chlorzoxazone has been researched along with Cystic Fibrosis in 5 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hence these compounds may be useful to treat cystic fibrosis (CF) airway disease." | 5.31 | Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells. ( Forman, HJ; Fuller, CM; Gao, L; Matalon, S; Sorscher, EJ; Venglarik, CJ; Yankaskas, JR, 2001) |
| " In our pursuit to identify potent modulators of Cl(-) secretion that may be useful to overcome the Cl(-) secretory defect in cystic fibrosis (CF), we have identified chlorzoxazone [5-chloro-2(3H)-benzoxazolone], a clinically used centrally acting muscle relaxant, as a stimulator of Cl(-) secretion in several epithelial cell types, including T84, Calu-3, and human bronchial epithelium." | 3.70 | Stimulation of Cl(-) secretion by chlorzoxazone. ( Bridges, RJ; Devor, DC; Gerlach, AC; Gondor, M; Pilewski, JM; Singh, AK, 2000) |
| "Hence these compounds may be useful to treat cystic fibrosis (CF) airway disease." | 1.31 | Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells. ( Forman, HJ; Fuller, CM; Gao, L; Matalon, S; Sorscher, EJ; Venglarik, CJ; Yankaskas, JR, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 2 |
| Singh, AK | 1 |
| Devor, DC | 1 |
| Gerlach, AC | 1 |
| Gondor, M | 1 |
| Pilewski, JM | 1 |
| Bridges, RJ | 1 |
| Gao, L | 2 |
| Broughman, JR | 1 |
| Iwamoto, T | 1 |
| Tomich, JM | 1 |
| Venglarik, CJ | 2 |
| Forman, HJ | 2 |
| Yankaskas, JR | 1 |
| Fuller, CM | 1 |
| Matalon, S | 1 |
| MacVinish, LJ | 1 |
| Keogh, J | 1 |
| Cuthbert, AW | 1 |
5 other studies available for chlorzoxazone and Cystic Fibrosis
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Stimulation of Cl(-) secretion by chlorzoxazone.
Topics: Amiloride; Anions; Bronchi; Bumetanide; Cell Membrane; Cells, Cultured; Charybdotoxin; Chlorine; Chl | 2000 |
Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia.
Topics: Cell Line, Transformed; Chloride Channels; Chlorzoxazone; Cystic Fibrosis; Drug Synergism; Electric | 2001 |
Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells.
Topics: Amiloride; Animals; Benzimidazoles; Calcium Channel Agonists; Cell Polarity; Cells, Cultured; Chlori | 2001 |
EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes.
Topics: Animals; Benzimidazoles; Calcium Channel Agonists; Cell Polarity; Charybdotoxin; Chlorides; Chlorzox | 2001 |