cholecalciferol and Erythema

Topics: Animals; Cholecalciferol; Environment; Erythema; Herpes Simplex; Humans; Lighting; Melatonin; Models, Biological; Psoriasis; Seasons; Spectrum Analysis; Sunlight

Sunburn and other health risks associated with excess sun exposure place huge economic burdens on societies, and create discomfort and disease within susceptible individuals. Oral supplements that reduce sunburn may be advantageous. This study evaluated the safety and efficacy of Bend Skincare Anti-Aging Formula to ameliorate sunburn induced with a solar simulator.. Subjects (n = 28) with Fitzpatrick skin phototypes I, II, or III took 4 capsules daily of the supplement providing 1400 mg of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), 120 mg of gamma-linolenic acid (GLA), 5 mg of lutein, 2.5 mg of zeaxanthin, and 1000 IU of vitamin D3 for 8 weeks. Skin on each subject's back was exposed to a progressive sequence of timed ultraviolet (UV) radiation exposure doses at baseline, and after 4- and 8-week treatment to determine their minimal erythema dose (MED). Results were compared before and after treatment using 3 paired t tests and subsequently 3 linear mixed models.. Treatment significantly improved tolerance to UV exposure as evidenced by increased MED at 4 and 8 weeks compared with baseline (P < .001). This protection increased with prolonged use of Bend Skincare Anti-Aging Formula as demonstrated by progressively increased MED between baseline and 4 weeks, and again between 4 and 8 weeks (P < .001). Nearly 86% of patients responded to treatment within 4 weeks and 100% of patients responded by the end of the study, resulting in a 39% mean increase in MED at 4 weeks, and an 84% mean increase in MED at 8 weeks compared with baseline. Treatment was well tolerated with no product associated adverse events (AE) and only a few mild and expected side effects.. Bend Skincare Anti-Aging Formula safely and effectively provides significant skin photoprotection that increases with continued use.

Topics: Adult; Aged; Cholecalciferol; Erythema; Fatty Acids, Omega-3; Female; Humans; Lutein; Male; Middle Aged; Skin Aging; Time Factors; Ultraviolet Rays; Zeaxanthins

To assess the effectiveness of three UV emitting lamps on the cutaneous production of vitamin D. Human skin samples (skin types II, III and IV) obtained from surgery were exposed to three different UV emitting lamps for varying times and then extracted and chromatographed to determine the vitamin D. It was observed that the spectral output of the 3 lamps had different effects on the cutaneous production of vitamin D. The spectral output of the experimental UVB emitting lamps significantly influenced the cutaneous production of vitamin D

Topics: 8-Hydroxy-2'-Deoxyguanosine; Cholecalciferol; Dose-Response Relationship, Radiation; Erythema; Humans; Nitric Oxide; Skin; Ultraviolet Rays

It is well known that excessive exposure to solar ultraviolet (UV) radiation can have serious adverse effects. Many everyday materials influence the UV radiation received by humans, for example, those used in construction and on the exterior of buildings such as plastics and glass can reduce the UV exposure of persons exposed to solar radiation. In this paper we analyse the spectral transmission of solar radiation of widely used materials using the transmittance parameter. The measurements were performed on clear days, at 8 h and 12 solar hours, in July 2018 (five days) and in January 2019 (three days). The spectral transmittances of these materials and the integrated transmittances in the UVB from 300 nm, UVA, visible (VIS) and near infrared ranges (NIR) were calculated. In summer in the UVB range from 300 nm methacrylate and smoked glass have the highest transmittance values (56%) and polycarbonate present the lowest (30%). In the VIS and NIR ranges methacrylate (95%) and smoked glass (80%) have the highest transmittances and polycarbonate the lowest (45%). In general the 8 h transmittances are higher than those at 12 h and are also higher in winter than summer. For two biological functions (erythemal and DNA-damage) and for the UVB range from 300 nm, the transmittance for most materials (except fibreglass) is in the range 6-14%. The exposure times obtained show that erythemal damage could occur after long exposure to solar radiation through the materials studied, information which should be made available to the general public.

