chlorthalidone has been researched along with Obesity in 15 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " We prospectively examined randomization to first-step chlorthalidone, a thiazide-type diuretic; amlodipine, a calcium-channel blocker; and lisinopril, an angiotensin-converting enzyme inhibitor, on BP control and cardiovascular outcomes in a hypertensive cohort stratified by baseline BMI [kg/m(2); normal weight (BMI <25), overweight (BMI = 25-29." | 5.19 | Blood pressure control and cardiovascular outcomes in normal-weight, overweight, and obese hypertensive patients treated with three different antihypertensives in ALLHAT. ( Barzilay, JI; Dart, RA; Davis, BR; Einhorn, PT; Graves, JW; Pressel, SL; Reisin, E; Retta, TM; Saklayen, MG; Yamal, JM, 2014) |
| " They were randomized to a usual diet (n = 296) or to a weight loss diet (n = 291) and within each diet group to placebo, chlorthalidone, 25 mg/d, or atenolol, 50 mg/d." | 5.07 | Reduction in long-term antihypertensive medication requirements. Effects of weight reduction by dietary intervention in overweight persons with mild hypertension. ( Blaufox, MD; Cutler, JA; Davis, BR; Kirchner, K; Langford, HG; Oberman, A; Wassertheil-Smoller, S; Zimbaldi, N, 1993) |
| "Blood pressure and proteinuria are important determinants of progressive renal failure in patients with renal diseases." | 2.41 | [Intensive treatment of blood pressure in patients with kidney disease and proteinuria]. ( Huysmans, FT; Wetzels, JF, 2000) |
| "Chlorthalidone, 12." | 1.39 | Obesity and hypertension: It's about more than the numbers. ( Ferdinand, KC, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferdinand, KC | 1 |
| Reisin, E | 2 |
| Graves, JW | 1 |
| Yamal, JM | 1 |
| Barzilay, JI | 1 |
| Pressel, SL | 1 |
| Einhorn, PT | 1 |
| Dart, RA | 1 |
| Retta, TM | 1 |
| Saklayen, MG | 1 |
| Davis, BR | 4 |
| Czarina Acelajado, M | 1 |
| Calhoun, DA | 1 |
| MEES, EJ | 1 |
| GEYSKES, GG | 1 |
| CAMPSCARDONA, J | 1 |
| LINKE, H | 1 |
| Cassinello Ogea, C | 1 |
| Girón Nombiela, JA | 1 |
| Ruiz Tramazaygues, J | 1 |
| Izquierdo Villarroya, B | 1 |
| Sánchez Tirado, JA | 1 |
| Almajano Domínguez, RM | 1 |
| Oro Fraile, J | 1 |
| Oberman, A | 3 |
| Blaufox, MD | 3 |
| Wassertheil-Smoller, S | 3 |
| Zimbaldi, N | 3 |
| Kirchner, K | 2 |
| Wylie-Rosett, J | 2 |
| Langford, HG | 3 |
| Siegel, D | 1 |
| Saliba, P | 1 |
| Haffner, S | 1 |
| Cutler, JA | 1 |
| Jennings, S | 1 |
| Hataway, H | 1 |
| Stern, J | 1 |
| Huysmans, FT | 1 |
| Wetzels, JF | 1 |
| Weed, SG | 1 |
| Abrantes, IB | 1 |
| Villela, RA | 1 |
| Stuart, PC | 1 |
| Abrantes, ML | 1 |
| Abitbol, L | 1 |
| Pereira, AF | 1 |
| de Abrantes, IB | 1 |
| Villela, R | 1 |
| Villela, AA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000542] | Phase 3 | 0 participants | Interventional | 1993-08-31 | Completed | ||
| Prospective Evaluation of Adrenal Function After Living Donor Nephrectomy With or Without Ligation of the Adrenal Vein[NCT00251836] | 30 participants (Actual) | Observational | 2007-01-31 | Completed | |||
| [NCT00000513] | Phase 3 | 0 participants | Interventional | 1984-04-30 | Completed | ||
| [NCT00000525] | Phase 3 | 233 participants (Actual) | Interventional | 1986-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorthalidone and Obesity
| Article | Year |
|---|---|
Treatment of resistant hypertension.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Ambulatory Care; Antihypertensive Agents; Black or African Ame | 2009 |
[Intensive treatment of blood pressure in patients with kidney disease and proteinuria].
Topics: Antihypertensive Agents; Atenolol; Chlorthalidone; Dose-Response Relationship, Drug; Enalapril; Glom | 2000 |
7 trials available for chlorthalidone and Obesity
| Article | Year |
|---|---|
Blood pressure control and cardiovascular outcomes in normal-weight, overweight, and obese hypertensive patients treated with three different antihypertensives in ALLHAT.
Topics: Aged; Aged, 80 and over; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agen | 2014 |
Lack of effectiveness of a low-sodium/high-potassium diet in reducing antihypertensive medication requirements in overweight persons with mild hypertension. TAIM Research Group. Trial of Antihypertensive Interventions and Management.
Topics: Adult; Antihypertensive Agents; Atenolol; Chlorthalidone; Combined Modality Therapy; Diet, Sodium-Re | 1994 |
Glucose and insulin levels during diuretic therapy in hypertensive men.
Topics: Adult; Aged; Blood Glucose; Chlorthalidone; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Hy | 1994 |
Reduction in long-term antihypertensive medication requirements. Effects of weight reduction by dietary intervention in overweight persons with mild hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Chlorthalidone; Female; Humans; Hypertension; Male; | 1993 |
Trial of antihypertensive intervention and management: greater efficacy with weight reduction than with a sodium-potassium intervention.
Topics: Adult; Analysis of Variance; Atenolol; Blood Pressure; Body Weight; Chlorthalidone; Combined Modalit | 1993 |
The treatment of obese hypertensive black women: a comparative study of chlorthalidone versus clonidine.
Topics: Black People; Blood Pressure; Chlorthalidone; Clonidine; Double-Blind Method; Drug Therapy, Combinat | 1992 |
[Use of chlorthalidone in obesity].
Topics: Adult; Aged; Chlorthalidone; Clinical Trials as Topic; Diet, Reducing; Female; Humans; Male; Middle | 1965 |
6 other studies available for chlorthalidone and Obesity
| Article | Year |
|---|---|
Obesity and hypertension: It's about more than the numbers.
Topics: Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug | 2013 |
A COMPARATIVE STUDY OF THE DIURETICS CHLORTHALIDONUM AND CYCLOPENTHIAZIDUM.
Topics: Benzothiadiazines; Bicarbonates; Biomedical Research; Blood; Chlorides; Chlorthalidone; Diet, Sodium | 1964 |
[WATER DEPLETION IN WEIGHT REDUCTION. CLINICAL EXPERIENCE WITH G 33182 (HYGROTON)].
Topics: Chlorthalidone; Drug Therapy; Obesity; Water; Weight Loss | 1964 |
[The effect of hygroton on normal persons, adipose subjects and patients with edemas of various origins].
Topics: Adiposity; Chlorthalidone; Diuretics; Edema; Edetic Acid; Obesity | 1961 |
[Severe perioperative hypotension after nephrectomy with adrenalectomy].
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Aged; Angiotensin-Converting Enzyme Inh | 2002 |
[Clinical tests using chlorthalidone in the treatment of obesity].
Topics: Adolescent; Adult; Chlorthalidone; Female; Humans; Male; Middle Aged; Obesity | 1969 |