chlorthalidone has been researched along with Sensitivity and Specificity in 9 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Based on the 90% confidence interval of the individual ratios for Cmax and AUC0-inf, it was concluded that the test formulation is bioequivalent to the reference Hyzaar formulation with respect to the rate and extent of absorption of both LOS and HCTZ." | 2.74 | Simultaneous determination of losartan and hydrochlorothiazide in human plasma by LC/MS/MS with electrospray ionization and its application to pharmacokinetics. ( Andraus, MH; Azevedo, CP; Borges, BC; Borges, NC; Moreira, RF; Moreno, RA; Salvadori, MC, 2009) |
| "Azilsartan Medoxomil (AZL) angiotensin II receptor blocker and chlorthalidone (CLT) were determined by ultraperformance liquid chromatography (UPLC) method in their combined dosage form, they were both subjected to forced degradation studies under extensive stress conditions." | 1.51 | Stability-Indicating RP-UPLC Method for Simultaneous Determination of Azilsartan Medoxomil and Chlorthalidone in Tablets in the Presence of Its Degradation Products. ( Hussein, LA; Ibrahim, MA; Magdy, NN, 2019) |
| " Our results indicated that the serial sampling technique would reduce the number of animals and also compound usage, as well as improve the quality of pharmacokinetic data." | 1.38 | A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics. ( Kurawattimath, V; Mandlekar, S; Mariappan, TT; Pocha, K; Trivedi, RK, 2012) |
| " The components in each mixture have been simultaneously determined in three commercial dosage forms with high accuracy and without interference from commonly encountered excipients and additives." | 1.33 | Determination of antihypertensive mixtures by use of a chemometrics-assisted spectrophotometric method. ( Mohamed, Ael-M; Salem, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hussein, LA | 1 |
| Magdy, NN | 1 |
| Ibrahim, MA | 1 |
| Ramakrishna, R | 1 |
| Puttrevu, SK | 1 |
| Bhateria, M | 1 |
| Bala, V | 1 |
| Sharma, VL | 1 |
| Bhatta, RS | 1 |
| Shah, JV | 1 |
| Patel, DP | 1 |
| Shah, PA | 1 |
| Sanyal, M | 1 |
| Shrivastav, PS | 1 |
| Iriarte, G | 1 |
| Gonzalez, O | 1 |
| Ferreirós, N | 1 |
| Maguregui, MI | 1 |
| Alonso, RM | 1 |
| Jiménez, RM | 1 |
| Salvadori, MC | 1 |
| Moreira, RF | 1 |
| Borges, BC | 1 |
| Andraus, MH | 1 |
| Azevedo, CP | 1 |
| Moreno, RA | 1 |
| Borges, NC | 1 |
| Kurawattimath, V | 1 |
| Pocha, K | 1 |
| Mariappan, TT | 1 |
| Trivedi, RK | 1 |
| Mandlekar, S | 1 |
| Mohamed, Ael-M | 1 |
| Salem, H | 1 |
| Salado, S | 1 |
| Vera-Avila, LE | 1 |
| Giachetti, C | 1 |
| Tenconi, A | 1 |
| Canali, S | 1 |
| Zanolo, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| No Pharmacokinetic Interaction Between Chlorthalidone and Losartan, in Healthy Volunteers Under Fasting Conditions, Administered in Fixed Combination Against Individual Components Administered Jointly and Separately[NCT05090449] | Phase 1 | 36 participants (Actual) | Interventional | 2019-05-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for chlorthalidone and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous determination of losartan and hydrochlorothiazide in human plasma by LC/MS/MS with electrospray ionization and its application to pharmacokinetics.
Topics: Administration, Oral; Adult; Chlorthalidone; Chromatography, High Pressure Liquid; Cross-Over Studie | 2009 |
8 other studies available for chlorthalidone and Sensitivity and Specificity
| Article | Year |
|---|---|
Stability-Indicating RP-UPLC Method for Simultaneous Determination of Azilsartan Medoxomil and Chlorthalidone in Tablets in the Presence of Its Degradation Products.
Topics: Benzimidazoles; Chlorthalidone; Chromatography, High Pressure Liquid; Drug Stability; Linear Models; | 2019 |
Simultaneous determination of azilsartan and chlorthalidone in rat and human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Topics: Animals; Benzimidazoles; Chlorthalidone; Chromatography, Liquid; Humans; Linear Models; Male; Oxadia | 2015 |
Simultaneous quantification of atenolol and chlorthalidone in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Atenolol; Chlorthalidone; Chromatography, High Pressure Liquid; Drug Stability; Humans; Linear Model | 2016 |
Validation of a fast liquid chromatography-UV method for the analysis of drugs used in combined cardiovascular therapy in human plasma.
Topics: Cardiovascular Agents; Chlorthalidone; Chromatography, Liquid; Drug Stability; Fatty Acids, Monounsa | 2009 |
A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics.
Topics: Amodiaquine; Animals; Area Under Curve; Blood Specimen Collection; Chloroquine; Chlorthalidone; Chro | 2012 |
Determination of antihypertensive mixtures by use of a chemometrics-assisted spectrophotometric method.
Topics: Amiloride; Antihypertensive Agents; Atenolol; Chlorthalidone; Least-Squares Analysis; Molecular Stru | 2005 |
On-line solid-phase extraction and high-performance liquid chromatographic determination of chlorthalidone in urine.
Topics: Adult; Antihypertensive Agents; Chlorthalidone; Chromatography, High Pressure Liquid; Diuretics; Dru | 1997 |
Simultaneous determination of atenolol and chlorthalidone in plasma by high-performance liquid chromatography. Application to pharmacokinetic studies in man.
Topics: Antihypertensive Agents; Atenolol; Chlorthalidone; Chromatography, High Pressure Liquid; Humans; Ref | 1997 |