cholecalciferol and Otosclerosis

Topics: Cholecalciferol; Humans; Male; Middle Aged; Otoacoustic Emissions, Spontaneous; Otosclerosis; Tinnitus; Vitamin D Deficiency; Vitamins

A rat animal model was used to study the ultrastructure of submucosal calcifications induced in the middle ear following inoculation with Streptococcus pyogenes and high doses of parenteral vitamin D3. The morphological changes present in affected animals resembled the classical picture of tympanosclerosis. While calcification occurred about bacterial remnants and myelin structures, the most important calcification centers were lysosomal and non-lysosomal matrix vesicles in the extracellular spaces. These formed band-like calcifications close to the basal membrane without affecting the epithelial layer. This animal model offers the possibility of studying the effect of various therapeutic regimens in the treatment of the dynamic tympanosclerotic process.

Topics: Animals; Calcinosis; Cholecalciferol; Ear, Middle; Epithelium; Microscopy, Electron; Mucous Membrane; Otosclerosis; Rats; Rats, Inbred Strains; Streptococcal Infections; Streptococcus pyogenes

Topics: Animals; Calcinosis; Calciphylaxis; Cholecalciferol; Disease Models, Animal; Ear, Middle; Granulation Tissue; Guinea Pigs; Histocytochemistry; Male; Ossification, Heterotopic; Otosclerosis; Tympanic Membrane

Topics: Animals; Calcinosis; Calciphylaxis; Cholecalciferol; Disease Models, Animal; Ear, Middle; Guinea Pigs; Male; Mucous Membrane; Ossification, Heterotopic; Otosclerosis; Tympanic Membrane