cholecalciferol and Pruritus

It is generally accepted that topical steroid ointment and anti-histamine drug are the first choice of the treatment on pruritic skin diseases such as contact dermatitis, urticaria, prurigo, or pruritus cutanea. Among these diseases, prurigo is one of the most refractory skin disease to the common therapies. In this review, we would like to summarize the effect of vitamin D(3) to refractory skin disease on the basis of our clinical study.

Topics: Administration, Topical; Animals; Cell Adhesion Molecules; Cell Differentiation; Cell Division; Cholecalciferol; Cytokines; Depression, Chemical; Epidermal Cells; Humans; Keratinocytes; Pruritus

This prospective study is aimed at observing the number of nasal itching and sneezing in rats from the macroscopic level and examine the pathological changes of nasal mucosa, Th1 and Th2-related cytokines, and Treg/Th17 by vitamin D3 administration from the microscopic level, in order to explore the role of vitamin D in allergic rhinitis and to provide theoretical guidance for prevention and treatment.. There were significant differences in nasal itching and sneezing between the administration groups and the positive groups. Meanwhile, the level of Th1 and Treg in the administration groups increased, while the level of Th2 and Th17 decreased, indicating that the balance of Th1/Th2 was corrected. Our study revealed that vitamin D3 has preventive and therapeutic effects on allergic rhinitis, which provides theoretical guidance for practical application.

Topics: Animals; Cholecalciferol; Cytokines; Disease Models, Animal; Prospective Studies; Pruritus; Rats; Rhinitis, Allergic; Sneezing; T-Lymphocytes, Regulatory; Vitamin D