chlorzoxazone has been researched along with Acute Post-operative Pain in 3 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No analgesic effect of single-dose chlorzoxazone was demonstrated in patients with acute pain after spine surgery." | 9.22 | The effect of chlorzoxazone on acute pain after spine surgery. A randomized, blinded trial. ( Dahl, JB; Fomsgaard, JS; Martusevicius, R; Mathiesen, O; Nielsen, RV; Siegel, H, 2016) |
| "Severe preoperative and acute postoperative pain have been associated with the development of chronic postoperative pain." | 6.94 | Investigating the Effect of Perioperative Chlorzoxazone on Acute Postoperative Pain After Total Hip and Knee Replacement Surgery. ( Arendt-Nielsen, L; Beck, J; Laursen, M; Nielsen, PT; Petersen, KK; Simonsen, O; Skrejborg, P; Ulrich, M, 2020) |
| "No analgesic effect of single-dose chlorzoxazone was demonstrated in patients with acute pain after spine surgery." | 5.22 | The effect of chlorzoxazone on acute pain after spine surgery. A randomized, blinded trial. ( Dahl, JB; Fomsgaard, JS; Martusevicius, R; Mathiesen, O; Nielsen, RV; Siegel, H, 2016) |
| "In study IV we hypothesized that intraoperative ketamine would reduce postoperative opioid consumption and persistent pain after spinal fusion surgery in chronic pain patients with opioid dependency." | 4.98 | Adjuvant analgesics for spine surgery. ( Nielsen, RV, 2018) |
| "Severe preoperative and acute postoperative pain have been associated with the development of chronic postoperative pain." | 2.94 | Investigating the Effect of Perioperative Chlorzoxazone on Acute Postoperative Pain After Total Hip and Knee Replacement Surgery. ( Arendt-Nielsen, L; Beck, J; Laursen, M; Nielsen, PT; Petersen, KK; Simonsen, O; Skrejborg, P; Ulrich, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Skrejborg, P | 1 |
| Petersen, KK | 1 |
| Beck, J | 1 |
| Ulrich, M | 1 |
| Simonsen, O | 1 |
| Nielsen, PT | 1 |
| Arendt-Nielsen, L | 1 |
| Laursen, M | 1 |
| Nielsen, RV | 2 |
| Fomsgaard, JS | 1 |
| Siegel, H | 1 |
| Martusevicius, R | 1 |
| Mathiesen, O | 1 |
| Dahl, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Structured Rehabilitation Program on Pain and Function in Patients With Total Knee Replacement[NCT04694625] | 26 participants (Actual) | Interventional | 2021-01-10 | Completed | |||
| Efficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind Trial[NCT06062550] | Phase 4 | 312 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial[NCT06087510] | Phase 4 | 312 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial[NCT04791059] | Phase 4 | 200 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
| Effect of Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia on Long-term Outcomes Following Scoliosis Correction Surgery: 2-year Follow-up of a Randomized Controlled Trial[NCT05718544] | Phase 4 | 199 participants (Actual) | Interventional | 2023-01-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorzoxazone and Acute Post-operative Pain
| Article | Year |
|---|---|
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
Adjuvant analgesics for spine surgery.
Topics: Analgesia; Analgesics, Opioid; Chlorzoxazone; Chronic Pain; Dexamethasone; Humans; Intraoperative Pe | 2018 |
2 trials available for chlorzoxazone and Acute Post-operative Pain
| Article | Year |
|---|---|
Investigating the Effect of Perioperative Chlorzoxazone on Acute Postoperative Pain After Total Hip and Knee Replacement Surgery.
Topics: Analgesics; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Chlorzoxazone; Double-B | 2020 |
The effect of chlorzoxazone on acute pain after spine surgery. A randomized, blinded trial.
Topics: Acute Pain; Adult; Aged; Analgesia, Patient-Controlled; Chlorzoxazone; Female; Humans; Male; Middle | 2016 |