cholecalciferol and Myositis-Ossificans

Fibrodysplasia ossificans progressiva (FOP) is a debilitating rare disease known for episodic endochondral heterotopic ossification (HO) caused by gain-of-function mutations in ACVR1/ALK2. However, disease severity varies among patients with identical mutations suggesting disease-modifying factors, including diet, may have therapeutic implications. The roles of vitamin D. In vitro and in vivo studies suggest vitamin D suppresses inflammation, while clinical studies suggest that vitamin D

Topics: Activins; Animals; Bone Morphogenetic Proteins; Cholecalciferol; Chondrogenesis; Humans; Myositis Ossificans; Signal Transduction