Page last updated: 2024-10-25

chlorthalidone and Hypotension, Postural

chlorthalidone has been researched along with Hypotension, Postural in 5 studies

Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (60.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Juraschek, SP	1
Simpson, LM	1
Davis, BR	1
Beach, JL	1
Ishak, A	1
Mukamal, KJ	1
Agarwal, R	1
Sinha, AD	1
Pappas, MK	1
Ammous, F	1
MILLIEZ, P	1
FRITEL, D	1
REY, LP	1
Locatelli, C	1
Conte, G	1
Palatini, P	1
Stritoni, P	1
Spandri, P	1
Braggion, M	1
Amery, AK	1
Bossaert, H	1
Fagard, RH	1
Verstraete, M	1

Clinical Trials (3)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
[NCT00000542]	Phase 3	0 participants	Interventional	1993-08-31	Completed
DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease[NCT02875886]	Phase 4	28 participants (Actual)	Interventional	2016-09-30	Completed
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933]	Phase 2	34 participants (Actual)	Interventional	2019-06-18	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-3.4
Treatment Grup	-13.5

Change in Extracellular Water

Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	litres (Mean)
Placebo	-0.15
Treatment Grup	2.55

Change in Extracellular Water / Total Body Water Ratio

Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	percentage of ECW/TBW (Mean)
Placebo	-0.24
Treatment Grup	-2.92

Change in Mean Arterial Pressure

decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-5.4
Treatment Grup	-18.1

Change in Systolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-10
Treatment Grup	-26.1

Change in the Fractional Excretion of Sodium

Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	percentage of sodium excreted (Mean)
Placebo	-0.348
Treatment Grup	0.598

Change in Total Body Water

Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	litres (Mean)
Placebo	-0.075
Treatment Grup	-4.36

Trials

2 trials available for chlorthalidone and Hypotension, Postural

Article	Year
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014
Clonidine versus methyldopa. A double blind cross-over study comparing side effects of clonidine and methyldopa administered together with chlorthalidone at a dosage producing the same blood pressure lowering effect. Acta cardiologica, 1972, Volume: 21, Issue:1 Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Consti	1972

Other Studies

3 other studies available for chlorthalidone and Hypotension, Postural

Article	Year
Effects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults: The ALLHAT Trial. Hypertension (Dallas, Tex. : 1979), 2019, Volume: 74, Issue:4 Topics: Accidental Falls; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Atenolol; Chlorthali	2019
[CLINICAL TRIAL OF A HYPOTENSIVE DRUG: 3,4-DIHYDROXY-D-L-PHENYLALANINE OR METHYLDOPA]. La Presse medicale, 1964, Oct-17, Volume: 72 Topics: Antihypertensive Agents; Chlorothiazide; Chlorthalidone; Eye Manifestations; Humans; Hydrochlorothia	1964
[A case of severe transitory postural hypotension]. Bollettino della Societa italiana di cardiologia, 1980, Volume: 25, Issue:7 Topics: Aged; Antihypertensive Agents; Brain Ischemia; Chlorthalidone; Female; Humans; Hypotension, Orthosta	1980