chlorthalidone and Hyponatremia studies

Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.

Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"To investigate differences in risk of hyponatremia between chlorthalidone and hydrochlorothiazide, adjusted for daily dose, we conducted a population-based case-control study within the Dutch IPCI (Integrated Primary Care Information) database."	7.80	Risk of hyponatremia with diuretics: chlorthalidone versus hydrochlorothiazide. ( Rodenburg, EM; Straus, SM; Stricker, BH; Sturkenboom, MC; van Blijderveen, JC; Verhamme, KM; Zietse, R, 2014)
"Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension."	7.79	Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. ( Dhalla, IA; Gomes, T; Hellings, C; Juurlink, DN; Mamdani, MM; Nagge, J; Persaud, N; Yao, Z, 2013)
"Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension."	3.79	Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. ( Dhalla, IA; Gomes, T; Hellings, C; Juurlink, DN; Mamdani, MM; Nagge, J; Persaud, N; Yao, Z, 2013)
"A 52-year-old woman developed severe hyponatremia following treatment for hypertension with chlorthalidone."	3.68	Extrapyramidal syndrome responsive to dopaminergic treatment following recovery from central pontine myelinolysis. ( Goldhammer, Y; Sadeh, M, 1993)
"She was comatose for more than a month, apparently from extrapontine myelinolysis."	1.27	Thiazide-induced hyponatremia: an unusual neurologic course. ( Frankl, O; Lieberman, P; Mozes, B; Olchovsky, D; Pines, A; Werner, D, 1986)

Research

Studies (19)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change in Diastolic Blood Pressure

Change in Extracellular Water

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (57.89)	18.7374
1990's	1 (5.26)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (21.05)	24.3611
2020's	3 (15.79)	2.80

Authors	Studies
Bensabre, S	1
Zisimopoulou, S	1
Pechère-Bertschi, A	1
Rosenberg, K	1
Ravioli, S	1
Bahmad, S	1
Funk, GC	1
Schwarz, C	1
Exadaktylos, A	1
Lindner, G	1
Liang, W	1
Ma, H	1
Cao, L	1
Yan, W	1
Yang, J	1
Dhalla, IA	1
Gomes, T	1
Yao, Z	1
Nagge, J	1
Persaud, N	1
Hellings, C	1
Mamdani, MM	1
Juurlink, DN	1
Agarwal, R	1
Sinha, AD	1
Pappas, MK	1
Ammous, F	1
van Blijderveen, JC	1
Straus, SM	1
Rodenburg, EM	1
Zietse, R	1
Stricker, BH	1
Sturkenboom, MC	1
Verhamme, KM	1
VIDAL, J	1
MIROUZE, J	1
GUIN, JJ	1
BAGROS, P	1
SIEGENTHALER, P	1
HALLER, J	1
HALLER, R	1
HAMPAI, A	1
MULLER, AF	2
GRANTHAM, JJ	1
BROWN, RW	1
SCHLOERB, PR	1
Sadeh, M	1
Goldhammer, Y	1
Radó, J	1
Csányi, P	1
Mozes, B	1
Pines, A	1
Werner, D	1
Olchovsky, D	1
Lieberman, P	1
Frankl, O	1
Curtis, J	1
Horrigan, F	1
Ahearn, D	1
Varney, R	1
Sandler, SG	1
Fichman, MP	1
Vorherr, H	1
Kleeman, CR	1
Telfer, N	1
Schmidt, P	1
Conger, JD	1
McIntyre, JA	1
Jacoby, WJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease[NCT02875886]	Phase 4	28 participants (Actual)	Interventional	2016-09-30	Completed
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933]	Phase 2	34 participants (Actual)	Interventional	2019-06-18	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	mmHg (Mean)
Placebo	-3.4
Treatment Grup	-13.5

Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Extracellular Water / Total Body Water Ratio

Intervention	litres (Mean)
Placebo	-0.15
Treatment Grup	2.55

Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Mean Arterial Pressure

Intervention	percentage of ECW/TBW (Mean)
Placebo	-0.24
Treatment Grup	-2.92

decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Systolic Blood Pressure

Change in the Fractional Excretion of Sodium

Intervention	mmHg (Mean)
Placebo	-5.4
Treatment Grup	-18.1

Intervention	mmHg (Mean)
Placebo	-10
Treatment Grup	-26.1

Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Total Body Water

Intervention	percentage of sodium excreted (Mean)
Placebo	-0.348
Treatment Grup	0.598

Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28

Article	Year
Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis. Journal of cellular and molecular medicine, 2017, Volume: 21, Issue:11 Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Chlorthalidone; Cholesterol; Diuretics; Huma	2017
[Predictable, desirable and undesirable effects of the diuretic treatment]. Schweizerische medizinische Wochenschrift, 1968, May-18, Volume: 98, Issue:20 Topics: Biological Transport; Chlorothiazide; Chlorthalidone; Diuresis; Diuretics; Ethacrynic Acid; Furosemi	1968

