cholecalciferol and Down-Syndrome

Individuals with Down syndrome (DS) exhibit impaired olfactory function and are at a higher risk of developing Alzheimer's disease (AD). Olfactory dysfunction may be an early clinical symptom of AD. Recent studies have demonstrated that vitamin D3 (VD3) exerts neuroprotective effects in mouse models of AD. In this study, we investigated the effects of VD3 on the morphology, immunolocalization, and markers involved in neuropathogenic processes, apoptosis, proliferation, cell survival, and clearance of amyloid peptides, along with neuronal markers in the olfactory bulb (OB) of an adult female mouse model of DS. Morphological and molecular analyses revealed that trisomic mice exhibited a volume reduction in the external plexiform layer, a decrease in the number of mitral and granule cells, and an increase in the expression of amyloid-β 42, caspase-3 p12, and P-glycoprotein. VD3 reversed certain morphological abnormalities in the OB of control trisomic mice (Ts

Topics: Alzheimer Disease; Animals; ATP Binding Cassette Transporter, Subfamily B; Caspase 3; Cholecalciferol; Dietary Supplements; Disease Models, Animal; Down Syndrome; Female; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Neuroprotective Agents; Olfactory Bulb

Renal dysfunction has been reported in individuals with Down syndrome (DS); however, the causes and mechanisms involved remain unknown. Here, we present a proposal for how the triplication of the amyloid beta precursor protein (APP) and, mainly the amyloid β peptide 1-42 (Aβ. Twenty female mice (14-week-old) belonging to the B6EiC3Sn-Rb(12.Ts171665Dn)2Cje/CjeDnJ lineage were divided into four experimental groups (n = 5/group): common diet; trisomy (Ts) and wild-type (Wt); and high doses VD. Our results showed that VD. Finally, the results showed that VD

Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspase 3; Cholecalciferol; Dietary Supplements; Disease Models, Animal; Down Syndrome; Female; Kidney; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Peptide Fragments