cholecalciferol and Hyperlipidemias

Topics: Bone and Bones; Bone Density; Bone Density Conservation Agents; Cholecalciferol; Collagen Diseases; Diphosphonates; Glucocorticoids; Humans; Hyperlipidemias; Osteoporosis; Vitamin K 2

Topics: Anemia, Hypochromic; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Cardiac Output; Cholecalciferol; Chronic Kidney Disease-Mineral and Bone Disorder; Erythropoiesis; Glucose; Hemolytic-Uremic Syndrome; Humans; Hyperlipidemias; Hypertension, Renal; Infertility, Male; Kidney Failure, Chronic; Male; Parathyroid Hormone; Peripheral Nervous System Diseases; Phosphates; Renal Dialysis; Triglycerides

Topics: Alcoholism; Animals; Cholecalciferol; Choline Deficiency; Ethanol; Fatty Liver; Glutamates; Humans; Hyperlipidemias; Hypoglycemia; Intestinal Absorption; Iron; Ketones; Liver Cirrhosis; Magnesium Deficiency; Mitosis; Nutritional Physiological Phenomena; Rats; Thiamine; Thiamine Deficiency; Uric Acid; Vitamin B 6 Deficiency; Zinc

Our study aimed to examine the effects of daily consumption of vitamin D3-supplemented yogurt (VDY) drink on insulin resistance and lipid profiles in pregnant gestational diabetes mellitus (GDM) patients.. Participants aged 24-32 years in their second trimester were randomly assigned to consume either plain yogurt or VDY daily for 16 weeks. Metabolic and lipid profiles including levels of fasting plasma glucose (FPG), serum insulin, triacylglycerol (TAG), total cholesterol (TC) and low-density lipoprotein (LDL) were assessed at baseline (week 0) and end of trial (week 16).. After 16 weeks of intervention, insulin-related variables including FPG and serum insulin levels were markedly lower in VDY group participants. Insulin resistance parameters, such as homeostasis model of assessment of insulin resistance and β cell function, were also significantly reduced in VDY group participants. Moreover, levels of TAG, TC and LDL, as well as the TC to high-density lipoprotein ratio, had also significantly decreased in the VDY group.. Daily consumption of VDY drink improves insulin resistance and lipid profiles in women with GDM.

Topics: Adult; Beverages; Biomarkers; Calcifediol; China; Cholecalciferol; Diabetes, Gestational; Double-Blind Method; Female; Food, Fortified; Humans; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Lipids; Maternal Nutritional Physiological Phenomena; Patient Dropouts; Pregnancy; Pregnancy Trimester, Second; Yogurt; Young Adult

Inverse associations between 25-OH vitamin D levels and cardiovascular morbidity and mortality have been reported.. Our goals were to 1) investigate effects of correcting inadequate D status on lipids, 2) determine whether free 25-OH D is better correlated with lipids than total 25-OH D.. A randomized, double-blind placebo-controlled trial was performed.. Participants resided in the general community.. Adults with inadequate D status were randomized to D3: 14 men, 12 women, age 60 ± 8 years (mean ± SD) or placebo: 12 men, 11 women: 59 ±12 years.. Responses to 12-week oral vitamin D3 titrated (1000-3000 IU/d) to achieve 25-OH D levels ≥25 ng/mL were compared to placebo.. Measurements were 25-OH D (tandem mass spectometry), free 25-OH D (direct immunoassay), lipids (directly measured triglyceride, cholesterol, and subfractions; plant sterols and cholesterol synthesis precursors), and safety labs before and after 6 and 12 weeks D3 or placebo. Data were analyzed by repeated measures ANOVA and linear regression.. Vitamin D3 was titrated to 1000 IU/d in 15/26 (58%), to 2000 IU/d in 10, and 3000 IU/d in one patient. D3 had no effect on cholesterol or cholesterol subfractions except for trends for decreases in atorvastatin-treated patients (cholesterol, P = .08; low-density lipoprotein [LDL] cholesterol, P = .05). Decreased campesterol concentrations (P = .05) were seen with D3 but not placebo in statin-treated patients. Relationships between total 25-OH D and lipids were not detected, but inverse linear relationships were detected between free 25-OH D and triglycerides (P = .03 for all participants [n = 49], P = .03 in all statin-treated [n = 19], and P = .0009 in atorvastatin-treated [n = 11]), and between free 25-OH D and LDL cholesterol (P = .08 overall, P = .02 in all statin-treated, and P = .03 for atorvastatin-treated), and total cholesterol (P = .09 overall; P = .04 for all statin-treated, and P = .05 for atorvastatin-treated).. Vitamin D lipid-lowering effects appear limited to statin-treated patients and are likely due to decreased cholesterol absorption. Relationships between lipids and D metabolites were only detected when free 25-OH D was measured, suggesting the superiority of determining free 25-OH D levels compared to total 25-OH vitamin D levels when analyzing biologic responses.

