cholecalciferol and Rett-Syndrome

Low bone mass is a frequent and early complication of girls with Rett syndrome. As a consequence of the low bone mass, Rett patients are at an increased risk of fragility fractures. This study aimed to investigate the long-term influences of mobility on bone status in girls with Rett syndrome.. In 58 girls with Rett syndrome, biochemical parameters and quantitative ultrasound parameters at phalanges (amplitude-dependent speed of sound: AD-SoS and bone transmission time: BTT) were measured at baseline and after 5 and 10 years. The subjects were divided into two groups: nonambulatory (n = 28) and ambulatory (n = 30).. In nonambulatory Rett subjects, the values of AD-SoS and BTT were significantly lower than in ambulatory Rett subjects at each time point. However, during the 10-year follow-up both ambulatory and nonambulatory Rett patients showed a similar worsening in their bone status.. This longitudinal study suggests that both ambulatory and nonambulatory Rett subjects present a progressive deterioration of bone status as assessed by quantitative ultrasound parameters, and the ambulatory impairment and the nutritional status seem to play a key role in the deterioration of bone status.

Topics: Absorptiometry, Photon; Adolescent; Bone and Bones; Bone Density; Child; Child Nutrition Sciences; Child, Preschool; Cholecalciferol; Disabled Persons; Female; Finger Phalanges; Follow-Up Studies; Fractures, Bone; Humans; Infant; Longitudinal Studies; Nutritional Status; Rett Syndrome; Surveys and Questionnaires; Ultrasonography; Vitamin D; Walking