cholecalciferol and Alcoholism

Topics: Alcoholism; Calcium; Cholecalciferol; Humans; Hypocalcemia; Magnesium; Magnesium Deficiency; Phosphorus Acids

Topics: Alcoholism; Animals; Cholecalciferol; Choline Deficiency; Ethanol; Fatty Liver; Glutamates; Humans; Hyperlipidemias; Hypoglycemia; Intestinal Absorption; Iron; Ketones; Liver Cirrhosis; Magnesium Deficiency; Mitosis; Nutritional Physiological Phenomena; Rats; Thiamine; Thiamine Deficiency; Uric Acid; Vitamin B 6 Deficiency; Zinc

The chronic use of ethanol causes neuropathy and atrophy of type II fibers and promotes vitamin D decrease. This study evaluated cholecalciferol effects on the deep fibular nerve and extensor digitorum longus (EDL) muscle using an UChB ethanol-preferring rats model. Blood analyses were carried out to measure levels of 25-hydroxycholecalciferol (25(OH)D), calcium (Ca

Topics: Alcoholism; Animals; Cholecalciferol; Dietary Supplements; Disease Models, Animal; Ethanol; Muscle Fibers, Skeletal; Oxidative Stress; Rats; Vitamin D

To elucidate effects of chronic ethanol consumption on clinical chemical parameters reflecting overall calcium homeostasis 34 hospitalized male alcoholics and 35 age-matched controls were studied during the winter season. Serum concentrations of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 were reduced by 28% (p less than 0.01) and 24% (p less than 0.02) among the alcoholics as compared to the controls, respectively. Dietary intake of vitamin D3 did not differ significantly between the groups. The calcium level was below lower limit of reference in nine alcoholics (26%). Serum concentrations of parathyroid hormone and phosphorus were within normal ranges in both groups, and no differences were observed in levels of magnesium, vitamin D-binding protein, calcitonin, or alkaline phosphatase. In conclusion, it is possible that the activities of enzymes crucial in vitamin D3 metabolism may be altered in alcoholics.

Topics: Adult; Aged; Alcoholism; Calcifediol; Calcitonin; Calcitriol; Calcium; Cholecalciferol; Diet; Homeostasis; Humans; Male; Middle Aged; Parathyroid Hormone

To assess the role of hepatic function and alcohol on vitamin D metabolism, serum 25-hydroxyvitamin D (25-OHD) levels were measured in 20 healthy nonalcoholic control subjects, 31 "inactive" cirrhotics whose alcoholism was in remission, 8 alcoholic cirrhotics, and 15 alcoholics with normal liver function. Cirrhosis but not alcoholism, was assoicated with low serum 25-OHD levels. The aminopyrine breath test (ABT) was performed because aminopyrine, like vitamin D3, is metabolized by hepatic microsomes; the ABT correlated highly (r = 0.74, rho less than 0.01) with serum 25-OHD in the inactive cirrhotics. After an intravenous injection of 120 mug vitamin D3, serum 25-OHD rose significantly within 24 hr in 6 healthy controls and 2 patients with celiac disease but not in 6 inactive cirrhotics. The data suggest impaired 25-hydroxylation of vitamin-D impaired in patients with cirrhosis, related predominantly to the degree of hepatic dysfunction.

Topics: Adult; Alcoholism; Cholecalciferol; Ethanol; Humans; Hydroxycholecalciferols; Liver Cirrhosis; Liver Function Tests; Microsomes, Liver; Middle Aged; Vitamin D