chlorzoxazone has been researched along with Fatty Liver in 7 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver (NAFL) have a different prognosis and should be dealt with differently." | 1.34 | Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis. ( Chtioui, H; Dufour, JF; Ledermann, M; Semela, D; Zimmermann, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gade, C | 1 |
| Dalhoff, K | 1 |
| Petersen, TS | 1 |
| Riis, T | 1 |
| Schmeltz, C | 1 |
| Chabanova, E | 1 |
| Christensen, HR | 1 |
| Mikus, G | 1 |
| Burhenne, J | 1 |
| Holm, JC | 1 |
| Holst, H | 1 |
| Prompila, N | 1 |
| Wittayalertpanya, S | 1 |
| Komolmit, P | 1 |
| Varela, NM | 1 |
| Quiñones, LA | 1 |
| Orellana, M | 1 |
| Poniachik, J | 1 |
| Csendes, A | 1 |
| Smok, G | 1 |
| Rodrigo, R | 1 |
| Cáceres, DD | 1 |
| Videla, LA | 1 |
| Chalasani, N | 1 |
| Gorski, JC | 1 |
| Asghar, MS | 1 |
| Asghar, A | 1 |
| Foresman, B | 1 |
| Hall, SD | 1 |
| Crabb, DW | 1 |
| Emery, MG | 1 |
| Fisher, JM | 1 |
| Chien, JY | 1 |
| Kharasch, ED | 1 |
| Dellinger, EP | 1 |
| Kowdley, KV | 1 |
| Thummel, KE | 1 |
| Chtioui, H | 1 |
| Semela, D | 1 |
| Ledermann, M | 1 |
| Zimmermann, A | 1 |
| Dufour, JF | 1 |
| Leclercq, I | 1 |
| Horsmans, Y | 1 |
| Desager, JP | 1 |
| Pauwels, S | 1 |
| Geubel, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fish Oil and Diet for the Treatment of Non-Alcoholic Steatohepatitis (NASH)[NCT00845845] | Phase 2 | 12 participants (Actual) | Interventional | 2006-03-31 | Terminated (stopped due to Terminated due to low enrollment.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for chlorzoxazone and Fatty Liver
| Article | Year |
|---|---|
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Topics: Administration, Oral; Adolescent; Area Under Curve; Body Mass Index; Child; Chlorzoxazone; Cytochrom | 2018 |
6 other studies available for chlorzoxazone and Fatty Liver
| Article | Year |
|---|---|
Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease.
Topics: Adult; Case-Control Studies; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 C | 2008 |
Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women.
Topics: Adult; Case-Control Studies; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 C | 2008 |
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Body Mass Index; Chlorzoxazone; Cholesterol, HDL; Cytoc | 2003 |
CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
Topics: Blood Glucose; Chlorzoxazone; Cytochrome P-450 CYP2E1; Enzyme Activation; Fatty Liver; Female; Gastr | 2003 |
Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis.
Topics: Adult; Biopsy; Biotransformation; Chlorzoxazone; Cytochrome P-450 CYP2E1; Diagnosis, Differential; F | 2007 |
Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity.
Topics: Adult; Alanine Transaminase; Aminopyridines; Area Under Curve; Aspartate Aminotransferases; Breath T | 1999 |