Page last updated: 2024-10-25

chlorthalidone and Stroke

chlorthalidone has been researched along with Stroke in 23 studies

Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
"Serum uric acid independently predicts cardiovascular events in older persons with isolated systolic hypertension."9.09Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). ( Applegate, WB; Di Bari, M; Franse, LV; Pahor, M; Shorr, RI; Somes, GW; Wan, JY, 2000)
"Stroke: common 'GG' homozygotes had higher risk on lisinopril versus amlodipine [hazard ratio (HR)=1."5.14Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study. ( Arnett, DK; Boerwinkle, E; Davis, BR; Eckfeldt, JH; Ford, CE; Leiendecker-Foster, C; Lynch, AI, 2009)
"The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind, active, controlled clinical trial conducted to determine whether newer antihypertensive agents, including doxazosin, an alpha-blocker, differ from chlorthalidone, a diuretic, with respect to coronary heart disease (CHD) and other cardiovascular disease (CVD) events in hypertensive patients at high risk of CHD."5.10Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). ( , 2003)
"Serum uric acid independently predicts cardiovascular events in older persons with isolated systolic hypertension."5.09Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP). ( Applegate, WB; Di Bari, M; Franse, LV; Pahor, M; Shorr, RI; Somes, GW; Wan, JY, 2000)
"The aim of this study was to investigate whether there is a genotype-by-treatment interaction in patients experiencing stroke and treated with one of three antihypertensive drugs, that is chlorthalidone, amlodipine, or lisinopril."3.80Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study. ( Arnett, DK; Boerwinkle, E; Davis, BR; Eckfeldt, JH; Ford, CE; Irvin, MR; Sørensen, IF; Sørensen, P; Vazquez, AI, 2014)
"There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management."3.77Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis. ( Bleske, BE; Dorsch, MP; Erickson, SR; Gillespie, BW; Weder, AB, 2011)
"Asymptomatic carotid stenosis is when this narrowing occurs in people without a history or symptoms of this disease."3.01Pharmacological interventions for asymptomatic carotid stenosis. ( Cassola, N; Clezar, CN; Flumignan, CD; Flumignan, RL; Nakano, LC; Trevisani, VF, 2023)
"Incident stroke was significantly decreased by treatment in the Systolic Hypertension in Elderly Program (SHEP) Trial, but the reduction in fatal events was not statistically significant."2.73Long-term fatal outcomes in subjects with stroke or transient ischemic attack: fourteen-year follow-up of the systolic hypertension in the elderly program. ( Davis, BR; Kostis, JB; Patel, AB; Pressel, SL; Shea, ML; Wilson, AC, 2008)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (56.52)29.6817
2010's8 (34.78)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
Itoga, NK1
Tawfik, DS1
Montez-Rath, ME1
Chang, TI1
Clezar, CN1
Flumignan, CD1
Cassola, N1
Nakano, LC1
Trevisani, VF1
Flumignan, RL1
Haywood, LJ3
Davis, BR9
Piller, LB2
Simpson, LM1
Ghosh, A1
Einhorn, PT1
Ford, CE6
Probstfield, JL4
Soliman, EZ1
Wright, JT3
Oparil, S3
Cushman, WC2
Furberg, CD1
Habib, GB2
Margolis, K1
Whelton, PK2
Sørensen, IF1
Vazquez, AI1
Irvin, MR1
Sørensen, P1
Boerwinkle, E3
Eckfeldt, JH3
Arnett, DK3
Yamal, JM1
Alderman, MH1
Calhoun, DA1
Fendley, HF1
Franklin, SS1
Pressel, SL2
Sastrasinh, S1
Thomopoulos, C1
Parati, G1
Zanchetti, A1
Bath, PM1
Geeganage, CM1
Gray, LJ1
Lynch, AI2
Leiendecker-Foster, C2
Dorsch, MP1
Gillespie, BW1
Erickson, SR1
Bleske, BE1
Weder, AB1
Zhang, X1
Rahman, M1
Cutler, JA1
Barzilay, JI1
Brown, CD1
Colon, PJ1
Fine, LJ1
Grimm, RH1
Gupta, AK1
Baimbridge, C1
Henriquez, MA1
Ilamaythi, E1
Preston, R1
Scott, I1
Stowasser, M1
Düsing, R1
Diener, HC1
Rahn, KH1
Kuwajima, I1
Yusuf, S1
Patel, AB1
Kostis, JB1
Wilson, AC1
Shea, ML1
Perry, HM1
Price, TR1
Applegate, WB2
Fields, WS1
Guralnik, JM1
Kuller, L1
Pressel, S1
Stamler, J1
Koval, PG1
McDiarmid, T1
Franse, LV1
Pahor, M1
Di Bari, M1
Shorr, RI1
Wan, JY1
Somes, GW1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000542]Phase 30 participants Interventional1993-08-31Completed
Pharmacological Association of the Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism on Blood Pressure and Cardiovascular Risk in Relation to Anti-hypertensive Treatment[NCT00006294]37,939 participants (Actual)Observational1999-09-30Completed
[NCT00000514]Phase 30 participants Interventional1984-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for chlorthalidone and Stroke