Topics: Administration, Oral; Aged; Cholecalciferol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Linear Models; Lipid Metabolism; Lipids; Male; Middle Aged; Vitamin D; Vitamins

Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury (MI). The present study aimed to illustrate the pattern of myocardial injury induced in diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-dehydrogingerdione (10-DHGD) intake either individually or in combination form.

Topics: Animals; Aorta; Biomarkers; Blood Glucose; Cholecalciferol; Diabetes Mellitus, Experimental; Fatty Acid Binding Protein 3; Glycated Hemoglobin; Glycopeptides; Guaiacol; Hyperlipidemias; Lipids; Male; Myocardium; Rats, Wistar; RNA, Messenger

Vitamin D deficiency is one of the most common chronic medical conditions in the world and also prevalent in Australia. A growing body of evidence suggests that low vitamin D also has adverse effects on cardiovascular health, including coronary risk factors and adverse cardiovascular outcomes such as myocardial infarction, cardiac failure and stroke. There is some evidence suggesting that a greater proportion of people with cardiovascular disease have low vitamin D compared to the general population. We examined the prevalence of vitamin D deficiency and insufficiency in elective cardiothoracic surgical patients presenting to the Alfred Hospital in Melbourne, Australia and compared this to recent Victorian statistics for people of the same age group.. Consecutive adult elective cardiothoracic surgical patients listed for either coronary artery bypass graft surgery or heart valve repair or replacement surgery attending The Alfred Hospital, Melbourne between July 2011 and October 2012 were invited to participate. This ensured that patients were enrolled over all four seasons. Fasting serum samples were taken on the day of surgery, immediately after admission. Eighty volunteers participated in the study. Of the group, 40% were due to have coronary artery bypass graft surgery, 35% valve surgery and 25% a combination of the two; 74% reported having hypertension, 69% hyperlipidaemia, 26% diabetes and 39% had a BMI >30 kg/m(2).. Test results revealed that 92.5% of patients had Vitamin D levels < 75 nmol/L, 67.5% had levels < 60 nmol/L, 52.5% had levels between 30-59 nmol/L and 15% had levels < 30 nmol/L. Inadequate vitamin D levels were found in 80% of obese patients (BMI > 30 kg/m(2)) compared to 59% of non-obese patients.. Based on our small screening study, a substantial proportion of elective cardiothoracic surgical patients have less than optimal serum vitamin D3 levels prior to surgery. We found two-thirds of patients had serum vitamin D levels below 60 nmol/L, placing them at higher risk of falls. This finding is of concern as these patients would have received multiple consultations with various medical practitioners prior to hospital admission and yet their inadequate vitamin D status remained. Failing to identify patients with low vitamin D and correcting it with supplementation places older adults at unnecessary risk, especially of falls, which are associated with a high risk of mortality. In an ageing population with CVD, vitamin D status needs to be assessed and any inadequacy corrected. Whether low vitamin D status prior to cardiac surgery affects post-surgery outcomes, is another issue which deserves future investigation.

Topics: Aged; Australia; Cardiac Surgical Procedures; Cardiac Valve Annuloplasty; Cholecalciferol; Coronary Artery Bypass; Diabetes Mellitus; Female; Heart Valve Prosthesis Implantation; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Obesity; Prevalence; Vitamin D Deficiency

Authors by a new combined diet consisting of cholesterol vitamin D3 and sour cream produced clinico-biochemical changes characteristic for atherosclerosis in a very short period in rabbits. This diet caused severe lipoproteinaemia, hypercholesterinaemia and microscopis and macroscopic changes in the aortic wall. Authors assume, that this diet is suitable for producin atherosclerosis in a short period.

Topics: Animals; Arteriosclerosis; Cholecalciferol; Cholesterol; Diet, Atherogenic; Hypercholesterolemia; Hyperlipidemias; Rabbits

Topics: Cholecalciferol; Cholesterol; Chromatography; Glycerides; Hyperlipidemias; Hyperlipoproteinemia Type I; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type III; Metabolism; Sterols; Tendons; Xanthomatosis