cholecalciferol and Lactose-Intolerance

To investigate the effects of milk with inulin and vitamin D3 on bone health and gastrointestinal symptoms in lactose intolerance( LI) population.. A total of 42 volunteers diagnosed as LI by breath hydrogen test were randomized into A or B group. Whole milk supplemented with inulin( 150 mg /100 g), vitamin D3( 2. 0μg /100 g), casein phosphopeptides( 5. 0 mg /100 m L), milk minerals( 40 mg /100 g), and low-lactose whole milk were given to A or B groups respectively. Bone mass density( BMD), calcium absorption and gastrointestinal symptoms were measured at the 0th and6 th week of the intervention.. After 6 weeks, BMD increased significantly in group A( P = 0. 013). In group B, BMD also increased but the trend was not significant. Calcium absorption increased in group A but decreased slightly in group B, the trends in both groups lacked of statistic significant. Gastrointestinal symptoms were ameliorated in both groups, but still there was no significance. For all the measurements, there was nostatistic significant difference between groups.. Milk with inulin and vitamin D3 could improve bone health in LI population, gastrointestinal symptoms after drinking this certain milk were analogous to low lactose milk.

Topics: Animals; Breath Tests; Calcium, Dietary; Cholecalciferol; Humans; Inulin; Lactose Intolerance; Milk; Treatment Outcome; Vitamin D

As decreased bone mineral density (BMD) is a common problem in cystic fibrosis (CF) and milk products may have pivotal dietary role affecting BMD, we aimed to assess the potential influence of adult-type hypolactasia (ATH) and lactose malabsorption (LM) on BMD in adolescent and young adult patients. In 95 CF pancreatic-insufficient patients aged 10-25 years (without liver cirrhosis, steatosis and cholestasis, diabetes mellitus, systemic glucocorticoid therapy), lumbar BMD, the nutritional status, pulmonary function, vitamin D3 concentration, calcium intake and single-nucleotide polymorphism upstream of the lactase gene were assessed. In subjects with the -13910 C/C genotype predisposing to ATH, the presence of LM was determined with the use of a hydrogen-methane breath test (BT). BMD and calcium intake were significantly lower in patients with the C/C genotype (P<0.028 and P<0.043, respectively). The abnormal BMD was stated more frequently in patients with the C/C genotype (P<0.042) and with LM (P<0.007). BMD, daily calcium intake and serum vitamin D concentration were significantly lower in LM subjects than in the other patients (P<0.037, P<0.000004 and P<0.0038, respectively). In logistic regression analysis, the relationship between examined parameters and BMD, was found to be statistically significant (P<0.001). However, only standardized body weight and LM were documented to influence BMD (P<0.025 and P<0.044, respectively). In conclusion, LM seems to be an independent risk factor for decreased BMD in CF patients.

Topics: Adult; Body Weight; Bone Demineralization, Pathologic; Bone Density; Breath Tests; Calcium; Child; Cholecalciferol; Cystic Fibrosis; Female; Humans; Lactase; Lactose Intolerance; Male; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Factors