ArticleYear
Pharmacological interventions for asymptomatic carotid stenosis.
    The Cochrane database of systematic reviews, 2023, 08-04, Volume: 8

    Topics: Aspirin; Atherosclerosis; Atorvastatin; Carotid Stenosis; Chlorthalidone; Fluvastatin; Hemorrhage; H

2023
Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs--overview and meta-analyses.
    Journal of hypertension, 2015, Volume: 33, Issue:2

    Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibit

2015
[Recent intervention studies with antihypertensive drugs and their influence on guidelines].
    Medizinische Klinik (Munich, Germany : 1983), 2003, Dec-15, Volume: 98, Issue:12

    Topics: Adrenergic beta-Antagonists; Aged; Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Convert

2003
[ALLHAT trial--antithesis to the overuse of vasodilating antihypertensive drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypert

2004

Trials

11 trials available for chlorthalidone and Stroke

ArticleYear
Risk Factors Influencing Outcomes of Atrial Fibrillation in ALLHAT.
    Journal of the National Medical Association, 2018, Volume: 110, Issue:4

    Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; C

2018
Mortality and morbidity during and after Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: results by sex.
    Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:5

    Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Chlorthalido

2013
Stroke outcomes among participants randomized to chlorthalidone, amlodipine or lisinopril in ALLHAT.
    Journal of the American Society of Hypertension : JASH, 2014, Volume: 8, Issue:11

    Topics: Age Factors; Aged; Amlodipine; Cause of Death; Chlorthalidone; Confidence Intervals; Dose-Response R

2014
Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study.
    Pharmacogenetics and genomics, 2009, Volume: 19, Issue:6

    Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel

2009
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-

2012
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-

2012
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-

2012
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Aged; Alleles; Amlodipine; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Double-

2012
Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFR.
    Clinical journal of the American Society of Nephrology : CJASN, 2012, Volume: 7, Issue:6

    Topics: Amlodipine; Antihypertensive Agents; Canada; Chlorthalidone; Chronic Disease; Coronary Disease; Doub

2012
Are thiazide diuretics preferred as first-line therapy for hypertension? An appraisal of The Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
    Internal medicine journal, 2003, Volume: 33, Issue:7

    Topics: Aged; Amlodipine; Benzothiadiazines; Blood Chemical Analysis; Chlorthalidone; Diuretics; Dose-Respon

2003
Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:3

    Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Blood Pressure; Chlorthalidone; Coronary Dise

2003
Long-term fatal outcomes in subjects with stroke or transient ischemic attack: fourteen-year follow-up of the systolic hypertension in the elderly program.
    Stroke, 2008, Volume: 39, Issue:4

    Topics: Adult; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cause of Death; Chlorthalidone; F

2008
Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP).
    JAMA, 2000, Jul-26, Volume: 284, Issue:4

    Topics: Aged; Antihypertensive Agents; Atenolol; Brain Ischemia; Cerebral Hemorrhage; Chlorthalidone; Double

2000
Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP).
    Journal of hypertension, 2000, Volume: 18, Issue:8

    Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Biomarkers; Cardiovascular Dis

2000

Other Studies

8 other studies available for chlorthalidone and Stroke

ArticleYear
Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study.
    Journal of the American College of Cardiology, 2021, 10-26, Volume: 78, Issue:17

    Topics: Aged; Amlodipine; Blood Pressure; Blood Pressure Determination; Cardiovascular Diseases; Chlorthalid

2021
Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study.
    Pharmacogenetics and genomics, 2014, Volume: 24, Issue:11

    Topics: Aged; Amlodipine; Chlorthalidone; Female; Genotype; Humans; Lisinopril; Male; Middle Aged; Pharmacog

2014
Ordinal reanalysis of the SHEP trial.
    Stroke, 2008, Volume: 39, Issue:9

    Topics: Antihypertensive Agents; Chlorthalidone; Clinical Trials as Topic; Data Interpretation, Statistical;

2008
Chlorthalidone reduces cardiovascular events compared with hydrochlorothiazide: a retrospective cohort analysis.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:4

    Topics: Adult; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Cholesterol; Heart

2011
[The new (old) knowledge in primary prevention of stroke. It depends on lowering of blood pressure].
    MMW Fortschritte der Medizin, 2003, Volume: 145 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive

2003
[Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized].
    MMW Fortschritte der Medizin, 2003, Volume: 145 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Alcohol Drinking; Anticholesteremic

2003
Preventing vascular events due to elevated blood pressure.
    Circulation, 2006, May-09, Volume: 113, Issue:18

    Topics: Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Comorbidity; Doxazosin; Drug Thera

2006
How effective is doxazosin compared with chlorthalidone in the treatment of hypertension?
    The Journal of family practice, 2000, Volume: 49, Issue:7

    Topics: Aged; Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Coronary Disease; Diuretics;

2000