chlorzoxazone has been researched along with Acute Kidney Injury in 5 studies
Chlorzoxazone: A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
chlorzoxazone : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, the time-dependent pharmacokinetic parameters of CZX and OH-CZX were evaluated after the intravenous administration of CZX (20 mg/kg) to control rats, and the 2 h, 24 h and 96 h KPLPS rats along with the time-dependent changes in the protein expression of hepatic Cyp2e1." | 1.35 | Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. ( Choi, YH; Jung, HY; Kang, HE; Kim, SH; Lee, MG, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, HY | 1 |
| Kang, HE | 1 |
| Choi, YH | 1 |
| Kim, SH | 3 |
| Lee, MG | 4 |
| Moon, YJ | 1 |
| Lee, AK | 1 |
| Chung, HC | 1 |
| Kim, EJ | 3 |
| Lee, DC | 1 |
| Lee, I | 3 |
| Kim, SG | 3 |
| Chung, W | 1 |
| Ahn, CY | 1 |
| Kwon, JW | 1 |
| Kim, WB | 1 |
| Yasuhara, M | 1 |
| Levy, G | 1 |
5 other studies available for chlorzoxazone and Acute Kidney Injury
| Article | Year |
|---|---|
Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels.
Topics: Acute Kidney Injury; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Disease Models, Animal; Drug I | 2009 |
Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats.
Topics: Acute Kidney Injury; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; C | 2003 |
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Topics: Acute Kidney Injury; Animals; Area Under Curve; Blood Proteins; Catalysis; Chlorzoxazone; Chromatogr | 2003 |
Effects of glucose on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Topics: Acute Kidney Injury; Animals; Chlorzoxazone; Drug Interactions; Glucose; Infusions, Intravenous; Mal | 2003 |
Kinetics of drug action in disease states. XXVII. Effect of experimental renal failure on the pharmacodynamics of zoxazolamine and chlorzoxazone.
Topics: Acute Kidney Injury; Animals; Benzoxazoles; Chlorzoxazone; Ligation; Male; Muscle Relaxants, Central | 1988 |