chlorzoxazone has been researched along with Acute Liver Injury, Drug-Induced in 17 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment." | 1.35 | Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats. ( Chen, J; Dong, G; He, C; Liu, Y; Peng, R; Yue, J, 2009) |
| "The necrosis was predominantly localised in the intermediate zone of the hepatic lobules with vacuolisation of the centrilobular zones." | 1.31 | Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs. ( Buchet, JP; Haufroid, V; Hoet, P; Lison, D; Rahier, J; Sempoux, C, 2002) |
| " The risk factors for the development of liver cell necrosis following ingestion of paracetamol in therapeutic dosage are discussed." | 1.30 | [Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage]. ( Krähenbühl, S; Kronenberg, A; Streuli, R; Zimmermann, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Yang, W | 1 |
| Liang, Z | 1 |
| Wen, C | 1 |
| Jiang, X | 1 |
| Wang, L | 1 |
| Yue, J | 1 |
| Dong, G | 1 |
| He, C | 1 |
| Chen, J | 1 |
| Liu, Y | 1 |
| Peng, R | 1 |
| Hoet, P | 1 |
| Buchet, JP | 1 |
| Sempoux, C | 1 |
| Haufroid, V | 1 |
| Rahier, J | 1 |
| Lison, D | 1 |
| Yokogawa, K | 1 |
| Watanabe, M | 1 |
| Takeshita, H | 1 |
| Nomura, M | 1 |
| Mano, Y | 1 |
| Miyamoto, K | 1 |
| Tang, H | 1 |
| Min, G | 1 |
| Ge, B | 1 |
| Li, Y | 1 |
| Liu, X | 1 |
| Jiang, S | 1 |
| Nightingale, SL | 1 |
| Kronenberg, A | 1 |
| Krähenbühl, S | 1 |
| Zimmermann, A | 1 |
| Streuli, R | 1 |
| Tanaka, E | 1 |
| Lindholm, L | 1 |
1 review available for chlorzoxazone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
16 other studies available for chlorzoxazone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Cytochrome P-450 CYP2 | 2022 |
Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Aniline Compounds; Animals; Aspartate Aminotransf | 2009 |
Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs.
Topics: Administration, Inhalation; Administration, Oral; Alanine Transaminase; Animals; Animals, Outbred St | 2002 |
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 2004 |
Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs.
Topics: Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Bilirubin; Caffeine; C | 2008 |
From the Food and Drug Administration.
Topics: Chemical and Drug Induced Liver Injury; Chlorzoxazone; Computer Communication Networks; Drug Labelin | 1995 |
Chlorzoxazone hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Chlorzoxazone; Drug Evaluation; Humans; Muscle Relaxants, Ce | 1996 |
[Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Drug | 1998 |
Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat.
Topics: Aniline Hydroxylase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorzox | 2001 |
[Fever, skin and liver reactions in a patient treated with Paraflex comp].
Topics: Aged; Benzoxazoles; Chemical and Drug Induced Liver Injury; Chlorzoxazone; Dextropropoxyphene; Drug | 1979 |