chlorzoxazone has been researched along with Alcohol Drinking in 4 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In conclusion, in individuals with moderate alcohol consumption, there was no alteration in the hepatic CYP3A activity, but the reduced midazolam oral bioavailability suggests that moderate alcohol consumption may cause intestinal CYP3A induction." | 2.71 | Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. ( Chalasani, N; Gorski, JC; Hall, SD; Kolwankar, D; Liangpunsakul, S; Pinto, A, 2005) |
| " Comparison of these values with a study by other investigators using a suspension dosage form suggested that relative Ftablet approximately 0." | 2.67 | Variability in the disposition of chlorzoxazone. ( Becker, CE; de Vries, JD; Hoener, BA; Horie, S; Salphati, L, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hopf, FW | 1 |
| Simms, JA | 1 |
| Chang, SJ | 1 |
| Seif, T | 1 |
| Bartlett, SE | 1 |
| Bonci, A | 1 |
| Liangpunsakul, S | 1 |
| Kolwankar, D | 1 |
| Pinto, A | 1 |
| Gorski, JC | 1 |
| Hall, SD | 1 |
| Chalasani, N | 1 |
| de Vries, JD | 1 |
| Salphati, L | 1 |
| Horie, S | 1 |
| Becker, CE | 1 |
| Hoener, BA | 1 |
| McCarver, DG | 1 |
| Byun, R | 1 |
| Hines, RN | 1 |
| Hichme, M | 1 |
| Wegenek, W | 1 |
2 trials available for chlorzoxazone and Alcohol Drinking
| Article | Year |
|---|---|
Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics.
Topics: Adult; Alcohol Drinking; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chlorzoxazo | 2005 |
Variability in the disposition of chlorzoxazone.
Topics: Administration, Oral; Adult; Alcohol Drinking; Asian People; Black People; Blood Proteins; Chlorzoxa | 1994 |
2 other studies available for chlorzoxazone and Alcohol Drinking
| Article | Year |
|---|---|
Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats.
Topics: Action Potentials; Alcohol Drinking; Alcohols; Animals; Apamin; Behavior, Animal; Calcium Channel Ag | 2011 |
A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake.
Topics: Alcohol Drinking; Black People; Chlorzoxazone; Cytochrome P-450 CYP2E1; DNA; Enzyme Induction; Ethan | 1998 |