cholecalciferol has been researched along with Rodent-Diseases* in 3 studies
3 other study(ies) available for cholecalciferol and Rodent-Diseases
| Article | Year |
|---|---|
SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET.
An 8 yr, intact male red-rumped agouti ( Dasyprocta leporina) was evaluated for weight loss. Examination revealed poor body condition, hypercalcemia, elevated serum 25-hydroxyvitamin D, metastatic calcification of soft tissues, and hyperechoic kidneys. The diet, formulated for laboratory rodents, contained elevated levels of vitamin D Topics: Animal Feed; Animals; Animals, Zoo; Cholecalciferol; Dasyproctidae; Diet; Drug Overdose; Male; Rodent Diseases | 2018 |
Vitamin D3 intoxication in naked mole-rats (Heterocephalus glaber) leads to hypercalcaemia and increased calcium deposition in teeth with evidence of abnormal skin calcification.
Naked mole-rats have no access to obvious sources of vitamin D and therefore have an impoverished vitamin D status. In an investigation into the effects of vitamin D supplementation, inadvertently supraphysiological doses of 130,000 times the normal dose of vitamin D were administered. Within 5 days animals appeared lethargic, with reduced food intake. All but one of the seven animals were killed and blood was collected. Plasma vitamin D metabolites 25(OH)D and 1,25(OH)2D and calcium were determined. Both vitamin D metabolite concentrations exceeded the upper limits of sensitivity of the assays (> 100 ng/ml 25(OH)D and > 210 pg/ml 1,25(OH)2D). Active calcium uptake in the intestine was evident along with concomitant increases in calcium concentration in plasma, bone, and teeth. The remaining animal survived, but showed scab-like formations in the skin around the lower jaw and along the nipple line. X-ray analyses revealed calcium deposition in these cornified regions, although there was no evidence of metastatic calcification in other tissues. Deposition of excess calcium in skin that is regularly sloughed off and in teeth that are continuously worn down and replaced may reduce the vitamin D-induced hypercalcaemia and thus alleviate the effects of vitamin D intoxication. Topics: Animals; Calcinosis; Calcium; Cholecalciferol; Hypercalcemia; Rodent Diseases; Rodentia; Skin Diseases; Tooth | 1995 |
[Experimental studies on extraosseous calcification in hypervitaminosis D3. I. Significance of proteoglycans in the early stages of calcification in the rat].
Topics: Animals; Aorta; Calcinosis; Calcium; Cholecalciferol; Female; Kidney; Male; Myocardium; Proteoglycans; Rats; Rats, Inbred Strains; Rodent Diseases | 1982 |