chlorzoxazone has been researched along with Body Weight in 6 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further, the conventional chlorzoxazone method for in vivo phenotyping was studied by adjusting the dose to body weight in 10 healthy volunteers." | 5.12 | Phenotyping of cytochrome P450 2E1 in vitro and in vivo. ( Ernstgård, L; Johanson, G; Karlsson, AS; Warholm, M, 2007) |
| " The dose-response profile for renal CYP1A1 parallels that in the liver of either species but EROD-activities are 10-20 times lower than in the liver." | 1.32 | Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. ( Hack, A; Roos, PH; Tschirbs, S; Welge, P; Wilhelm, M, 2004) |
| "Chlormethiazole inhibited the increase in the ethanol-induced CYP2E1 activity in vivo, as measured by chlorzoxazone 6-hydroxylation, but did not affect the level of CYP2E1 apoprotein." | 1.31 | Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. ( Donohue, TM; Fang, C; French, BA; French, SW; Fu, P; Gouillon, Z; Hagbjork, AL; Ingelman-Sundberg, M; Li, J; Lucas, D, 2000) |
| "Starvation has been previously demonstrated to induce CYP2E1 activity (assayed as chlorzozazone-6-hydroxylase activity) in mammals and this study was undertaken to determine the effects of starvation on liver chlorzozaxone-6-hydroxylase and ethoxy-resorufin-O-deethylase activity (a CYP1A1 activity) in juvenile winter flounder liver microsomes." | 1.30 | Effects of starvation on liver microsomal P450 activity in juvenile Pleuronectes americanus. ( Crivello, J; Wall, KL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, XP | 1 |
| Han, XM | 1 |
| Jiang, CH | 1 |
| Huang, SL | 1 |
| Liu, ZQ | 1 |
| Zhu, B | 1 |
| Zhou, G | 1 |
| Zhou, HH | 1 |
| Roos, PH | 1 |
| Tschirbs, S | 1 |
| Hack, A | 1 |
| Welge, P | 1 |
| Wilhelm, M | 1 |
| Ernstgård, L | 1 |
| Johanson, G | 1 |
| Karlsson, AS | 1 |
| Warholm, M | 1 |
| Alcorn, J | 1 |
| Elbarbry, FA | 1 |
| Allouh, MZ | 1 |
| McNamara, PJ | 1 |
| Wall, KL | 1 |
| Crivello, J | 1 |
| Gouillon, Z | 1 |
| Lucas, D | 1 |
| Li, J | 1 |
| Hagbjork, AL | 1 |
| French, BA | 1 |
| Fu, P | 1 |
| Fang, C | 1 |
| Ingelman-Sundberg, M | 1 |
| Donohue, TM | 1 |
| French, SW | 1 |
1 trial available for chlorzoxazone and Body Weight
| Article | Year |
|---|---|
Phenotyping of cytochrome P450 2E1 in vitro and in vivo.
Topics: Adult; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP2E1; Female; Humans; Male; Middle Aged | 2007 |
5 other studies available for chlorzoxazone and Body Weight
| Article | Year |
|---|---|
Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP2E1; Female; Hum | 2002 |
Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils.
Topics: Administration, Oral; Animals; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP1A1; Dose-Response Re | 2004 |
Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity.
Topics: Age Factors; Aging; Animals; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 C | 2007 |
Effects of starvation on liver microsomal P450 activity in juvenile Pleuronectes americanus.
Topics: Animals; Body Weight; Chlorzoxazone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Flounder; Ind | 1999 |
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole.
Topics: Animals; Apoenzymes; Body Weight; Chlormethiazole; Chlorzoxazone; Chymotrypsin; Cysteine Endopeptida | 2000 |