chlorthalidone has been researched along with Innate Inflammatory Response in 5 studies
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experiments determined whether the combination of endothelin A (ETA) receptor antagonist [ABT-627, atrasentan; (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid] and a thiazide diuretic (chlorthalidone) would be more effective at lowering blood pressure and reducing renal injury in a rodent model of metabolic syndrome compared with either treatment alone." | 7.80 | Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome. ( Jeon, Y; Jin, C; Kleven, DT; Pollock, DM; Pollock, JS; White, JJ, 2014) |
| "Experiments determined whether the combination of endothelin A (ETA) receptor antagonist [ABT-627, atrasentan; (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid] and a thiazide diuretic (chlorthalidone) would be more effective at lowering blood pressure and reducing renal injury in a rodent model of metabolic syndrome compared with either treatment alone." | 3.80 | Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome. ( Jeon, Y; Jin, C; Kleven, DT; Pollock, DM; Pollock, JS; White, JJ, 2014) |
| "Seventy patients with symptomatic carotid artery stenosis were randomized to irbesartan (300 mg/d) or chlorthalidone (50 mg/d) for 4 months before endarterectomy." | 2.71 | Blockade of the angiotensin II type 1 receptor stabilizes atherosclerotic plaques in humans by inhibiting prostaglandin E2-dependent matrix metalloproteinase activity. ( Bei, R; Bucci, M; Cipollone, F; Cuccurullo, C; Cuccurullo, F; de Cesare, D; De Luca, M; Fazia, M; Iezzi, A; Mezzetti, A; Muraro, R; Pini, B; Spigonardo, F; Ucchino, S; Zucchelli, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Jin, C | 2 |
| O'Boyle, S | 1 |
| Kleven, DT | 2 |
| Pollock, JS | 2 |
| Pollock, DM | 2 |
| White, JJ | 2 |
| Jeon, Y | 1 |
| Yamanari, H | 1 |
| Nakamura, K | 1 |
| Miura, D | 1 |
| Yamanari, S | 1 |
| Ohe, T | 1 |
| Cipollone, F | 1 |
| Fazia, M | 1 |
| Iezzi, A | 1 |
| Pini, B | 1 |
| Cuccurullo, C | 1 |
| Zucchelli, M | 1 |
| de Cesare, D | 1 |
| Ucchino, S | 1 |
| Spigonardo, F | 1 |
| De Luca, M | 1 |
| Muraro, R | 1 |
| Bei, R | 1 |
| Bucci, M | 1 |
| Cuccurullo, F | 1 |
| Mezzetti, A | 1 |
2 trials available for chlorthalidone and Innate Inflammatory Response
| Article | Year |
|---|---|
Spironolactone and chlorthalidone in uncontrolled elderly hypertensive patients treated with calcium antagonists and angiotensin II receptor-blocker: effects on endothelial function, inflammation, and oxidative stress.
Topics: Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pre | 2009 |
Blockade of the angiotensin II type 1 receptor stabilizes atherosclerotic plaques in humans by inhibiting prostaglandin E2-dependent matrix metalloproteinase activity.
Topics: Aged; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agent | 2004 |
3 other studies available for chlorthalidone and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Antihypertensive and anti-inflammatory actions of combined azilsartan and chlorthalidone in Dahl salt-sensitive rats on a high-fat, high-salt diet.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Arterial Pressure; Benzimidazoles; Chlor | 2014 |
Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antihypertensive Agents; Arterial Pressure; Atrasentan; Cell A | 2014 |