Topics: Cholecalciferol; DNA Damage; Erythema; Glass; Humans; Methacrylates; Plastics; Seasons; Sunlight; Ultraviolet Rays

Cholecalciferol (vitamin D3), produced in the skin by UVB irradiation (290-315nm) of 7-dehydrocholesterol, is metabolized in the liver into 25-hydroxyvitamin D [25(OH)D] which is a major circulating metabolite.. To examine changes in serum concentrations of cholecalciferol and its metabolites after UVB exposure of different skin areas.. 21 healthy Caucasians (skin type II and III, aged 23-47years) were exposed to broadband UVB (290-320nm) and randomized to either exposure to one minimal erythema dose given as a single dose, or a suberythemic dose given for 3 subsequent days. The following areas were exposed: face and back of hands, upper half of the body and the whole body, respectively. Serum cholecalciferol and 25(OH)D were measured immediately before start and 24h after the 1st and last exposure, respectively.. Subjects with whole body exposure had an average S-cholecalciferol increase per dose unit of 0.18ngml(-1)mJ(-1)cm(2), 0.95 CI: (0.16, 0.20), upper body treatment 0.13ngml(-1)mJ(-1)cm(2), 0.95 CI: (0.10, 0.15) and face and hands exposure 0.013ngml(-1)mJ(-1)cm(2), 0.95 CI: (-0.012, 0.037). The increase in cholecalciferol correlated positively to the UVB dose and skin erythema and negatively to body mass index (BMI) when controlling for other factors. Exposure of face and hands induces smaller cholecalciferol production in comparison with exposure of larger skin areas.. Size of the exposed skin area, UVB dose, skin erythema and BMI were the major determinants for serum levels of skin synthesized cholecalciferol. Exposure of hands and face induces smaller cholecalciferol production in comparison with exposure of larger skin areas.

Topics: Adult; Body Mass Index; Body Surface Area; Cholecalciferol; Dose-Response Relationship, Radiation; Erythema; Female; Humans; Male; Middle Aged; Random Allocation; Seasons; Skin; Ultraviolet Rays; Vitamin D; Young Adult

Polysulphone (PS) dosimetry is a well-known technique broadly used to assess the erythemally effective solar UV dose received by anatomical sites (personal exposure). We investigate the capability of PS dosimetry to convert doses absorbed by PS badges into biologically effective solar UV exposures taking as examples two relevant effects for human skin: erythema induction and pre-vitamin D3 production. PS calibration curves for erythemal and pre-vitamin D3 were distinctly determined by using an empirical relationship between the biologically effective UV exposures and the PS absorbance change. This relationship is parameterized by a coefficient, distinct for each of the two considered biological effects, multiplying the same cubic polynomial function. It is shown how the multiplying coefficient is related to the ratio between the biologically effective and the PS weighted irradiances which is the prevailing factor affecting the accuracy of the calibration and, consequently, the capability of PS films for measuring biologically effective solar UV exposures. The points addressed in this paper can be extended to other biological effects of interest whose action spectra have some similarity with the PS film response.

Topics: Absorption; Algorithms; Calibration; Cholecalciferol; Dose-Response Relationship, Radiation; Erythema; Film Dosimetry; Humans; Linear Models; Models, Biological; Ozone; Polymers; Skin; Sulfones; Sunlight; Ultraviolet Rays

While erythemal irradiance as a potentially damaging effect to the skin has been extensively studied and short-term forecasts have been issued to the public to reduce detrimental immediate and long-term effects such as sunburn and skin cancer by overexposure, beneficial effects to human health such as vitamin D(3) production by UV radiation and melatonin suppression by blue visible light have attained more and more attention, though both of them have not become part of forecasting yet. Using 4years of solar radiation data measured at the mid-latitude site Lindenberg (52°N), and forecast daily maximum UV index values, an overall good correspondence has been found. The data base of solar UV radiation and illuminance has also been used to analyze effects of clouds and aerosols on the effective irradiance. Optically thick clouds can strongly modify the ratios between erythemal and vitamin D(3) effective irradiance such that direct radiative transfer modeling of the latter in future UV forecasts should be preferably used. If parameterizations of vitamin D(3) effective irradiance from erythemal irradiance are used instead, the optical cloud depth would have to be taken into account to avoid an overestimation of vitamin D(3) with parameterizations neglecting cloud optical depth. Particular emphasis for the beneficial effects has been laid in our study on low exposure. Daily doses of solar irradiation for both vitamin D(3) and melatonin suppression do not reach minimum threshold doses even with clear sky and unobstructed horizon during the winter months.

