 48 children 6 months to 6 years of age (defined as young children), and the other had 40 children 7 to 12 years of age (defined as older children). The control group consisted of 40 young children and 32 older children. Clinical findings for patients were recorded. Serum was tested for concentrations of vitamin A, vitamin D3, and immunoglobulin E.. World Health Organization definitions were used for vitamin A deficiency (< 0.7 μmol/L) and marginal vitamin A deficiency (0.7 to 1.05 μmol/L). The average level of serum vitamin A in the case group was significantly lower than that in the control group (P < .001). Analyses failed to find significant differences in vitamin D3 or immunoglobulin E levels between the case and control groups. The average vitamin A level in young children with multiple chalazia (0.65 ± 0.12 μmol/L) was low. Blepharitis was less prevalent than low serum vitamin A levels in the young child subgroup (odds ratios, 8.5 and 96.9, respectively), but higher than in older children (odds ratios, 17.5 and 9.0, respectively).. Low serum vitamin A is associated with a chalazion in young children in southwest China, especially young children with multiple chalazia.

Topics: Blepharitis; Case-Control Studies; Chalazion; Child; Child, Preschool; China; Cholecalciferol; Female; Humans; Immunoglobulin E; Infant; Male; Prevalence; Prospective Studies; Risk Factors; Vitamin A; Vitamin A Deficiency

The aim of this study was to estimate the concentration of cholecalciferol and 13-cis-retinoic acid (RA) in the plasma and pleural fluid of patients with tuberculosis (TB) against controls.. Plasma levels of cholecalciferol and 13-cis-RA were measured in 22 patients with TB and healthy controls and their pleural fluids levels were measured in 6 TB patients and diseased controls by established high-performance liquid chromatography-based procedure.. Cholecalciferol levels in plasma and pleural fluid of patients with TB and healthy controls were 67.45 (10.71) nmol/L and 21.40 (8.58) nmol/L compared with 117.43 (18.40) nmol/L (P < 0.001) and 94.73 (33.34) nmol/L (P = 0.0049), respectively. 13-cis-RA level in the plasma of patients with TB and healthy controls were 1.51 (0.72) nmol/L and 6.67 (0.81) nmol/L (P < 0.001), respectively. 13-cis-RA was not detectable in pleural fluid. The levels of both the agents were lower in patients with TB than in controls.. It was observed that in patients with TB there is a combined deficiency of cholecalciferol and 13-cis-RA compared with healthy volunteers. Because cholecalciferol and 13-cis-RA are in equilibrium with active ingredients of vitamins A and D, we feel that there is a combined deficiency of these vitamins in patients with TB. There is an evidence that concomitant vitamin A and D supplementation can kill intracellular Mycobacterium tuberculosis in vitro. Therefore, the observations made in this study can pave the path for a trial of combined supplementation of available formulations of vitamin A and D (cholecalciferol and 13-cis-RA) for novel anti-tubercular drug therapy. Because such an approach is host-based it has potential to treat even multidrug-resistant and extensively drug-resistant forms of TB.

Topics: Adolescent; Adult; Aged; Case-Control Studies; Cholecalciferol; Dietary Supplements; Drug Resistance, Multiple, Bacterial; Female; Humans; Isotretinoin; Male; Middle Aged; Mycobacterium tuberculosis; Tuberculosis; Vitamin A Deficiency; Vitamin D Deficiency; Young Adult

Topics: Animal Feed; Animals; Cattle; Cattle Diseases; Cholecalciferol; Lameness, Animal; Male; Rickets; Vitamin A Deficiency

Topics: Alkaline Phosphatase; Animal Nutritional Physiological Phenomena; Animals; Bone and Bones; Calcitonin; Calcium; Calcium, Dietary; Cholecalciferol; Hydroxyproline; Intestinal Mucosa; Male; Rats; Time Factors; Vitamin A; Vitamin A Deficiency

Topics: Animals; Chickens; Cholecalciferol; Deficiency Diseases; Fertility; Insemination, Artificial; Liver; Male; Nutritional Requirements; Poultry Diseases; Reproduction; Riboflavin; Riboflavin Deficiency; Seasons; Semen; Spermatozoa; Testis; Vitamin A; Vitamin A Deficiency

Topics: Adenine Nucleotides; Adenosine Triphosphate; Animal Nutritional Physiological Phenomena; Animals; Avitaminosis; Chickens; Cholecalciferol; Chromatography, Paper; Folic Acid Deficiency; Liver; Male; Nucleotidyltransferases; Phosphotransferases; Riboflavin Deficiency; Sulfates; Sulfur Isotopes; Sulfuric Acids; Sulfurtransferases; Taurine; Thiamine Deficiency; Vitamin A Deficiency; Vitamin B 6 Deficiency; Vitamin D Deficiency

Topics: Administration, Oral; Animals; Bone Diseases; Cholecalciferol; Diet; Ergocalciferols; Gout; Haplorhini; Hypercalcemia; Kidney; Macaca; Nephrocalcinosis; Uric Acid; Vitamin A Deficiency