chlorzoxazone has been researched along with Innate Inflammatory Response in 5 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorzoxazone (CZ) is a classical FDA-approved drug, and shows anti-inflammatory effects." | 5.56 | Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo. ( Bai, Y; Ma, X, 2020) |
| "Patients with advanced stage ovarian cancer and healthy volunteers were recruited." | 2.90 | Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation. ( Aboagye, EO; Clarke, S; Edwards, RJ; Lee, P; Liddle, C; Lozan-Kuehne, JP; Maslen, L; Ramaswami, R; Sharma, R; Trousil, S, 2019) |
| "Chlorzoxazone (CZ) is a classical FDA-approved drug, and shows anti-inflammatory effects." | 1.56 | Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo. ( Bai, Y; Ma, X, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Deng, L | 1 |
| Li, H | 1 |
| Su, X | 1 |
| Zhang, Y | 1 |
| Xu, H | 1 |
| Fan, L | 1 |
| Fan, J | 1 |
| Han, Q | 1 |
| Bai, X | 1 |
| Zhao, RC | 1 |
| Bai, Y | 1 |
| Ma, X | 1 |
| Trousil, S | 1 |
| Lee, P | 1 |
| Edwards, RJ | 1 |
| Maslen, L | 1 |
| Lozan-Kuehne, JP | 1 |
| Ramaswami, R | 1 |
| Aboagye, EO | 1 |
| Clarke, S | 1 |
| Liddle, C | 1 |
| Sharma, R | 1 |
| Tindberg, N | 1 |
| Baldwin, HA | 1 |
| Cross, AJ | 1 |
| Ingelman-Sundberg, M | 1 |
1 trial available for chlorzoxazone and Innate Inflammatory Response
| Article | Year |
|---|---|
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.
Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme | 2019 |
4 other studies available for chlorzoxazone and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Topics: Animals; Cell Proliferation; Chlorzoxazone; Forkhead Box Protein O3; Humans; Inflammation; Lymphocyt | 2020 |
Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Astrocytes; Behavior, Animal; Cell D | 2020 |
Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury.
Topics: Animals; Astrocytes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Chlormethiazole; Chlorzoxazon | 1996 |