Article	Year
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014
Chlorthalidone for poorly controlled hypertension in chronic kidney disease: an interventional pilot study. American journal of nephrology, 2014, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Chlo	2014

Article	Year
[Hyponatremia and thiazides]. Revue medicale suisse, 2021, Sep-15, Volume: 17, Issue:750 Topics: Antihypertensive Agents; Chlorthalidone; Humans; Hyponatremia; Indapamide; Thiazides	2021
Electrolyte Disorders Common in Thiazide Diuretic Users. The American journal of nursing, 2022, 01-01, Volume: 122, Issue:1 Topics: Chlorthalidone; Cross-Sectional Studies; Humans; Hypokalemia; Hyponatremia; Sodium Chloride Symporte	2022
Risk of Electrolyte Disorders, Syncope, and Falls in Patients Taking Thiazide Diuretics: Results of a Cross-Sectional Study. The American journal of medicine, 2021, Volume: 134, Issue:9 Topics: Accidental Falls; Aged; Antihypertensive Agents; Chlorthalidone; Cross-Sectional Studies; Female; Hu	2021
Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study. Annals of internal medicine, 2013, Mar-19, Volume: 158, Issue:6 Topics: Aged; Antihypertensive Agents; Chlorthalidone; Follow-Up Studies; Hospitalization; Humans; Hydrochlo	2013
Risk of hyponatremia with diuretics: chlorthalidone versus hydrochlorothiazide. The American journal of medicine, 2014, Volume: 127, Issue:8 Topics: Adolescent; Adult; Aged; Case-Control Studies; Chlorthalidone; Diuretics; Female; Humans; Hydrochlor	2014
[HYPONATREMIC COMA DURING TREATMENT WITH SALIDIURETICS]. Marseille medical, 1963, Volume: 100 Topics: Chlorthalidone; Coma; Diet, Sodium-Restricted; Geriatrics; Hyponatremia; Pulmonary Emphysema; Toxico	1963
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS]. Vie medicale (Paris, France : 1920), 1964, Volume: 45 Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics;	1964
EFFECT OF EXPERIMENTAL SALT DEPLETION AND ALDOSTERONE LOAD ON SODIUM AND CHLORIDE CONCENTRATION IN THE SWEAT OF PATIENTS WITH CYSTIC FIBROSIS OF THE PANCREAS AND OF NORMAL CHILDREN. Archives of disease in childhood, 1964, Volume: 39 Topics: Adolescent; Aldosterone; Biochemical Phenomena; Biochemistry; Body Weight; Child; Chlorides; Chlorth	1964
ASYMPTOMATIC HYPONATREMIA AND BRONCHOGENIC CARCINOMA: THE DELETERIOUS EFFECT OF DIURETICS. The American journal of the medical sciences, 1965, Volume: 249 Topics: Carcinoma, Bronchogenic; Chlorothiazide; Chlorthalidone; Digitoxin; Diuretics; Drug Therapy; Hyponat	1965
Extrapyramidal syndrome responsive to dopaminergic treatment following recovery from central pontine myelinolysis. European neurology, 1993, Volume: 33, Issue:1 Topics: Basal Ganglia Diseases; Biperiden; Carbidopa; Chlorthalidone; Coma; Drug Therapy, Combination; Femal	1993
[Hyponatremia caused by water intoxication induced by diuretics]. Orvosi hetilap, 1989, Jan-01, Volume: 130, Issue:1 Topics: Adult; Chlorthalidone; Diuretics; Humans; Hypertension; Hyponatremia; Male; Water Intoxication	1989
Thiazide-induced hyponatremia: an unusual neurologic course. Southern medical journal, 1986, Volume: 79, Issue:5 Topics: Acute Disease; Brain Edema; Chlorthalidone; Coma; Demyelinating Diseases; Female; Humans; Hypokalemi	1986
Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma. JAMA, 1972, Jun-19, Volume: 220, Issue:12 Topics: Adult; Chlorthalidone; Dehydration; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans;	1972
Diuretic-induced hyponatremia. Annals of internal medicine, 1971, Volume: 75, Issue:6 Topics: Adult; Aged; Alkalosis; Bendroflumethiazide; Biological Assay; Blood Urea Nitrogen; Bromine; Carbon	1971
[Diuresis and diuretics]. Wiener klinische Wochenschrift, 1971, Jun-25, Volume: 83, Issue:25 Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder	1971
Central pontine myelinolysis associated with inappropriate antidiuretic hormone secretion. The American journal of medicine, 1969, Volume: 47, Issue:5 Topics: Autopsy; Chlorthalidone; Demyelinating Diseases; Female; Humans; Hypertonic Solutions; Hyponatremia;	1969

chlorthalidone and Hyponatremia