cholecalciferol and Hirsutism

The objective of this study was to investigate the effect of vitamin D treatment on androgen levels and hirsutism scores in overweight women with PCOS.. A prospective, randomized, double-blind, placebo-controlled clinical study was conducted at King Abdullah University Hospital in Irbid, Jordan. Overweight Jordanian females aged 18-49 years with vitamin D deficiency and PCOS (n = 60) were assigned to two groups: the treatment group (n = 30) who received 50,000 IU per week of vitamin D. After receiving the treatment for 12 consecutive weeks, the levels of total testosterone, parathyroid hormone, free androgen index, and hirsutism score were significantly decreased (P < 0.001), and the levels of 25-hydroxyvitamin D (25(OH)D), sex hormone binding globulin, and phosphorus were significantly increased (P < 0.05). Furthermore, significant changes were observed in ovarian volume and follicle numbers and size ultrasonography, and in the regularity of the menstrual cycle (P < 0.001). In the placebo group, no significant changes were observed in either androgen levels, hirsutism score, or menstrual regularity.. Vitamin D. NCT02328404.

Topics: Adolescent; Adult; Androgens; Cholecalciferol; Dietary Supplements; Double-Blind Method; Female; Hirsutism; Humans; Jordan; Middle Aged; Overweight; Parathyroid Hormone; Polycystic Ovary Syndrome; Prospective Studies; Testosterone; Treatment Outcome; Vitamin D; Vitamin D Deficiency; Vitamins; Young Adult