Topics: Cholecalciferol; Databases, Factual; Erythema; Health; Humans; Melatonin; Radiation Dosage; Radiation Monitoring; Time; Ultraviolet Rays

While there is limited documentation that certain indoor tanning lamps effectively produce vitamin D, the diversity of such devices has not been extensively surveyed. This study compares the spectral effectiveness of a variety of tanning units, and solar spectra, for ultraviolet (UV) photosynthesis of pre-vitamin D3 (preD3) and UV induced erythema. Well-established techniques exist for the calculation of spectral effectiveness for photobiological responses that have defined action spectra. Using spectroradiometric data from sunlamp measurements, and standard solar reference spectra, we computed effective irradiances using the CIE action spectrum for the production of preD3 in human skin and the ISO/CIE human erythema reference action spectrum. We found, as with sunlight at different times or latitude, the preD3 and erythemal effectiveness of sunlamps varied as a function of the UV-B proportion of the spectrum. Ratios of sunlamp preD3 to erythemal effectiveness ranged from approximately 0.5 to nearly 2.0, similar to ratios for sunlight. Optimal risk to benefit conditions for preD3 from solar UV exposure occurs under high solar altitude, low zenith angle, midday midsummer sunlight. Analogous optimal preD3 exposure conditions are provided by low to intermediate pressure sunlamps with greater UV-B spectral overlap with the preD3 action spectrum. Similar to low altitude or high latitude sunlight, high pressure tanning units, filtered for negligible UV-B emissions, have insignificant vitamin D benefit. We conclude that while vitamin D can be made by both UVB exposure from indoor tanning units and by exposure UVB from sunlight, the effect is also comparably variable. Unlike sunlight, indoor tanning offers privacy and environmental conditions for practical full body exposure, lowering the requisite exposure per skin surface area, and device timers limit the potential of overexposure. Guidance for optimal use of tanning sources for vitamin D benefit is needed.

Topics: Cholecalciferol; Erythema; Humans; Light; Skin; Skin Aging; Skin Neoplasms; Skin Pigmentation; Sunbathing; Sunlight; Ultraviolet Rays

The short wavelength cut-off (lambdac), the wavelength of the maximum spectral UV (lambdaMax) of spectral pre-vitamin D3 effective solar UV irradiance (UVD3), and the spectral erythemal UV (UVEry) were compared at 5-min intervals over a 6-month period at solar zenith angles (SZA) ranging from 4.7 degrees to 80 degrees. Averaged over the entire period, lambdac for UVD3 is higher by 1.05 nm than that for UVEry. The lambdaMax is higher for UVD3 compared to UVEry for SZA55 degrees), the ratio of lambdaMax for UVD3 to that for UVEry is less than 1. As the erythemal action spectrum extends into the UVA, the ratio of UVD3 to UVEry irradiances decreases with increasing SZA, along with a decrease in the ratio of lambdaMax for UVD3 compared to UVEry. The changes in lambdac and lambdaMax influence both personal UVD3 and UVEry exposure and, to take this into account, a dual calibration technique for polysulphone dosimeters has been developed to simultaneously provide measurements of both types of exposure.

Topics: Cholecalciferol; Erythema; Humans; Radiobiology; Relative Biological Effectiveness; Skin; Ultraviolet Rays

Topics: Animals; Antineoplastic Agents; Cholecalciferol; Dose-Response Relationship, Radiation; Erythema; Mice; Skin; Ultraviolet Rays

Topics: Cholecalciferol; Erythema; Female; Humans; Male; Photosynthesis; Skin Pigmentation; Ultraviolet Rays