chlorzoxazone has been researched along with Disease Models, Animal in 17 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorzoxazone (CZ) is a classical FDA-approved drug, and shows anti-inflammatory effects." | 5.56 | Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo. ( Bai, Y; Ma, X, 2020) |
| "The mechanisms underlying hyperacusis in FXS are still largely unknown and effective therapies are lacking." | 1.91 | Hyperacusis in the Adult ( Bouleau, Y; Dulon, D; Ferraguto, C; Peineau, T; Pietropaolo, S, 2023) |
| "Chlorzoxazone (CZ) is a classical FDA-approved drug, and shows anti-inflammatory effects." | 1.56 | Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo. ( Bai, Y; Ma, X, 2020) |
| "Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment." | 1.35 | Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats. ( Chen, J; Dong, G; He, C; Liu, Y; Peng, R; Yue, J, 2009) |
| " Thus, the time-dependent pharmacokinetic parameters of CZX and OH-CZX were evaluated after the intravenous administration of CZX (20 mg/kg) to control rats, and the 2 h, 24 h and 96 h KPLPS rats along with the time-dependent changes in the protein expression of hepatic Cyp2e1." | 1.35 | Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. ( Choi, YH; Jung, HY; Kang, HE; Kim, SH; Lee, MG, 2009) |
| "Chlormethiazole inhibited the increase in the ethanol-induced CYP2E1 activity in vivo, as measured by chlorzoxazone 6-hydroxylation, but did not affect the level of CYP2E1 apoprotein." | 1.31 | Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. ( Donohue, TM; Fang, C; French, BA; French, SW; Fu, P; Gouillon, Z; Hagbjork, AL; Ingelman-Sundberg, M; Li, J; Lucas, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 7 (41.18) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Tang, L | 1 |
| Gao, XH | 1 |
| Zhao, B | 1 |
| Luo, JR | 1 |
| Shi, XY | 1 |
| Ge, R | 1 |
| Ban, SR | 1 |
| Li, QS | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ferraguto, C | 1 |
| Bouleau, Y | 1 |
| Peineau, T | 1 |
| Dulon, D | 1 |
| Pietropaolo, S | 1 |
| Du, X | 1 |
| Carvalho-de-Souza, JL | 1 |
| Wei, C | 1 |
| Carrasquel-Ursulaez, W | 1 |
| Lorenzo, Y | 1 |
| Gonzalez, N | 1 |
| Kubota, T | 1 |
| Staisch, J | 1 |
| Hain, T | 1 |
| Petrossian, N | 1 |
| Xu, M | 1 |
| Latorre, R | 1 |
| Bezanilla, F | 1 |
| Gomez, CM | 1 |
| Bai, Y | 1 |
| Ma, X | 1 |
| Bushart, DD | 1 |
| Huang, H | 1 |
| Man, LJ | 1 |
| Morrison, LM | 1 |
| Shakkottai, VG | 1 |
| Egorova, PA | 2 |
| Gavrilova, AV | 1 |
| Bezprozvanny, IB | 2 |
| Zakharova, OA | 1 |
| Vlasova, OL | 1 |
| Yue, J | 1 |
| Dong, G | 1 |
| He, C | 1 |
| Chen, J | 1 |
| Liu, Y | 1 |
| Peng, R | 1 |
| Jung, HY | 1 |
| Kang, HE | 1 |
| Choi, YH | 1 |
| Kim, SH | 3 |
| Lee, MG | 3 |
| Alviña, K | 2 |
| Khodakhah, K | 2 |
| Hopf, FW | 1 |
| Simms, JA | 1 |
| Chang, SJ | 1 |
| Seif, T | 1 |
| Bartlett, SE | 1 |
| Bonci, A | 1 |
| Chung, W | 1 |
| Kim, EJ | 1 |
| Lee, I | 2 |
| Kim, SG | 2 |
| Kim, YC | 1 |
| Ko, SH | 1 |
| Gouillon, Z | 1 |
| Lucas, D | 1 |
| Li, J | 1 |
| Hagbjork, AL | 1 |
| French, BA | 1 |
| Fu, P | 1 |
| Fang, C | 1 |
| Ingelman-Sundberg, M | 1 |
| Donohue, TM | 1 |
| French, SW | 1 |
17 other studies available for chlorzoxazone and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI).
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Benzoxazoles; Disease Models, Animal; Drug Des | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Hyperacusis in the Adult
Topics: Animals; Auditory Pathways; Chlorzoxazone; Disease Models, Animal; Fragile X Mental Retardation Prot | 2023 |
Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia.
Topics: Adolescent; Animals; Animals, Newborn; Cell Line; Cerebellum; Chlorzoxazone; Dependovirus; Disease M | 2020 |
Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Astrocytes; Behavior, Animal; Cell D | 2020 |
A Chlorzoxazone-Baclofen Combination Improves Cerebellar Impairment in Spinocerebellar Ataxia Type 1.
Topics: Animals; Ataxin-1; Baclofen; Calcium Channels, T-Type; Cerebellum; Chlorzoxazone; Disease Models, An | 2021 |
In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2.
Topics: Action Potentials; Aging; Animals; Cerebellum; Chlorzoxazone; Disease Models, Animal; Injections, In | 2021 |
In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model.
Topics: 1-Naphthylamine; Action Potentials; Aging; Animals; Chlorzoxazone; Disease Models, Animal; Injection | 2016 |
Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Aniline Compounds; Animals; Aspartate Aminotransf | 2009 |
Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels.
Topics: Acute Kidney Injury; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Disease Models, Animal; Drug I | 2009 |
KCa channels as therapeutic targets in episodic ataxia type-2.
Topics: Analysis of Variance; Animals; Benzimidazoles; Cerebellar Ataxia; Cerebellum; Chlorzoxazone; Disease | 2010 |
The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Behavior, Animal; Cerebellar Ataxia; | 2010 |
Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats.
Topics: Action Potentials; Alcohol Drinking; Alcohols; Animals; Apamin; Behavior, Animal; Calcium Channel Ag | 2011 |
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Topics: Acute Kidney Injury; Animals; Area Under Curve; Blood Proteins; Catalysis; Chlorzoxazone; Chromatogr | 2003 |
Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h.
Topics: Animals; Area Under Curve; Chlorzoxazone; Cytochrome P-450 CYP2E1; Dehydration; Dietary Supplements; | 2006 |
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole.
Topics: Animals; Apoenzymes; Body Weight; Chlormethiazole; Chlorzoxazone; Chymotrypsin; Cysteine Endopeptida | 2000 |