cholecalciferol and Hair-Diseases

Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

Topics: Alopecia; Animals; Cell Differentiation; Cell Proliferation; Cholecalciferol; Cholesterol; Cicatrix; Hair; Hair Diseases; Hair Follicle; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrichosis; Ichthyosis; Keratinocytes; Lipid Metabolism; Lipids; Mice; Mutation; Peroxisome Proliferator-Activated Receptors; Phenotype; Signal Transduction; Skin Physiological Phenomena; Steroids; Sterols

The rate of premature greying, referred to as canities, varies among populations, and effective treatments are lacking. However, few studies at the molecular level have been reported.. Comparing lipid profiles of individuals with premature canities and healthy volunteers to explore the mechanism of premature canities.. Ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to detect lipids in the hair follicle root. Multivariate data analysis was used to show lipid changes in follicle roots.. We identified lipids in the hair follicle root that differ between black and white hair and analysed key lipids contributing to white hair development. We divided the samples into three groups: PC-WH (Premature canities-White hair), PC-PH (Premature canities-Pigmented hair), Control-PH (Pigmented hair). Phosphatidylethanolamine (PE), phosphatidylcholine (PC), vitamin D3 (VD3) and cholesterol in Control-PH were higher than those in PC-WH. Sphingomyelin (SP), phosphatidic acid (PA), VD3 and diglyceride (DG) were lower in PC-WH than in PC-PH. Levels of VD3 were highest in Control-PH, gradually decreased as the severity of PC-PH increased and were lowest in PC-WH.. There are 7 main class candidate compounds involved in the generation of white hair. VD3 showed a substantial decrease in white hair and was a potential target for further studies of premature canities.

Topics: Adolescent; Adult; Biomarkers; Case-Control Studies; Cholecalciferol; Cholesterol; Chromatography, Liquid; Diglycerides; Hair Color; Hair Diseases; Hair Follicle; Humans; Lipids; Mass Spectrometry; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Sphingomyelins; Young Adult

PIBIDS syndrome (photosensitivity, ichthyosis, brittle hair, intellectual impairment, decreased fertility and short stature) is a variant of trichothiodystrophy. It is a rare form of autosomal recessive congenital ichthyosis. Short stature is a vital component of PIBIDS syndrome. We present the cases of two siblings in whom we diagnosed PIBIDS syndrome. On evaluation for short stature, they were found to have severe vitamin D deficiency, which on correction led to the patients having considerable gain in stature. With this case, we would also like to propose that vitamin D deficiency could be one of the treatable causes of short stature in PIBIDS syndrome.

Topics: Adolescent; Child; Cholecalciferol; Consanguinity; Emollients; Growth Disorders; Hair Diseases; Humans; Ichthyosis; Male; Photosensitivity Disorders; Siblings; Sunscreening Agents; Trichothiodystrophy Syndromes; Vitamin D Deficiency; Vitamins